Protein Alignment ABCA and abt-1

DIOPT Version :9

• Sequence 1: NP_608445.2
• Gene: ABCA / 33103
• FlyBaseID: FBgn0031170
• Length: 1714
• Species: Drosophila melanogaster
• Sequence 2: NP_001293854.1
• Gene: abt-1 / 182849
• WormBaseID: WBGene00000019
• Length: 1558
• Species: Caenorhabditis elegans
• Alignment Length: 1775
• Identity: 319/1775 - (17%)
• Similarity: 589/1775 - (33%)
• Gaps: 555/1775 - (31%)

  Fly    42 LVLVRTLVDTEQKGVRY--YNEQNLTDLNLLQHSLHRSSYLGKLIALIAPNRRRKNGGFSKFEFI 104
            |||.:||::|.:| :.|  .:||.:.|.:.:|..:||
 Worm   131 LVLFKTLIETGKK-IEYKIISEQGVFDKHCIQCDVHR---------------------------- 166

  Fly   105 LCYSPVNPVLKKLVEEAWQSLGKNKICESENATQLELDTVSKNAFAGVQFDDAWANLTENDPLPN 169
                      ||                                        .|.|..|...:.|
 Worm   167 ----------KK----------------------------------------TWGNAVEAQVVVN 181

  Fly   170 DFHFALRFPAELRTATIAIANTWLTMRLFPTIDLTGPRNEGDDDGGIPPGYLREGFLPLQHSLSM 234
            .|.:                  ||..                          ..||
 Worm   182 RFLY------------------WLVK--------------------------SRGF--------- 193

  Fly   235 AYLRQKSGEQDLPNVVMKRYPFPAYIFDPL-LEGMSSIMSLIILLSFIYPCTYITKYITAEKEKQ 298
               .::|....|.||.:|...     .||: |:..|.:..|.|||..|  |:.:......::...
 Worm   194 ---NKRSPHWQLSNVYVKHSG-----NDPMFLKRQSDLFLLWILLLPI--CSRLIDLWNNDRSSG 248

  Fly   299 LKEVMKIMGLSNWLHWTAWFVKSFIMLTISAILIAILVKINWSEDVAVLTHANFTALVFFLIIYI 363
            ...    |.||.......:|:..|:.....|::|:::|.|   .:|.|:.....:..:.|::.|.
 Worm   249 YYN----MFLSLHARRFHYFIAKFVFWYGIALIISLIVFI---VNVLVVPAVFCSTYLQFVVCYA 306

  Fly   364 VSSICFCFMMATFFSRASTAAAVTGLIWFIAYIPYSFTINSYDDLSLSSKLGWSLISNTAMGFGI 428
            ...|.|...:||.|..:...|.:.|.:..:|                 .:.|:..:.: .:|| .
 Worm   307 ACIISFAIFLATTFPGSPLFAKIVGFLSMVA-----------------GEFGFGTVYH-GIGF-F 352

  Fly   429 KLILGFEGTGEGLQWSNFFTPVSVDDTLTL---GAVMIMMLVSCVIYMIICLYVEQVMPGSFGVP 490
            :|.:...|..|       |....:|...||   |..::::.||.......||:..:        |
 Worm   353 QLCVRHFGKSE-------FDGPWIDAVCTLCMTGNCVLLITVSIYFDTYFCLFTME--------P 402

  Fly   491 RPWNFPFTREFWC---------------------GEREYTGVEDIPNGHVE------QRDPKAFE 528
            ..:.||..:::|.                     |..|.|    :...|.|      ....|...
 Worm   403 LAFYFPLEKDYWMPEARSPQLDTFFVKQIILLKPGRSEIT----VKKAHDEILPAKTSTGSKYIP 463

  Fly   529 TEPEGKHIGLQMRH-LKKRFGNKMVVKGLSMNMFEDEITVLLGHNGAGKTTTISMLTGMFPPTSG 592
            ..|..|.:.|.:.: :.||..|...||.:|:.:...|:..|.||:|.|....:|::.|...|..|
 Worm   464 PTPIVKGVPLVVLYGICKRIENHWRVKQVSLTVHLGEVVTLYGHHGCGSGEILSIIAGQMKPEYG 528

  Fly   593 TAIINGSDIRTNIEGARMSLGI-----CPQHNVLFDEMSVSNHIRFFSRMKGLRGKAVEQEVAKY 652
            ..:         :|.::..|.|     .|..|.|    :|..::|..|:|:|:  .|....:.:.
 Worm   529 EVM---------MEQSQRPLMISKTTDVPNVNYL----NVIQYLRLISKMRGV--SASTSHIDEM 578

  Fly   653 LKMIELEDKANVASSKLSGGMKRKLSVCCALCGDTKVVLCDEPSSGMDPSARRQLWDLLQQEKVG 717
            |:.::|....|.:...||...|.:|.:.....|...:||.|.|:....|..:..::..:::.|..
 Worm   579 LEELDLIKVKNRSLDLLSTTQKERLRIAAVFVGQPDLVLIDFPTMECLPEWKFMVFRFIEKRKEK 643

  Fly   718 RTLLLTTHFMDEADVLGDRIAIMCDGELKCQGTSFFLKKQYGSGYRLICVKRDDCETNEVTALLN 782
            |:::::::..:|.:.:.|::.:|.:|.:...|:....|....|.:.:..     ...|..|   :
 Worm   644 RSIIVSSYDPEETEAISDKVVLMSEGYVVLNGSCEAFKHSINSVFEIRI-----WPNNRFT---D 700

  Fly   783 KYIPGLKPECDIGAELSYQLPDSASAKFEEMFGQLEEQSDELHLNGYGVGITSMEEVFMKVGAEK 847
            :.|.|:.....:|   ..|:.:.|.. ||...|::......|:.....:.:..::.|..|...|.
 Worm   701 EQIKGMMKTLTLG---DNQMKNDARF-FETPNGKIRVTLPILYRRSIPLILRELDAVHEKFRIEF 761

  Fly   848 DNTG--NIKD-------QHEIMNGGSGFRGEDDNESVQSDGIFSENRRLLQGLQLLSNQWKAMLL 903
            ...|  ||.|       :|:.::..|.|.                        ||..:..|...|
 Worm   762 YELGKPNIHDIYANACYEHQQLDPLSTFD------------------------QLRDHYTKQQPL 802

  Fly   904 KKFLYTWRNKLLL------LIQNIMPV-FFVVVTILIIKTQGTFQELKPIT--ISLTQYPLAVTV 959
            .|..|.::|.:.:      ||:....| .|:::|::|:.:..:.:.....|  ||||.|...:|:
 Worm   803 NKKTYFFKNMIHIFKDGRFLIETAAVVGLFLILTVIILLSYHSVESDSHQTREISLTSYESPITI 867

  Fly   960 L---DRSNVQNGTGYEIANKYEDLARSYGSNYGLELTGTQGFEDYILDLGKTIQVRINSRYLVAA 1021
            .   ....|..|..:|..::...|..:....|..: |.....|...:..|..:...|...:.|:.
 Worm   868 YCDECEKEVIEGVTFEKKSRVLQLENNQAVLYWKD-TAKADKELITVSRGDALFTMIVQNFAVSQ 931

  Fly  1022 TITESKITAWLNNQALHTAPLTVNMVHNAIADKLFGSSVKIQVTNAPLPYTTSTLLSQLST-GNN 1085
            .|  ||||.                .|..|  |||..|..::         |:|.:|..|| .|:
 Worm   932 MI--SKITG----------------KHPQI--KLFLESENVR---------TATEISGFSTVFND 967

  Fly  1086 LGTQLASNL---CFCMCFVSSIYILFLIKERESRAKLLQFVGGVKVWTFWL-------------S 1134
            :.:..|:.:   .:.:.::::::.:|                   |:||.:             .
 Worm   968 ISSSKAAMILTESYSLMYITAVFQMF-------------------VYTFSVVLPLRLVSTNMGPQ 1013

  Fly  1135 QFICDFASYIVTALIVVITIVCFQETGLSTFGELGRYYLLLLLFGFAVLP-----------FIYI 1188
            ..|..:..|:....|.|..:|.|              .::.::.|||||.           ::..
 Worm  1014 SMILPWPRYVYFGFIYVFQLVVF--------------LVIAIILGFAVLSMGFFATNTTSCYLRF 1064

  Fly  1189 MSLFFREPATGFARVSIVNIFCGMALFIVVVVMSSELFDTKDTADILGWIFRIFPHFSLAMSLNK 1253
            :|.:|...|:...          :..|:|        |:.::|..::..|..|   .||:::...
 Worm  1065 LSAWFLSYASTLP----------LIYFLV--------FNIQNTKSVIPIILAI---SSLSVTFPN 1108

  Fly  1254 VYTNTATRNACAKAGALPPILLCELVPQCCNLKP------YFAWEEPGVLPETVYMAVTG----- 1307
            :..:.:..|..:...      |.:.|...|.|.|      ..|:...|...|.....:|.
 Worm  1109 LVASFSAENQVSLQS------LIQFVSWSCMLNPPSSLQVLAAFLNAGESLEKNSGTITSLILFC 1167

  Fly  1308 -------VVFFLIIIVLEFRLINELMFKI---------RQLISKP------------PPPPT--- 1341
                   |:|.|:|....|..|.:..||.         |....||            .|..|
 Worm  1168 GAQFWIIVIFVLVIFQPGFSYIQQYWFKSSTVLYSSFERGTTLKPGARIKNSYIFVTNPLGTMED 1232

  Fly  1342 ------EGQLDDDVANERERILQMSSNELATKNLVLD---RVTKYYGQFMAVNQVSLCV-----Q 1392
                  .|.:.:..|...|.:.:.:|:.:|..::.:|   .:|.|  :...|.:::...     |
 Worm  1233 AQDKGASGNIPNRPAAGTEPVQKPTSDYIAGSSMSIDDMSYITNY--EENLVEKMATMTSWNDKQ 1295

  Fly  1393 EVECFGLLGVNGAGKTTTFKMMTGDERISSGA-----------AYVQGLSLESNMNSIY------ 1440
            ||.         ...:.||.|  ||:.....|           .::..:.:..|:::||
 Worm  1296 EVP---------VDNSATFLM--GDQTKLKSALLTTIAKINKNEHIAFVPIVENISTIYTPFELL 1349

  Fly  1441 KMIGYCPQFDALLDDLTGREVLRIFCMLRGVQESRIRQLSEDLAKSFGFMKHIDKQTHAYSGGNK 1505
            :...||..|:...|.::                        .|..:|...:|.:.|.......::
 Worm  1350 ENAAYCNGFEITDDHIS------------------------YLLDAFDLKEHANTQIKLLPCIDR 1390

  Fly  1506 RKLSTAIAVIGSPSVIYLDEPTTGMDPAARRQLWNMVCRIRDSGKSIVLTSHSMEECEALCTRLA 1570
            |.|.....::..|:::.:|:....:..:....:|:...|:|.:|..|:.|||.....|...|..|
 Worm  1391 RILMLLAKLVIKPNIVIIDQLEMFLPHSKMMTVWSFCARLRKNGLGIIYTSHHSGFAEHTATCCA 1455

  Fly  1571 IMVNGEFKCIGSTQHLKNKFSKGLILKIKVRRNLEALRQARLSGGYARNPD----------EQTV 1625
            .|..|:|        ::|.....:..|..|   ||.:.:.      |.:|.          |::|
 Worm  1456 HMYKGQF--------VRNLLPTSIKAKCTV---LEVVPKT------ASDPKVLLHMLQKEMEESV 1503

  Fly  1626 PAQMSQRDIDAV--KEFVET 1643
            ....:.|:|...  |:.|||
 Worm  1504 KLPSTSRNITLAMYKDGVET 1523

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ABCA	NP_608445.2	ABC2_membrane_4	254..434	CDD:289500	35/180 (19%)
		ABC2_membrane_3	<269..475	CDD:289468	41/208 (20%)
		CcmA	538..843	CDD:224054	63/310 (20%)
		ABC_subfamily_A	538..755	CDD:213230	49/222 (22%)
		ABC2_membrane_3	913..1316	CDD:289468	81/460 (18%)
		ABC_subfamily_A	1369..1587	CDD:213230	42/242 (17%)
		drrA	1376..1702	CDD:130256	55/302 (18%)
abt-1	NP_001293854.1	rim_protein	<256..>676	CDD:130324	93/475 (20%)
		P-loop_NTPase	474..677	CDD:393306	48/217 (22%)
		ABC2_membrane_3	<917..1176	CDD:378925	56/347 (16%)
		CcmA	<1328..1491	CDD:224054	36/203 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920