DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ABCA and abca2

DIOPT Version :9

Sequence 1:NP_608445.2 Gene:ABCA / 33103 FlyBaseID:FBgn0031170 Length:1714 Species:Drosophila melanogaster
Sequence 2:XP_031746716.1 Gene:abca2 / 100498548 XenbaseID:XB-GENE-969968 Length:2496 Species:Xenopus tropicalis


Alignment Length:2044 Identity:610/2044 - (29%)
Similarity:934/2044 - (45%) Gaps:525/2044 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    80 LGKLIALIAPNRRRKNGGFSKFEFILCYSPVNPVLKKLVEEA----------------WQSLGK- 127
            ||.|:.|:..|.:            :.||||...:.|::.:|                |.::.. 
 Frog   496 LGLLVHLMTSNPK------------ILYSPVGTEVDKVIRKANETFAFVGNVTRYAWMWLNISAE 548

  Fly   128 ---------------------------------------NKICESE----NATQL--ELDT---- 143
                                                   .|:..|.    ||:.|  :|||    
 Frog   549 IRGLLEEGILQRRIEWLQQFTNDLQKHPELLNGSDSELLRKVLSSNFTMPNASSLLQQLDTIDNA 613

  Fly   144 ----------VSKNAFAGVQFDDAWANLTEND--------------------PLPNDFHFALRFP 178
                      ||.:.|.|...:|:..|.|.|.                    .||....:.:|..
 Frog   614 ACGWTRFMSKVSVDIFKGFPNEDSIVNYTLNQAYHDNVTVFASVIFQTQKDGSLPPHVMYKIRQN 678

  Fly   179 AELRTATIAIANT-WLTMRLFPTIDLTGPRNEGDDDGGIPPGYLREGFLPLQHSLSMAYLRQKSG 242
            :.....|..|... |               ..|.:.||  ..|...||:.:|..:..|.:....|
 Frog   679 SSFTEKTNEIRRAYW---------------RPGPNTGG--RFYFLYGFVWIQDMMDRAIISTIVG 726

  Fly   243 EQDL-PNVVMKRYPFPAYIFDPLLEGMSSIMSLIILLSFIYPCTYITKYITAEKEKQLKEVMKIM 306
            ...: |...::.:|:|.|..|..|..:..:|.|.:::|::|....:.::|.||||.:||||||:|
 Frog   727 HDVVEPGNYVQMFPYPCYTRDDFLFVIEHMMPLCMVISWVYSVAMMIQHIVAEKEHRLKEVMKMM 791

  Fly   307 GLSNWLHWTAWFVKSFIMLTISAILIAILVKINWSEDVAVLTHANFTALVFFLIIYIVSSICFCF 371
            ||:|.:||.|||:..|:.|:||...:..::|..     .||.|:|...:..||.||.|::|.|||
 Frog   792 GLNNAVHWVAWFITGFVQLSISVTALTGILKYG-----QVLMHSNVFIIWLFLSIYAVATIMFCF 851

  Fly   372 MMATFFSRASTAAAVTGLIWFIAYIPYSFTI----NSYDDLSLSSKLGWSLISNTAMGFGIKLIL 432
            :::..:|:|..|:|..|:|:|::|:||.:..    .::|.::...|...||:|.||.|.|.|...
 Frog   852 LVSVLYSKAKLASACGGIIYFLSYVPYMYVAIREEVAHDKITAFEKCIASLMSTTAFGLGSKYFA 916

  Fly   433 GFEGTGEGLQWSNFF-TPVSVDDTLTLGAVMIMMLVSCVIYMIICLYVEQVMPGSFGVPRPWNFP 496
            .:|..|.|:||..|. :||..|| ..|...|:|:::..::|.|:..|:|.|.||.:|:||||.||
 Frog   917 LYEVAGVGIQWRTFSQSPVEGDD-FNLMLSMMMLIIDTMVYGILTWYIEAVHPGMYGLPRPWYFP 980

  Fly   497 FTREFWCGEREYTGVEDIPNGHVE--------QRDPK----------AFET---------EPEGK 534
            |.|.:|.|           :|.:|        .|.|:          |.|:         |.|..
 Frog   981 FQRSYWLG-----------SGRIETWEWSWPWSRPPRLSIMEEDQACAMESRRLDETRGIEEEPS 1034

  Fly   535 HIGLQ--MRHLKK--RFGNKMVVKGLSMNMFEDEITVLLGHNGAGKTTTISMLTGMFPPTSGTAI 595
            |:.|.  :..|.|  :.|.|:.:..||:|:.|:::...|||||||||||:|:|||:||||||:|.
 Frog  1035 HLPLVVCIDKLTKIYKTGKKLALNKLSLNLHENQVVSFLGHNGAGKTTTMSILTGLFPPTSGSAT 1099

  Fly   596 INGSDIRTNIEGARMSLGICPQHNVLFDEMSVSNHIRFFSRMKGLRGKAVEQEVAKYLKMIELED 660
            |.|.||||.:...|.|:|:|||||||||:::|..|:.|:||:||:..:.:.:|:.|.::.:||.:
 Frog  1100 IYGHDIRTEMNEIRKSMGMCPQHNVLFDKLTVEEHLWFYSRLKGMAEEEIRKEMDKMIEDLELSN 1164

  Fly   661 KANVASSKLSGGMKRKLSVCCALCGDTKVVLCDEPSSGMDPSARRQLWDLLQQEKVGRTLLLTTH 725
            |.:.....|||||||||||..|..|.:|.|:.|||::|:||.|||.:|||:.:.|.|||:||:||
 Frog  1165 KRHSLVQTLSGGMKRKLSVAIAFVGGSKAVILDEPTAGVDPYARRAIWDLILKYKQGRTILLSTH 1229

  Fly   726 FMDEADVLGDRIAIMCDGELKCQGTSFFLKKQYGSGYRLICVKRDD--------------CETNE 776
            .|||||:|||||||:..|:|||.|:..|||..||.||:|..||...              |....
 Frog  1230 HMDEADLLGDRIAIISHGKLKCYGSPLFLKSTYGDGYKLTVVKNQSGPDTGHTGPSCISPCSEPR 1294

  Fly   777 VTALLNKYIPGLKPECDIGAELSYQLPDSASAK--FEEMFGQLEEQSDELHLNGYGVGITSMEEV 839
            |:..:.||:.......|...||||.||..:..|  ||.:|..||:...:|.|..:|:..|::|||
 Frog  1295 VSQFIKKYVASCLLVSDTNTELSYILPSESVRKGCFERLFQHLEQNLSDLELTSFGLMDTTLEEV 1359

  Fly   840 FMKVGAE----KDNTGNIKDQHEIM-------NGGSG---------------------------- 865
            |:||..|    :::..:||:..:..       :||:|                            
 Frog  1360 FLKVSEEDQSLENSDADIKESKKDTLRPLIQPDGGTGSPLTDALEKPEVELNNFASEAKTSQSPS 1424

  Fly   866 ------------FRGEDDNESVQSDGIFS---------ENRRL-----------------LQGLQ 892
                        .||::.....:..|.:|         ||..|                 |:|..
 Frog  1425 SLRSGSSSSVGSVRGDEGGAYAEFYGDYSPLFDNLQDAENLSLHEPETEEQVLDGQGSYKLEGSW 1489

  Fly   893 LLSNQWKAMLLKKFLYTWRNKLLLLIQNIMPVFFVVVTILIIKTQGTFQELKPITISLTQY---- 953
            |...|:..:::|:|....||...|..|.::|.|||.|.:.:..:.....:|.|:.:|.:||    
 Frog  1490 LKLRQFHGLIVKRFHCAKRNTKALFSQILLPAFFVCVAMTVALSVPEIGDLPPLILSPSQYHNYT 1554

  Fly   954 ------------------------------------PLAV-----------TVLDR----SNVQN 967
                                                |..:           :.||:    .|:.:
 Frog  1555 QPKGNFVPYANEEQPEYRIKLSPDAGPQQLVNTFHLPSGIGATCVLKTAFNSTLDQLVQSLNMNS 1619

  Fly   968 GTGYEIANKY---------------------------------EDLARSY--------------- 984
            .....:|.:|                                 |||:|.:               
 Frog  1620 SESKMLAAQYFDAMCVDSFTQGLPLSNFVPPPPSPAPSDYPPDEDLSRLWNATTFPPEPVQAEAV 1684

  Fly   985 ---------------------GSNYGLELTGTQGFEDYILDLGKTIQVRINSR----YL------ 1018
                                 |:.:... :|..|....:..:...|.|.|:.|    ||      
 Frog  1685 TSTPSLPRRIHEPIRCTCSMQGTGFSCP-SGVGGHPHQMKVVTGDIMVAISGRNVSEYLLYTSDR 1748

  Fly  1019 -------------VAATITES----------KIT------AWLNNQALHTAPLTVNMVHNAI--- 1051
                         |...|..|          ||.      |:.||:..|:.|..:|.::||:   
 Frog  1749 FRLHRYGALTFGNVQKAIPASFGAKAPPMLRKIAVRHTAQAYYNNKGYHSMPTYLNALNNALLRA 1813

  Fly  1052 ---ADKLFGSSVKIQVTNAPLPYTTSTL-LSQLSTGNNLGTQLASNLCFCMCFVSSIYILFLIKE 1112
               ..|...::..|.|||.|:..|:::| |..|..|.::  .:|..:...|.||.:.:::||:.|
 Frog  1814 NLPKGKGNPAAYGITVTNHPMNKTSASLSLDYLLQGTDV--VIAIFIIVAMSFVPASFVVFLVAE 1876

  Fly  1113 RESRAKLLQFVGGVKVWTFWLSQFICDFASYIVTALIVVITIVCFQETGLSTFGELGRYYLLLLL 1177
            :.::||.||||.|.....:||:.::.|..:|:|.|...:|.:..|.....::.........|.||
 Frog  1877 KSTKAKHLQFVSGCNPVIYWLANYVWDMLNYLVPATCCIIILFVFDLPAYTSPTNFPAVLSLFLL 1941

  Fly  1178 FGFAVLPFIYIMSLFFREPATGFARVSIVNIFCGMALFIVVVVMSSELF----DTKDTADILGWI 1238
            :|:::.|.:|..|.:|..|:|.:..:.::|:|.|:...:...::  :||    |.|.....|...
 Frog  1942 YGWSITPIMYPASFWFEVPSTAYVFLIVINLFIGITATVATFLL--QLFEHDKDLKLVNSYLKSC 2004

  Fly  1239 FRIFPHFSLAMSLNKVYTNTATRNACAKAGALPPILLCELVPQCCNLKPYFAWEEPGVLPETVYM 1303
            |.|||:::|...|.::..|.......||.|            |...:|..|.|:.  |....|.|
 Frog  2005 FLIFPNYNLGHGLMEMAYNEYINEYYAKIG------------QFDKMKSPFEWDI--VTRGLVAM 2055

  Fly  1304 AVTGVVFFLIIIVLEFRLINELMFKIRQLISKPPPPPTEGQLDD---DVANERERILQ-MSSNEL 1364
            .:.|.|.|.|.|:.::....:..   |..||..|       ::|   ||||||:|:|: .:.|::
 Frog  2056 TIEGFVGFFITIMCQYHFFRKPQ---RLPISNKP-------IEDDDVDVANERQRVLRGGADNDM 2110

  Fly  1365 ATKNLVLDRVTKYY-----GQFMAVNQVSLCVQEVECFGLLGVNGAGKTTTFKMMTGDERISSGA 1424
                |.::.:||.|     |:.:||:::.:.|:..|||||||||||||||||||:||||..:.|.
 Frog  2111 ----LKIENLTKVYKSRKMGRILAVDRLCVGVRPGECFGLLGVNGAGKTTTFKMLTGDESTTGGE 2171

  Fly  1425 AYVQGLSLESNMNSIYKMIGYCPQFDALLDDLTGREVLRIFCMLRGV----QESRIRQLSEDLAK 1485
            |::.|.|:...:..:.:.||||||||||.|:||.:|.|.::..|||:    :|..::...|.|. 
 Frog  2172 AFINGHSILKELLQVQQTIGYCPQFDALFDELTAQEHLELYTRLRGIPWKDEERVVKWALEKLE- 2235

  Fly  1486 SFGFMKHIDKQTHAYSGGNKRKLSTAIAVIGSPSVIYLDEPTTGMDPAARRQLWNMVCRIRDSGK 1550
               ..|:.||....||||||||||||||:||.||.|:||||||||||.|||.|||::..|..:|:
 Frog  2236 ---LAKYADKPAGTYSGGNKRKLSTAIALIGYPSFIFLDEPTTGMDPKARRFLWNLILDIIKTGR 2297

  Fly  1551 SIVLTSHSMEECEALCTRLAIMVNGEFKCIGSTQHLKNKFSKGLILKIKVRRNLEALRQARLSGG 1615
            |:|||||||||||||||||||||||..||:||.|||||:|..|.::.::.:.::           
 Frog  2298 SLVLTSHSMEECEALCTRLAIMVNGRLKCLGSIQHLKNRFGDGYMITVRTKSSI----------- 2351

  Fly  1616 YARNPDEQTVPAQMSQRDIDAVKEFVETEYPNSILQEEYQGILTFYIPLTGVKWSRIFGLMESNR 1680
                             ::..|..|....:|.::|:|.:...:.:.:....|..:::|..||...
 Frog  2352 -----------------NVKEVVRFFNRNFPEAVLKERHHTKVQYQLKSEQVSLAQVFSKMEQVL 2399

  Fly  1681 DQLNVEDYSVSQTTLEEIFLEFAKYQRED 1709
            |.|.:||||||||||:.:|:.|||.|.::
 Frog  2400 DVLGIEDYSVSQTTLDNVFVNFAKKQSDN 2428

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ABCANP_608445.2 ABC2_membrane_4 254..434 CDD:289500 67/183 (37%)
ABC2_membrane_3 <269..475 CDD:289468 76/210 (36%)
CcmA 538..843 CDD:224054 148/324 (46%)
ABC_subfamily_A 538..755 CDD:213230 114/220 (52%)
ABC2_membrane_3 913..1316 CDD:289468 116/576 (20%)
ABC_subfamily_A 1369..1587 CDD:213230 126/226 (56%)
drrA 1376..1702 CDD:130256 151/334 (45%)
abca2XP_031746716.1 rim_protein 1..2430 CDD:130324 610/2044 (30%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 160 1.000 Domainoid score I3998
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53524
OrthoDB 1 1.010 - - D131191at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
43.930

Return to query results.
Submit another query.