DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ABCA and Abca8a

DIOPT Version :9

Sequence 1:NP_608445.2 Gene:ABCA / 33103 FlyBaseID:FBgn0031170 Length:1714 Species:Drosophila melanogaster
Sequence 2:XP_006533124.3 Gene:Abca8a / 217258 MGIID:2386846 Length:1653 Species:Mus musculus


Alignment Length:1845 Identity:461/1845 - (24%)
Similarity:813/1845 - (44%) Gaps:408/1845 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    13 LLWKNWTLQWNHKWQMVIELVLPAIFSLLLVLVRTLVDTEQKGVRYYNEQNLTDLNLLQHSLHRS 77
            ||.||...:...|....:|.:..|:..|.|:|...|.:.       |:..:|.|::         
Mouse    49 LLCKNLLRKKRLKRDTFLEFLYTALILLSLILFLQLHEV-------YDFSSLPDVD--------- 97

  Fly    78 SYLGKLIALIAPNRRRKNGGFSKFEFILCYSPVNPVLKKLVEEAWQSL-----GKNKICESENAT 137
              ||::            ..|:...|::.|:|:.|..:::::..  ||     |:..:.......
Mouse    98 --LGRI------------DSFNDSTFMIVYTPITPTTQRIMDRV--SLVSYMTGRKILASPNEEN 146

  Fly   138 QLELDTVSKNAFAGVQFDDAWANLTENDPLPNDFHFALRFPAELRTATIAIANTWLTMRLFPTID 202
            ..||.::..:...||.|.:|::             :.|:|   ::.|.|            ||| 
Mouse   147 MTELISMRFSDVVGVIFTNAYS-------------YNLKF---IKGARI------------PTI- 182

  Fly   203 LTGPRNEGDDDGGIPPGY-----------LREGFLPLQHSLSMAYLR---QKSGEQDLPNVVMKR 253
                 .|..|.......|           .|:||:.||.:::.|.:.   ..|..:::.::..|.
Mouse   183 -----KEHQDHTAHCHSYGEIIYCGLSEFWRDGFVALQAAINAAIIEVTTNHSVMEEMMSLTGKY 242

  Fly   254 YPFPAYIFDPLLEGMSSIMSLIILLSFIYPCTYITKYITA---EKEKQLKEVMKIMGLSNWLHWT 315
            ....:::..   ||.::...|...:....|.||   ||:|   .:.|::|.:|.:|||.:...|.
Mouse   243 IKIDSFVGQ---EGTTTDCFLFFCIIRFSPLTY---YISAGVTRERKKMKGLMAVMGLRDSAFWL 301

  Fly   316 AWFVKSFIMLTISAILIAILVKINWSEDVAVLTHANFTALVFFLII------YIVSSICFCFMMA 374
            :|.:...:::.:..:|...:||:           ..|..|..|::|      |.:|.|...|:|:
Mouse   302 SWGLLYGVIVFVVTLLSTTIVKL-----------VQFVFLTGFMVIFSLFFFYGLSLISLSFLMS 355

  Fly   375 TFFSRASTAAAVT-------GLIWFIA---YIPYSFTINSYDDLSLSSKLGW--SLISNTAMGFG 427
            ....::.....|.       |.:.|.|   |:|.|              |.|  ||:|..|...|
Mouse   356 VLLKKSFLTDLVVFLLTVSCGSLGFTALYRYLPVS--------------LEWLLSLLSPFAFMLG 406

  Fly   428 -IKLI-LGFEGTGEGLQWSNFFTPVSVDDTLTLGAVMIMMLVSCVIYMIICLYVEQVMPGSFGVP 490
             ::|: |.::.........|   |..|..|:      .|:....|.|:::..|.|:|:|..:|..
Mouse   407 MVQLLRLDYDVNSNADPMGN---PNEVIGTI------FMLFFDGVFYLLLTFYFEKVLPSEYGRR 462

  Fly   491 RPWNFPFTREFWCG-----------EREYTGVEDIPNGHVEQRDPKAFE---TEPEGKHIGLQMR 541
            .|..|.....||.|           |.:|...:|            :||   .|..||. .:::|
Mouse   463 HPPLFFLKSSFWSGQNPANRTALDNETDYEFSDD------------SFEPVSMEFHGKE-AIRIR 514

  Fly   542 HLKKRFGNKM----VVKGLSMNMFEDEITVLLGHNGAGKTTTISMLTGMFPPTSGTAIINGSDI- 601
            :|.|.:..|.    .:|.|::::::.:||.:|||:||||:|.:::|:|:..||.|...|:.:.: 
Mouse   515 NLTKDYIQKSKRTEALKDLTLDVYKGQITAILGHSGAGKSTLLNVLSGLCVPTKGWVTIHNNKLS 579

  Fly   602 -RTNIEGARMSLGICPQHNVLFDEMSVSNHIRFFSRMKGLRGKAVEQEVAKYLKMIELEDKANVA 665
             .|::|......|:|||.||.||.::|..::|.|:::||::...|:.||.:.|..:::::..|:.
Mouse   580 EMTDLENISKLTGVCPQCNVQFDFLTVRENLRLFAKIKGIQAHEVDNEVQRVLLELDMKNTQNIL 644

  Fly   666 SSKLSGGMKRKLSVCCALCGDTKVVLCDEPSSGMDPSARRQLWDLLQQEKVGRTLLLTTHFMDEA 730
            ...||||.||||:...|:.||.::.|.|||::|:||.:|.::|:.|::.:..|.:|.:|.|||||
Mouse   645 VQNLSGGQKRKLTFGIAILGDPQIFLLDEPTAGLDPFSRHRVWNFLKERRADRVVLFSTQFMDEA 709

  Fly   731 DVLGDRIAIMCDGELKCQGTSFFLKKQYGSGYRLICVKRDDCETNEVTALLNKYIPGLKPECDIG 795
            |:|.||...:..|:|||.|:|.||||::|.||.|.....:.|....:|:|:.::||..|...:..
Mouse   710 DILADRKVFISKGKLKCAGSSLFLKKKWGIGYHLSLQLSETCVHERITSLVKQHIPDSKLSAESE 774

  Fly   796 AELSYQLPDSASAKFEEMFGQLEEQSDELHLNGYGVGITSMEEVFMKV-GAEKDNTGNIKDQHEI 859
            .:|||.||...:.||.:::..| |:|.:|.:..|||.||::.|||:|: |....:..:|....::
Mouse   775 GKLSYILPLERTNKFPDLYRDL-ERSPDLGIENYGVSITTLTEVFLKLEGKSSIDQSDIGMTEDV 838

  Fly   860 MNGGSGFRGEDDNESVQSDGIFSENRRLLQ----------GLQLLSNQWKAMLLKKFLYTWRNK- 913
            ..||:           :|...|:|..:|:.          |:.|...|..|:...:||.....: 
Mouse   839 QAGGA-----------RSPERFAEVEQLVSLLNGRCKMKGGMALWWQQLCAVTRLRFLKLKHERK 892

  Fly   914 ---LLLLIQNIMPVFFVVVTILIIKTQGTF-QELKPITISLT-----QYPLAVTVLDRSNVQNGT 969
               :|:|:..|..:..:...|..:..|..: .||.|....||     |.||...:     :.|.|
Mouse   893 SIVILILVLGIGLLHILSANIYRMVRQSDYCWELAPHMYFLTPGQQPQPPLTNLL-----IVNKT 952

  Fly   970 GYEIANKYEDLARSYGSNYGLELT--GTQ-GFEDYILDLGKTIQVRINSRYLVAATITESKITAW 1031
            |.:|.:....|.:   .|..||:.  ||: |.||          .:.|...:::........|..
Mouse   953 GAKIDDFIHSLEQ---QNIALEVDAFGTRNGTED----------SQYNGAIILSGDEKNYNFTLA 1004

  Fly  1032 LNNQALHTAPLTVNMVHNAIADKLFGSSVKIQVTNAPLP---------YTTSTLLSQLSTGNNLG 1087
            .|.:.|:..|:.|::|.|.:.. ||..|..||...:..|         |.....|..|       
Mouse  1005 CNTKRLNCFPVLVDIVSNGLLG-LFAPSAHIQTDRSTFPEENDHRKFDYLAYFFLWVL------- 1061

  Fly  1088 TQLASNLCFCMCFVSSIYILFLIKERESRAKLLQFVGGVKVWTFWLSQFICDFASYIVTALIVVI 1152
                     .|..|.....:..|.:.::||:...::.|:....:|..|.:.:...|  .|||:.|
Mouse  1062 ---------LMACVPPYISMTSIDDYKNRAQFQLWISGLSPSAYWFGQALFEVPVY--CALILSI 1115

  Fly  1153 TIVCFQETGLSTFGELGRYYLLLLLFG---FAVLPFIYIMSLFFREPATG-------FARVS--- 1204
            .|..:......:...:|..::.:|..|   .:|:...|::|..:|:....       |..||   
Mouse  1116 FIAFYASAPPESKFTVGDLFIQILYVGGYAMSVIFMTYVISFIYRKGRKNSGLWSLCFYIVSFFS 1180

  Fly  1205 ----IVNIFCGMALFIVVVVMSSEL--------FDTKDTADILGWIFRIFPHFSLAMSLNKVYTN 1257
                :::.|..::||:::.::....        |:.::.::|   ||.....:|...        
Mouse  1181 MCFMLIDYFRDISLFVLIALVPPATLGGCTLLHFENREFSEI---IFEPEREYSYLF-------- 1234

  Fly  1258 TATRNACAKAGALPPILLCELVPQCCNLKPYFAWEEPGVLPETVYMAVTGVVFFLIIIVLEFR-- 1320
                       .|.|:|             :||                  :|.:|:..:|.:  
Mouse  1235 -----------FLAPLL-------------HFA------------------IFVVILRCMERKFG 1257

  Fly  1321 ---LINELMFKIR----QLISKPPPPPTEGQLDDDVANERERILQMSSNELATKN------LVLD 1372
               :..:.:|:|.    ::.:.|..|..|   |:||:.||    ..::|.|.:.:      ::..
Mouse  1258 MKTMRTDPVFRISPRSDRVFNNPEDPDGE---DEDVSQER----VWTANALTSADFQEKPAIIAS 1315

  Fly  1373 RVTKYY-----------GQFMAVNQVSLCVQEVECFGLLGVNGAGKTTTFKMMTGDERISSGAAY 1426
            .:.|.|           .:.:|...:|.||::.|..||||.|||||:|:.||:||:.:.|:|...
Mouse  1316 CLRKEYKGKKKCFVLKSKKKIATRNISFCVRKGEVVGLLGHNGAGKSTSIKMITGETKPSAGQVL 1380

  Fly  1427 VQGLSLESNMNSIYKMIGYCPQFDALLDDLTGREVLRIFCMLRGVQESRIRQLSEDLAKSFGFMK 1491
            ::|    |:.......:|||||.:||..:||.||.|.||..::|:::|......|.||.:.....
Mouse  1381 LKG----SSTGDTPGFLGYCPQENALWLNLTVREHLEIFAAIKGMRKSDANVAIERLADALKLQD 1441

  Fly  1492 HIDKQTHAYSGGNKRKLSTAIAVIGSPSVIYLDEPTTGMDPAARRQLWNMV-CRIRDSGKSIVLT 1555
            .:.......|.|.||||...::::|:|||:.||||:|||||..::|:|..: ....::.:..:||
Mouse  1442 QLKSPVKTLSEGVKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQAIQATFSNTERGALLT 1506

  Fly  1556 SHSMEECEALCTRLAIMVNGEFKCIGSTQHLKNKFSKGLILKIKVRRNLEALRQARLSGGYARNP 1620
            :|.|.|.||:|.|:||||:|..:||||.||||:||.|..:|::||:                   
Mouse  1507 THYMAEAEAVCDRVAIMVSGRLRCIGSIQHLKSKFGKEYLLEMKVK------------------- 1552

  Fly  1621 DEQTVPAQMSQRDIDAVKEFVETEYPNSILQEEYQGILTFYIPLTGVK-WSRIFGLMESNRDQLN 1684
                .|:|:...:.:.::.|     |.:..||.|..::.:.:|...|: .|:.|..:|:.:...:
Mouse  1553 ----TPSQVEPLNTEIMRLF-----PQAARQERYSSLMVYKLPREDVQPLSQAFFKLETVKQSFD 1608

  Fly  1685 VEDYSVSQTTLEEIFLEFAKYQRED 1709
            :|:||:||:|||::|||.:|.|..|
Mouse  1609 LEEYSLSQSTLEQVFLELSKEQELD 1633

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ABCANP_608445.2 ABC2_membrane_4 254..434 CDD:289500 45/202 (22%)
ABC2_membrane_3 <269..475 CDD:289468 50/228 (22%)
CcmA 538..843 CDD:224054 114/310 (37%)
ABC_subfamily_A 538..755 CDD:213230 82/222 (37%)
ABC2_membrane_3 913..1316 CDD:289468 82/449 (18%)
ABC_subfamily_A 1369..1587 CDD:213230 85/229 (37%)
drrA 1376..1702 CDD:130256 115/338 (34%)
Abca8aXP_006533124.3 rim_protein <258..1630 CDD:130324 409/1562 (26%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167838404
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D131191at2759
OrthoFinder 1 1.000 - - FOG0000051
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100045
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
54.750

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