DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ABCA and Abca2

DIOPT Version :9

Sequence 1:	NP_608445.2	Gene:	ABCA / 33103	FlyBaseID:	FBgn0031170	Length:	1714	Species:	Drosophila melanogaster
Sequence 2:	XP_006497672.1	Gene:	Abca2 / 11305	MGIID:	99606	Length:	2464	Species:	Mus musculus

Alignment Length:	1907	Identity:	582/1907 - (30%)
Similarity:	901/1907 - (47%)	Gaps:	409/1907 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   135 NATQL--ELDTVSKNAFAGVQF--------------DDAWANLTEND------------------ 165
            |.|.|  :|||:...|...:||              :::..|.|.|.
Mouse   579 NGTALLQQLDTIDNAACGWIQFMSKVSVDIFKGFPDEESIVNYTLNQAYQDNVTVFASVIFQTRK 643

  Fly   166 --PLPNDFHFALRFPAELRTATIAIANT-WLTMRLFPTIDLTGPRNEGDDDGGIPPGYLREGFLP 227
              .||...|:.:|..:.....|..|... |               ..|.:.||  ..|...||:.
Mouse   644 DGSLPPHVHYKIRQNSSFTEKTNEIRRAYW---------------RPGPNTGG--RFYFLYGFVW 691

  Fly   228 LQHSLSMAYLRQKSGEQDL-PNVVMKRYPFPAYIFDPLLEGMSSIMSLIILLSFIYPCTYITKYI 291
            :|..:..|.:....|...: |...::.:|:|.|..|..|..:..:|.|.:::|::|......::|
Mouse   692 IQDMMERAIINTFVGHDVVEPGNYVQMFPYPCYTRDDFLFVIEHMMPLCMVISWVYSVAMTIQHI 756

  Fly   292 TAEKEKQLKEVMKIMGLSNWLHWTAWFVKSFIMLTISAILIAILVKINWSEDVAVLTHANFTALV 356
            .||||.:||||||.|||:|.:||.|||:..|:.|:||...:..::|..     .||.|::...:.
Mouse   757 VAEKEHRLKEVMKTMGLNNAVHWVAWFITGFVQLSISVTALTAILKYG-----QVLMHSHVLIIW 816

  Fly   357 FFLIIYIVSSICFCFMMATFFSRASTAAAVTGLIWFIAYIPYSFTI----NSYDDLSLSSKLGWS 417
            .||.:|.|::|.|||:::..:|:|..|:|..|:|:|::|:||.:..    .::|.::...|...|
Mouse   817 LFLAVYAVATIMFCFLVSVLYSKAKLASACGGIIYFLSYVPYMYVAIREEVAHDKITAFEKCIAS 881

  Fly   418 LISNTAMGFGIKLILGFEGTGEGLQWSNFF-TPVSVDDTLTLGAVMIMMLVSCVIYMIICLYVEQ 481
            |:|.||.|.|.|....:|..|.|:||..|. :||..||...|.|| .|::|..|:|.::..|:|.
Mouse   882 LMSTTAFGLGSKYFALYEVAGVGIQWHTFSQSPVEGDDFNLLLAV-TMLMVDTVVYGVLTWYIEA 945

  Fly   482 VMPGSFGVPRPWNFPFTREFWCGEREYTGVE-DIPNGH--------------VEQR---DPKAFE 528
            |.||.:|:||||.||..:.:|.|.......| ..|..|              :|.|   :.:..|
Mouse   946 VHPGMYGLPRPWYFPLQKSYWLGSGRTEAWEWSWPWAHTPRLSVMEEDQACAMESRHFEETRGME 1010

  Fly   529 TEPEGKHIGLQMRHLKKRFGN--KMVVKGLSMNMFEDEITVLLGHNGAGKTTTISMLTGMFPPTS 591
            .||....:.:.:..|.|.:.|  ||.:..||:|::|:::...|||||||||||:|:|||:|||||
Mouse  1011 EEPTHLPLVVCVDKLTKVYKNDKKMALNKLSLNLYENQVVSFLGHNGAGKTTTMSILTGLFPPTS 1075

  Fly   592 GTAIINGSDIRTNIEGARMSLGICPQHNVLFDEMSVSNHIRFFSRMKGLRGKAVEQEVAKYLKMI 656
            |:|.|.|.||||.::..|.:||:|||||||||.::|..|:.|:||:|.:..:.:.:|..|.::.:
Mouse  1076 GSATIYGHDIRTEMDEIRKNLGMCPQHNVLFDRLTVEEHLWFYSRLKSMAQEEIRKETDKMIEDL 1140

  Fly   657 ELEDKANVASSKLSGGMKRKLSVCCALCGDTKVVLCDEPSSGMDPSARRQLWDLLQQEKVGRTLL 721
            ||.:|.:.....|||||||||||..|..|.::.::.|||::|:||.|||.:|||:.:.|.|||:|
Mouse  1141 ELSNKRHSLVQTLSGGMKRKLSVAIAFVGGSRAIILDEPTAGVDPYARRAIWDLILKYKPGRTIL 1205

  Fly   722 LTTHFMDEADVLGDRIAIMCDGELKCQGTSFFLKKQYGSGYRLICVKR----------------- 769
            |:||.|||||:|||||||:..|:|||.|:..|||..||.||||..||:
Mouse  1206 LSTHHMDEADLLGDRIAIISHGKLKCCGSPLFLKGAYGDGYRLTLVKQPAEPGTSQEPGLASSPS 1270

  Fly   770 -----DDCETNEVTALLNKYIPGLKPECDIGAELSYQLPDSASAK--FEEMFGQLEEQSDELHLN 827
                 ..|...:|:..:.|::.......|...||||.||..|..|  ||.:|.|||...|.|||:
Mouse  1271 GCPRLSSCSEPQVSQFIRKHVASSLLVSDTSTELSYILPSEAVKKGAFERLFQQLEHSLDALHLS 1335

  Fly   828 GYGVGITSMEEVFMKVGAE----KDNTGNIKD-QHEIMNGGSGF--------------------- 866
            .:|:..|::||||:||..|    :::..::|: :.:::.|..|.
Mouse  1336 SFGLMDTTLEEVFLKVSEEDQSLENSEADVKESRKDVLPGAEGLTAVGGQAGNLARCSELAQSQA 1400

  Fly   867 -----------RGED---------------------DNESVQSDGI-----FSENRRLLQGLQLL 894
                       |||:                     ||.|:|...:     ..:..|.|:|..|.
Mouse  1401 SLQSASSVGSARGEEGTGYSDGYGDYRPLFDNLQDPDNVSLQEAEMEALAQVGQGSRKLEGWWLK 1465

  Fly   895 SNQWKAMLLKKFLYTWRNKLLLLIQNIMPVFFVVVTILIIKTQGTFQELKPITISLTQY------ 953
            ..|:..:|:|:|....||...|..|.::|.|||.|.:.:..:.....:|.|:.:|.:||
Mouse  1466 MRQFHGLLVKRFHCARRNSKALCSQILLPAFFVCVAMTVALSVPEIGDLPPLVLSPSQYHNYTQP 1530

  Fly   954 -----PLA-------------------------------VTVLDRS----------NVQNGTGYE 972
                 |.|                               .|.:.:|          |:.:|....
Mouse  1531 RGNFIPYANEERQEYRLRLSPDASPQQLVSTFRLPSGVGATCVLKSPANGSLGPMLNLSSGESRL 1595

  Fly   973 IANKYEDLARSYGSNYGLELT-------------------------------------------- 993
            :|.::.|.........||.|:
Mouse  1596 LAARFFDSMCLESFTQGLPLSNFVPPPPSPAPSDSPVSPDEDSLQAWNMSLPPTAGPETWTSAPS 1660

  Fly   994 ----------------GTQGF-----------------------------EDYIL---------- 1003
                            || ||                             .:|:|
Mouse  1661 LPRLVHEPVRCTCSAQGT-GFSCPSSVGGHPPQMRVVTGDILTDITGHNVSEYLLFTSDRFRLHR 1724

  Fly  1004 -------DLGKTIQVRINSRY--LVAATITESKITAWLNNQALHTAPLTVNMVHNAI------AD 1053
                   ::.|:|.....:|.  :|.............||:..|:.|..:|.::|||      ..
Mouse  1725 YGAITFGNVQKSIPASFGARVPPMVRKIAVRRVAQVLYNNKGYHSMPTYLNSLNNAILRANLPKS 1789

  Fly  1054 KLFGSSVKIQVTNAPLPYTTSTL-LSQLSTGNNLGTQLASNLCFCMCFVSSIYILFLIKERESRA 1117
            |...::..|.|||.|:..|:::| |..|..|.::  .:|..:...|.||.:.:::||:.|:.::|
Mouse  1790 KGNPAAYGITVTNHPMNKTSASLSLDYLLQGTDV--VIAIFIIVAMSFVPASFVVFLVAEKSTKA 1852

  Fly  1118 KLLQFVGGVKVWTFWLSQFICDFASYIVTALIVVITIVCFQETGLSTFGELGRYYLLLLLFGFAV 1182
            |.||||.|.....:||:.::.|..:|:|.|...||.:..|.....::.........|.||:|:::
Mouse  1853 KHLQFVSGCNPVIYWLANYVWDMLNYLVPATCCVIILFVFDLPAYTSPTNFPAVLSLFLLYGWSI 1917

  Fly  1183 LPFIYIMSLFFREPATGFARVSIVNIFCGMALFIVVVVMSSELF----DTKDTADILGWIFRIFP 1243
            .|.:|..|.:|..|::.:..:.::|:|.|:...:...::  :||    |.|.....|...|.|||
Mouse  1918 TPIMYPASFWFEVPSSAYVFLIVINLFIGITATVATFLL--QLFEHDKDLKVVNSYLKSCFLIFP 1980

  Fly  1244 HFSLAMSLNKVYTNTATRNACAKAGALPPILLCELVPQCCNLKPYFAWEEPGVLPETVYMAVTGV 1308
            :::|...|.::..|.......||.|            |...:|..|.|:.  |....|.|.|.|.
Mouse  1981 NYNLGHGLMEMAYNEYINEYYAKIG------------QFDKMKSPFEWDI--VTRGLVAMTVEGF 2031

  Fly  1309 VFFLIIIVLEFRLINELMFKIRQLISKPPPPPTEGQLDD-DVANERERILQMSSNELATKNLVLD 1372
            |.|.:.|:.::..:.:         .:..|..|:...|| |||:||:|:|:..::....|   ::
Mouse  2032 VGFFLTIMCQYNFLRQ---------PQRLPVSTKPVEDDVDVASERQRVLRGDADNDMVK---IE 2084

  Fly  1373 RVTKYY-----GQFMAVNQVSLCVQEVECFGLLGVNGAGKTTTFKMMTGDERISSGAAYVQGLSL 1432
            .:||.|     |:.:||:::.|.|:..||||||||||||||:||||:||||..:.|.|:|.|.|:
Mouse  2085 NLTKVYKSRKIGRILAVDRLCLGVRPGECFGLLGVNGAGKTSTFKMLTGDESTTGGEAFVNGHSV 2149

  Fly  1433 ESNMNSIYKMIGYCPQFDALLDDLTGREVLRIFCMLRGVQESRIRQLSEDLAKSFGFMKHIDKQT 1497
            ..::..:.:.:|||||||||.|:||.||.|:::..|||:......|:.:...:.....|:.||..
Mouse  2150 LKDLLQVQQSLGYCPQFDALFDELTAREHLQLYTRLRGIPWKDEAQVVKWALEKLELTKYADKPA 2214

  Fly  1498 HAYSGGNKRKLSTAIAVIGSPSVIYLDEPTTGMDPAARRQLWNMVCRIRDSGKSIVLTSHSMEEC 1562
            ..||||||||||||||:||.|:.|:||||||||||.|||.|||::..:..:|:|:||||||||||
Mouse  2215 GTYSGGNKRKLSTAIALIGYPAFIFLDEPTTGMDPKARRFLWNLILDLIKTGRSVVLTSHSMEEC 2279

  Fly  1563 EALCTRLAIMVNGEFKCIGSTQHLKNKFSKGLILKIKVRRNLEALRQARLSGGYARNPDEQTVPA 1627
            |||||||||||||..:|:||.|||||:|..|.::.::.:
Mouse  2280 EALCTRLAIMVNGRLRCLGSIQHLKNRFGDGYMITVRTK-------------------------- 2318

  Fly  1628 QMSQRDIDAVKEFVETEYPNSILQEEYQGILTFYIPLTGVKWSRIFGLMESNRDQLNVEDYSVSQ 1692
              |.:::..|..|....:|.::|:|.:...:.:.:....:..:::|..||.....|.:|||||||
Mouse  2319 --SSQNVKDVVRFFNRNFPEAMLKERHHTKVQYQLKSEHISLAQVFSKMEQVVGVLGIEDYSVSQ 2381

  Fly  1693 TTLEEIFLEFAKYQREDTRANQ 1714
            |||:.:|:.|||.|.::....:
Mouse  2382 TTLDNVFVNFAKKQSDNVEQQE 2403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ABCA	NP_608445.2	ABC2_membrane_4	254..434	CDD:289500	65/183 (36%)
		ABC2_membrane_3	<269..475	CDD:289468	77/210 (37%)
		CcmA	538..843	CDD:224054	149/330 (45%)
		ABC_subfamily_A	538..755	CDD:213230	111/218 (51%)
		ABC2_membrane_3	913..1316	CDD:289468	113/573 (20%)
		ABC_subfamily_A	1369..1587	CDD:213230	121/222 (55%)
		drrA	1376..1702	CDD:130256	146/330 (44%)
Abca2	XP_006497672.1	rim_protein	58..2398	CDD:130324	582/1900 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838501
Domainoid	1	1.000	164	1.000	Domainoid score	I3920
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53524
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.660