Protein Alignment ABCA and ABCA8

DIOPT Version :9

• Sequence 1: NP_608445.2
• Gene: ABCA / 33103
• FlyBaseID: FBgn0031170
• Length: 1714
• Species: Drosophila melanogaster
• Sequence 2: NP_001275914.1
• Gene: ABCA8 / 10351
• HGNCID: 38
• Length: 1621
• Species: Homo sapiens
• Alignment Length: 1800
• Identity: 470/1800 - (26%)
• Similarity: 824/1800 - (45%)
• Gaps: 322/1800 - (17%)

  Fly    13 LLWKNWTLQWNHKWQMVIELVLPAIFSLLLVLVRTLVDTEQKGVRYYNEQNLTDLNLLQHSLHRS 77
            ||.||:.    .||:|..|.::..:.||||:|...:         |.:...:.|.:.|     .:
Human    15 LLCKNFL----KKWRMKRESLMEWLNSLLLLLCLYI---------YPHSHQVNDFSSL-----LT 61

  Fly    78 SYLGKLIALIAPNRRRKNGGFSKFEFILCYSPVNPVLKKLVEEAWQSLGKNKICESENATQLELD 142
            ..||::            ..|::..|.:.|:||.                       |.||..::
Human    62 MDLGRV------------DTFNESRFSVVYTPVT-----------------------NTTQQIMN 91

  Fly   143 TVSKNAF------AGVQFDDAWANLTENDP-------LPNDFHFALRF------PAELRTATIAI 188
            .|:...|      .|:..:::....|.|.|       ..|.:.:.|:|      ||:....
Human    92 KVASTPFLAGKEVLGLPDEESIKEFTANYPEEIVRVTFTNTYSYHLKFLLGHGMPAKKEHK---- 152

  Fly   189 ANTWLTMRLFPTIDLTGPRNEGDDDGGIPPG-YLREGFLPLQHSLSMAYLR---QKSGEQDLPNV 249
                         |.|....|.::|...... :.:|||:.||.:::.|.:.   ..|..::|.:|
Human   153 -------------DHTAHCYETNEDVYCEVSVFWKEGFVALQAAINAAIIEITTNHSVMEELMSV 204

  Fly   250 VMKRYPFPAYIFDPLLEGMSSIMS-------LIILLSFIYPCTYITKYITAEKEKQLKEVMKIMG 307
            ..|.....::|      |.|.:::       :|...||||   |.:..:|.|: |::|.:|.:||
Human   205 TGKNMKMHSFI------GQSGVITDLYLFSCIISFSSFIY---YASVNVTRER-KRMKALMTMMG 259

  Fly   308 LSNWLHWTAWFVKSFIMLTISAILIAILVKINWSEDVAVLTHANFTALVFFLIIYIVSSICFCFM 372
            |.:...|.:|.:.....:.|.|:.:|::::   |....:|  :.|..:....::|.:|.:...|:
Human   260 LRDSAFWLSWGLLYAGFIFIMALFLALVIR---STQFIIL--SGFMVVFSLFLLYGLSLVALAFL 319

  Fly   373 MATFFSRASTAAAVTGLIWFIAYIPY---SFTINSYDDLSLSSKLGW--SLISNTAMGFGIKLIL 432
            |:....:    :.:|||:.|:..:.:   .|| :.|..|..|  |.|  ||:|..|...|:..:|
Human   320 MSILVKK----SFLTGLVVFLLTVFWGCLGFT-SLYRHLPAS--LEWILSLLSPFAFMLGMAQLL 377

  Fly   433 GFEGTGEGLQWSNFFTPVSVDDTLTLGAVMIMMLVSCVIYMIICLYVEQVMPGSFGVPRPWNFPF 497
            ..:....    ||.| |...|.:..:.|...|:.....:|:.:.:|.|:::|..:|..||..|..
Human   378 HLDYDLN----SNAF-PHPSDGSNLIVATNFMLAFDTCLYLALAIYFEKILPNEYGHRRPPLFFL 437

  Fly   498 TREFW--CGEREYTGVEDIPNGHVEQRDPK---AFETEP---EGKHIGLQMRHLKKRFGNK---- 550
            ...||  ..:.::..:||..:.     ||.   :||..|   :||. .:::|::.|.:..|
Human   438 KSSFWSQTQKTDHVALEDEMDA-----DPSFHDSFEQAPPEFQGKE-AIRIRNVTKEYKGKPDKI 496

  Fly   551 MVVKGLSMNMFEDEITVLLGHNGAGKTTTISMLTGMFPPTSGTAIINGSDI--RTNIEGARMSLG 613
            ..:|.|..:::|.:||.:|||:||||:|.:::|:|:..||.|:..|..:.:  ..::|......|
Human   497 EALKDLVFDIYEGQITAILGHSGAGKSTLLNILSGLSVPTKGSVTIYNNKLSEMADLENLSKLTG 561

  Fly   614 ICPQHNVLFDEMSVSNHIRFFSRMKGLRGKAVEQEVAKYLKMIELEDKANVASSKLSGGMKRKLS 678
            :|||.||.||.::|..::|.|:::||:..:.|::|:.:.|..:|:::..:|.:..||||.||||:
Human   562 VCPQSNVQFDFLTVRENLRLFAKIKGILPQEVDKEIQRVLLELEMKNIQDVLAQNLSGGQKRKLT 626

  Fly   679 VCCALCGDTKVVLCDEPSSGMDPSARRQLWDLLQQEKVGRTLLLTTHFMDEADVLGDRIAIMCDG 743
            ...|:.||.::.|.|||::|:||.:|.|:|:||::.|..|.:|.:|.||||||:|.||...:..|
Human   627 FGIAILGDPQIFLLDEPTAGLDPFSRHQVWNLLKERKTDRVILFSTQFMDEADILADRKVFLSQG 691

  Fly   744 ELKCQGTSFFLKKQYGSGYRLICVKRDDCETNEVTALLNKYIPGLKPECDIGAELSYQLPDSASA 808
            :|||.|:|.||||::|.||.|.....:.|....:|:|:.::||..|.......:|.|.||...:.
Human   692 KLKCAGSSLFLKKKWGIGYHLSLQLNEICVEENITSLVKQHIPDAKLSAKSEGKLIYTLPLERTN 756

  Fly   809 KFEEMFGQLEEQSDELHLNGYGVGITSMEEVFMKVGAEKDNTGNIKDQHEIMNGGSGFRGEDDNE 873
            ||.|::..|:...| |.:..|||.:|::.|||:|:  |..:|.|..| ..|:......:.:|...
Human   757 KFPELYKDLDSYPD-LGIENYGVSMTTLNEVFLKL--EGKSTINESD-IAILGEVQAEKADDTER 817

  Fly   874 SVQSDGIFS---ENRRLLQGLQLLSNQWKAMLLKKFLYTWRNK------LLLLIQNIMPVFFVVV 929
            .|:.:.:.|   :.|:.:.|:.|...|..|:...:.|.....:      ||:|:....|:.....
Human   818 LVEMEQVLSSLNKMRKTIGGVALWRQQICAIARVRLLKLKHERKALLALLLILMAGFCPLLVEYT 882

  Fly   930 TILIIKTQGTFQELKPITISLTQYPLAVTVLDRSNVQNGTGYEIANKYEDLARSY-GSNYGLELT 993
            .:.|.:...|: ||.|....|.........|.:..:.|.||..|    :|..:|. ..|..||:.
Human   883 MVKIYQNSYTW-ELSPHLYFLAPGQQPHDPLTQLLIINKTGASI----DDFIQSVEHQNIALEVD 942

  Fly   994 --GTQGFEDYILDLGKTIQVRINSRYLVAATITESKITAWLNNQALHTAPLTVNMVHNAIADKLF 1056
              ||:...|         ....|....|.........:...|.:.|:..|:.:::|.|.:.. :.
Human   943 AFGTRNGTD---------DPSYNGAITVCCNEKNYSFSLACNAKRLNCFPVLMDIVSNGLLG-MV 997

  Fly  1057 GSSVKIQVTNAPLPYTTSTLLSQLSTGNNLGTQLASNLCFCMCFVSSI--YI-LFLIKERESRAK 1118
            ..||.|:...       ||.|.. ...|.:|  ..:.:.|.:...||.  || :..|.:.::||:
Human   998 KPSVHIRTER-------STFLEN-GQDNPIG--FLAYIMFWLVLTSSCPPYIAMSSIDDYKNRAR 1052

  Fly  1119 LLQFVGGVKVWTFWLSQFICDFASYIVTALIVVITIVCFQETGLSTFGELGRYYLLLLL------ 1177
            ....:.|:....:|..|.:.|.:.|.:  :.|.|.::.:    :|.|.::    ||.::
Human  1053 SQLRISGLSPSAYWFGQALVDVSLYFL--VFVFIYLMSY----ISNFEDM----LLTIIHIIQIP 1107

  Fly  1178 ----FGFAVLPFIYIMSLFFREPATGFARVSIVNIFCGMALFIVVVVMSSELFDTKDTADILGWI 1238
                :.|:::...|::|..||:.    .:.|.:..||    |.||.|.|           :.|:.
Human  1108 CAVGYSFSLIFMTYVISFIFRKG----RKNSGIWSFC----FYVVTVFS-----------VAGFA 1153

  Fly  1239 FRIFPHFSLAMSLNKVYTNTATRNACAKAGALPPILL--CELVPQCCNLKPYFAWEEPGVLPETV 1301
            |.||     ...:..::|           ..:||..:  |..:.........|:.|...|.|..|
Human  1154 FSIF-----ESDIPFIFT-----------FLIPPATMIGCLFLSSHLLFSSLFSEERMDVQPFLV 1202

  Fly  1302 YMA--VTGVVFFLIIIVLEFRLINELM-----FKI----RQLISKPPPPPTEGQLDDDVANERER 1355
            ::.  :..::|...:..||::...:.|     |:|    ..:...|..|  ||: |:||..||.|
Human  1203 FLIPFLHFIIFLFTLRCLEWKFGKKSMRKDPFFRISPRSSDVCQNPEEP--EGE-DEDVQMERVR 1264

  Fly  1356 ILQMSSNELATKN------LVLDRVTKYY-----GQF------MAVNQVSLCVQEVECFGLLGVN 1403
                ::|.|.:.|      ::...:.|.|     |.|      :|...||.||::.|..||||.|
Human  1265 ----TANALNSTNFDEKPVIIASCLRKEYAGKRKGCFSKRKNKIATRNVSFCVRKGEVLGLLGHN 1325

  Fly  1404 GAGKTTTFKMMTGDERISSGAAYVQGLSLESNMNSIYKMIGYCPQFDALLDDLTGREVLRIFCML 1468
            ||||:|:.|::|||.:.::|...::|    |......:.:|||||.:||..:||.|:.|.::..:
Human  1326 GAGKSTSIKVITGDTKPTAGQVLLKG----SGGGDALEFLGYCPQENALWPNLTVRQHLEVYAAV 1386

  Fly  1469 RGVQESRIRQLSEDLAKSFGFMKHIDKQTHAYSGGNKRKLSTAIAVIGSPSVIYLDEPTTGMDPA 1533
            :|:::.........|..:......:.......|.|.||||...::::|:|||:.||||:|||||.
Human  1387 KGLRKGDAEVAITRLVDALKLQDQLKSPVKTLSEGIKRKLCFVLSILGNPSVVLLDEPSTGMDPE 1451

  Fly  1534 ARRQLWNMV-CRIRDSGKSIVLTSHSMEECEALCTRLAIMVNGEFKCIGSTQHLKNKFSKGLILK 1597
            .::|:|..: ...|::.:..:||:|.|.|.||:|.|:||||:|..:||||.||||:||.|..:|:
Human  1452 GQQQMWQAIRATFRNTERGALLTTHYMAEAEAVCDRVAIMVSGRLRCIGSIQHLKSKFGKDYLLE 1516

  Fly  1598 IKVRRNLEALRQARLSGGYARNPDEQTVPAQMSQRDIDAVKEFVETEYPNSILQEEYQGILTFYI 1662
            :|| :||                      ||:.....:.::.|     |.:..||.|..::.:.:
Human  1517 MKV-KNL----------------------AQVEPLHAEILRLF-----PQAARQERYSSLMVYKL 1553

  Fly  1663 PLTGVK-WSRIFGLMESNRDQLNVEDYSVSQTTLEEIFLEFAKYQ 1706
            |:..|: .::.|..:|..:...::|:||:||:|||::|||.:|.|
Human  1554 PVEDVQPLAQAFFKLEKVKQSFDLEEYSLSQSTLEQVFLELSKEQ 1598

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ABCA	NP_608445.2	ABC2_membrane_4	254..434	CDD:289500	46/191 (24%)
		ABC2_membrane_3	<269..475	CDD:289468	52/217 (24%)
		CcmA	538..843	CDD:224054	114/310 (37%)
		ABC_subfamily_A	538..755	CDD:213230	84/222 (38%)
		ABC2_membrane_3	913..1316	CDD:289468	84/428 (20%)
		ABC_subfamily_A	1369..1587	CDD:213230	82/229 (36%)
		drrA	1376..1702	CDD:130256	113/338 (33%)
ABCA8	NP_001275914.1	rim_protein	<235..>790	CDD:130324	182/582 (31%)
		ABC_subfamily_A	480..703	CDD:213230	84/222 (38%)
		rim_protein	<1033..1598	CDD:130324	178/648 (27%)
		ABC_subfamily_A	1285..1506	CDD:213230	82/224 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148311
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.650