DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ABCA and ABCA13

DIOPT Version :9

Sequence 1:	NP_608445.2	Gene:	ABCA / 33103	FlyBaseID:	FBgn0031170	Length:	1714	Species:	Drosophila melanogaster
Sequence 2:	XP_011513432.1	Gene:	ABCA13 / 154664	HGNCID:	14638	Length:	5059	Species:	Homo sapiens

Alignment Length:	2011	Identity:	565/2011 - (28%)
Similarity:	938/2011 - (46%)	Gaps:	438/2011 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 WQMVIELV-LPA--IFSLLLVLVR----------TLVDTEQKGVRYYNEQNLTDL-----NLLQH 72
            |....||. ||.  ::||:::|.|          ||:.:|..|:.    .:|.|:     .||..
Human  3139 WIAAEELCSLPGSKVYSLIVLLSRNLDVRAFIYKTLMPSEANGLL----NSLLDIVSSLSALLAK 3199

  Fly    73 SLHRSSYLG------KLIAL--------IAPNRRRKNGGFSKFEFIL---CYSPVN--------- 111
            :.|...||.      |:.||        ::.|.:.::..|..|:|::   |....:
Human  3200 AQHVFEYLPEFLHTFKITALLETLDFQQVSQNVQARSSAFGSFQFVMKMVCKDQASFLSDSNMFI 3264

  Fly   112 --PVLKKLVEE------------------------------AWQSL-----GK----------NK 129
              |.:|:|:|:                              .|..|     ||          ||
Human  3265 NLPRVKELLEDDKEKFNIPEDSTPFCLKLYQEILQLPNGALVWTFLKPILHGKILYTPNTPEINK 3329

  Fly   130 ICESEN-------------ATQLELDTVSKNAFAGVQFD---DAWAN-----------------L 161
            :.:..|             .|.||:.::.:.:.:|..|:   :|..|                 |
Human  3330 VIQKANYTFYIVDKLKTLSETLLEMSSLFQRSGSGQMFNQLQEALRNKFVRNFVENQLHIDVDKL 3394

  Fly   162 TEN--------DPLPND-----FHF------------AL-RFPA-------ELRTATIAIANTWL 193
            ||.        |.:.|.     |.|            || ||.|       |.:...:...|::|
Human  3395 TEKLQTYGGLLDEMFNHAGAGRFRFLGSILVNLSSCVALNRFQALQSVDILETKAHELLQQNSFL 3459

  Fly   194 -----------------TMRLFPTIDLT---------------------GPRNEGDDDGGIPPGY 220
                             :::|.|.:..|                     .|:|...|  |....|
Human  3460 ASIIFSNSLFDKNFRSESVKLPPHVSYTIRTNVLYSVRTDVVKNPSWKFHPQNLPAD--GFKYNY 3522

  Fly   221 LREGFLPLQHSLSMAYLRQKSGEQDL-PNVVMKRYPFPAYIFDPLLEGMSSIMSLIILLSFIYPC 284
            :   |.|||..:..|.:..::|::.| |....:..|:|.:..|..|..:.....||::|:::...
Human  3523 V---FAPLQDMIERAIILVQTGQEALEPAAQTQAAPYPCHTSDLFLNNVGFFFPLIMMLTWMVSV 3584

  Fly   285 TYITKYITAEKEKQLKEVMKIMGLSNWLHWTAWFVKSFIMLTISAILIAILVKINWSEDVAVLTH 349
            ..:.:.:..|:|.|::|.|::||:...:|:.|||:::..:||||:..:||::|.:     .:..|
Human  3585 ASMVRKLVYEQEIQIEEYMRMMGVHPVIHFLAWFLENMAVLTISSATLAIVLKTS-----GIFAH 3644

  Fly   350 ANFTALVFFLIIYIVSSICFCFMMATFFSRASTAAAVTGLIWFIAYIPYSFTINSYDDLSLSSKL 414
            :|...:..||:.:.:|.:...::::.|||:|:|||..|.|::.|:::||...:..::.||..::.
Human  3645 SNTFIVFLFLLDFGMSVVMLSYLLSAFFSQANTAALCTSLVYMISFLPYIVLLVLHNQLSFVNQT 3709

  Fly   415 GWSLISNTAMGFGIKLILGFEGTGEGLQWSNFFTPVSVDDTLTLGAVMIMMLVSCVIYMIICLYV 479
            ...|:|.||.|.|:..|...||...|:||:|.:..:. ...:|.|.|..|:|....:|.:...|:
Human  3710 FLCLLSTTAFGQGVFFITFLEGQETGIQWNNMYQALE-QGGMTFGWVCWMILFDSSLYFLCGWYL 3773

  Fly   480 EQVMPGSFGVPRPWNFPFTREFW------CGEREY---------TGVEDIPNGHVEQRDPKAFET 529
            ..::||:||:.:||.||||..:|      ..:|:|         ....|.....::.|     |.
Human  3774 SNLIPGTFGLRKPWYFPFTASYWKSVGFLVEKRQYFLSSSLFFFNENFDNKGSSLQNR-----EG 3833

  Fly   530 EPEGKHIGLQMRHLKKRF-GNKMVVKGLSMNMFEDEITVLLGHNGAGKTTTISMLTGMFPPTSGT 593
            |.||...|:.:..:.|.: |:|.||:.||:..:.|:||.|||.|||||||.||||||:.||||||
Human  3834 ELEGSAPGVTLVSVTKEYEGHKAVVQDLSLTFYRDQITALLGTNGAGKTTIISMLTGLHPPTSGT 3898

  Fly   594 AIINGSDIRTNIEGARMSLGICPQHNVLFDEMSVSNHIRFFSRMKGLR--GKAVEQEVAKYLKMI 656
            .||||.:::|::...||.||:|||.::|.|.::|..|:..|:.:|..:  .|.:.|:|.:.|:.:
Human  3899 IIINGKNLQTDLSRVRMELGVCPQQDILLDNLTVREHLLLFASIKAPQWTKKELHQQVNQTLQDV 3963

  Fly   657 ELEDKANVASSKLSGGMKRKLSVCCALCGDTKVVLCDEPSSGMDPSARRQLWDLLQQEKVGRTLL 721
            :|....:..:..||||:|||||:..|..|.::.|:.|||:||:||.:|..|||:|.:.:.|||::
Human  3964 DLTQHQHKQTRALSGGLKRKLSLGIAFMGMSRTVVLDEPTSGVDPCSRHSLWDILLKYREGRTII 4028

  Fly   722 LTTHFMDEADVLGDRIAIMCDGELKCQGTSFFLKKQYGSGYRLICVKRDD-CETNE------VTA 779
            .|||.:|||:.|.||:|::..|.|:|.|..|.||:.||.|.||...::.. .|.::      ||:
Human  4029 FTTHHLDEAEALSDRVAVLQHGRLRCCGPPFCLKEAYGQGLRLTLTRQPSVLEAHDLKDMACVTS 4093

  Fly   780 LLNKYIPGLKPECDIGAELSYQLP-DSASAKFEEMFGQLEEQSDELHLNGYGVGITSMEEVFMKV 843
            |:..|||....:...|:||:|.:| |:..|..:.:|..|:|...:|||.|||:..|::||||:.:
Human  4094 LIKIYIPQAFLKDSSGSELTYTIPKDTDKACLKGLFQALDENLHQLHLTGYGISDTTLEEVFLML 4158

  Fly   844 GAEKDNTGNIK--DQHEIMNGG-----SGFRGEDDNESVQSDGIFSENRRLLQGLQLLSNQWKAM 901
            ..:.:...:|.  .:.|:.|..     ||:.|.....:.            :||:|||..|..|:
Human  4159 LQDSNKKSHIALGTESELQNHRPTGHLSGYCGSLARPAT------------VQGVQLLRAQVAAI 4211

  Fly   902 LLKKFLYTWRNKLLLLIQNIMPVFFVVVTILIIKTQGTFQELKPITISLTQYPLAVTV------- 959
            |.::...|.|.....|...::||.||.:.:.:...:....|..|:.::...|..|.|.
Human  4212 LARRLRRTLRAGKSTLADLLLPVLFVALAMGLFMVRPLATEYPPLRLTPGHYQRAETYFFSSSGG 4276

  Fly   960 --LDRSNVQNGTGYEIANKYED-----------------------------------------LA 981
              ||.:.|       :..|:.|                                         .:
Human  4277 DNLDLTRV-------LLRKFRDQDLPCADLNPRQKNSSCWRTDPFSHPEFQDSCGCLKCPNRSAS 4334

  Fly   982 RSYGSNY-GLELTGTQGF--EDYILDL-------GKTIQVRINSRY-----LVAATITESKITAW 1031
            ..|.:|: |..|....||  |:|:|..       |.:..::|.|..     .::...|.:|:  |
Human  4335 APYLTNHLGHTLLNLSGFNMEEYLLAPSEKPRLGGWSFGLKIPSEAGGANGNISKPPTLAKV--W 4397

  Fly  1032 LNNQALHTAPLTVNMVHNAIADKLFGSSV---KIQVTNAPLPYTTSTLLSQLSTGNNLGTQLASN 1093
            .|.:..|:.|..:|.::|.|..:....:|   :..:|....|| ...||::        .::..:
Human  4398 YNQKGFHSLPSYLNHLNNLILWQHLPPTVDWRQYGITLYSHPY-GGALLNE--------DKILES 4453

  Fly  1094 LCFC---MCFVSSIYIL------FLIKERESRAKLLQFVGGVKVWTFWLSQFICDFASYIVTALI 1149
            :..|   :|.|....||      .::::|...||.||.:.|:....:|.:.|:.|...|:|:..:
Human  4454 IRQCGVALCIVLGFSILSASIGSSVVRDRVIGAKRLQHISGLGYRMYWFTNFLYDMLFYLVSVCL 4518

  Fly  1150 VVITIVCFQETGLSTFGELGRYYLLLLLFGFAVLPFIYIMSLFFREPATGFARVSIVNIFCGMAL 1214
            .|..||.||.|..:....|....|||.|||:|.||::|:||..|......|.....:|...|:..
Human  4519 CVAVIVAFQLTAFTFRKNLAATALLLSLFGYATLPWMYLMSRIFSSSDVAFISYVSLNFIFGLCT 4583

  Fly  1215 FIVVVV-----MSSELFDTKDTADILGWIFRIFPHFSLAMSLNKVYTNTATRNACAKAGALPPIL 1274
            .::.::     :.|:..:.::..|:|.|:|.|||.|.|...|.::..|....:.....|....:.
Human  4584 MLITIMPRLLAIISKAKNLQNIYDVLKWVFTIFPQFCLGQGLVELCYNQIKYDLTHNFGIDSYVS 4648

  Fly  1275 LCELVPQCCNLKPYFAWEEPGVLPETVYMAVTGVVFFLIIIVLEFRLI------NELMFKIRQLI 1333
            ..|:        .:..|       ..|.:|..|.|..|:.::|.:.|:      :.|...::.
Human  4649 PFEM--------NFLGW-------IFVQLASQGTVLLLLRVLLHWDLLRWPRGHSTLQGTVKS-- 4696

  Fly  1334 SKPPPPPTEGQLDDDVANERERILQMSSNELATKNLVLDRVTKYYGQF----MAVNQVSLCVQEV 1394
            ||          |.||..|.:|:.:..:|   ...|||..::|:|.:|    :||..:||.:.:.
Human  4697 SK----------DTDVEKEEKRVFEGRTN---GDILVLYNLSKHYRRFFQNIIAVQDISLGIPKG 4748

  Fly  1395 ECFGLLGVNGAGKTTTFKMMTGDERISSGAAYVQ---GLSLE-SNMNSIYKMIGYCPQFDALLDD 1455
            |||||||||||||:|||||:.|:..::||.|.::   |.::: |:..:...:||||||.|||.:.
Human  4749 ECFGLLGVNGAGKSTTFKMLNGEVSLTSGHAIIRTPMGDAVDLSSAGTAGVLIGYCPQQDALDEL 4813

  Fly  1456 LTGREVLRIFCMLRGVQESRIRQLSEDLAKSFGFMKHIDKQTHAYSGGNKRKLSTAIAVIGSPSV 1520
            |||.|.|..:|.|||:....|.:::.||.:......|.||....||||.|||||||:|::|.|.:
Human  4814 LTGWEHLYYYCSLRGIPRQCIPEVAGDLIRRLHLEAHADKPVATYSGGTKRKLSTALALVGKPDI 4878

  Fly  1521 IYLDEPTTGMDPAARRQLWNMVCRIRDSGKSIVLTSHSMEECEALCTRLAIMVNGEFKCIGSTQH 1585
            :.||||::||||.::|.||..:.:....|.:.|||||||||||||||||||||||.|||:||.||
Human  4879 LLLDEPSSGMDPCSKRYLWQTIMKEVREGCAAVLTSHSMEECEALCTRLAIMVNGSFKCLGSPQH 4943

  Fly  1586 LKNKFSKGLILKIKVRRNLEALRQARLSGGYARNPDEQTVPAQMSQRDIDAVKEFVETEYPNSIL 1650
            :||:|..|..:|:.:.:  ||.:...:|                     |.:|.:    :|....
Human  4944 IKNRFGDGYTVKVWLCK--EANQHCTVS---------------------DHLKLY----FPGIQF 4981

  Fly  1651 QEEYQGILTFYIPLTGVKW---SRIFGLMESNRDQLNVEDYSVSQTTLEEIFLEFAKYQRE 1708
            :.::..:|.:::|   .:|   :.:|.::|:|:..||::.||::|||||::|:.||..|::
Human  4982 KGQHLNLLEYHVP---KRWGCLADLFKVIENNKTFLNIKHYSINQTTLEQVFINFASEQQQ 5039

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ABCA	NP_608445.2	ABC2_membrane_4	254..434	CDD:289500	51/179 (28%)
		ABC2_membrane_3	<269..475	CDD:289468	59/205 (29%)
		CcmA	538..843	CDD:224054	132/315 (42%)
		ABC_subfamily_A	538..755	CDD:213230	97/219 (44%)
		ABC2_membrane_3	913..1316	CDD:289468	101/484 (21%)
		ABC_subfamily_A	1369..1587	CDD:213230	114/225 (51%)
		drrA	1376..1702	CDD:130256	138/336 (41%)
ABCA13	XP_011513432.1	rim_protein	3068..5049	CDD:130324	565/2011 (28%)
		ABC_subfamily_A	3842..4062	CDD:213230	97/219 (44%)
		ABC_subfamily_A	4719..4945	CDD:213230	114/225 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148387
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	1	1.100	-	-	O	PTHR19229
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.750