Protein Alignment Abca3 and Abca4

DIOPT Version :10

• Sequence 1: NP_608445.2
• Gene: Abca3 / 33103
• FlyBaseID: FBgn0031170
• Length: 1714
• Species: Drosophila melanogaster
• Sequence 2: NP_031404.1
• Gene: Abca4 / 11304
• MGIID: 109424
• Length: 2310
• Species: Mus musculus
• Alignment Length: 1845
• Identity: 583/1845 - (31%)
• Similarity: 908/1845 - (49%)
• Gaps: 352/1845 - (19%)

  Fly   111 NPVLKKLVEEAWQSLGKNKICESENATQLELDTVSKNAF-AGVQFDD--AWANLTENDPLPNDFH 172
            |..|:.||.:.::|..     :....||..|..:.:|.| |||.|..  .||:     .||....
Mouse   514 NQYLECLVLDKFESYD-----DEVQLTQRALSLLEENRFWAGVVFPGMYPWAS-----SLPPHVK 568

  Fly   173 FALRFPAELRTATIAIANTWLTMRLFPTIDLTGPRNEGDDDGGIPPGYLREGFLPLQHSLSMAYL 237
            :.:|...::...|..|.:.:..         :|||.:..:|.    .|:..||..||..:....:
Mouse   569 YKIRMDIDVVEKTNKIKDRYWD---------SGPRADPVEDF----RYIWGGFAYLQDMVEQGIV 620

  Fly   238 RQKSGEQDLPNVVMKRYPFPAYIFDPLLEGMSSIMSLIILLSFIYPCTYITKYITAEKEKQLKEV 302
            :.:...:....|.:::.|:|.::.|..:..::....:.::|::||..:...|.|..|||.:|||.
Mouse   621 KSQMQAEPPIGVYLQQMPYPCFVDDSFMIILNRCFPIFMVLAWIYSVSMTVKGIVLEKELRLKET 685

  Fly   303 MKIMGLSNWLHWTAWFVKSFIMLTISAILIAILVKINWSEDVAVLTHANFTALVFFLIIYIVSSI 367
            :|..|:||.:.|..||:.||.::.:|..|:.:.:...     .:|.:::...|..||:.:..::|
Mouse   686 LKNQGVSNAVIWCTWFLDSFSIMALSIFLLTLFIMHG-----RILHYSDPFILFLFLLAFATATI 745

  Fly   368 CFCFMMATFFSRASTAAAVTGLIWFIAYIPYSFTINSYDDLSLSSKLGWSLISNTAMGFGIKLIL 432
            ...|:::|.||:||.|||.:|:|:|..|:|:.......|.::...|...||:|:.|.|||.:.::
Mouse   746 MQSFLLSTLFSKASLAAACSGVIYFTLYLPHVLCFAWQDRMTADLKTTVSLLSSVAFGFGTEYLV 810

  Fly   433 GFEGTGEGLQWSNFFTPVSVDDTLTLGAVMIMMLVSCVIYMIICLYVEQVMPGSFGVPRPWNFPF 497
            .||..|.||||||........|..:....|.|||:...:|.::..|::||.||.:|.|.||.|..
Mouse   811 RFEEQGLGLQWSNIGKSPLEGDEFSFLLSMKMMLLDAALYGLLAWYLDQVFPGDYGTPLPWYFLL 875

  Fly   498 TREFW-----CGEREYTGVEDIPNGHVEQRDPK--------AFETEPEGKHIGLQMRHLKKRF-- 547
            ...:|     |..||...:|.......|..||:        .||.|..|...|:.:::|.|.|
Mouse   876 QESYWLGGEGCSTREERALEKTEPLTEEMEDPEHPEGMNDSFFERELPGLVPGVCVKNLVKVFEP 940

  Fly   548 GNKMVVKGLSMNMFEDEITVLLGHNGAGKTTTISMLTGMFPPTSGTAIINGSDIRTNIEGARMSL 612
            ..:..|..|::..:|::||..|||||||||||:|:|||:.||||||.:|.|.||.||::..|.||
Mouse   941 SGRPAVDRLNITFYENQITAFLGHNGAGKTTTLSILTGLLPPTSGTVLIGGKDIETNLDVVRQSL 1005

  Fly   613 GICPQHNVLFDEMSVSNHIRFFSRMKGLRGKAVEQEVAKYLKMIELEDKANVASSKLSGGMKRKL 677
            |:|||||:||..::|:.||.|::::||...:..:.|:...|:...|..|.|..:..|||||:|||
Mouse  1006 GMCPQHNILFHHLTVAEHILFYAQLKGRSWEEAQLEMEAMLEDTGLHHKRNEEAQDLSGGMQRKL 1070

  Fly   678 SVCCALCGDTKVVLCDEPSSGMDPSARRQLWDLLQQEKVGRTLLLTTHFMDEADVLGDRIAIMCD 742
            ||..|..||:|||:.|||:||:||.:||.:||||.:.:.|||::::||.|||||:|||||||:..
Mouse  1071 SVAIAFVGDSKVVVLDEPTSGVDPYSRRSIWDLLLKYRSGRTIIMSTHHMDEADLLGDRIAIISQ 1135

  Fly   743 GELKCQGTSFFLKKQYGSGYRLICVK--------RDDCE-----------------TNEVTA--- 779
            |.|.|.||..|||..:|:|:.|..|:        |..||                 .:|:|.
Mouse  1136 GRLYCSGTPLFLKNCFGTGFYLTLVRKMKNIQSQRGGCEGVCSCTSKGFSTRCPTRVDEITEEQV 1200

  Fly   780 ----------LLNKYIPGLK-PECDIGAELSYQLPDS--ASAKFEEMFGQLEEQSDELHLNGYGV 831
                      |:..::|..| .|| ||.||.:.||:.  ....:..:|.:|||...:|.|:.:|:
Mouse  1201 LDGDVQELMDLVYHHVPEAKLVEC-IGQELIFLLPNKNFKQRAYASLFRELEETLADLGLSSFGI 1264

  Fly   832 GITSMEEVFMKV----GAEKDNTGNIKDQHEIMNGGSGFR----------------------GED 870
            ..|.:||:|:||    ||.....|..:.:.|    .:|.|                      |:.
Mouse  1265 SDTPLEEIFLKVTEDAGAGSMFVGGAQQKRE----QAGLRHPCSAPTEKLRQYAQAPHTCSPGQV 1325

  Fly   871 D------NESVQSDGI-FSENRRL-LQGLQLLSNQWKAMLLKKFLYTWRNKLLLLIQNIMPVFFV 927
            |      :...:..|: |:...|| ||.:|       |:|:|:|.:|.|::...:.|.::|..||
Mouse  1326 DPPKGQPSPEPEDPGVPFNTGARLILQHVQ-------ALLVKRFHHTIRSRKDFVAQIVLPATFV 1383

  Fly   928 VVTILIIKTQGTFQELKPITISLTQY------------------PLAVTVLDRSNVQN------- 967
            .:.:::......|.|...:|:....|                  .||..:|:|....|
Mouse  1384 FLALMLSIIVPPFGEFPALTLHPWMYGHQYTFFSMDEPNNEHLEVLADVLLNRPGFGNRCLKEEW 1448

  Fly   968 -------------------------------------------------------GTG------- 970
                                                                   |.|
Mouse  1449 LPEYPCINATSWKTPSVSPNITHLFQKQKWTAAHPSPSCKCSTREKLTMLPECPEGAGGLPPPQR 1513

  Fly   971 --------YEIANK---------YEDLARS------------YGSNYGLELTGT--------QGF 998
                    .::.|:         |..|.||            ||   |:.:.|.        :..
Mouse  1514 TQRSTEVLQDLTNRNISDYLVKTYPALIRSSLKSKFWVNEQRYG---GISIGGKLPAIPISGEAL 1575

  Fly   999 EDYILDLGKTIQV------RINSRYL---VAATITESKITAWLNNQALHTAPLTVNMVHNAIA-- 1052
            ..::..||:.:.|      |..|:.:   :....|...|..|.||:..|.....:|:.||||.
Mouse  1576 VGFLSGLGQMMNVSGGPVTREASKEMLDFLKHLETTDNIKVWFNNKGWHALVSFLNVAHNAILRA 1640

  Fly  1053 -------DKLFGSSVKIQVTNAPLPYTTSTL--LSQLSTGNNLGTQLASNLCFCMCFVSSIYILF 1108
                   .:.:|    |.|.:.||..|...|  ::.|:|  ::...:|..:.|.|.||.:.::|:
Mouse  1641 SLPRDRDPEEYG----ITVISQPLNLTKEQLSDITVLTT--SVDAVVAICVIFAMSFVPASFVLY 1699

  Fly  1109 LIKERESRAKLLQFVGGVKVWTFWLSQFICDFASYIVTALIVVITIVCFQETGLSTFGELGRYYL 1173
            ||:||.::||.|||:.||...|:||:.|:.|..:|.|:|.:||...:.||:...::...|.....
Mouse  1700 LIQERVTKAKHLQFISGVSPTTYWLTNFLWDIMNYAVSAGLVVGIFIGFQKKAYTSPDNLPALVS 1764

  Fly  1174 LLLLFGFAVLPFIYIMSLFFREPATGFARVSIVNIFCGMALFIVVVVMSSELFDTKDTA----DI 1234
            ||:|:|:||:|.:|..|..|..|:|.:..:|..|:|.|:....:..|:  |||:...|.    .:
Mouse  1765 LLMLYGWAVIPMMYPASFLFEVPSTAYVALSCANLFIGINSSAITFVL--ELFENNRTLLRFNAM 1827

  Fly  1235 LGWIFRIFPHFSLAMSLNKVYTNTATRNACAKAG----ALPPILLCELVPQCCNLKPYFAWEEPG 1295
            |..:..:||||.|...|..:..:.|..:..|:.|    |.|                 |.|:..|
Mouse  1828 LRKLLIVFPHFCLGRGLIDLALSQAVTDVYAQFGEEYSANP-----------------FQWDLIG 1875

  Fly  1296 VLPETVYMAVTGVVFFLIIIVLEFRLINELMFKIRQLISKPPPPPTEGQLDDDVANERERILQMS 1360
              ...|.||:.|||:||:.::::..      |.:.:.|::|...|...: |||||.||:|::
Mouse  1876 --KNLVAMAIEGVVYFLLTLLIQHH------FFLTRWIAEPAREPVFDE-DDDVAEERQRVM--- 1928

  Fly  1361 SNELATKNLVLDRVTKYY--GQFMAVNQVSLCVQEVECFGLLGVNGAGKTTTFKMMTGDERISSG 1423
            |....|..|.|:.:||.|  ....||:::.:.|:..|||||||||||||||||||:|||..::||
Mouse  1929 SGGNKTDILKLNELTKVYSGSSSPAVDRLCVGVRPGECFGLLGVNGAGKTTTFKMLTGDTTVTSG 1993

  Fly  1424 AAYVQGLSLESNMNSIYKMIGYCPQFDALLDDLTGREVLRIFCMLRGVQESRIRQLSEDLAKSFG 1488
            .|.|.|.|:.::::.:::.:||||||||:.|.|||||.|.::..||||....|.:::....:|.|
Mouse  1994 DATVAGKSILTSISDVHQNMGYCPQFDAIDDLLTGREHLYLYARLRGVPSKEIEKVANWGIQSLG 2058

  Fly  1489 FMKHIDKQTHAYSGGNKRKLSTAIAVIGSPSVIYLDEPTTGMDPAARRQLWNMVCRIRDSGKSIV 1553
            ...:.|:....||||||||||||||:.|.|.::.||||||||||.|||.|||.:..|...|:::|
Mouse  2059 LSLYADRLAGTYSGGNKRKLSTAIALTGCPPLLLLDEPTTGMDPQARRMLWNTIVSIIREGRAVV 2123

  Fly  1554 LTSHSMEECEALCTRLAIMVNGEFKCIGSTQHLKNKFSKGLILKIKVRRNLEALRQARLSGGYAR 1618
            ||||||||||||||||||||.|.|:|:|:.||||.||..|.|:.:|:                 :
Mouse  2124 LTSHSMEECEALCTRLAIMVKGTFQCLGTIQHLKYKFGDGYIVTMKI-----------------K 2171

  Fly  1619 NPDEQTVPAQMSQRDIDAVKEFVETEYPNSILQEEYQGILTFYIPLTGVKWSRIFGLMESNRDQL 1683
            :|.:..:|      |::.|::|.:..:|.|:.:|.:..:|.|.:|.:.:  :|||.|:.|::|.|
Mouse  2172 SPKDDLLP------DLNPVEQFFQGNFPGSVQRERHHSMLQFQVPSSSL--ARIFQLLISHKDSL 2228

  Fly  1684 NVEDYSVSQTTLEEIFLEFAKYQRE 1708
            .:|:|||:||||:::|:.|||.|.|
Mouse  2229 LIEEYSVTQTTLDQVFVNFAKQQTE 2253

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Abca3	NP_608445.2	rim_protein	<137..1708	CDD:130324	577/1817 (32%)
Abca4	NP_031404.1	rim_protein	1..2271	CDD:130324	583/1845 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	891..910		4/18 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1311..1344		3/32 (9%)
		Essential for ATP binding and ATPase activity. /evidence=ECO:0000250|UniProtKB:P78363	2243..2248		1/4 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2266..2310