DRSC/TRiP Functional Genomics Resources

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Protein Alignment Abca3 and Abca8a

DIOPT Version :10

Sequence 1:NP_608445.2 Gene:Abca3 / 33103 FlyBaseID:FBgn0031170 Length:1714 Species:Drosophila melanogaster
Sequence 2:XP_006533124.3 Gene:Abca8a / 217258 MGIID:2386846 Length:1653 Species:Mus musculus


Alignment Length:1845 Identity:461/1845 - (24%)
Similarity:813/1845 - (44%) Gaps:408/1845 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    13 LLWKNWTLQWNHKWQMVIELVLPAIFSLLLVLVRTLVDTEQKGVRYYNEQNLTDLNLLQHSLHRS 77
            ||.||...:...|....:|.:..|:..|.|:|...|.:.       |:..:|.|::         
Mouse    49 LLCKNLLRKKRLKRDTFLEFLYTALILLSLILFLQLHEV-------YDFSSLPDVD--------- 97

  Fly    78 SYLGKLIALIAPNRRRKNGGFSKFEFILCYSPVNPVLKKLVEEAWQSL-----GKNKICESENAT 137
              ||::            ..|:...|::.|:|:.|..:::::..  ||     |:..:.......
Mouse    98 --LGRI------------DSFNDSTFMIVYTPITPTTQRIMDRV--SLVSYMTGRKILASPNEEN 146

  Fly   138 QLELDTVSKNAFAGVQFDDAWANLTENDPLPNDFHFALRFPAELRTATIAIANTWLTMRLFPTID 202
            ..||.::..:...||.|.:|::             :.|:|   ::.|.|            ||| 
Mouse   147 MTELISMRFSDVVGVIFTNAYS-------------YNLKF---IKGARI------------PTI- 182

  Fly   203 LTGPRNEGDDDGGIPPGY-----------LREGFLPLQHSLSMAYLR---QKSGEQDLPNVVMKR 253
                 .|..|.......|           .|:||:.||.:::.|.:.   ..|..:::.::..|.
Mouse   183 -----KEHQDHTAHCHSYGEIIYCGLSEFWRDGFVALQAAINAAIIEVTTNHSVMEEMMSLTGKY 242

  Fly   254 YPFPAYIFDPLLEGMSSIMSLIILLSFIYPCTYITKYITA---EKEKQLKEVMKIMGLSNWLHWT 315
            ....:::..   ||.::...|...:....|.||   ||:|   .:.|::|.:|.:|||.:...|.
Mouse   243 IKIDSFVGQ---EGTTTDCFLFFCIIRFSPLTY---YISAGVTRERKKMKGLMAVMGLRDSAFWL 301

  Fly   316 AWFVKSFIMLTISAILIAILVKINWSEDVAVLTHANFTALVFFLII------YIVSSICFCFMMA 374
            :|.:...:::.:..:|...:||:           ..|..|..|::|      |.:|.|...|:|:
Mouse   302 SWGLLYGVIVFVVTLLSTTIVKL-----------VQFVFLTGFMVIFSLFFFYGLSLISLSFLMS 355

  Fly   375 TFFSRASTAAAVT-------GLIWFIA---YIPYSFTINSYDDLSLSSKLGW--SLISNTAMGFG 427
            ....::.....|.       |.:.|.|   |:|.|              |.|  ||:|..|...|
Mouse   356 VLLKKSFLTDLVVFLLTVSCGSLGFTALYRYLPVS--------------LEWLLSLLSPFAFMLG 406

  Fly   428 -IKLI-LGFEGTGEGLQWSNFFTPVSVDDTLTLGAVMIMMLVSCVIYMIICLYVEQVMPGSFGVP 490
             ::|: |.::.........|   |..|..|:      .|:....|.|:::..|.|:|:|..:|..
Mouse   407 MVQLLRLDYDVNSNADPMGN---PNEVIGTI------FMLFFDGVFYLLLTFYFEKVLPSEYGRR 462

  Fly   491 RPWNFPFTREFWCG-----------EREYTGVEDIPNGHVEQRDPKAFE---TEPEGKHIGLQMR 541
            .|..|.....||.|           |.:|...:|            :||   .|..||. .:::|
Mouse   463 HPPLFFLKSSFWSGQNPANRTALDNETDYEFSDD------------SFEPVSMEFHGKE-AIRIR 514

  Fly   542 HLKKRFGNKM----VVKGLSMNMFEDEITVLLGHNGAGKTTTISMLTGMFPPTSGTAIINGSDI- 601
            :|.|.:..|.    .:|.|::::::.:||.:|||:||||:|.:::|:|:..||.|...|:.:.: 
Mouse   515 NLTKDYIQKSKRTEALKDLTLDVYKGQITAILGHSGAGKSTLLNVLSGLCVPTKGWVTIHNNKLS 579

  Fly   602 -RTNIEGARMSLGICPQHNVLFDEMSVSNHIRFFSRMKGLRGKAVEQEVAKYLKMIELEDKANVA 665
             .|::|......|:|||.||.||.::|..::|.|:::||::...|:.||.:.|..:::::..|:.
Mouse   580 EMTDLENISKLTGVCPQCNVQFDFLTVRENLRLFAKIKGIQAHEVDNEVQRVLLELDMKNTQNIL 644

  Fly   666 SSKLSGGMKRKLSVCCALCGDTKVVLCDEPSSGMDPSARRQLWDLLQQEKVGRTLLLTTHFMDEA 730
            ...||||.||||:...|:.||.::.|.|||::|:||.:|.::|:.|::.:..|.:|.:|.|||||
Mouse   645 VQNLSGGQKRKLTFGIAILGDPQIFLLDEPTAGLDPFSRHRVWNFLKERRADRVVLFSTQFMDEA 709

  Fly   731 DVLGDRIAIMCDGELKCQGTSFFLKKQYGSGYRLICVKRDDCETNEVTALLNKYIPGLKPECDIG 795
            |:|.||...:..|:|||.|:|.||||::|.||.|.....:.|....:|:|:.::||..|...:..
Mouse   710 DILADRKVFISKGKLKCAGSSLFLKKKWGIGYHLSLQLSETCVHERITSLVKQHIPDSKLSAESE 774

  Fly   796 AELSYQLPDSASAKFEEMFGQLEEQSDELHLNGYGVGITSMEEVFMKV-GAEKDNTGNIKDQHEI 859
            .:|||.||...:.||.:::..| |:|.:|.:..|||.||::.|||:|: |....:..:|....::
Mouse   775 GKLSYILPLERTNKFPDLYRDL-ERSPDLGIENYGVSITTLTEVFLKLEGKSSIDQSDIGMTEDV 838

  Fly   860 MNGGSGFRGEDDNESVQSDGIFSENRRLLQ----------GLQLLSNQWKAMLLKKFLYTWRNK- 913
            ..||:           :|...|:|..:|:.          |:.|...|..|:...:||.....: 
Mouse   839 QAGGA-----------RSPERFAEVEQLVSLLNGRCKMKGGMALWWQQLCAVTRLRFLKLKHERK 892

  Fly   914 ---LLLLIQNIMPVFFVVVTILIIKTQGTF-QELKPITISLT-----QYPLAVTVLDRSNVQNGT 969
               :|:|:..|..:..:...|..:..|..: .||.|....||     |.||...:     :.|.|
Mouse   893 SIVILILVLGIGLLHILSANIYRMVRQSDYCWELAPHMYFLTPGQQPQPPLTNLL-----IVNKT 952

  Fly   970 GYEIANKYEDLARSYGSNYGLELT--GTQ-GFEDYILDLGKTIQVRINSRYLVAATITESKITAW 1031
            |.:|.:....|.:   .|..||:.  ||: |.||          .:.|...:::........|..
Mouse   953 GAKIDDFIHSLEQ---QNIALEVDAFGTRNGTED----------SQYNGAIILSGDEKNYNFTLA 1004

  Fly  1032 LNNQALHTAPLTVNMVHNAIADKLFGSSVKIQVTNAPLP---------YTTSTLLSQLSTGNNLG 1087
            .|.:.|:..|:.|::|.|.:.. ||..|..||...:..|         |.....|..|       
Mouse  1005 CNTKRLNCFPVLVDIVSNGLLG-LFAPSAHIQTDRSTFPEENDHRKFDYLAYFFLWVL------- 1061

  Fly  1088 TQLASNLCFCMCFVSSIYILFLIKERESRAKLLQFVGGVKVWTFWLSQFICDFASYIVTALIVVI 1152
                     .|..|.....:..|.:.::||:...::.|:....:|..|.:.:...|  .|||:.|
Mouse  1062 ---------LMACVPPYISMTSIDDYKNRAQFQLWISGLSPSAYWFGQALFEVPVY--CALILSI 1115

  Fly  1153 TIVCFQETGLSTFGELGRYYLLLLLFG---FAVLPFIYIMSLFFREPATG-------FARVS--- 1204
            .|..:......:...:|..::.:|..|   .:|:...|::|..:|:....       |..||   
Mouse  1116 FIAFYASAPPESKFTVGDLFIQILYVGGYAMSVIFMTYVISFIYRKGRKNSGLWSLCFYIVSFFS 1180

  Fly  1205 ----IVNIFCGMALFIVVVVMSSEL--------FDTKDTADILGWIFRIFPHFSLAMSLNKVYTN 1257
                :::.|..::||:::.::....        |:.::.::|   ||.....:|...        
Mouse  1181 MCFMLIDYFRDISLFVLIALVPPATLGGCTLLHFENREFSEI---IFEPEREYSYLF-------- 1234

  Fly  1258 TATRNACAKAGALPPILLCELVPQCCNLKPYFAWEEPGVLPETVYMAVTGVVFFLIIIVLEFR-- 1320
                       .|.|:|             :||                  :|.:|:..:|.:  
Mouse  1235 -----------FLAPLL-------------HFA------------------IFVVILRCMERKFG 1257

  Fly  1321 ---LINELMFKIR----QLISKPPPPPTEGQLDDDVANERERILQMSSNELATKN------LVLD 1372
               :..:.:|:|.    ::.:.|..|..|   |:||:.||    ..::|.|.:.:      ::..
Mouse  1258 MKTMRTDPVFRISPRSDRVFNNPEDPDGE---DEDVSQER----VWTANALTSADFQEKPAIIAS 1315

  Fly  1373 RVTKYY-----------GQFMAVNQVSLCVQEVECFGLLGVNGAGKTTTFKMMTGDERISSGAAY 1426
            .:.|.|           .:.:|...:|.||::.|..||||.|||||:|:.||:||:.:.|:|...
Mouse  1316 CLRKEYKGKKKCFVLKSKKKIATRNISFCVRKGEVVGLLGHNGAGKSTSIKMITGETKPSAGQVL 1380

  Fly  1427 VQGLSLESNMNSIYKMIGYCPQFDALLDDLTGREVLRIFCMLRGVQESRIRQLSEDLAKSFGFMK 1491
            ::|    |:.......:|||||.:||..:||.||.|.||..::|:::|......|.||.:.....
Mouse  1381 LKG----SSTGDTPGFLGYCPQENALWLNLTVREHLEIFAAIKGMRKSDANVAIERLADALKLQD 1441

  Fly  1492 HIDKQTHAYSGGNKRKLSTAIAVIGSPSVIYLDEPTTGMDPAARRQLWNMV-CRIRDSGKSIVLT 1555
            .:.......|.|.||||...::::|:|||:.||||:|||||..::|:|..: ....::.:..:||
Mouse  1442 QLKSPVKTLSEGVKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQAIQATFSNTERGALLT 1506

  Fly  1556 SHSMEECEALCTRLAIMVNGEFKCIGSTQHLKNKFSKGLILKIKVRRNLEALRQARLSGGYARNP 1620
            :|.|.|.||:|.|:||||:|..:||||.||||:||.|..:|::||:                   
Mouse  1507 THYMAEAEAVCDRVAIMVSGRLRCIGSIQHLKSKFGKEYLLEMKVK------------------- 1552

  Fly  1621 DEQTVPAQMSQRDIDAVKEFVETEYPNSILQEEYQGILTFYIPLTGVK-WSRIFGLMESNRDQLN 1684
                .|:|:...:.:.::.|     |.:..||.|..::.:.:|...|: .|:.|..:|:.:...:
Mouse  1553 ----TPSQVEPLNTEIMRLF-----PQAARQERYSSLMVYKLPREDVQPLSQAFFKLETVKQSFD 1608

  Fly  1685 VEDYSVSQTTLEEIFLEFAKYQRED 1709
            :|:||:||:|||::|||.:|.|..|
Mouse  1609 LEEYSLSQSTLEQVFLELSKEQELD 1633

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Abca3NP_608445.2 rim_protein <137..1708 CDD:130324 436/1713 (25%)
Abca8aXP_006533124.3 rim_protein <258..1630 CDD:130324 409/1562 (26%)

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