DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ABCA and ABCA7

DIOPT Version :9

Sequence 1:NP_608445.2 Gene:ABCA / 33103 FlyBaseID:FBgn0031170 Length:1714 Species:Drosophila melanogaster
Sequence 2:XP_024307083.1 Gene:ABCA7 / 10347 HGNCID:37 Length:2151 Species:Homo sapiens


Alignment Length:1908 Identity:613/1908 - (32%)
Similarity:922/1908 - (48%) Gaps:349/1908 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    29 VIELVLPAIFSLL-----LVLVRTLVDTEQKGVRYYNEQNLTDLNLLQHSLHRSSYLGKLIALIA 88
            |.|::.|.||:.:     :.:::.|:..:.:|.|.........:..|:..|...|          
Human   327 VWEMLGPRIFTFMNDSSNVAMLQRLLQMQDEGRRQPRPGGRDHMEALRSFLDPGS---------- 381

  Fly    89 PNRRRKNGGFSKFEFILCYSPVNPVLKKL--VEEAWQSLGKNKICESENA-TQLELDTVSKNAF- 149
                   ||:|..:   .::.|..::..|  |.|. .||.|.:...||.| ....|..::::.| 
Human   382 -------GGYSWQD---AHADVGHLVGTLGRVTEC-LSLDKLEAAPSEAALVSRALQLLAEHRFW 435

  Fly   150 AGVQF---DDAWANLTEN---DPLPNDFHFALRFPAELRTATIAIANTWLTMRLF---PTID-LT 204
            |||.|   :|: ::.||:   |..|......:|...::.|.|..|.:     |.:   |..| ||
Human   436 AGVVFLGPEDS-SDPTEHPTPDLGPGHVRIKIRMDIDVVTRTNKIRD-----RFWDPGPAADPLT 494

  Fly   205 GPRNEGDDDGGIPPGYLREGFLPLQHSLSMAYLRQKSGEQDLPNVVMKRYPFPAYIFDPLLEGMS 269
            ..|            |:..||:.||..:..|.:|..||......:.:::.|:|.|:.|..|..:|
Human   495 DLR------------YVWGGFVYLQDLVERAAVRVLSGANPRAGLYLQQMPYPCYVDDVFLRVLS 547

  Fly   270 SIMSLIILLSFIYPCTYITKYITAEKEKQLKEVMKIMGLSNWLHWTAWFVKSFIMLTISAILIAI 334
            ..:.|.:.|::||..|...|.:..|||.:|::.|:.||||..:.|..||:.......:||.|:.:
Human   548 RSLPLFLTLAWIYSVTLTVKAVVREKETRLRDTMRAMGLSRAVLWLGWFLSCLGPFLLSAALLVL 612

  Fly   335 LVKINWSEDVAVLTHANFTALVFFLIIYIVSSICFCFMMATFFSRASTAAAVTGLIWFIAYIPYS 399
            ::|:.   |:...:|.....|  ||..:.|:::...|:::.|||||:.|||..||.:|..|:||.
Human   613 VLKLG---DILPYSHPGVVFL--FLAAFAVATVTQSFLLSAFFSRANLAAACGGLAYFSLYLPYV 672

  Fly   400 FTINSYDDLSLSSKLGWSLISNTAMGFGIKLILGFEGTGEGLQWSNFFT-PVSVDDTLTLGAVMI 463
            ..:...|.|....::..||:|..|.|||.:.:...|..|||.||.|..| |.:  |..:|..|..
Human   673 LCVAWRDRLPAGGRVAASLLSPVAFGFGCESLALLEEQGEGAQWHNVGTRPTA--DVFSLAQVSG 735

  Fly   464 MMLVSCVIYMIICLYVEQVMPGSFGVPRPWNFPFTREFWCGEREYTGVEDIPNGHVEQRDPKAF- 527
            ::|:...:|.:...|:|.|.||.:|:|.||||||.|.:|||.|........|.    ..|||.. 
Human   736 LLLLDAALYGLATWYLEAVCPGQYGIPEPWNFPFRRSYWCGPRPPKSPAPCPT----PLDPKVLV 796

  Fly   528 ETEPEGKHIGLQMRHLKKRF--GNKMVVKGLSMNMFEDEITVLLGHNGAGKTTTISMLTGMFPPT 590
            |..|.|...|:.:|.|:|||  ..:..::|||::.::..||..|||||||||||:|:|:|:|||:
Human   797 EEAPPGLSPGVSVRSLEKRFPGSPQPALRGLSLDFYQGHITAFLGHNGAGKTTTLSILSGLFPPS 861

  Fly   591 SGTAIINGSDIRTNIEGARMSLGICPQHNVLFDEMSVSNHIRFFSRMKGLRGKAVEQEVAKYLKM 655
            .|:|.|.|.|:|:::...|..||:|||:|||||.::|..|:.|:.|:|||....|..|..:.|:.
Human   862 GGSAFILGHDVRSSMAAIRPHLGVCPQYNVLFDMLTVDEHVWFYGRLKGLSAAVVGPEQDRLLQD 926

  Fly   656 IELEDKANVASSKLSGGMKRKLSVCCALCGDTKVVLCDEPSSGMDPSARRQLWDLLQQEKVGRTL 720
            :.|..|.:|.:..|||||:|||||..|..|.::||:.|||::|:||::||.:|:||.:.:.||||
Human   927 VGLVSKQSVQTRHLSGGMQRKLSVAIAFVGGSQVVILDEPTAGVDPASRRGIWELLLKYREGRTL 991

  Fly   721 LLTTHFMDEADVLGDRIAIMCDGELKCQGTSFFLKKQYGSGYRLICVK-RDDCETNE-------- 776
            :|:||.:|||::||||:|::..|.|.|.|:..||::..||||.|..|| |....|||        
Human   992 ILSTHHLDEAELLGDRVAVVAGGRLCCCGSPLFLRRHLGSGYYLTLVKARLPLTTNEKADTDMEG 1056

  Fly   777 ---------------------VTALLNKYIPGLKPECDIGAELSYQLPDSAS--AKFEEMFGQLE 818
                                 :.||:..::||.:...::..||...||.:.:  ..|..:|.:|:
Human  1057 SVDTRQEKKNGSQGSRVGTPQLLALVQHWVPGARLVEELPHELVLVLPYTGAHDGSFATLFRELD 1121

  Fly   819 EQSDELHLNGYGVGITSMEEVFMKV----GAEKDNTGNIKDQHEIMNGGSGF------------- 866
            .:..||.|.|||:..||:||:|:||    .|:.|.......|| :..|.:|.             
Human  1122 TRLAELRLTGYGISDTSLEEIFLKVVEECAADTDMEDGSCGQH-LCTGIAGLDVTLRLKMPPQET 1185

  Fly   867 ---RGEDDNESVQSD-GIFSENRRLLQGLQLLSNQWKAMLLKKFLYTWRNKLLLLIQNIMPVFFV 927
               .||....:.::| |...:....:||..|...|.:|:|||:||...|::..|..|.::|..||
Human  1186 ALENGEPAGSAPETDQGSGPDAVGRVQGWALTRQQLQALLLKRFLLARRSRRGLFAQIVLPALFV 1250

  Fly   928 ---VVTILIIKTQGTFQELKPITISLTQYPLAVT------------------------------- 958
               :|..||:...|.:..|:   :|.|.|...|:                               
Human  1251 GLALVFSLIVPPFGHYPALR---LSPTMYGAQVSFFSEDAPGDPGRARLLEALLQEAGLEEPPVQ 1312

  Fly   959 -----------------VLDRSN------------------------------------------ 964
                             ||...|                                          
Human  1313 HSSHRFSAPEVPAEVAKVLASGNWTPESPSPACQCSRPGARRLLPDCPAAAGGPPPPQAVTGSGE 1377

  Fly   965 -VQNGTGYEIAN----KYEDLARS------------YGSNYGLELTGTQGFEDYILDLGKTIQ-- 1010
             |||.||..:::    .|..|.|.            ||   |..|.|.........:||::::  
Human  1378 VVQNLTGRNLSDFLVKTYPRLVRQGLKTKKWVNEVRYG---GFSLGGRDPGLPSGQELGRSVEEL 1439

  Fly  1011 --------------VRINSRYLVAATITESKITAWLNNQALHTAPLTVNMVHNAIADKLF----- 1056
                          |..|......:...:..:..|.||:..|:....||...|||.....     
Human  1440 WALLSPLPGGALDRVLKNLTAWAHSLDAQDSLKIWFNNKGWHSMVAFVNRASNAILRAHLPPGPA 1504

  Fly  1057 GSSVKIQVTNAPLPYTTSTLLSQLSTGNNLGT--QLASNLC--FCMCFVSSIYILFLIKERESRA 1117
            ..:..|...|.||..|.    .|||.|..:.:  .:..::|  |.|.||.:.:.|.||:||.:||
Human  1505 RHAHSITTLNHPLNLTK----EQLSEGALMASSVDVLVSICVVFAMSFVPASFTLVLIEERVTRA 1565

  Fly  1118 KLLQFVGGVKVWTFWLSQFICDFASYIVTALIVVITIVCFQETGLSTFGELGRYYLLLLLFGFAV 1182
            |.||.:||:....:||..|:.|..:|:|.|.|||:..:.||:........|....|||||:|:::
Human  1566 KHLQLMGGLSPTLYWLGNFLWDMCNYLVPACIVVLIFLAFQQRAYVAPANLPALLLLLLLYGWSI 1630

  Fly  1183 LPFIYIMSLFFREPATGFARVSIVNIFCG----MALFIVVVVMSSELFDTKDTADILGWIFRIFP 1243
            .|.:|..|.||..|:|.:..::.:|:|.|    ||.|::.:....:|   ::.:.||..:|.|||
Human  1631 TPLMYPASFFFSVPSTAYVVLTCINLFIGINGSMATFVLELFSDQKL---QEVSRILKQVFLIFP 1692

  Fly  1244 HFSLAMSLNKVYTNTATRNACAKAGALPPILLCELVPQCCNLKPYFAWEEPGVLPETVYMAVTGV 1308
            ||.|...|..:..|.|..:|..:.|..             ..:....||..|  ...:.|.:.|.
Human  1693 HFCLGRGLIDMVRNQAMADAFERLGDR-------------QFQSPLRWEVVG--KNLLAMVIQGP 1742

  Fly  1309 VFFLIIIVLEFRLINELMFKIRQLI---SKPPPP----PTEGQLDDDVANERERILQMSSNELAT 1366
            :|.|..::|:.|         .||:   |.|.|.    |..|:.|:|||.||||::|.     ||
Human  1743 LFLLFTLLLQHR---------SQLLPQYSVPRPRVRSLPLLGEEDEDVARERERVVQG-----AT 1793

  Fly  1367 KN--LVLDRVTKYY-GQFM-AVNQVSLCVQEVECFGLLGVNGAGKTTTFKMMTGDERISSGAAYV 1427
            :.  |||..:||.| ||.| ||:::.|.:...||||||||||||||:||:|:|||...|.|.|.:
Human  1794 QGDVLVLRNLTKVYRGQRMPAVDRLCLGIPPGECFGLLGVNGAGKTSTFRMVTGDTLASRGEAVL 1858

  Fly  1428 QGLSLESNMNSIYKMIGYCPQFDALLDDLTGREVLRIFCMLRGVQESRIRQLSEDLAKSFGFMKH 1492
            .|.|:....::.:..:|||||.||:.:.|||||.|.:...||||.|:::.|.:.......|...:
Human  1859 AGHSVAREPSAAHLSMGYCPQSDAIFELLTGREHLELLARLRGVPEAQVAQTAGSGLARLGLSWY 1923

  Fly  1493 IDKQTHAYSGGNKRKLSTAIAVIGSPSVIYLDEPTTGMDPAARRQLWNMVCRIRDSGKSIVLTSH 1557
            .|:....|||||||||:||:|::|.|:|::||||||||||:|||.|||.:..:...|:|::||||
Human  1924 ADRPAGTYSGGNKRKLATALALVGDPAVVFLDEPTTGMDPSARRFLWNSLLAVVREGRSVMLTSH 1988

  Fly  1558 SMEECEALCTRLAIMVNGEFKCIGSTQHLKNKFSKGLILKIKVRRNLEALRQARLSGGYARNPDE 1622
            |||||||||:||||||||.|:|:||.||||.:|:.|..|.::                       
Human  1989 SMEECEALCSRLAIMVNGRFRCLGSPQHLKGRFAAGHTLTLR----------------------- 2030

  Fly  1623 QTVPAQMSQRDIDAVKEFVETEYPNSILQEEYQGILTFYIPLTG-VKWSRIFGLMESNRDQLNVE 1686
              |||..||    ....||..|:|.:.|:|.:.|.|.|.:|..| ...:|:||.:..:..:..||
Human  2031 --VPAARSQ----PAAAFVAAEFPGAELREAHGGRLRFQLPPGGRCALARVFGELAVHGAEHGVE 2089

  Fly  1687 DYSVSQTTLEEIFLEFAKYQRED 1709
            |:|||||.|||:||.|:|.|.:|
Human  2090 DFSVSQTMLEEVFLYFSKDQGKD 2112

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ABCANP_608445.2 ABC2_membrane_4 254..434 CDD:289500 58/179 (32%)
ABC2_membrane_3 <269..475 CDD:289468 67/206 (33%)
CcmA 538..843 CDD:224054 136/338 (40%)
ABC_subfamily_A 538..755 CDD:213230 102/218 (47%)
ABC2_membrane_3 913..1316 CDD:289468 123/541 (23%)
ABC_subfamily_A 1369..1587 CDD:213230 118/219 (54%)
drrA 1376..1702 CDD:130256 151/328 (46%)
ABCA7XP_024307083.1 rim_protein 1..2114 CDD:130324 613/1908 (32%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165148327
Domainoid 1 1.000 61 1.000 Domainoid score I10503
eggNOG 1 0.900 - - E2759_KOG0059
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53524
OrthoDB 1 1.010 - - D131191at2759
OrthoFinder 1 1.000 - - FOG0000051
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100045
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
87.660

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