DRSC/TRiP Functional Genomics Resources

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Protein Alignment Abca3 and Abca5

DIOPT Version :10

Sequence 1:NP_608445.2 Gene:Abca3 / 33103 FlyBaseID:FBgn0031170 Length:1714 Species:Drosophila melanogaster
Sequence 2:NP_671752.2 Gene:Abca5 / 217265 MGIID:2386607 Length:1642 Species:Mus musculus


Alignment Length:1827 Identity:486/1827 - (26%)
Similarity:816/1827 - (44%) Gaps:342/1827 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 WDKFVLLLWKNWTLQWNHKWQMVIELVLPAIFSLLLVLVRTLVDTEQKGVRYYNEQNLTDLNLLQ 71
            |.:...||.||:.::...|...|.|::.|..|...|:|| :::...:|    |.|  ::|:.|  
Mouse    11 WRQTRTLLLKNYLIKCRTKKSSVQEILFPLFFLFWLILV-SMMHPNKK----YEE--VSDIEL-- 66

  Fly    72 HSLHRSSYLGKLIALIAPNRRRKNGGFSKFEFILCYSPVNPVLKKLVEEAWQSLGKNKICESENA 136
                  |.:.|               ||....||.|:||..:...:::..........|...|.|
Mouse    67 ------SPMDK---------------FSLSNVILGYTPVTNITSSIMQRVSTDHLPKVIVTEEYA 110

  Fly   137 TQLEL--DTVSKNA-FAGVQFDDAWANLTENDPLPNDFHFALRFPAELRTATIAIANTWLTMRLF 198
            .:.||  .::||:: |.||.|.|..:             :.|||..|:    |.:::.::..|  
Mouse   111 NEKELVAASLSKSSNFVGVVFKDTMS-------------YELRFFPEM----IPVSSIYMNSR-- 156

  Fly   199 PTIDLTGPRNEGDDDGGIPPGYLREGFLPLQHSLSMAYLRQK------SGEQDLPNVVMKRYPFP 257
                      ||.........|...||..||.|:..|.::.|      |..:....|:|..   .
Mouse   157 ----------EGCSKTCDAAQYWSLGFTVLQASIDAAIIQLKTNVSVWSELESTKAVIMGE---A 208

  Fly   258 AYI-FDPLLEGMSSIMSLIILLSFIYPCTYITKYITAEKEKQLKEVMKIMGLSNWLHWTAWFVKS 321
            |.: .|....|:..|..:|....|.|   ::..:|.|||||:|||.:|||||.:...|.:|.:..
Mouse   209 AVVEIDTFPRGVILIYLVIAFSPFGY---FLAIHIVAEKEKKLKEFLKIMGLHDTAFWLSWVLLY 270

  Fly   322 FIMLTISAILIAILVKINWSEDVAVLTHANFTALVFFLI--IYIVSSICFCFMMATFFSRASTAA 384
            ..::.:.::|:|::.       .|.......:::|.||:  :|.:||:.|..|:...|.::..  
Mouse   271 ASLIFLMSLLMAVIA-------TASSLFPQSSSIVIFLLFFLYGLSSVFFALMLTPLFKKSKH-- 326

  Fly   385 AVTGLIWFIAYIPYSFT------INSYDDLSLSSKLGW--SLISNTAMGFGIKLILGFEGTGEGL 441
              .|::.|...:.:.|.      |.|:     ...|.|  |.:...|...||..::..|...||.
Mouse   327 --VGVVEFFVTVVFGFVGLLIVLIESF-----PRSLVWLFSPLCQCAFLIGIAQVMHLEDFNEGA 384

  Fly   442 QWSNFFTPVSVDDTLTLGAVMIMMLVSCVIYMIICLYVEQVMPGSFGVPRPWNFPFTREFWC-GE 505
            .:||.     .:....|...:||:.:..|.|:::.:|::||:||.||:.|...:.....:|. .:
Mouse   385 LFSNL-----TEGPYPLIITIIMLALDSVFYVLLAVYLDQVIPGEFGLRRSSLYFLKPSYWSKNK 444

  Fly   506 REYTGV-EDIPNGHVEQRD-PKAFETEPEGKHI----GLQMRHLKKRFGNKMVVKGLSMNMFEDE 564
            |.|..: |...||::...: .:...:|..||..    |:| :..:|:..|...::.||.:::|.:
Mouse   445 RNYKELSEGNINGNISLNEIVEPVSSEFIGKEAIRISGIQ-KSYRKKTENVEALRNLSFDIYEGQ 508

  Fly   565 ITVLLGHNGAGKTTTISMLTGMFPPTSGTAIING---SDIRTNIEGARMSLGICPQHNVLFDEMS 626
            ||.||||:|.||:|.:::|.|:.||:.|.|.|.|   |:|....| ||..:|||||.::.||.::
Mouse   509 ITALLGHSGTGKSTLMNILCGLCPPSDGFASIYGHRVSEIDEMFE-ARKMIGICPQSDINFDVLT 572

  Fly   627 VSNHIRFFSRMKGLRGKAVEQEVAKYLKMIELEDKANVASSKLSGGMKRKLSVCCALCGDTKVVL 691
            |..::...:.:||:....:.|||.|.|..::::...:..:.|||||.||||||..|:.|:.|::|
Mouse   573 VEENLSILASIKGIPANNIIQEVQKVLLDLDMQAIKDNQAKKLSGGQKRKLSVGIAVLGNPKILL 637

  Fly   692 CDEPSSGMDPSARRQLWDLLQQEKVGRTLLLTTHFMDEADVLGDRIAIMCDGELKCQGTSFFLKK 756
            .|||::||||.:|..:|:||:..|..|..:.:||||||||:|.||.|::..|.|||.|:|.|||.
Mouse   638 LDEPTAGMDPCSRHIVWNLLKYRKANRVTVFSTHFMDEADILADRKAVISQGMLKCVGSSIFLKS 702

  Fly   757 QYGSGYRLICVKRDDCETNEVTALLNKYIPGLKPECDIGAELSYQLPDSASAKFEEMFGQLEEQS 821
            ::|.||||.......|.|..:::|:.::||..........:|.|.||.....||..:|..|:..|
Mouse   703 KWGIGYRLSMYIDRYCATESLSSLVRQHIPAAALLQQNDQQLVYSLPFKDMDKFSGLFSALDIHS 767

  Fly   822 DELHLNGYGVGITSMEEVFMKVGAEKDNTGNIKDQHEIMNGGSGFRGEDDNESVQSDGIFSENRR 886
            : |.:..|||.:|::|:||:|:..|.:     .||.:.    |.|..:...|...|.. |.|   
Mouse   768 N-LGVISYGVSMTTLEDVFLKLEVEAE-----IDQADY----SVFTQQPREEETDSKS-FDE--- 818

  Fly   887 LLQGLQLLS----------NQWKAML----------LKKFLYTWRNKLLLLIQNIMPVFFVVVTI 931
            :.|.|.:||          :.||..:          ||:...:.|..||||:     :||.|...
Mouse   819 MEQSLLILSETKASSVSTMSLWKQQVSTIAKFHFLSLKRESKSVRAVLLLLL-----IFFAVQIF 878

  Fly   932 LIIKTQGTFQELKPITISLTQYPLAVTVLDRSN-------VQNGTGYEIANKYEDLARSYGSNYG 989
            :..........:.||.:....|.|...  |:.:       :||.|..:|....|..|.       
Mouse   879 MFFLHHSFKNAVVPIKLVPDLYFLKPG--DKPHKYKTSLLLQNSTDSDINGLIEFFAH------- 934

  Fly   990 LELTGTQGFEDYILDLGKTIQVRI--NSRYLVAA------TITESK----ITAWLNNQALHTAPL 1042
                             :.|.|.:  :|.|:.||      .:..|:    .:|..|:..::..|:
Mouse   935 -----------------QNIMVAMFNDSDYVSAAPHSAALNVVRSEKDYVFSAVFNSTMVYCLPV 982

  Fly  1043 TVNMVHNAIADKLFGSSVKIQVTNAPLPYTTSTLLSQLSTGNNLGTQLASNLCFCMCFVSSIYIL 1107
            .:|::.|...       ..:.||.|  ..|.||...|..|......:|..........|:::...
Mouse   983 MMNIISNYYL-------YHLNVTEA--IQTWSTPFIQEITDIVFKIELYFQAALLGIIVTAMPPY 1038

  Fly  1108 FLIKERESRAKLLQF----VGGVKVWTFWLSQFICDFASYIVTALIVVITIVCFQETGLSTFGEL 1168
            |.::..|:. |:..:    :.|:....:|:.|.:.|...:.|..::::.::..|..         
Mouse  1039 FAMENAENH-KIKAYTQLKLSGLLPSAYWVGQAVVDIPLFFVVLILMLGSLFAFHH--------- 1093

  Fly  1169 GRYY---------LLLLLFGFAVLPFIYIMSLFFREPATGFARVSIVN-------IFCGMALFIV 1217
            |.|:         ..|:.:..:|:.|.||.|..|::         |:|       |:...||..|
Mouse  1094 GLYFYPAKFLAVVFCLIAYVPSVILFTYIASFTFKK---------ILNTKEFWSFIYSVTALACV 1149

  Fly  1218 VVVMSSELFDTKDTADILGWIFRIFPHFSLAMSLNKVYTNTATRNACAKAGALPPILLCEL---- 1278
            .:..::.......||        :| |::..::: .:|                |:|.|.:    
Mouse  1150 AITETTFFLQYAVTA--------VF-HYTFCIAI-PIY----------------PLLGCLISFIK 1188

  Fly  1279 -----VPQCCNLKPYFAWEEPGVLPETVYMAVTGVVFFLIII-----VLEFRLINELMFKIRQLI 1333
                 :|:  |...|..|:.   |...|.|.....:.::.::     :...|.|.:..| .|.|.
Mouse  1189 GSWKNMPK--NENTYNPWDR---LLVAVIMPYLQCILWIFLLQHYEKIHGGRSIRKDPF-FRALS 1247

  Fly  1334 SKP-----PPPPTEGQLDDDVANERERILQMSSNELATKN--LVLDRVTKYYG---QFM------ 1382
            .|.     |.||.....|:||..||.::.::...:...:.  :::..:.|.|.   .|:      
Mouse  1248 QKAKNKKFPEPPINEDEDEDVKAERLKVKELMGCQCCEEKPAIMVCNLHKEYDDKKDFLHSRKTT 1312

  Fly  1383 --AVNQVSLCVQEVECFGLLGVNGAGKTTTFKMMTGDERISSGAAYVQGL-SLESNMNSIYKMIG 1444
              |...:|.||::.|..||||.|||||:|....:.||...:||..::... |..|..:...|.:|
Mouse  1313 KVATKYISFCVKKGEILGLLGPNGAGKSTVINTLVGDVEPTSGKIFLGDYGSHSSEDDESIKCMG 1377

  Fly  1445 YCPQFDALLDDLTGREVLRIFCMLRGVQESRIRQLSEDLAKSFGFMKHIDKQTHAYSGGNKRKLS 1509
            ||||.:.|..|||.:|...|:..::|:....::::...:.|:....:|:.|.......|.||||.
Mouse  1378 YCPQTNPLWPDLTLQEHFEIYGAVKGMSPGDMKEVISRITKALDLKEHLQKTVKKLPAGIKRKLC 1442

  Fly  1510 TAIAVIGSPSVIYLDEPTTGMDPAARRQLWNMV-CRIRDSGKSIVLTSHSMEECEALCTRLAIMV 1573
            .|::::|:|.|..||||:|||||.|::.:|..: ...::..::.:||:|.|||.||:|.|:||||
Mouse  1443 FALSMLGNPQVTLLDEPSTGMDPRAKQHMWRAIRTAFKNKKRAALLTTHYMEEAEAVCDRVAIMV 1507

  Fly  1574 NGEFKCIGSTQHLKNKFSKGLILKIKVRRNLEALRQARLSGGYARNPDEQTVPAQMSQRDIDAVK 1638
            :|:.:|||:.||||:||.||..|:||::..:|.|...||                  ||:|..: 
Mouse  1508 SGQLRCIGTVQHLKSKFGKGYFLEIKLKDWIENLEIDRL------------------QREIQYI- 1553

  Fly  1639 EFVETEYPNSILQEEYQGILTFYIPLTGVK-WSRIFGLMESNRDQLNVEDYSVSQTTLEEIFLEF 1702
                  :||:..||.:..||.|.||...|: .|:.|..:|..:....:|:||.||.|||::|:|.
Mouse  1554 ------FPNASRQESFSSILAFKIPKEDVQSLSQSFAKLEEAKRTFAIEEYSFSQATLEQVFVEL 1612

  Fly  1703 AKYQRED 1709
            .|.|.|:
Mouse  1613 TKEQEEE 1619

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Abca3NP_608445.2 rim_protein <137..1708 CDD:130324 455/1694 (27%)
Abca5NP_671752.2 rim_protein <84..1618 CDD:130324 459/1721 (27%)

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