DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ABCA and abca12

DIOPT Version :9

Sequence 1:	NP_608445.2	Gene:	ABCA / 33103	FlyBaseID:	FBgn0031170	Length:	1714	Species:	Drosophila melanogaster
Sequence 2:	XP_031748843.1	Gene:	abca12 / 101731410	XenbaseID:	XB-GENE-6041943	Length:	7516	Species:	Xenopus tropicalis

Alignment Length:	1816	Identity:	530/1816 - (29%)
Similarity:	872/1816 - (48%)	Gaps:	322/1816 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 TDLNLLQHSLHRSSYLGKLIALIAPNRRRKNGGFSKFEFILCYSPVNPVLKKLVEEAWQSLGKNK 129
            |::|.:|.....::.:..|::.:..||               ..|:|.|
Frog  5826 TNINNIQQFQPIATVINNLLSCMTYNR---------------IQPMNSV---------------- 5859

  Fly   130 ICESENATQLELDTVSKNAFAGVQFD---DAWANLTENDPLPNDFHFALRFPAELRTATIAIANT 191
              |...|..:||...:| .||.|.||   :.......:..||....:.:.....|...|..|..:
Frog  5860 --EEMQAKAVELQNNNK-LFAAVAFDLPSETTGQSKASFNLPKQIKYTISMEPVLSEDTNIIRKS 5921

  Fly   192 WLTMRLFPTIDLTGPRNEGDDDGGIPPGYLRE---GFLPLQHSLSMAYLRQKSGEQDLPNVVM-- 251
            :.|                    .:|...|.:   ||:.||.::..|.:..:: .:.:.||.:
Frog  5922 YWT--------------------PVPASSLNKYSRGFVYLQENIDRAIIEMQT-NKSVANVGLQY 5965

  Fly   252 KRYPFPAYIFDPLLEGMSSIMSLIILLSFIYPCTYITKYITAEKEKQLKEVMKIMGLSNWLHWTA 316
            :..|||.|..|..|..|...:.:.::::::...:...|.|..|||.:|.|.|::||:::..|:.|
Frog  5966 QSVPFPCYKRDRFLASMGYTLPIALMITWVLFISAFVKKIVHEKEMRLHEYMRMMGVNSSSHFCA 6030

  Fly   317 WFVK--SFIMLTISAILIAILVKINWSEDVAVLTHANFTALVFFLIIYIVSSICFCFMMATFFSR 379
            ||::  ||:::|:|  ::.:|:|..     .:|..:|...|....:.|.::.|...::::.||..
Frog  6031 WFIESASFLLITVS--ILVLLLKFG-----QILPSSNGFILFLLFLDYSLTIIAMSYLISVFFHN 6088

  Fly   380 ASTAAAVTGLIWFIAYIPYSFTINSYDDLSLSSKLGWSLISNTAMGFGIKLILGFEGTGEGLQWS 444
            .:.|.....||:.|.:.|:.........||.|:|....:.|.||:...|:.::.:|....|:|||
Frog  6089 TNVAGLSGSLIYIITFFPFIVIATKSSVLSFSAKTLLCIFSPTALSNAIQYVVYYEEQSVGIQWS 6153

  Fly   445 NFFTPVSVDDTLTLGAVMIMMLVSCVIYMIICLYVEQVMPGSFGVPRPWNFPFTREFW---CGER 506
            |.:....:.|::|.|.:..::.:..:||.::..|:..|.||.:|:|.||.|||...||   ||..
Frog  6154 NMYISPLLGDSMTFGWLCWLLFIDAMIYFLVGFYIRMVFPGKYGIPAPWYFPFQMSFWLKCCGLE 6218

  Fly   507 E----------YTGV--EDIPNGHVEQRDPKAF-ETEPEGKHIGLQMRHLKKRFGNKMVVKGLSM 558
            .          :|.:  ::|.:....:.|..:. |.||....:|:.:..|.|.|.:|..|..|::
Frog  6219 SLRPTKSSGLTFTNIMADNIYHKKGAENDLCSLNEQEPNDLTVGVSLHGLTKVFQSKTAVNNLNL 6283

  Fly   559 NMFEDEITVLLGHNGAGKTTTISMLTGMFPPTSGTAIINGSDIRTNIEGARMSLGICPQHNVLFD 623
            |.:|..||.||||||||||||:|||||:|..:|||..:.|.|||||::.||.::|:|.|::|.||
Frog  6284 NFYEGHITALLGHNGAGKTTTLSMLTGLFGASSGTIYVYGDDIRTNLDRARSNMGVCMQYDVHFD 6348

  Fly   624 EMSVSNHIRFFSRMKGLRGKA--VEQEVAKYLKMIELEDKANVASSKLSGGMKRKLSVCCALCGD 686
            .::...|:..:..:|......  :..||.:.||...|.:..:.....||||||||||:|.||.|.
Frog  6349 HLTTKEHLLLYGSIKAPHWTRAHLHIEVKRNLKDTGLYNHRHKPVKALSGGMKRKLSICIALIGG 6413

  Fly   687 TKVVLCDEPSSGMDPSARRQLWDLLQQEKVGRTLLLTTHFMDEADVLGDRIAIMCDGELKCQGTS 751
            :|||:.|||::|:||.:||.:|:::.::|..:|::|:||.:|||:||.||||.:..|.|||.||.
Frog  6414 SKVVILDEPTTGVDPCSRRSIWEVISKQKKDKTIILSTHHLDEAEVLSDRIAFLEQGGLKCCGTP 6478

  Fly   752 FFLKKQYGSGYRLICVKR-------DDCETNEVTALLNKYIPGLKPECDIGAELSYQLPD---SA 806
            .:||:::||||.|...|:       ::|:...||.|:..:||....:.|:|.||.|.||.   ..
Frog  6479 LYLKQKFGSGYHLTLTKKFPNRENQEECDVELVTDLIKSHIPEACLKEDVGGELVYLLPSFNAEI 6543

  Fly   807 SAKFEEMFGQLEEQSDELHLNGYGVGITSMEEVFMKVGAEKD-------------------NTGN 852
            |..:..:...|:.:.::||:..||:..|::||||:|:....|                   |..|
Frog  6544 SGAYLSLLQALDSRMNDLHIGCYGISDTTIEEVFLKLTDNLDEDEQDAMAWSSTKTVVPIPNEEN 6608

  Fly   853 IKDQHEIMNGGSGFRGEDDNESVQSDGIFSENRRLLQGLQLLSNQWKAMLLKKFLYTWRNKLLLL 917
            :..|.|:......|...||....        |...|.|:.||..:..|:.:|:|..:.||...|:
Frog  6609 LHVQDELSLTNYRFTDRDDQPLT--------NEEKLTGVSLLLKKIMAIFIKRFHNSRRNWKGLI 6665

  Fly   918 IQNIMPVFFVVVTI--------------LIIKTQ-----------GTFQELKPITIS-LTQYP-L 955
            .|.::||.|||:.:              |::...           |.:.|.....:| :..:| :
Frog  6666 SQVLLPVLFVVIAMGLGSLSSSAVSFPELLLTPDLYGTSSQSVAFGLYNESSSNLVSAMNSFPGI 6730

  Fly   956 AVTVLDRSN---VQNGTGYEIANKYEDLARSYGS---NYGLE-------------------LTGT 995
            ..:.|::::   .|||.|...:   ::.:.||||   :.|..                   |...
Frog  6731 DNSCLNQNSNCLSQNGLGLWTS---DNQSLSYGSCNCSTGAPVCDASSAAPPHRRTFSEQMLYNV 6792

  Fly   996 QGF--EDYILDLG-KTIQVR----------INSRY--LVA--ATITESKITAWLNNQALHTAPLT 1043
            .|:  |.|:|... :.||.|          ::|:.  ||.  ..:|.||:  |.||...|:.|..
Frog  6793 SGYNMESYLLTTNLQFIQKRYGGWSFGIPWVSSKLETLVPQNPNMTISKV--WFNNDGPHSLPAF 6855

  Fly  1044 VNMVHNAIADKLFGSS----VKIQVTNAPLPYTTSTLLSQLSTGNNLGTQLASNLCFCMCF--VS 1102
            :|...|.:......|:    ..|.|.:.||   :.|::...:|...:.|.:|  ||....:  .:
Frog  6856 INSFSNFLLRTNLPSNESDQYSISVASKPL---SGTVIQTSTTVTLVNTLIA--LCVLAGYSITT 6915

  Fly  1103 SIYILFLIKERESRAKLLQFVGGVKVWTFWLSQFICDFASYIVTALIVVITIVCFQETGLSTFGE 1167
            :.:..:::||..|.||.||.:.||....:|::.||.|...|::...:.:.||..|:......:..
Frog  6916 ASFATYVVKEHHSGAKRLQHIAGVGETCYWVTNFIYDSIIYLIPVSLSLATIAIFKLPAFYDYPN 6980

  Fly  1168 LGRYYLLLLLFGFAVLPFIYIMSLFFREPATGFARVSIVNIFCGMALFIVVVVM----------S 1222
            ||...||.:|||||...::|:::..|:.|...|.....:|:|.|:...|...|:          .
Frog  6981 LGAMSLLFILFGFATFSWMYLLAGTFKSPGNAFITYVSINLFIGINTIISTSVVYFLYVQRSPSD 7045

  Fly  1223 SELFDTKDTADILGWIFRIFPHFSLAMSL------------NKVYTNTATRNACAKAGALPPILL 1275
            |:......|..:|..:|:|||.|.....:            :.:|..|:|.|
Frog  7046 SDYQSLNQTYTVLTDVFKIFPQFCFGYGMIMLSQQQALQMQSAIYGGTSTTN------------- 7097

  Fly  1276 CELVPQCCNLKPYFAWEEPGVLPETVYMAVTGVVFFLIIIVLEFRLINE-LMFKIRQ-------- 1331
                        .|:.:..|.:...  ||:.|...||:.:     |||: ::|..:.
Frog  7098 ------------IFSMDILGWMLSA--MAIQGAFCFLLRL-----LINDGIIFSFKSFVKRNCMK 7143

  Fly  1332 ---LISKPPPPPTEGQLDDDVANERERILQMSSNELATKNLVLDRVTKYY---GQFM-AVNQVSL 1389
               :::|.|      :.|:||..||||:   .|.:.....|.|..:||.|   |:.| |||.::|
Frog  7144 SYLVVTKNP------EEDEDVRAERERV---DSGQADPDLLQLQGLTKVYHHVGKNMVAVNNMTL 7199

  Fly  1390 CVQEVECFGLLGVNGAGKTTTFKMMTGDERISSGAAYVQGL--SLES--NMNSIYKMIGYCPQFD 1450
            .:...|||||||||||||||||||:|||...|.|...|:..  :||:  ..|:.:...|||||.|
Frog  7200 SIPAGECFGLLGVNGAGKTTTFKMLTGDVAPSKGNIQVRNNAGNLENVLGFNTDWSAFGYCPQED 7264

  Fly  1451 ALLDDLTGREVLRIFCMLRGVQESRIRQLSEDLAKSFGFMKHIDKQTHAYSGGNKRKLSTAIAVI 1515
            ||.:.|||.|.|..:..|.|:.|.:|:.:|..|.:....:::.|:.|.|||.|.:||||||:|:|
Frog  7265 ALDELLTGEEHLYFYARLHGIPEKKIKAVSFSLLQKLQLVQYKDRTTAAYSCGTRRKLSTALALI 7329

  Fly  1516 GSPSVIYLDEPTTGMDPAARRQLWNMVCRIRDSGKSIVLTSHSMEECEALCTRLAIMVNGEFKCI 1580
            |.||::.||||::||||..:|.||.::........::|||||||||||||||||||||.|:|:||
Frog  7330 GRPSILLLDEPSSGMDPKTKRHLWKIISEEVKEKCAVVLTSHSMEECEALCTRLAIMVKGKFQCI 7394

  Fly  1581 GSTQHLKNKFSKGLILKIKVRRNLEALRQARLSGGYARNPDEQTVPAQMSQRDIDAVKEFVETEY 1645
            ||.||:|::|..|..:|:.::.                           |..:::|:..|:...:
Frog  7395 GSLQHIKSRFGSGFTVKMHLKD---------------------------SSVNVEALTSFMCRHF 7432

  Fly  1646 PNSILQEEYQGILTFYIPLTGVKWSRIFGLMESNRDQLNVEDYSVSQTTLEEIFLEFAKYQ 1706
            ||:.|::::..::.:::|:|....:.||.|:|:|:..|::..:|||||||:|:|:.||:.|
Frog  7433 PNTYLKDQHFTMVEYHVPVTAGGVAGIFDLLEANKSDLDIIHFSVSQTTLDEVFINFAQSQ 7493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ABCA	NP_608445.2	ABC2_membrane_4	254..434	CDD:289500	47/181 (26%)
		ABC2_membrane_3	<269..475	CDD:289468	51/207 (25%)
		CcmA	538..843	CDD:224054	130/316 (41%)
		ABC_subfamily_A	538..755	CDD:213230	98/218 (45%)
		ABC2_membrane_3	913..1316	CDD:289468	108/499 (22%)
		ABC_subfamily_A	1369..1587	CDD:213230	115/225 (51%)
		drrA	1376..1702	CDD:130256	139/333 (42%)
abca12	XP_031748843.1	rim_protein	4..>82	CDD:130324
abca12	XP_031748843.1	rim_protein	5675..7493	CDD:130324	529/1814 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010