Protein Alignment Abca3 and ABCA1

DIOPT Version :10

• Sequence 1: NP_608445.2
• Gene: Abca3 / 33103
• FlyBaseID: FBgn0031170
• Length: 1714
• Species: Drosophila melanogaster
• Sequence 2: NP_005493.2
• Gene: ABCA1 / 19
• HGNCID: 29
• Length: 2261
• Species: Homo sapiens
• Alignment Length: 1933
• Identity: 628/1933 - (32%)
• Similarity: 977/1933 - (50%)
• Gaps: 362/1933 - (18%)

  Fly    24 HKWQMVIELVLPAIFSLL-----LVLVRTLVDTEQKGVRYYNEQNLTDLNLLQHSLHRSSYLGKL 83
            |..:.:.|.:.|.|::.:     :.|||.|:|:....  ::.||.|..|:.....         :
Human   410 HDLEGMWEELSPKIWTFMENSQEMDLVRMLLDSRDND--HFWEQQLDGLDWTAQD---------I 463

  Fly    84 IALIA--PNRRRKNGGFSKFEFILCYSPVNPVLKKLVEEAWQSLGKNKICESENATQLE------ 140
            :|.:|  |...:.:.| |.:.:...::..|..::.:          ::..|..|..:||
Human   464 VAFLAKHPEDVQSSNG-SVYTWREAFNETNQAIRTI----------SRFMECVNLNKLEPIATEV 517

  Fly   141 ------LDTVSKNAF-AGVQFDDAWANLTENDPLPNDFHFALRFPAELRTATIAIANTWLTMRLF 198
                  ::.:.:..| ||:.|........|   ||:...:.:|         :.|.|...|.::.
Human   518 WLINKSMELLDERKFWAGIVFTGITPGSIE---LPHHVKYKIR---------MDIDNVERTNKIK 570

  Fly   199 PTIDLTGPRNEGDDDGGIPPGYLREGFLPLQHSLSMAYLRQKSGEQDLPNVVMKRYPFPAYIFDP 263
            ......|||.:..:|    ..|:..||..||..:..|.:|..:|.:....|.|::.|:|.|:.|.
Human   571 DGYWDPGPRADPFED----MRYVWGGFAYLQDVVEQAIIRVLTGTEKKTGVYMQQMPYPCYVDDI 631

  Fly   264 LLEGMSSIMSLIILLSFIYPCTYITKYITAEKEKQLKEVMKIMGLSNWLHWTAWFVKSFIMLTIS 328
            .|..||..|.|.:.|::||....|.|.|..|||.:|||.|:||||.|.:.|.:||:.|.|.|.:|
Human   632 FLRVMSRSMPLFMTLAWIYSVAVIIKGIVYEKEARLKETMRIMGLDNSILWFSWFISSLIPLLVS 696

  Fly   329 AILIAILVKINWSEDVAVLTHANFTALVFFLIIYIVSSICFCFMMATFFSRASTAAAVTGLIWFI 393
            |.|:.:::|:.     .:|.:::.:.:..||.::.|.:|..||:::|.||||:.|||..|:|:|.
Human   697 AGLLVVILKLG-----NLLPYSDPSVVFVFLSVFAVVTILQCFLISTLFSRANLAAACGGIIYFT 756

  Fly   394 AYIPYSFTINSYDDLSLSSKLGWSLISNTAMGFGIKLILGFEGTGEGLQWSNFFTPVSVDDTLTL 458
            .|:||...:...|.:..:.|:..||:|..|.|||.:....||..|.|:||.|.|.....:|...|
Human   757 LYLPYVLCVAWQDYVGFTLKIFASLLSPVAFGFGCEYFALFEEQGIGVQWDNLFESPVEEDGFNL 821

  Fly   459 GAVMIMMLVSCVIYMIICLYVEQVMPGSFGVPRPWNFPFTREFWCGEREYTGVEDIPNGHVEQRD 523
            ...:.|||....:|.::..|:|.|.||.:|:||||.||.|:.:|.||.  :..:..|..:.::..
Human   822 TTSVSMMLFDTFLYGVMTWYIEAVFPGQYGIPRPWYFPCTKSYWFGEE--SDEKSHPGSNQKRIS 884

  Fly   524 PKAFETEPEGKHIGLQMRHLKK--RFGNKMVVKGLSMNMFEDEITVLLGHNGAGKTTTISMLTGM 586
            ....|.||....:|:.:::|.|  |.|.|:.|.||::|.:|.:||..|||||||||||:|:|||:
Human   885 EICMEEEPTHLKLGVSIQNLVKVYRDGMKVAVDGLALNFYEGQITSFLGHNGAGKTTTMSILTGL 949

  Fly   587 FPPTSGTAIINGSDIRTNIEGARMSLGICPQHNVLFDEMSVSNHIRFFSRMKGLRGKAVEQEVAK 651
            ||||||||.|.|.|||:.:...|.:||:|||||||||.::|..||.|::|:|||..|.|:.|:.:
Human   950 FPPTSGTAYILGKDIRSEMSTIRQNLGVCPQHNVLFDMLTVEEHIWFYARLKGLSEKHVKAEMEQ 1014

  Fly   652 YLKMIEL-EDKANVASSKLSGGMKRKLSVCCALCGDTKVVLCDEPSSGMDPSARRQLWDLLQQEK 715
            ....:.| ..|....:|:|||||:|||||..|..|.:|||:.|||::|:||.:||.:|:||.:.:
Human  1015 MALDVGLPSSKLKSKTSQLSGGMQRKLSVALAFVGGSKVVILDEPTAGVDPYSRRGIWELLLKYR 1079

  Fly   716 VGRTLLLTTHFMDEADVLGDRIAIMCDGELKCQGTSFFLKKQYGSGYRLICVKRD---------- 770
            .|||::|:||.|||||||||||||:..|:|.|.|:|.|||.|.|:||.|..||:|
Human  1080 QGRTIILSTHHMDEADVLGDRIAIISHGKLCCVGSSLFLKNQLGTGYYLTLVKKDVESSLSSCRN 1144

  Fly   771 -----------------------------DCETNEVTA---LLNKYIPGLKPECDIGAELSYQLP 803
                                         |..|.:|:|   |:.|::...:...|||.||:|.||
Human  1145 SSSTVSYLKKEDSVSQSSSDAGLGSDHESDTLTIDVSAISNLIRKHVSEARLVEDIGHELTYVLP 1209

  Fly   804 DSASAK--FEEMFGQLEEQSDELHLNGYGVGITSMEEVFMKVGAE--------------KDNTGN 852
            ..|:.:  |.|:|.:::::..:|.::.||:..|::||:|:||..|              :.|...
Human  1210 YEAAKEGAFVELFHEIDDRLSDLGISSYGISETTLEEIFLKVAEESGVDAETSDGTLPARRNRRA 1274

  Fly   853 IKDQHEIMNGGSGFRGED---------DNESVQSD---GIFSENRRLLQGLQLLSNQWKAMLLKK 905
            ..|:...:.   .|..:|         |.||.::|   |:..:....::|.:|...|:.|:|.|:
Human  1275 FGDKQSCLR---PFTEDDAADPNDSDIDPESRETDLLSGMDGKGSYQVKGWKLTQQQFVALLWKR 1336

  Fly   906 FLYTWRNKLLLLIQNIMPVFFVVVTI---LIIKTQGTFQ--ELKPI------------------T 947
            .|...|::.....|.::|..||.:.:   ||:...|.:.  ||:|.                  |
Human  1337 LLIARRSRKGFFAQIVLPAVFVCIALVFSLIVPPFGKYPSLELQPWMYNEQYTFVSNDAPEDTGT 1401

  Fly   948 ISL--------------------------------TQYPLAVTVLDRSNVQNG------------ 968
            :.|                                |..|:..|::|.  .|||
Human  1402 LELLNALTKDPGFGTRCMEGNPIPDTPCQAGEEEWTTAPVPQTIMDL--FQNGNWTMQNPSPACQ 1464

  Fly   969 ------------------------------------TG-----YEIANKYEDLARS--------- 983
                                                ||     |.:....:.:|:|
Human  1465 CSSDKIKKMLPVCPPGAGGLPPPQRKQNTADILQDLTGRNISDYLVKTYVQIIAKSLKNKIWVNE 1529

  Fly   984 --YGSNYGLELTGTQGF------EDYILDLGKTIQVRINS---RYL------VAATITESKITAW 1031
              || .:.|.::.||..      .|.|..:.|.:::..:|   |:|      :....|::.:..|
Human  1530 FRYG-GFSLGVSNTQALPPSQEVNDAIKQMKKHLKLAKDSSADRFLNSLGRFMTGLDTKNNVKVW 1593

  Fly  1032 LNNQALHTAPLTVNMVHNAI--ADKLFG---SSVKIQVTNAPLPYTTSTLLSQLSTGNNLGTQLA 1091
            .||:..|.....:|:::|||  |:...|   |...|...|.||..|...|........::...::
Human  1594 FNNKGWHAISSFLNVINNAILRANLQKGENPSHYGITAFNHPLNLTKQQLSEVALMTTSVDVLVS 1658

  Fly  1092 SNLCFCMCFVSSIYILFLIKERESRAKLLQFVGGVKVWTFWLSQFICDFASYIVTALIVVITIVC 1156
            ..:.|.|.||.:.:::|||:||.|:||.|||:.|||...:|||.|:.|..:|:|.|.:|:|..:|
Human  1659 ICVIFAMSFVPASFVVFLIQERVSKAKHLQFISGVKPVIYWLSNFVWDMCNYVVPATLVIIIFIC 1723

  Fly  1157 FQETGLSTFGELGRYYLLLLLFGFAVLPFIYIMSLFFREPATGFARVSIVNIFCGMALFIVVVVM 1221
            ||:....:...|....|||||:|:::.|.:|..|..|:.|:|.:..::.||:|.|:...:...|:
Human  1724 FQQKSYVSSTNLPVLALLLLLYGWSITPLMYPASFVFKIPSTAYVVLTSVNLFIGINGSVATFVL 1788

  Fly  1222 SSELF-DTK--DTADILGWIFRIFPHFSLAMSLNKVYTNTATRNACAKAGA---LPPILLCELVP 1280
              ||| |.|  :..|||..:|.|||||.|...|..:..|.|..:|..:.|.   :.|:
Human  1789 --ELFTDNKLNNINDILKSVFLIFPHFCLGRGLIDMVKNQAMADALERFGENRFVSPL------- 1844

  Fly  1281 QCCNLKPYFAWEEPGVLPETVYMAVTGVVFFLIIIVLEFRLINELMFKIRQLISKPPPPPTEGQL 1345
                     :|:..|  .....|||.|||||||.:::::|      |.||       |.|...:|
Human  1845 ---------SWDLVG--RNLFAMAVEGVVFFLITVLIQYR------FFIR-------PRPVNAKL 1885

  Fly  1346 ------DDDVANERERILQ-MSSNELATKNLVLDRVTKYYGQFM--AVNQVSLCVQEVECFGLLG 1401
                  |:||..||:|||. ...|::    |.:..:||.|.:..  ||:::.:.:...|||||||
Human  1886 SPLNDEDEDVRRERQRILDGGGQNDI----LEIKELTKIYRRKRKPAVDRICVGIPPGECFGLLG 1946

  Fly  1402 VNGAGKTTTFKMMTGDERISSGAAYVQGLSLESNMNSIYKMIGYCPQFDALLDDLTGREVLRIFC 1466
            ||||||::||||:|||..::.|.|::...|:.||::.:::.:||||||||:.:.|||||.:..|.
Human  1947 VNGAGKSSTFKMLTGDTTVTRGDAFLNKNSILSNIHEVHQNMGYCPQFDAITELLTGREHVEFFA 2011

  Fly  1467 MLRGVQESRIRQLSEDLAKSFGFMKHIDKQTHAYSGGNKRKLSTAIAVIGSPSVIYLDEPTTGMD 1531
            :||||.|..:.::.|...:..|.:|:.:|....||||||||||||:|:||.|.|::|||||||||
Human  2012 LLRGVPEKEVGKVGEWAIRKLGLVKYGEKYAGNYSGGNKRKLSTAMALIGGPPVVFLDEPTTGMD 2076

  Fly  1532 PAARRQLWNMVCRIRDSGKSIVLTSHSMEECEALCTRLAIMVNGEFKCIGSTQHLKNKFSKGLIL 1596
            |.|||.|||....:...|:|:||||||||||||||||:||||||.|:|:||.|||||:|..|..:
Human  2077 PKARRFLWNCALSVVKEGRSVVLTSHSMEECEALCTRMAIMVNGRFRCLGSVQHLKNRFGDGYTI 2141

  Fly  1597 KIKVRRNLEALRQARLSGGYARNPDEQTVPAQMSQRDIDAVKEFVETEYPNSILQEEYQGILTFY 1661
            .:            |::|.   ||            |:..|::|....:|.|:|:|:::.:|.:.
Human  2142 VV------------RIAGS---NP------------DLKPVQDFFGLAFPGSVLKEKHRNMLQYQ 2179

  Fly  1662 IPLTGVKWSRIFGLMESNRDQLNVEDYSVSQTTLEEIFLEFAKYQRED 1709
            :|.:....:|||.::..::.:|::||||||||||:::|:.|||.|.:|
Human  2180 LPSSLSSLARIFSILSQSKKRLHIEDYSVSQTTLDQVFVNFAKDQSDD 2227

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Abca3	NP_608445.2	rim_protein	<137..1708	CDD:130324	606/1810 (33%)
ABCA1	NP_005493.2	rim_protein	6..2236	CDD:130324	628/1933 (32%)
		Annulus domain 1. /evidence=ECO:0000305|PubMed:35974019	69..80
		Annulus domain 2. /evidence=ECO:0000305|PubMed:35974019	368..379
		Gateway domain. /evidence=ECO:0000305|PubMed:35974019	564..594		7/33 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1283..1312		7/31 (23%)