DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ABCA and abca1

DIOPT Version :9

Sequence 1:NP_608445.2 Gene:ABCA / 33103 FlyBaseID:FBgn0031170 Length:1714 Species:Drosophila melanogaster
Sequence 2:XP_004910916.1 Gene:abca1 / 100491942 XenbaseID:XB-GENE-1001143 Length:2311 Species:Xenopus tropicalis


Alignment Length:1977 Identity:630/1977 - (31%)
Similarity:982/1977 - (49%) Gaps:417/1977 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    31 ELVLPAIFSLL-----LVLVRTLVDTEQKGVRYYNEQNLTDLNLLQHSLHRSSYLGKLIALIAPN 90
            |.|.|.|.:.:     :.|:|||:  ..||.:.:.:|.|........::.|  :|.|..|.:   
 Frog   421 EEVRPQIKNFMESSQEMDLIRTLL--TNKGSKTFLDQQLNSTGWTTENISR--FLAKETADV--- 478

  Fly    91 RRRKNGGF-----------------SKFEFILCYSPVNPVL--KKLVEEAWQSLGKNKICESENA 136
             ..:||.|                 |:|...:....:.||.  :.|::::.:.|.:.|.      
 Frog   479 -ETENGPFYSWREALNETDRVVLTLSRFMECVNLDKLEPVATEEMLIDKSMELLNERKF------ 536

  Fly   137 TQLELDTVSKNAFAGVQFDDAWANLTENDPLPNDFHFALRFPAELRTATIAIANTWLTMRLFPTI 201
                        :||:.|.|.....||   ||:...:.:|         :.|.|...|.::....
 Frog   537 ------------WAGIVFMDMPEEETE---LPHHVKYKIR---------MDIDNVERTNKIKDGY 577

  Fly   202 DLTGPRNEGDDDGGIPPGYLREGFLPLQHSLSMAYLRQKSGEQDLPNVVMKRYPFPAYIFDPLLE 266
            ...|||.:..:|    ..|:..||..||..:..|.:|.::|.:....:.:::.|:|.|:.|..|.
 Frog   578 WDPGPRADPFED----MRYIWGGFSYLQDVVEQAIIRVQTGVEKRTGIYVQQMPYPCYVDDIFLR 638

  Fly   267 GMSSIMSLIILLSFIYPCTYITKYITAEKEKQLKEVMKIMGLSNWLHWTAWFVKSFIMLTISAIL 331
            .||..|.|.:.|::||....|.|.|..|||.:|||.|:||||.|.:.|.:||:.|.|.|.:||.|
 Frog   639 VMSRSMPLFMTLAWIYSVAVIIKGIVYEKEARLKETMRIMGLDNGILWLSWFISSLIPLLMSAAL 703

  Fly   332 IAILVKINWSEDVAVLTHANFTALVFFLIIYIVSSICFCFMMATFFSRASTAAAVTGLIWFIAYI 396
            :.:::|..     .:|.:::.:.:..||.::.|.:|..||:::|.||||:.|||..|:|:|..|:
 Frog   704 LVLILKTG-----NLLPYSDPSVVFVFLSVFAVVTISQCFLISTIFSRANLAAACGGIIYFTLYL 763

  Fly   397 PYSFTINSYDDLSLSSKLGWSLISNTAMGFGIKLILGFEGTGEGLQWSNFFTPVSVDDTLTLGAV 461
            ||...:...|.:..:.|:..|.:|..|.|||.::....|..|.|:||.|.......::...:...
 Frog   764 PYVLCVAWQDYVGYTLKIFASFLSPVAFGFGCEVFALLEEQGVGVQWDNLLESPLEENGYNITTS 828

  Fly   462 MIMMLVSCVIYMIICLYVEQVMPGSFGVPRPWNFPFTREFWCGE--REYTGVEDIPNGHVEQRDP 524
            ..|||...::|.|:..|:|.|.||.:|:||||.||||:.:||||  :||.....:..|..|    
 Frog   829 GFMMLFDTLLYGIMTWYIEAVFPGQYGIPRPWYFPFTKSYWCGEECKEYNQPHTVQKGSSE---- 889

  Fly   525 KAFETEPEGKHIGLQMRHLKK--RFGNKMVVKGLSMNMFEDEITVLLGHNGAGKTTTISMLTGMF 587
            ...|.||....:|:.:::|.|  |.|.|:.|.||::|.:|.:||..|||||||||||:|:|||:|
 Frog   890 VCMEEEPSHLPLGVSIQNLVKIYRNGKKVAVDGLTLNFYEGQITSFLGHNGAGKTTTMSILTGLF 954

  Fly   588 PPTSGTAIINGSDIRTNIEGARMSLGICPQHNVLFDEMSVSNHIRFFSRMKGLRGKAVEQEVAKY 652
            |||:|||.|...||||.:...|.:||:|||||||||.::|..||.|::|:|||..:.|:.|:.:.
 Frog   955 PPTTGTAYIMKKDIRTELNSIRQNLGVCPQHNVLFDALTVEEHIWFYARLKGLSEEKVKAEMEQM 1019

  Fly   653 LKMIELEDKANVASSKLSGGMKRKLSVCCALCGDTKVVLCDEPSSGMDPSARRQLWDLLQQEKVG 717
            :..:.|..|....:|:|||||:|||||..|..|.:|||:.|||::|:||.:||.:|:||.:.:.|
 Frog  1020 VNDVGLPHKKKYKTSQLSGGMQRKLSVALAFVGGSKVVILDEPTAGVDPYSRRGIWELLIKYRQG 1084

  Fly   718 RTLLLTTHFMDEADVLGDRIAIMCDGELKCQGTSFFLKKQYGSGYRLICVKRDD------C---- 772
            ||::|:||.|||||:|||||||:..|:|.|.|:|.|||.|.|:||.|..||||:      |    
 Frog  1085 RTIILSTHHMDEADILGDRIAIISHGKLCCVGSSLFLKNQLGTGYYLTLVKRDNDSSLSSCRNSS 1149

  Fly   773 --------ETNEVTA-------------------------------------------------- 779
                    |:::.||                                                  
 Frog  1150 STMSYLKKESSKQTACKQHPSPMIAAPSASGTTAAVITKHSKHTAGQKKEAKDREDSVSQSSSDA 1214

  Fly   780 -----------------------LLNKYIPGLKPECDIGAELSYQLPDSASAK--FEEMFGQLEE 819
                                   |:||::|..:...|||.||:|.||..|:.:  |.|:|.::::
 Frog  1215 GLGSDHESDTMTIGLTDVSAISNLINKHVPEARLVEDIGHELTYVLPYEAAKEGAFVELFHEIDD 1279

  Fly   820 QSDELHLNGYGVGITSMEEVFMKVGAEKDNTGNIKDQHEIMNG---------------------- 862
            :..:|.::.||:..|::||:|:||.   |:||   ...|..:|                      
 Frog  1280 RLSDLGISSYGIADTTLEEIFLKVA---DDTG---VDAETSDGTLPARRKRYAFGDHQSCLRPFT 1338

  Fly   863 -GSGFRGED---DNESVQSD---GIFSENRRLLQGLQLLSNQWKAMLLKKFLYTWRNKLLLLIQN 920
             ...|...|   |.||.::|   ||..:....|:...|:..|:.|:|.|:.||..|::.....|.
 Frog  1339 EDDAFDTNDSDMDPESRETDYLSGIDGKGSYQLKSWNLMRQQFTALLWKRLLYAKRSRKGFFAQI 1403

  Fly   921 IMPVFFVVVTI---LIIKTQGTFQ--ELKP------ITISLTQYP-------LAVTVLDRSNVQN 967
            ::|..||::.:   ||:...|.:.  ||:|      .|......|       |...::|:...  
 Frog  1404 VLPAVFVLIALVFSLIVPPFGKYPSLELEPWMYDEQYTFFSNDAPDDQGTQALLKALIDKPGF-- 1466

  Fly   968 GT----GYEI-----ANKYEDLARSYGS----------NYGLE---------------------- 991
            ||    |:.:     :.:.|:.:..:.|          |:.:|                      
 Frog  1467 GTACMEGHSVMKVSCSGEEEEWSTQFVSQSVMDLFLNGNWTMENPSPSCECSSDKRKKMLPICPP 1531

  Fly   992 --------------------LTGTQGFEDYILD-----LGKTIQVRI---------------NSR 1016
                                ||| :...||::.     :.|:::.:|               ||.
 Frog  1532 GAGGLPPFQRRQNTSDILQNLTG-RNISDYLVKTYSQIIEKSLKNKIWVNEFRYGGFSLGASNSP 1595

  Fly  1017 YL-----VAATI------------------------------TESKITAWLNNQALHTAPLTVNM 1046
            .|     |.|:|                              |:..:..|.||:..|.....:|:
 Frog  1596 ALPPNEEVVASINHIKKRLELPQNGAANRFLDSFGAFMKGLDTKDNVKVWFNNKGWHAVGAFLNV 1660

  Fly  1047 VHNAI-ADKL----FGSSVKIQVTNAPLPYTTSTLLSQLSTGNNLGTQLASNLCFCMCFVSSIYI 1106
            ::||| ..||    ..:|..|...|.||..|...|........::...::..:.|.|.||.:.::
 Frog  1661 MNNAILRSKLREGEDPASYGITAFNHPLNLTKEQLSEVALMTTSVDVLVSICVIFAMSFVPASFV 1725

  Fly  1107 LFLIKERESRAKLLQFVGGVKVWTFWLSQFICDFASYIVTALIVVITIVCFQETGLSTFGELGRY 1171
            :|||:||.|:||.:|.:.|||...:||:.|:.|..:|:|.|.:|:|..:|||:....:...|...
 Frog  1726 VFLIQERVSKAKHMQCISGVKPVIYWLANFVWDMCNYVVPATLVIIIFICFQQDSYVSSSNLPVL 1790

  Fly  1172 YLLLLLFGFAVLPFIYIMSLFFREPATGFARVSIVNIFCG----MALFIVVVVMSSELFDTKDTA 1232
            .|||||:|:::.|.:|..|..|:.|:|.:..::.||:|.|    :|.|::.:..:::|   .:..
 Frog  1791 ALLLLLYGWSITPLMYPASFIFKIPSTAYVVLTSVNLFIGINGSVATFVLELFTNNKL---SNIN 1852

  Fly  1233 DILGWIFRIFPHFSLAMSLNKVYTNTATRNACAKAGA---LPPILLCELVPQCCNLKPYFAWEEP 1294
            :||..:..|||||.|...|..:..|.|..:|..:.|.   :.|:                :|:..
 Frog  1853 EILKSVLLIFPHFCLGRGLIDMVKNQAMADALERFGENRFVSPM----------------SWDLV 1901

  Fly  1295 GVLPETVYMAVTGVVFFLIIIVLEFRLINELMFKIRQLISKPPPPPTEGQLDDDVANERERILQM 1359
            |  .....|||.|||||.|.:::::|    ...|.|.:.:|.||...|   |:|||.||:||.:.
 Frog  1902 G--RNLFAMAVEGVVFFAITLMIQYR----FFIKPRPVNAKLPPVVDE---DEDVARERQRINEG 1957

  Fly  1360 SSNELATKNLVLDRVTKYY--GQFMAVNQVSLCVQEVECFGLLGVNGAGKTTTFKMMTGDERISS 1422
            ..|::    |.|..:||.|  .:..||:::.:.:...|||||||||||||||||||:|||..:::
 Frog  1958 GRNDI----LELKGLTKIYRMKRKPAVDRLCVGIPPGECFGLLGVNGAGKTTTFKMLTGDTDVTA 2018

  Fly  1423 GAAYVQGLSLESNMNSIYKMIGYCPQFDALLDDLTGREVLRIFCMLRGVQESRIRQLSEDLAKSF 1487
            |.|:::..|:..|::.:::.:||||||||:.:.|||||.|.::.:||||.|..:.:::|...:..
 Frog  2019 GEAFLKNHSILRNIHEVHQNMGYCPQFDAINELLTGREHLELYALLRGVPEKEVCKVAEWAIRKL 2083

  Fly  1488 GFMKHIDKQTHAYSGGNKRKLSTAIAVIGSPSVIYLDEPTTGMDPAARRQLWNMVCRIRDSGKSI 1552
            |.:|:.:|....||||||||||||||:||.|.|::||||||||||.|||.|||....:...|:|:
 Frog  2084 GLVKYSEKHAGNYSGGNKRKLSTAIALIGGPPVVFLDEPTTGMDPKARRFLWNCALSVIKEGRSV 2148

  Fly  1553 VLTSHSMEECEALCTRLAIMVNGEFKCIGSTQHLKNKFSKGLILKIKVRRNLEALRQARLSGGYA 1617
            ||||||||||||||||:||||||.|||:||.|||||:|..|..:.:            |::|.  
 Frog  2149 VLTSHSMEECEALCTRMAIMVNGRFKCLGSVQHLKNRFGDGYTIIV------------RIAGS-- 2199

  Fly  1618 RNPDEQTVPAQMSQRDIDAVKEFVETEYPNSILQEEYQGILTFYIPLTGVKWSRIFGLMESNRDQ 1682
             ||            |:..|:||....:|.|:|:|:::.:|.:.:..:....:|||.::..|:.:
 Frog  2200 -NP------------DLKPVEEFFSHAFPGSVLKEKHRSMLQYQLRSSQSSLARIFSILSKNKKR 2251

  Fly  1683 LNVEDYSVSQTTLEEIFLEFAKYQRED 1709
            |::||||||||||:::|:.|||.|.:|
 Frog  2252 LHIEDYSVSQTTLDQVFVNFAKDQSDD 2278

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ABCANP_608445.2 ABC2_membrane_4 254..434 CDD:289500 66/179 (37%)
ABC2_membrane_3 <269..475 CDD:289468 70/205 (34%)
CcmA 538..843 CDD:224054 152/399 (38%)
ABC_subfamily_A 538..755 CDD:213230 114/218 (52%)
ABC2_membrane_3 913..1316 CDD:289468 125/548 (23%)
ABC_subfamily_A 1369..1587 CDD:213230 121/219 (55%)
drrA 1376..1702 CDD:130256 152/327 (46%)
abca1XP_004910916.1 rim_protein 1..2272 CDD:130324 625/1969 (32%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 160 1.000 Domainoid score I3998
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D131191at2759
OrthoFinder 1 1.000 - - FOG0000051
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
44.010

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