Protein Alignment ABCA and Abca9

DIOPT Version :9

• Sequence 1: NP_608445.2
• Gene: ABCA / 33103
• FlyBaseID: FBgn0031170
• Length: 1714
• Species: Drosophila melanogaster
• Sequence 2: NP_671753.2
• Gene: Abca9 / 217262
• MGIID: 2386796
• Length: 1623
• Species: Mus musculus
• Alignment Length: 1872
• Identity: 461/1872 - (24%)
• Similarity: 809/1872 - (43%)
• Gaps: 458/1872 - (24%)

  Fly    13 LLWKNWTLQWNHKWQMVIELVLPAIFSLLLVLVRTLVDTEQKGVRYYNEQNLTDLNLLQHSLHRS 77
            ||.|||.    .|::|..|.:|..:|||||:|....:.:....|....|.::.||..:.:
Mouse    15 LLCKNWL----RKFRMRRETLLEWLFSLLLILFVYQLSSNLHQVHDAPEMSVVDLGRVDN----- 70

  Fly    78 SYLGKLIALIAPNRRRKNGGFSKFEFILCYSP----VNPVLKKLVEEAWQSLGKNKICESENATQ 138
                                |:...:::.::|    .:.::.|:....:.. |:..:...:..:.
Mouse    71 --------------------FNDSNYMMVFAPESEATHEIMNKVASAPFMK-GRTIVACPDEKSM 114

  Fly   139 LELDTVSKNAFAGVQFDDAWANLTENDPLPNDFHFALRFPAELRTATIAIANTWLTMRLFPTIDL 203
            .|||.........|.|.|.             |.:.|:|             :| ..|:
Mouse   115 NELDLNYSIDAVRVIFKDT-------------FSYHLKF-------------SW-GQRI------ 146

  Fly   204 TGPRNEGDDDGGIP------------PGYLREGFLPLQHSLS---MAYLRQKSGEQDLPNVV--- 250
              |:.:...|...|            ..:..:||:..|.:::   :..:...|..::|.:|:
Mouse   147 --PKTKEHKDHSAPCEPLNNKMICENSAFWEKGFVAFQAAINAGIIEMITNHSVMEELMSVIGSN 209

  Fly   251 MKRYPFPA--------YIFDPLLEGMSSIMSLIILLSFIYPCTYITKYITAEKEKQLKEVMKIMG 307
            ||..||.|        :||          ..:|...|.||   |::..||.|:: .:..:|.:||
Mouse   210 MKMPPFIAQGGVATDFFIF----------FCVISFSSLIY---YLSVNITQERQ-YMTTLMAMMG 260

  Fly   308 LSNWLHWTAWFVKSFIMLTISAILIAILVKINWSEDVAVLTHANFTALVFFLIIYIVSSICFCFM 372
            |.....|.:|.:.....:.:.|:|::::||   |..|.|||  .|..:....:.|.:|.|...|:
Mouse   261 LRESAFWLSWSLMYAGFILVVAVLMSLIVK---SAQVVVLT--GFMVVFLLFLFYGLSLITLSFL 320

  Fly   373 MATFFSRASTAAAVTGLIWFI------------------AYI--------PYSFTINSYDDLSLS 411
            |:....:    ..:|||..||                  |::        |::||..    ::..
Mouse   321 MSVLIKK----PFLTGLAIFILTVFWGSLGFTALYKHLPAFVEWTLCFLSPFAFTTG----MAQL 377

  Fly   412 SKLGWSLISNTAMGFGIKLILGFEGTGEGLQWSNFFTPVSVDDTLTLGAVMIMMLVSCVIYMIIC 476
            ..|.:.:.||..:.                         |.:::..:.|.:.|:::..::|:::.
Mouse   378 IHLDYDVNSNVNLN-------------------------SPNNSYLIMATLFMLVLDALLYLVLA 417

  Fly   477 LYVEQVMPGSFGVPRPWNFPFTREFWCGEREYTGVEDIPNGHVEQRDPKAFET-EP-----EGKH 535
            ||.:::....:|..|...|.....:|...|   |...:...:....||...:: ||     :||.
Mouse   418 LYFDKITLSKYGHQRSPLFFLKSSYWFKRR---GASHVVLENEIDSDPSLNDSLEPVSPEFQGKE 479

  Fly   536 IGLQMRHLKKRFGNK----MVVKGLSMNMFEDEITVLLGHNGAGKTTTISMLTGMFPPTSGTAII 596
             .:::::|||.:..|    ..::||..:::|.:||.||||:||||||.|:.|:|:.|||:|:..|
Mouse   480 -AIRIKNLKKEYSGKHGKVEALRGLGFDIYEGQITALLGHSGAGKTTLINTLSGLSPPTTGSVTI 543

  Fly   597 NGSDI--RTNIEGARMSLGICPQHNVLFDEMSVSNHIRFFSRMKGLRGKAVEQEVAKYLKMIELE 659
            ....:  ..:.:......|:|||.||.|..::|..::|.|:::||:....|||||.:.|:.:|:|
Mouse   544 YNQTVSEMDDSDAVLTITGVCPQSNVQFGFLTVRENLRLFAKIKGILPHEVEQEVQQVLQDLEME 608

  Fly   660 DKANVASSKLSGGMKRKLSVCCALCGDTKVVLCDEPSSGMDPSARRQLWDLLQQEKVGRTLLLTT 724
            :..::.:..||||.||||::..|:.||.:|:|.|||::|:||.:|.::|:||::.:.||.::.:|
Mouse   609 NIQDILAQNLSGGQKRKLTLGIAILGDPQVLLLDEPTAGLDPLSRHRIWNLLKERRAGRVIVFST 673

  Fly   725 HFMDEADVLGDRIAIMCDGELKCQGTSFFLKKQYGSGYRLICVKRDDCETNEVTALLNKYIPGLK 789
            .||||||:|.||...:.:|.|||.|:|.||||::|.||.|.....:.|:...:|:|:.|:|...:
Mouse   674 QFMDEADILADRKVFISNGRLKCAGSSLFLKKKWGIGYHLSLHLNEACDPEGITSLVKKHISDAR 738

  Fly   790 PECDIGAELSYQLPDSASAKFEEMFGQLEEQSDELHLNGYGVGITSMEEVFMKVGAEKDNTGNIK 854
            ........|.|.||...:.||.:::..|:..|:: .:..|||.:|::.|||:|:..:     ::.
Mouse   739 LTTQSEERLVYILPLERTNKFPDLYRDLDRCSNQ-GIEDYGVSMTTLNEVFLKLEGK-----SMA 797

  Fly   855 DQHEIMNGGSGFRGEDDNESVQSDGIFSENRRLLQGLQLLSNQ-----------WKAML-----L 903
            |:.::     |..|.     :||||. .:...|::..|:||..           |:..|     :
Mouse   798 DESDV-----GICGR-----LQSDGA-RDMESLVELEQVLSLDSSGSSVSGMALWRQQLCAVAKV 851

  Fly   904 KKFLYTWRNKLLLLIQNIMPVFFV--VVTILIIKT--QGTFQELKPITISLT-----QYPLAVTV 959
            :.|......|.|:.:..:..:.||  ::..|:.|.  :.....|.|....|:     |.||...:
Mouse   852 RFFKLKNERKSLMTVLLLFGISFVPQLLEHLVYKVYHKSYSWGLSPSMYFLSPGQPPQDPLTHLL 916

  Fly   960 LDRSNVQNGTGYEIANKYEDLARSYGSNYGLELTGTQ-GFEDYILDLGKTIQVRINS-RYLVAAT 1022
                 |.|.||..|.| :....|..|....|:..||: |.|:.:.:...|:.....: |:.||.
Mouse   917 -----VINRTGSSIDN-FVHALRQQGIALDLDALGTRNGTEEALYNGAITVLGEEKALRFSVAC- 974

  Fly  1023 ITESKITAWLNNQALHTAPLTVNMVHNAIADKLFGSSVKIQ-----------------VTNA--- 1067
                      |.:.|:..|:.::::.|.:.. :|.||.:||                 ::||
Mouse   975 ----------NAKRLNCFPVLMDIISNGLLG-IFNSSERIQTDRSTVFEEHMLYEYGFMSNAFFW 1028

  Fly  1068 -PL-----PYTT--------STLLSQLSTGNNLGTQLASNLCFCMCFVSSIY--ILFLIKERESR 1116
             |:     ||..        ..:||||.|.   |...::..|........||  ||||::..:|.
Mouse  1029 IPVAASLTPYIAMGSISDHKKKVLSQLWTS---GLYPSAYWCGQALVDIPIYFLILFLMQIMDSV 1090

  Fly  1117 AKLLQFVGGVKVWTFWLSQFICD--------FASYIVTAL--------------IVVITIVCFQE 1159
            ....:|   :.|....|.|..|.        |.:|:::.:              .:::||.....
Mouse  1091 FSSEEF---ISVMESLLIQIPCSIGYASSLIFMTYVISFIFRNGRKNSGIWSFFFLIVTIFFIIA 1152

  Fly  1160 TGLSTFGELGRYYLLLLLFGFAVLPFIYIMSLFFREPATGFARVSIVNIFCGMALFIVVVVMSSE 1224
            |.::.:|     :|.||:..|.|.||..|.||..      |:.||.
Mouse  1153 TDINEYG-----FLELLICTFLVPPFTLIGSLLI------FSEVSY------------------- 1187

  Fly  1225 LFDTKDTADILGWIFRIFPHFSLAMSLNKVYTNTATRNACAKAGALPPILLCELVPQCCNLKPYF 1289
                 |:.|.||                     |:....         :.|..|:|
Mouse  1188 -----DSVDYLG---------------------TSESQL---------VFLALLIP--------- 1208

  Fly  1290 AWEEPGVLPETVYMAVTGVVFFLIIIVLEFRLINELMFKIRQLISKPP------PPPTE-GQLDD 1347
                        |:..  ::||.|:..|| |.:.:...::..:....|      |.|.| |:.|:
Mouse  1209 ------------YLHF--LLFFFILRCLE-RYLRKKSLRVDPVFRISPRSCPAVPNPEEPGEEDE 1258

  Fly  1348 DVANERERIL-QMSSNELATKNLVLDRVTK--YYGQF----------MAVNQVSLCVQEVECFGL 1399
            ||..||.|.. .|::.:...|.:::....:  |.|:.          :|...:|.||::.|..||
Mouse  1259 DVQMERVRTTGAMATLQTDEKPVIIASCLRKEYIGRTKRCFSKMKKKIATRNISFCVKKGEVLGL 1323

  Fly  1400 LGVNGAGKTTTFKMMTGDERISSGAAYVQGLSLESNMNSIYKMIGYCPQFDALLDDLTGREVLRI 1464
            ||.|||||:||..|:|||...::|..:::|    |...:....:|||||.:.|..:||.:|.|.:
Mouse  1324 LGHNGAGKSTTISMITGDTIPTAGQVFLKG----SGGGAALGFLGYCPQENVLWPNLTVKEHLEL 1384

  Fly  1465 FCMLRGVQESRIRQLSEDLAKSFGFMKHIDKQTHAYSGGNKRKLSTAIAVIGSPSVIYLDEPTTG 1529
            :..::|:::.........|..:.....|:.......|.|.||||...::::|:|.|:.||||:||
Mouse  1385 YAAVKGLKKKDAVVTITRLVNALKLQDHLKALVRTLSEGVKRKLCFVLSILGNPPVVLLDEPSTG 1449

  Fly  1530 MDPAARRQLWNMV-CRIRDSGKSIVLTSHSMEECEALCTRLAIMVNGEFKCIGSTQHLKNKFSKG 1593
            |||..::|:|..: ....::.:..:||:|.|.|.||:|.|:||||:|..:||||.||||:||.|.
Mouse  1450 MDPEGQQQMWQAIRATFTNTERGALLTTHYMAEAEAVCDRVAIMVSGRLRCIGSIQHLKSKFGKD 1514

  Fly  1594 LILKIKVRRNLEALRQARLSGGYARNPDEQTVPAQMSQRDIDAVKEFVETEYPNSILQEEYQGIL 1658
            .:|::||:                       .|:|:...:.:.::.|     |.:..||.|..::
Mouse  1515 YLLEMKVK-----------------------TPSQVEPLNTEIMRLF-----PQAARQERYSSLM 1551

  Fly  1659 TFYIPLTGVK-WSRIFGLMESNRDQLNVEDYSVSQTTLEEIFLEFAKYQRED 1709
            .:.:|:..|: .|..|..:|..::..::|:||:||:|||::|||.:|.|..|
Mouse  1552 VYKLPVEDVRPLSEAFFKLERLKENFDLEEYSLSQSTLEQVFLELSKEQELD 1603

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ABCA	NP_608445.2	ABC2_membrane_4	254..434	CDD:289500	46/213 (22%)
		ABC2_membrane_3	<269..475	CDD:289468	45/231 (19%)
		CcmA	538..843	CDD:224054	116/310 (37%)
		ABC_subfamily_A	538..755	CDD:213230	89/222 (40%)
		ABC2_membrane_3	913..1316	CDD:289468	93/471 (20%)
		ABC_subfamily_A	1369..1587	CDD:213230	78/230 (34%)
		drrA	1376..1702	CDD:130256	108/339 (32%)
Abca9	NP_671753.2	rim_protein	<128..1600	CDD:130324	433/1724 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838507
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.650