DRSC/TRiP Functional Genomics Resources

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Protein Alignment Abca3 and ABCA3

DIOPT Version :10

Sequence 1:NP_608445.2 Gene:Abca3 / 33103 FlyBaseID:FBgn0031170 Length:1714 Species:Drosophila melanogaster
Sequence 2:NP_001080.2 Gene:ABCA3 / 21 HGNCID:33 Length:1704 Species:Homo sapiens


Alignment Length:1784 Identity:673/1784 - (37%)
Similarity:1011/1784 - (56%) Gaps:179/1784 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 KFVLLLWKNWTLQWNHKWQMVIELVLPAIFSLLLVLVRTLVDTEQ-KGVRYYNEQNLTDLNLLQH 72
            :..||||||:|||.......|:||.||.:||.:|:.:|..:.:|. .....|..|::.:|.|   
Human     6 QLALLLWKNYTLQKRKVLVTVLELFLPLLFSGILIWLRLKIQSENVPNATIYPGQSIQELPL--- 67

  Fly    73 SLHRSSYLGKLIALIAPNRRRKNGGFSKF-----EFILCYSPV-NPVLKKLVEEAWQSLGKNK-- 129
                                     |..|     .:.|.|.|. :...|.:.|...::|..|.  
Human    68 -------------------------FFTFPPPGDTWELAYIPSHSDAAKTVTETVRRALVINMRV 107

  Fly   130 ---ICESENATQLELDTVSKNAFAGVQFDDAWANLTENDPLPNDFHFALRFPAELR------TAT 185
               ..|.:....:..|..|.:..|.|.|:..:.:  ..:|||....:.|||....|      |.:
Human   108 RGFPSEKDFEDYIRYDNCSSSVLAAVVFEHPFNH--SKEPLPLAVKYHLRFSYTRRNYMWTQTGS 170

  Fly   186 IAIANT--WLTMRLFPTIDLTGPRNEGDDDGGIPPGYLREGFLPLQHSLSMAYLRQKSGE----- 243
            ..:..|  |.|..|||.....|||.....||| .|||:|||||.:||::..|.:...:..     
Human   171 FFLKETEGWHTTSLFPLFPNPGPREPTSPDGG-EPGYIREGFLAVQHAVDRAIMEYHADAATRQL 234

  Fly   244 -QDLPNVVMKRYPFPAYIFDPLLEGMSSIMSLIILLSFIYPCTYITKYITAEKEKQLKEVMKIMG 307
             |.| .|.:||:|:|.:|.||.|..:...:.|::||||.|....|.:.:..|||::|||.|::||
Human   235 FQRL-TVTIKRFPYPPFIADPFLVAIQYQLPLLLLLSFTYTALTIARAVVQEKERRLKEYMRMMG 298

  Fly   308 LSNWLHWTAWFVKSFIMLTISAILIAILVKINWSEDVAVLTHANFTALVFFLIIYIVSSICFCFM 372
            ||:||||:|||:..|:.|.|:|..:.:|..:....:||||:.::.:.::.||:.:.:|:|.|.||
Human   299 LSSWLHWSAWFLLFFLFLLIAASFMTLLFCVKVKPNVAVLSRSDPSLVLAFLLCFAISTISFSFM 363

  Fly   373 MATFFSRASTAAAVTGLIWFIAYIPYSFTINSYDDLSLSSKLGWSLISNTAMGFGIKLILGFEGT 437
            ::||||:|:.|||..|.::|..||||.|....|:.::||.||...|:||.||..|.:||..||..
Human   364 VSTFFSKANMAAAFGGFLYFFTYIPYFFVAPRYNWMTLSQKLCSCLLSNVAMAMGAQLIGKFEAK 428

  Fly   438 GEGLQWSNFFTPVSVDDTLTLGAVMIMMLVSCVIYMIICLYVEQVMPGSFGVPRPWNFPFTREFW 502
            |.|:||.:..:||:|||....|.|:.|:|:..|:|.::..|:|.|.||.||||:||.|.....:|
Human   429 GMGIQWRDLLSPVNVDDDFCFGQVLGMLLLDSVLYGLVTWYMEAVFPGQFGVPQPWYFFIMPSYW 493

  Fly   503 CGE-REYTGVEDIPNGHVEQRDPKA------FETEPEGKHIGLQMRHLKK--RFGNK--MVVKGL 556
            ||: |...|.|:      |..||:.      ||.|||....|::::||.|  |.|||  ..|:.|
Human   494 CGKPRAVAGKEE------EDSDPEKALRNEYFEAEPEDLVAGIKIKHLSKVFRVGNKDRAAVRDL 552

  Fly   557 SMNMFEDEITVLLGHNGAGKTTTISMLTGMFPPTSGTAIINGSDIRTNIEGARMSLGICPQHNVL 621
            ::|::|.:|||||||||||||||:|||||:||||||.|.|:|.:|..::...|.|||:||||::|
Human   553 NLNLYEGQITVLLGHNGAGKTTTLSMLTGLFPPTSGRAYISGYEISQDMVQIRKSLGLCPQHDIL 617

  Fly   622 FDEMSVSNHIRFFSRMKGLRGKAVEQEVAKYLKMIELEDKANVASSKLSGGMKRKLSVCCALCGD 686
            ||.::|:.|:.|::::|||..:...:||.:.|.:|.||||.|..|..|||||:||||:..||...
Human   618 FDNLTVAEHLYFYAQLKGLSRQKCPEEVKQMLHIIGLEDKWNSRSRFLSGGMRRKLSIGIALIAG 682

  Fly   687 TKVVLCDEPSSGMDPSARRQLWDLLQQEKVGRTLLLTTHFMDEADVLGDRIAIMCDGELKCQGTS 751
            :||::.|||:||||..:||.:|||||::|..||::||||||||||:||||||||..|||:|.|:|
Human   683 SKVLILDEPTSGMDAISRRAIWDLLQRQKSDRTIVLTTHFMDEADLLGDRIAIMAKGELQCCGSS 747

  Fly   752 FFLKKQYGSGYRLICVKRDDCETNEVTALLNKYIPGLKPECDIGAELSYQLPDSASAKFEEMFGQ 816
            .|||::||:||.:..||...|...:::.|::.::|....|...|||||:.||..::.:||.:|.:
Human   748 LFLKQKYGAGYHMTLVKEPHCNPEDISQLVHHHVPNATLESSAGAELSFILPRESTHRFEGLFAK 812

  Fly   817 LEEQSDELHLNGYGVGITSMEEVFMKVGAEKDNTGNIKD--------QHEIMNG----GSGFRGE 869
            ||::..||.:..:|..||:|||||::||...|::.:|:.        |||....    .|...|.
Human   813 LEKKQKELGIASFGASITTMEEVFLRVGKLVDSSMDIQAIQLPALQYQHERRASDWAVDSNLCGA 877

  Fly   870 DDNESVQSDGI---FSENR---RLLQGLQLLSNQWKAMLLKKFLYTWRNKLLLLIQNIMPVFFVV 928
            .|    .||||   ..|.|   :|..||.|...|:.||.|||..|:||...::..|.::|:..|.
Human   878 MD----PSDGIGALIEEERTAVKLNTGLALHCQQFWAMFLKKAAYSWREWKMVAAQVLVPLTCVT 938

  Fly   929 VTILIIKTQGTFQELKPITISLTQY-----PLAVTVLDRSNVQNGT---GYEIANKYEDLARSYG 985
            :.:|.|.......:...:.::|.:|     |.:|.         ||   |.:::...:|..::.|
Human   939 LALLAINYSSELFDDPMLRLTLGEYGRTVVPFSVP---------GTSQLGQQLSEHLKDALQAEG 994

  Fly   986 SNYGLELTGTQGFEDYILDLGKTIQVRINSRYLVAATITE----SKITAWLNNQALHTAPLTVNM 1046
            .. ..|:.|  ..|::::..........|.|.||||:..:    :.:.|..||||.|:....:.:
Human   995 QE-PREVLG--DLEEFLIFRASVEGGGFNERCLVAASFRDVGERTVVNALFNNQAYHSPATALAV 1056

  Fly  1047 VHNAIADKLFGSSVKIQVTNAPLPYTT-STLLSQLSTGNNLGTQLASNLCFCMCFVSSIYILFLI 1110
            |.|.:...|.|....|.|:|.|.|.:. .....|.:.|.. |..:|.||.|.|.|::|.:.:..:
Human  1057 VDNLLFKLLCGPHASIVVSNFPQPRSALQAAKDQFNEGRK-GFDIALNLLFAMAFLASTFSILAV 1120

  Fly  1111 KERESRAKLLQFVGGVKVWTFWLSQFICDFASYIVTALIVVITIVCFQETGLSTFGELGRYYLLL 1175
            .||..:||.:|||.||.|.:||||..:.|..|:::.:|::::....|.....:..|.:....|||
Human  1121 SERAVQAKHVQFVSGVHVASFWLSALLWDLISFLIPSLLLLVVFKAFDVRAFTRDGHMADTLLLL 1185

  Fly  1176 LLFGFAVLPFIYIMSLFFREPATGFARVSIVNIFCGMALFIVVVVMSSELFDTKDTADILGWIFR 1240
            ||:|:|::|.:|:|:.||...||.:.|::|.||..|:|.|::|.:|.......::.:..|..:|.
Human  1186 LLYGWAIIPLMYLMNFFFLGAATAYTRLTIFNILSGIATFLMVTIMRIPAVKLEELSKTLDHVFL 1250

  Fly  1241 IFPHFSLAMSLNKVYTNTATRNACAKAGALPPILLCELVPQCC---NL---KPYFAWEEPGVLPE 1299
            :.|:..|.|:::..|.|..||..|..:         |:....|   |:   :.::||..|||...
Human  1251 VLPNHCLGMAVSSFYENYETRRYCTSS---------EVAAHYCKKYNIQYQENFYAWSAPGVGRF 1306

  Fly  1300 TVYMAVTGVVFFLIIIVLEFRLINEL---MFKIR------QLISKPPPPPTEGQLDDDVANERER 1355
            ...||.:|..:.:::.::|..|:..|   :..:|      :|.::.|..|.    |.|||:||.|
Human  1307 VASMAASGCAYLILLFLIETNLLQRLRGILCALRRRRTLTELYTRMPVLPE----DQDVADERTR 1367

  Fly  1356 ILQMSSNELATKNLVLDRVTKYYGQ---FMAVNQVSLCVQEVECFGLLGVNGAGKTTTFKMMTGD 1417
            ||..|.:.|....|::..::|.|.|   .:||:::||.||:.|||||||.|||||||||||:||:
Human  1368 ILAPSPDSLLHTPLIIKELSKVYEQRVPLLAVDRLSLAVQKGECFGLLGFNGAGKTTTFKMLTGE 1432

  Fly  1418 ERISSGAAYVQGLSLESNMNSIYKMIGYCPQFDALLDDLTGREVLRIFCMLRGVQESRIRQLSED 1482
            |.::||.|:|.|..:.|::..:.:.||||||||||||.:||||:|.::..|||:.|..|....|:
Human  1433 ESLTSGDAFVGGHRISSDVGKVRQRIGYCPQFDALLDHMTGREMLVMYARLRGIPERHIGACVEN 1497

  Fly  1483 LAKSFGFMKHIDKQTHAYSGGNKRKLSTAIAVIGSPSVIYLDEPTTGMDPAARRQLWNMVCRIRD 1547
            ..:......|.:|....|||||||||||.||:||.|:||:||||:|||||.|||.||:.|.|.|:
Human  1498 TLRGLLLEPHANKLVRTYSGGNKRKLSTGIALIGEPAVIFLDEPSTGMDPVARRLLWDTVARARE 1562

  Fly  1548 SGKSIVLTSHSMEECEALCTRLAIMVNGEFKCIGSTQHLKNKFSKGLILKIKVRRNLEALRQARL 1612
            |||:|::|||||||||||||||||||.|:|||:||.||||:||..|..|:.||:           
Human  1563 SGKAIIITSHSMEECEALCTRLAIMVQGQFKCLGSPQHLKSKFGSGYSLRAKVQ----------- 1616

  Fly  1613 SGGYARNPDEQTVPAQMSQRDIDAVKEFVETEYPNSILQEEYQGILTFYIPLTGVKWSRIFGLME 1677
                          ::..|..::..|.||:..:|.|:|::|:||::.:::|...:.|:::||::|
Human  1617 --------------SEGQQEALEEFKAFVDLTFPGSVLEDEHQGMVHYHLPGRDLSWAKVFGILE 1667

  Fly  1678 SNRDQLNVEDYSVSQTTLEEIFLEFAKYQ 1706
            ..:::..|:||||||.:||::||.||..|
Human  1668 KAKEKYGVDDYSVSQISLEQVFLSFAHLQ 1696

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Abca3NP_608445.2 rim_protein <137..1708 CDD:130324 640/1644 (39%)
ABCA3NP_001080.2 rim_protein 1..>43 CDD:130324 17/36 (47%)
rim_protein <131..1699 CDD:130324 638/1631 (39%)

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