DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ABCA and ABCA9

DIOPT Version :9

Sequence 1:	NP_608445.2	Gene:	ABCA / 33103	FlyBaseID:	FBgn0031170	Length:	1714	Species:	Drosophila melanogaster
Sequence 2:	XP_024306297.1	Gene:	ABCA9 / 10350	HGNCID:	39	Length:	1634	Species:	Homo sapiens

Alignment Length:	1821	Identity:	476/1821 - (26%)
Similarity:	815/1821 - (44%)	Gaps:	361/1821 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LLWKNWTLQWNHKWQMVIELVLPAIFSLLLVLVRTLVDTEQKGVRYYNEQNLTDLNLLQHSLH-- 75
            ||.||...:|..|.|.::|.    :||.||||           ..|....||       |.:|
Human    23 LLCKNCLKKWRMKRQTLLEW----LFSFLLVL-----------FLYLFFSNL-------HQVHDT 65

  Fly    76 ---RSSYLGKLIALIAPNRRRKNGGFSKFEFILCYSPVNPVLKKLVEEAWQSLGKNKICES---- 133
               .|..||::            ..|:...:::.::|.:...::::         ||:..:
Human    66 PQMSSMDLGRV------------DSFNDTNYVIAFAPESKTTQEIM---------NKVASAPFLK 109

  Fly   134 --------ENATQLELDTVSKNAFAGVQFDDAWANLTENDPLPNDFHFALRFP--AELR--TATI 186
                    :..:..|||.........|.|.|.::...:       |.:..|.|  .|.|  :|..
Human   110 GRTIMGWPDEKSMDELDLNYSIDAVRVIFTDTFSYHLK-------FSWGHRIPMMKEHRDHSAHC 167

  Fly   187 AIANTWLTMRLFPTIDLTGPRNEGDDDGGIPPGYLREGFLPLQHSLSMAYLRQKSG----EQ--D 245
            ...|..:             :.||.:       :..:||:..|.:::.|.:...:.    ||  .
Human   168 QAVNEKM-------------KCEGSE-------FWEKGFVAFQAAINAAIIEIATNHSVMEQLMS 212

  Fly   246 LPNVVMKRYPFPA--------YIFDPLLEGMSSIMSLIILLSFIYPCTYITKYITAEKEKQLKEV 302
            :..|.||..||.|        :||          ..:|...:|||   |::..:|.|:: .:..:
Human   213 VTGVHMKILPFVAQGGVATDFFIF----------FCIISFSTFIY---YVSVNVTQERQ-YITSL 263

  Fly   303 MKIMGLSNWLHWTAWFVKSFIMLTISAILIAILVKINWSEDVAVLTHANFTALVFFLIIYIVSSI 367
            |.:|||.....|.:|.:.....:.|.|.|:|::||   |..:.|||  .|..:....::|.:|.|
Human   264 MTMMGLRESAFWLSWGLMYAGFILIMATLMALIVK---SAQIVVLT--GFVMVFTLFLLYGLSLI 323

  Fly   368 CFCFMMATFFSRASTAAAVTGLI-------WFIAYIPYSFTINSYDDLSLSSKLGWS--LISNTA 423
            ...|:|:....:    ..:|||:       |.|...|..:|       .|.:.|.|:  |:|..|
Human   324 TLAFLMSVLIKK----PFLTGLVVFLLIVFWGILGFPALYT-------RLPAFLEWTLCLLSPFA 377

  Fly   424 MGFGIKLILGFEGTGEGLQWSNFFTPVSVDDTLTLGAVMIMMLVSCVIYMIICLYVEQVMPGSFG 488
            ...|:..::..:....    ||.....|.:..|.: |.:.|::...::|:::.||.::::|..:|
Human   378 FTVGMAQLIHLDYDVN----SNAHLDSSQNPYLII-ATLFMLVFDTLLYLVLTLYFDKILPAEYG 437

  Fly   489 VPRPWNFPFTREFWC--GEREYTGVEDIPNGHVEQRDPKAFE-TEPE--GKHIGLQMRHLKKRFG 548
            ......|.....||.  |...:..:|:..:......|  .|| ..||  ||. .:::::|||.:.
Human   438 HRCSPLFFLKSCFWFQHGRANHVVLENETDSDPTPND--CFEPVSPEFCGKE-AIRIKNLKKEYA 499

  Fly   549 NKM----VVKGLSMNMFEDEITVLLGHNGAGKTTTISMLTGMFPPTSGTAIINGSDI--RTNIEG 607
            .|.    .:||:..:::|.:||.||||:||||||.:::|:|:..||||:..:....:  ..:||.
Human   500 GKCERVEALKGVVFDIYEGQITALLGHSGAGKTTLLNILSGLSVPTSGSVTVYNHTLSRMADIEN 564

  Fly   608 ARMSLGICPQHNVLFDEMSVSNHIRFFSRMKGLRGKAVEQEVAKYLKMIELEDKANVASSKLSGG 672
            .....|.|||.||.|..::|..::|.|:::||:....||:||.:.::.:|:|:..::.:..||||
Human   565 ISKFTGFCPQSNVQFGFLTVKENLRLFAKIKGILPHEVEKEVQRVVQELEMENIQDILAQNLSGG 629

  Fly   673 MKRKLSVCCALCGDTKVVLCDEPSSGMDPSARRQLWDLLQQEKVGRTLLLTTHFMDEADVLGDRI 737
            ..|||:...|:.||.:|:|.|||::|:||.:|.::|:||::.|..|.:|.:|.|:||||:|.||.
Human   630 QNRKLTFGIAILGDPQVLLLDEPTAGLDPLSRHRIWNLLKEGKSDRVILFSTQFIDEADILADRK 694

  Fly   738 AIMCDGELKCQGTSFFLKKQYGSGYRLICVKRDDCETNEVTALLNKYIPGLKPECDIGAELSYQL 802
            ..:.:|:|||.|:|.||||::|.||.|.....:.|:...:|:|:.::|...|.......:|.|.|
Human   695 VFISNGKLKCAGSSLFLKKKWGIGYHLSLHLNERCDPESITSLVKQHISDAKLTAQSEEKLVYIL 759

  Fly   803 PDSASAKFEEMFGQLEEQSDELHLNGYGVGITSMEEVFMKVGAEKDNTGNIKDQHEIMNGGSGFR 867
            |...:.||.|::..|:..|:: .:..|||.||::.|||:|:..:     :..|:.:|     |..
Human   760 PLERTNKFPELYRDLDRCSNQ-GIEDYGVSITTLNEVFLKLEGK-----STIDESDI-----GIW 813

  Fly   868 GEDDNESVQSDGI---------------FSENRRLLQGLQLLSNQWKAMLLKKFLYTWRNK---- 913
            |:     :|:||.               |.|.|:.:.|:.|...|..|:...:||...:.:
Human   814 GQ-----LQTDGAKDIGSLVELEQVLSSFHETRKTISGVALWRQQVCAIAKVRFLKLKKERKSLW 873

  Fly   914 LLLLIQNIMPVFFVVVTILIIKTQGTFQ-ELKPITISLT-----QYPLAVTVLDRSNVQNGTGYE 972
            .:||:..|..:..::..:.....|.::. ||.|.|..|:     |.||...:     |.|.||..
Human   874 TILLLFGISFIPQLLEHLFYESYQKSYPWELSPNTYFLSPGQQPQDPLTHLL-----VINKTGST 933

  Fly   973 IANKYEDLARSYGSNYGLELT--GTQGFEDYILDLGKTIQVRINSRYLVAATITESKITAWLNNQ 1035
            |.|....|.|   .|..:|:.  ||:...|         ....|...:|:....:.:.:...|.:
Human   934 IDNFLHSLRR---QNIAIEVDAFGTRNGTD---------DPSYNGAIIVSGDEKDHRFSIACNTK 986

  Fly  1036 ALHTAPLTVNMVHNAIADKLFGSSVKIQVTNAPLPYTTSTLLSQLSTGNNLGTQLASNLCFCMCF 1100
            .|:..|:.::::.|.:.. :|.||..||...       ||...: ......|.:  ||..|.:..
Human   987 RLNCFPVLLDVISNGLLG-IFNSSEHIQTDR-------STFFEE-HMDYEYGYR--SNTFFWIPM 1040

  Fly  1101 VSSI--YI-LFLIKERESRAKLLQFVGGVKVWTFWLSQFICDFASYIVTALIVVI---------T 1153
            .:|.  || :..|.:.:.:|.....:.|:....:|..|.:.|.:.|.:..|::.|         .
Human  1041 AASFTPYIAMSSIGDYKKKAHSQLRISGLYPSAYWFGQALVDVSLYFLILLLMQIMDYIFSPEEI 1105

  Fly  1154 IVCFQETGLSTFGELGRYYLLLLLFGFAVLPFIYIMSLFFREPATGFARVSIVNIFCGMALFIVV 1218
            |...|...:.....:|  |:..|:|      ..|::|..||   .|.....|.:.|     |::|
Human  1106 IFIIQNLLIQILCSIG--YVSSLVF------LTYVISFIFR---NGRKNSGIWSFF-----FLIV 1154

  Fly  1219 VVMSSELFDTKDTADILGWIF--RIFPHFSLAMSLNKVYTNTATRNACAKAGALPPILLCELVPQ 1281
            |:.|....|..:.. .||..|  .:.|.|:|..||                     .:..|:.|.
Human  1155 VIFSIVATDLNEYG-FLGLFFGTMLIPPFTLIGSL---------------------FIFSEISPD 1197

  Fly  1282 CCNLKPYFAWEEPGVLPETVYMAVT-----GVVFFLIIIVLEFRLINELM-----FKI--RQLIS 1334
            ..:   |....|    .|.||:|:.     .::|..|:..||.....:||     |:|  |....
Human  1198 SMD---YLGASE----SEIVYLALLIPYLHFLIFLFILRCLEMNCRKKLMRKDPVFRISPRSNAI 1255

  Fly  1335 KPPPPPTEGQLDDDVANERERILQMSSNELATKN------LVLDRVTKYYG-----------QFM 1382
            .|.|...||: ::|:..||.|.:    |.:|.::      ::...:.|.|.           :.:
Human  1256 FPNPEEPEGE-EEDIQMERMRTV----NAMAVRDFDETPVIIASCLRKEYAGKKKNCFSKRKKKI 1315

  Fly  1383 AVNQVSLCVQEVECFGLLGVNGAGKTTTFKMMTGDERISSGAAYVQGLSLESNMNSIYKMIGYCP 1447
            |...||.||::.|..||||.|||||:||.||:|||.:.::|...::|    |........:||||
Human  1316 ATRNVSFCVKKGEVIGLLGHNGAGKSTTIKMITGDTKPTAGQVILKG----SGGGEPLGFLGYCP 1376

  Fly  1448 QFDALLDDLTGREVLRIFCMLRGVQESRIRQLSEDLAKSFGFMKHIDKQTHAYSGGNKRKLSTAI 1512
            |.:||..:||.|:.|.::..::|:::.........|..:......:.......|.|.||||...:
Human  1377 QENALWPNLTVRQHLEVYAAVKGLRKGDAMIAITRLVDALKLQDQLKAPVKTLSEGIKRKLCFVL 1441

  Fly  1513 AVIGSPSVIYLDEPTTGMDPAARRQLWNMV-CRIRDSGKSIVLTSHSMEECEALCTRLAIMVNGE 1576
            :::|:|||:.||||:|||||..::|:|.:: ...|::.:..:||:|.|.|.||:|.|:||||:|.
Human  1442 SILGNPSVVLLDEPSTGMDPEGQQQMWQVIRATFRNTERGALLTTHYMAEAEAVCDRVAIMVSGR 1506

  Fly  1577 FKCIGSTQHLKNKFSKGLILKIKVRRNLEALRQARLSGGYARNPDEQTVPAQMSQRDIDAVKEFV 1641
            .:||||.||||:||.|..:|::|: :||                      |||.....:.::.|
Human  1507 LRCIGSIQHLKSKFGKDYLLEMKL-KNL----------------------AQMEPLHAEILRLF- 1547

  Fly  1642 ETEYPNSILQEEYQGILTFYIPLTGVK-WSRIFGLMESNRDQLNVEDYSVSQTTLEEIFLEFAKY 1705
                |.:..||.:..::.:.:|:..|: .|:.|..:|..:...::|:||:||:|||::|||.:|.
Human  1548 ----PQAAQQERFSSLMVYKLPVEDVRPLSQAFFKLEIVKQSFDLEEYSLSQSTLEQVFLELSKE 1608

  Fly  1706 Q 1706
            |
Human  1609 Q 1609

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ABCA	NP_608445.2	ABC2_membrane_4	254..434	CDD:289500	48/196 (24%)
		ABC2_membrane_3	<269..475	CDD:289468	50/214 (23%)
		CcmA	538..843	CDD:224054	115/310 (37%)
		ABC_subfamily_A	538..755	CDD:213230	86/222 (39%)
		ABC2_membrane_3	913..1316	CDD:289468	90/433 (21%)
		ABC_subfamily_A	1369..1587	CDD:213230	82/229 (36%)
		drrA	1376..1702	CDD:130256	113/338 (33%)
ABCA9	XP_024306297.1	ABC2_membrane_3	53..416	CDD:315386	90/452 (20%)
ABCA9	XP_024306297.1	AAA	<245..1609	CDD:333001	419/1517 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148390
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.650