Protein Alignment ABCA and abt-4

DIOPT Version :9

• Sequence 1: NP_608445.2
• Gene: ABCA / 33103
• FlyBaseID: FBgn0031170
• Length: 1714
• Species: Drosophila melanogaster
• Sequence 2: NP_503175.1
• Gene: abt-4 / 178559
• WormBaseID: WBGene00000022
• Length: 1802
• Species: Caenorhabditis elegans
• Alignment Length: 1870
• Identity: 586/1870 - (31%)
• Similarity: 909/1870 - (48%)
• Gaps: 298/1870 - (15%)

  Fly    12 LLLWKNWTLQWNHKWQMVIELVLPAI-----FSLLLVLVRTLVDTEQKGVRYYNEQNLTDLNLLQ 71
            |||||||..|....|..:.|||:|.|     |.||:            |.....|...|:.....
 Worm     9 LLLWKNWLQQLRSPWFALFELVVPLILIGASFGLLI------------GFSGQFETTYTERKYAA 61

  Fly    72 HSLHRSSYLGKLIALIAPNRRRKNG----------------------GFSKF--EFILCYSPVNP 112
            ..:..|:|  .||....|:...|:.                      |.:|:  :.|..|:|:..
 Worm    62 WPVSGSAY--DLIMPTDPDDPIKSAIVEPYFLFNSQLTCQFLNTYTIGVNKYRMDIIFAYAPMTD 124

  Fly   113 VLKKLVEEAWQSLGKNKICESENA------------------------TQLELDTVSKNAF---- 149
            ..|:::::.......|.:.....|                        |:.|:.:..:..|
 Worm   125 ATKQIMDKIQNRYTANDLLNPVAAYIKGLYNITAVPVLNTNMTYKGFTTEGEMVSWMQGQFQSEC 189

  Fly   150 -----AGVQFDDAWANLTENDPLPNDFHFALRFPAELRTATIAIANT---WLTMRLFPTIDLTGP 206
                 ||:.|||:.|...:| |...||.:.:|.....|.:..|..:.   |.|...|....::||
 Worm   190 DNPLLAGIVFDDSIAKDLKN-PDKRDFTYTIRLSNTHRRSRNAFGDNSYPWDTSVSFAVQYVSGP 253

  Fly   207 RNEGDDDGGIPPGYLREGFLPLQHSLSMAYLRQKSGEQD-----LPNVVMKRYPFPAYIFDPLLE 266
            .|..|:||| .|||.:|||:.:|.::.:|.....:||..     |.:..:.|:|||.| ...::|
 Worm   254 INPDDNDGG-SPGYWQEGFMTVQRAVDVAITEIITGEDAQLTPLLDSYQVSRFPFPGY-STKIIE 316

  Fly   267 GMSSIMSLIILLSFIYPCTYITKYITAEKEKQLKEVMKIMGLSNWLHWTAWFVKSFIMLTISAIL 331
            ..:..|.:|::.||:....||.:.:..|||.:|||.|::||||.:::|.|.|:.::..||.:.|:
 Worm   317 IGAFFMPVIVIFSFMTSVIYIVRAVVVEKEDRLKEYMRVMGLSQFINWVAHFIINYAKLTFAVIV 381

  Fly   332 IAILVKINWSEDVAVLTHANFTALVFFLIIYIVSSICFCFMMATFFSRASTAAAVTGLIWFIAYI 396
            :.||:..       |...::.|.:..||:||....:.|.||:::|.:.|::|..::.:.|.:.|.
 Worm   382 LTILMHF-------VALKSDMTLMFVFLMIYAFDVVYFAFMISSFMNSATSATLISVVFWMLLYF 439

  Fly   397 PYSFTINSYDDLSLSSKLGWSLIS----NTAMGFGIKLILGFEGTGEGLQWSNFFTPVSVDDTLT 457
            .|:| .:|.|..: ...||:.||:    :.|:.:|::|:..:|...:||:|...|||.|.|:.||
 Worm   440 WYAF-FSSIDQTN-PYPLGYRLINCINPDIALNYGLQLLAAYETQADGLKWGELFTPPSPDNNLT 502

  Fly   458 LGAVMIMMLVSCVIYMIICLYVEQVMPGSFGVP-RPWNFPFTREFWCGEREYTGVEDIPNG---- 517
            .|..:|.::|..:|.:|:..|:|.|:||..||| :||.|... .:|           .||.
 Worm   503 FGHALIALIVDGIIMIILTWYIEAVIPGGEGVPQKPWFFVLP-SYW-----------FPNSGSKT 555

  Fly   518 --------HVEQRDPKAFETEPEGKHIGLQMRHLKKRF----------------GNKMVVKGLSM 558
                    .::..|....|.||......:.:.:|.|.:                |.|..|..|::
 Worm   556 VDSSDQFQQIQYADHVKLEKEPTDLIPTINVVNLTKTYGTSFFKKLFDCKFGKSGEKRAVSNLNL 620

  Fly   559 NMFEDEITVLLGHNGAGKTTTISMLTGMFPPTSGTAIINGSDIRTNIEGARMSLGICPQHNVLFD 623
            .|:..:.|||||||||||:||.|||||:..|:||:|.:|..||||::...|..:|:|||:|.||.
 Worm   621 KMYPGQCTVLLGHNGAGKSTTFSMLTGVASPSSGSAYVNDFDIRTSLPKIRREMGLCPQYNTLFG 685

  Fly   624 EMSVSNHIRFFSRMKGLRGKAVEQEVAKYLKMIELEDKANVASSKLSGGMKRKLSVCCALCGDTK 688
            .|:|..|:.||:::|.....  .:|..:.|..:.::.||:..:..||||.|||||:..||.|.::
 Worm   686 FMTVMEHLEFFAKLKERTWD--PEEAREILARLRIDFKADFMAGALSGGQKRKLSLAIALIGGSE 748

  Fly   689 VVLCDEPSSGMDPSARRQLWDLLQQEKVGRTLLLTTHFMDEADVLGDRIAIMCDGELKCQGTSFF 753
            ||:.|||:|||||.||.:.|.|:|:||..||:|||||||:|||:||||||||..|:|:|.|:..|
 Worm   749 VVMLDEPTSGMDPGARHETWTLIQREKERRTILLTTHFMEEADLLGDRIAIMAHGQLECCGSPMF 813

  Fly   754 LKKQYGSGYRLICVKRDDCETNEV---TALLNKYIPGLKPECDIGAELSYQLPDSASAKFEEMFG 815
            ||:|||.||.|..| .|...|.:|   |.::.:|||.......||.|.:|.|..:....|.::|.
 Worm   814 LKQQYGDGYHLTIV-YDTTSTPDVSKTTDIIREYIPEAHVFSYIGQEATYLLSATHRPIFPKLFK 877

  Fly   816 QLEEQSDELHLNGYGVGITSMEEVFMKVGAEKDNTGNIKDQHEIMNGGSGFRGEDDNESVQSDGI 880
            :||:...:..:..:||.||:|||||:|||...|...|.  :|.|.|        |.:|.::.|..
 Worm   878 ELEDHQTQCGITSFGVSITTMEEVFLKVGHTADERYNY--EHGIEN--------DISEMIEKDDP 932

  Fly   881 FSENRRL---LQGLQLLSNQWKAMLLKKFLYTWRNKLLLLIQNIMPVFFVVVTILIIKTQGTFQE 942
            ..::.|.   :.|..|.....|||..|:.::.:|.....|.|.:.||.::|:.:...:...:.:|
 Worm   933 ILQDLRAQVRVTGFTLQMQHAKAMFYKRAIFFFRKWTQFLPQLVFPVAYLVLMVFTSQVLPSVKE 997

  Fly   943 LKPITISL-------------------------------------TQYPLAVTVLD-RSNVQ--- 966
            ..|.||||                                     ||..:..||:| .|||:
 Worm   998 QDPQTISLAPFSDTKKAGHLVSDSGNYVTLLGGSQNLSSMVQGTVTQLGVTQTVVDITSNVEKFI 1062

  Fly   967 ----NGTGYEIANKYEDLARSYGSNYGLELTGTQGFEDYILDLGKTIQVRINSRYLVAATITESK 1027
                |..|          :|::|.:|.|      ||...:.:.               :|::...
 Worm  1063 MDQTNAMG----------SRTFGLHYAL------GFVPSMFNF---------------STVSVPS 1096

  Fly  1028 ITAWLNNQALHTAPLTVNMVHNAIADKLFGSSVKIQVTNAPLPYTTSTLLSQLSTGNNLGTQLAS 1092
            :..:.||..|:|..|.:....:.|..:...........|.|||.:|...|...:..:.....:|.
 Worm  1097 LKTFFNNFGLYTPALAITFTDSMILSQKQKKQYSFTAVNHPLPPSTQDTLKNTNRSDGAAFLIAY 1161

  Fly  1093 NL--CFCMCFVSSIYILFLIKERESRAKLLQFVGGVKVWTFWLSQFICDFASYIVTALIVVITIV 1155
            .|  .|.:|...  |..|||.||:.::|.:|.:.|::.|.|||:.||.|.|.:::..|.......
 Worm  1162 GLIVSFAVCVAG--YSQFLITERKKKSKHMQLLSGIRPWMFWLTAFIWDAAWFVIRILCFDAIFY 1224

  Fly  1156 CFQETGLS-TFGELGRYYLLLLLFGFAVLPFIYIMSLFFREPATGFARVSIVNIFCGMALFIVVV 1219
            .|..|..: .||.:....|..||:|:..|||.|....||.....||..|::.:|..||...|.|.
 Worm  1225 IFNITAYTHDFGVMLILTLSFLLYGWTALPFTYWFQFFFESAPKGFMMVTMYHILTGMIGSIAVP 1289

  Fly  1220 VMSSELFDTKDTADILGWIFR-IFPHFSLAMSLNKVYTNTATRNACAKAGALPPILLCELVPQCC 1283
            ::|..  .:.|...:...||. :||.::::......:.|...|.||.|.....|:.  :.|..||
 Worm  1290 IISQT--SSLDAGYLWSIIFAWLFPTYNISQIATVTFQNENVRIACKKLDCTIPMF--KAVTACC 1350

  Fly  1284 NL--------KPYFAWEEPGVLPETVYMAVTGVVFFLIIIVLEFRLINELMFKIRQLI-SKPPPP 1339
            ..        ...|.....|:|...:::||.|.::::.:.:.|    |:...|:..|| .:....
 Worm  1351 GTASERLYVDNVLFVGNRKGILVYVIFLAVQGFIYWIWVFMRE----NDQFTKLFALIRCRKADN 1411

  Fly  1340 PTEGQLDDDVANERE----------RILQMSSNELATKNLVLDRVTKYYGQFMAVNQVSLCVQEV 1394
            |.....|.|..:||:          .::|..:|...|. ||.:.:.|:||.|.||..|:..|...
 Worm  1412 PIWDITDTDKVDERDVEDSDVIAEKSVVQRLANNNKTA-LVSNNLVKWYGNFNAVKGVNFHVNSK 1475

  Fly  1395 ECFGLLGVNGAGKTTTFKMMTGDERISSGAAYVQGLSLESNMNSIYKMIGYCPQFDALLDDLTGR 1459
            :|||||||||||||:||:|:||:..||||.|||.|.|:::|........|||||:||::.:::|.
 Worm  1476 DCFGLLGVNGAGKTSTFQMLTGENSISSGDAYVNGWSVKNNWREAGANTGYCPQYDAIIKEMSGE 1540

  Fly  1460 EVLRIFCMLRGVQESRIRQLSEDLAKSFGFMKHIDKQTHAYSGGNKRKLSTAIAVIGSPSVIYLD 1524
            |.|.:|..:||:.|..|.:....:..:.|...:..:|...|||||||:||..||::|.|.|:.||
 Worm  1541 ETLYMFARIRGIPEKDIPKKVNAVIHAIGIGMYASRQIKTYSGGNKRRLSLGIAIVGLPDVLLLD 1605

  Fly  1525 EPTTGMDPAARRQLWNMVCRIRDSGKSIVLTSHSMEECEALCTRLAIMVNGEFKCIGSTQHLKNK 1589
            |||:|:||.|||.:||::.|:||.|.::|||||||:|||||||.|||||.|:|:|.||.||:|::
 Worm  1606 EPTSGVDPKARRIIWNILNRLRDLGTALVLTSHSMDECEALCTELAIMVYGKFRCYGSCQHIKSR 1670

  Fly  1590 FSKGLILKIKVRRNLEALRQARLSGGYARNPDEQTVPAQMSQRDIDAVKEFVETEYPNSILQEEY 1654
            :..|..|.|:::.               ||..|:|             |..::..:..|:::||:
 Worm  1671 YGSGYTLLIRLKN---------------RNDAEKT-------------KSTIKQTFRGSVIKEEH 1707

  Fly  1655 QGILTFYIPLTGVKWSRIFGLMESNRDQLNVEDYSVSQTTLEEIFLEFAK 1704
            ...|.|.||..|..|||:|..:|:....||.:|||:||||||::|:||::
 Worm  1708 VLQLNFDIPRDGDSWSRLFEKLETVSTSLNWDDYSLSQTTLEQVFIEFSR 1757

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ABCA	NP_608445.2	ABC2_membrane_4	254..434	CDD:289500	55/183 (30%)
		ABC2_membrane_3	<269..475	CDD:289468	65/209 (31%)
		CcmA	538..843	CDD:224054	140/323 (43%)
		ABC_subfamily_A	538..755	CDD:213230	106/232 (46%)
		ABC2_membrane_3	913..1316	CDD:289468	105/459 (23%)
		ABC_subfamily_A	1369..1587	CDD:213230	112/217 (52%)
		drrA	1376..1702	CDD:130256	144/325 (44%)
abt-4	NP_503175.1	ABC2_membrane_3	<281..523	CDD:289468	76/251 (30%)
		NosY	<377..524	CDD:224196	44/155 (28%)
		CcmA	581..905	CDD:224054	140/326 (43%)
		ABC_subfamily_A	586..815	CDD:213230	106/230 (46%)
		ABC2_membrane_3	<1078..1318	CDD:289468	67/264 (25%)
		ABC_subfamily_A	1450..1668	CDD:213230	112/217 (52%)
		drrA	1457..1755	CDD:130256	144/325 (44%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159943
Domainoid	1	1.000	146	1.000	Domainoid score	I2794
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37437
Inparanoid	1	1.050	837	1.000	Inparanoid score	I230
Isobase	1	0.950	-	0	Normalized mean entropy	S3774
OMA	1	1.010	-	-		QHG53524
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	1	1.000	-	-		otm14487
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	1	1.100	-	-	O	PTHR19229
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4336
SonicParanoid	1	1.000	-	-		X215
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	17	16.750