DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ABCA and Abca1

DIOPT Version :9

Sequence 1:NP_608445.2 Gene:ABCA / 33103 FlyBaseID:FBgn0031170 Length:1714 Species:Drosophila melanogaster
Sequence 2:XP_006537617.1 Gene:Abca1 / 11303 MGIID:99607 Length:2263 Species:Mus musculus


Alignment Length:1939 Identity:636/1939 - (32%)
Similarity:981/1939 - (50%) Gaps:372/1939 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    24 HKWQMVIELVLPAIFSLL-----LVLVRTLVDTEQKGVRYYNEQNLTDLNLLQHSLHRSSYLGKL 83
            |..:.:.|.:.|.|::.:     :.|||||:|:  :|...:.||.|..|:.....         :
Mouse   410 HDLEGMWEELSPQIWTFMENSQEMDLVRTLLDS--RGNDQFWEQKLDGLDWTAQD---------I 463

  Fly    84 IALIAPNR---RRKNGGFSKFEFILCYSPVNPVLKKLVEEAWQSLGKNKICESENATQLE----- 140
            :|.:|.|.   :..||  |.:.:...::..|..::.:          ::..|..|..:||     
Mouse   464 MAFLAKNPEDVQSPNG--SVYTWREAFNETNQAIQTI----------SRFMECVNLNKLEPIPTE 516

  Fly   141 -------LDTVSKNAF-AGVQFDDAWANLTENDPLPNDFHFALRFPAELRTATIAIANTWLTMRL 197
                   ::.:.:..| ||:.|.....:..|   ||:...:.:|         :.|.|...|.::
Mouse   517 VRLINKSMELLDERKFWAGIVFTGITPDSVE---LPHHVKYKIR---------MDIDNVERTNKI 569

  Fly   198 FPTIDLTGPRNEGDDDGGIPPGYLREGFLPLQHSLSMAYLRQKSGEQDLPNVVMKRYPFPAYIFD 262
            .......|||.:..:|    ..|:..||..||..:..|.:|..:|.:....|.:::.|:|.|:.|
Mouse   570 KDGYWDPGPRADPFED----MRYVWGGFAYLQDVVEQAIIRVLTGSEKKTGVYVQQMPYPCYVDD 630

  Fly   263 PLLEGMSSIMSLIILLSFIYPCTYITKYITAEKEKQLKEVMKIMGLSNWLHWTAWFVKSFIMLTI 327
            ..|..||..|.|.:.|::||....|.|.|..|||.:|||.|:||||.|.:.|.:|||.|.|.|.:
Mouse   631 IFLRVMSRSMPLFMTLAWIYSVAVIIKSIVYEKEARLKETMRIMGLDNGILWFSWFVSSLIPLLV 695

  Fly   328 SAILIAILVKINWSEDVAVLTHANFTALVFFLIIYIVSSICFCFMMATFFSRASTAAAVTGLIWF 392
            ||.|:.:::|:.     .:|.:::.:.:..||.::.:.:|..||:::|.||||:.|||..|:|:|
Mouse   696 SAGLLVVILKLG-----NLLPYSDPSVVFVFLSVFAMVTILQCFLISTLFSRANLAAACGGIIYF 755

  Fly   393 IAYIPYSFTINSYDDLSLSSKLGWSLISNTAMGFGIKLILGFEGTGEGLQWSNFFTPVSVDDTLT 457
            ..|:||...:...|.:..|.|:..||:|..|.|||.:....||..|.|:||.|.|.....:|...
Mouse   756 TLYLPYVLCVAWQDYVGFSIKIFASLLSPVAFGFGCEYFALFEEQGIGVQWDNLFESPVEEDGFN 820

  Fly   458 LGAVMIMMLVSCVIYMIICLYVEQVMPGSFGVPRPWNFPFTREFWCGER---------EYTGVED 513
            |...:.|||....:|.::..|:|.|.||.:|:||||.||.|:.:|.||.         ...||.:
Mouse   821 LTTAVSMMLFDTFLYGVMTWYIEAVFPGQYGIPRPWYFPCTKSYWFGEEIDEKSHPGSSQKGVSE 885

  Fly   514 IPNGHVEQRDPKAFETEPEGKHIGLQMRHLKK--RFGNKMVVKGLSMNMFEDEITVLLGHNGAGK 576
            |           ..|.||....:|:.:::|.|  |.|.|:.|.||::|.:|.:||..||||||||
Mouse   886 I-----------CMEEEPTHLRLGVSIQNLVKVYRDGMKVAVDGLALNFYEGQITSFLGHNGAGK 939

  Fly   577 TTTISMLTGMFPPTSGTAIINGSDIRTNIEGARMSLGICPQHNVLFDEMSVSNHIRFFSRMKGLR 641
            |||:|:|||:||||||||.|.|.|||:.:...|.:||:|||||||||.::|..||.|::|:|||.
Mouse   940 TTTMSILTGLFPPTSGTAYILGKDIRSEMSSIRQNLGVCPQHNVLFDMLTVEEHIWFYARLKGLS 1004

  Fly   642 GKAVEQEVAKYLKMIEL-EDKANVASSKLSGGMKRKLSVCCALCGDTKVVLCDEPSSGMDPSARR 705
            .|.|:.|:.:....:.| ..|....:|:|||||:|||||..|..|.:|||:.|||::|:||.:||
Mouse  1005 EKHVKAEMEQMALDVGLPPSKLKSKTSQLSGGMQRKLSVALAFVGGSKVVILDEPTAGVDPYSRR 1069

  Fly   706 QLWDLLQQEKVGRTLLLTTHFMDEADVLGDRIAIMCDGELKCQGTSFFLKKQYGSGYRLICVKRD 770
            .:|:||.:.:.|||::|:||.|||||:|||||||:..|:|.|.|:|.|||.|.|:||.|..||:|
Mouse  1070 GIWELLLKYRQGRTIILSTHHMDEADILGDRIAIISHGKLCCVGSSLFLKNQLGTGYYLTLVKKD 1134

  Fly   771 ------DCETNEVT-ALLNKYIPGLKPEC------------------------------------ 792
                  .|..:..| :.|.|.:||| |..                                    
Mouse  1135 VESSLSSCRNSSSTVSCLKKVVPGL-PAAGQSGGRGGEVQRLVALTQDVSAISNLIRKHVSEARL 1198

  Fly   793 --DIGAELSYQLPDSASAK--FEEMFGQLEEQSDELHLNGYGVGITSMEEVFMKVGAE------- 846
              |||.||:|.||..|:.:  |.|:|.:::::..:|.::.||:..|::||:|:||..|       
Mouse  1199 VEDIGHELTYVLPYEAAKEGAFVELFHEIDDRLSDLGISSYGISETTLEEIFLKVAEESGVDAET 1263

  Fly   847 -------KDNTGNIKDQHEIMNGGSGFRGED---------DNESVQSD---GIFSENRRLLQGLQ 892
                   :.|.....|:...::   .|..:|         |.||.::|   |:..:....|:|.:
Mouse  1264 SDGTLPARRNRRAFGDKQSCLH---PFTEDDAVDPNDSDIDPESRETDLLSGMDGKGSYQLKGWK 1325

  Fly   893 LLSNQWKAMLLKKFLYTWRNKLLLLIQNIMPVFFVVVTI---LIIKTQGTFQ--ELKP------- 945
            |...|:.|:|.|:.|...|::.....|.::|..||.:.:   ||:...|.:.  ||:|       
Mouse  1326 LTQQQFVALLWKRLLIARRSRKGFFAQIVLPAVFVCIALVFSLIVPPFGKYPSLELQPWMYNEQY 1390

  Fly   946 ---------------ITISLTQYP-----------------LA--------------VTVLDRSN 964
                           :..:||:.|                 ||              |.:....|
Mouse  1391 TFVSNDAPEDMGTQELLNALTKDPGFGTRCMEGNPIPDTPCLAGEEDWTISPVPQSIVDLFQNGN 1455

  Fly   965 -------------------------------------------VQNGTG-----YEIANKYEDLA 981
                                                       :||.||     |.:....:.:|
Mouse  1456 WTMKNPSPACQCSSDKIKKMLPVCPPGAGGLPPPQRKQKTADILQNLTGRNISDYLVKTYVQIIA 1520

  Fly   982 RS-----------YGSNYGLELTGTQGF------EDYILDLGKTIQVRINS---RYL------VA 1020
            :|           || .:.|.::.:|..      .|.|..:.|.:::..:|   |:|      :|
Mouse  1521 KSLKNKIWVNEFRYG-GFSLGVSNSQALPPSHEVNDAIKQMKKLLKLTKDSSADRFLSSLGRFMA 1584

  Fly  1021 ATITESKITAWLNNQALHTAPLTVNMVHNAI--ADKLFG---SSVKIQVTNAPLPYTTSTLLSQL 1080
            ...|::.:..|.||:..|.....:|:::|||  |:...|   |...|...|.||..|...|....
Mouse  1585 GLDTKNNVKVWFNNKGWHAISSFLNVINNAILRANLQKGENPSQYGITAFNHPLNLTKQQLSEVA 1649

  Fly  1081 STGNNLGTQLASNLCFCMCFVSSIYILFLIKERESRAKLLQFVGGVKVWTFWLSQFICDFASYIV 1145
            ....::...::..:.|.|.||.:.:::|||:||.|:||.|||:.|||...:|||.|:.|..:|:|
Mouse  1650 LMTTSVDVLVSICVIFAMSFVPASFVVFLIQERVSKAKHLQFISGVKPVIYWLSNFVWDMCNYVV 1714

  Fly  1146 TALIVVITIVCFQETGLSTFGELGRYYLLLLLFGFAVLPFIYIMSLFFREPATGFARVSIVNIFC 1210
            .|.:|:|..:|||:....:...|....|||||:|:::.|.:|..|..|:.|:|.:..::.||:|.
Mouse  1715 PATLVIIIFICFQQKSYVSSTNLPVLALLLLLYGWSITPLMYPASFVFKIPSTAYVVLTSVNLFI 1779

  Fly  1211 G----MALFIVVVVMSSELFDTKDTADILGWIFRIFPHFSLAMSLNKVYTNTATRNACAKAGA-- 1269
            |    :|.|::.:..:::|   .|..|||..:|.|||||.|...|..:..|.|..:|..:.|.  
Mouse  1780 GINGSVATFVLELFTNNKL---NDINDILKSVFLIFPHFCLGRGLIDMVKNQAMADALERFGENR 1841

  Fly  1270 -LPPILLCELVPQCCNLKPYFAWEEPGVLPETVYMAVTGVVFFLIIIVLEFRLINELMFKIRQLI 1333
             :.|:                :|:..|  .....|||.|||||||.:::::|      |.||...
Mouse  1842 FVSPL----------------SWDLVG--RNLFAMAVEGVVFFLITVLIQYR------FFIRPRP 1882

  Fly  1334 SKPPPPPTEGQLDDDVANERERILQ-MSSNELATKNLVLDRVTKYYGQFM--AVNQVSLCVQEVE 1395
            .|...||...: |:||..||:|||. ...|::    |.:..:||.|.:..  ||:::.:.:...|
Mouse  1883 VKAKLPPLNDE-DEDVRRERQRILDGGGQNDI----LEIKELTKIYRRKRKPAVDRICIGIPPGE 1942

  Fly  1396 CFGLLGVNGAGKTTTFKMMTGDERISSGAAYVQGLSLESNMNSIYKMIGYCPQFDALLDDLTGRE 1460
            ||||||||||||:|||||:|||..::.|.|::...|:.||::.:::.:||||||||:.:.|||||
Mouse  1943 CFGLLGVNGAGKSTTFKMLTGDTPVTRGDAFLNKNSILSNIHEVHQNMGYCPQFDAITELLTGRE 2007

  Fly  1461 VLRIFCMLRGVQESRIRQLSEDLAKSFGFMKHIDKQTHAYSGGNKRKLSTAIAVIGSPSVIYLDE 1525
            .:..|.:||||.|..:.::.|...:..|.:|:.:|....||||||||||||:|:||.|.|::|||
Mouse  2008 HVEFFALLRGVPEKEVGKVGEWAIRKLGLVKYGEKYASNYSGGNKRKLSTAMALIGGPPVVFLDE 2072

  Fly  1526 PTTGMDPAARRQLWNMVCRIRDSGKSIVLTSHSMEECEALCTRLAIMVNGEFKCIGSTQHLKNKF 1590
            |||||||.|||.|||....|...|:|:||||||||||||||||:||||||.|:|:||.|||||:|
Mouse  2073 PTTGMDPKARRFLWNCALSIVKEGRSVVLTSHSMEECEALCTRMAIMVNGRFRCLGSVQHLKNRF 2137

  Fly  1591 SKGLILKIKVRRNLEALRQARLSGGYARNPDEQTVPAQMSQRDIDAVKEFVETEYPNSILQEEYQ 1655
            ..|..:.:            |::|.   ||            |:..|:||....:|.|:|:|:::
Mouse  2138 GDGYTIVV------------RIAGS---NP------------DLKPVQEFFGLAFPGSVLKEKHR 2175

  Fly  1656 GILTFYIPLTGVKWSRIFGLMESNRDQLNVEDYSVSQTTLEEIFLEFAKYQRED 1709
            .:|.:.:|.:....:|||.::..::.:|::||||||||||:::|:.|||.|.:|
Mouse  2176 NMLQYQLPSSLSSLARIFSILSQSKKRLHIEDYSVSQTTLDQVFVNFAKDQSDD 2229

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ABCANP_608445.2 ABC2_membrane_4 254..434 CDD:289500 68/179 (38%)
ABC2_membrane_3 <269..475 CDD:289468 76/205 (37%)
CcmA 538..843 CDD:224054 153/354 (43%)
ABC_subfamily_A 538..755 CDD:213230 116/219 (53%)
ABC2_membrane_3 913..1316 CDD:289468 133/546 (24%)
ABC_subfamily_A 1369..1587 CDD:213230 119/219 (54%)
drrA 1376..1702 CDD:130256 151/327 (46%)
Abca1XP_006537617.1 rim_protein 6..2238 CDD:130324 636/1939 (33%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 159 1.000 Domainoid score I4067
eggNOG 1 0.900 - - E2759_KOG0059
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53524
OrthoDB 1 1.010 - - D131191at2759
OrthoFinder 1 1.000 - - FOG0000051
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100045
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
76.730

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