DRSC/TRiP Functional Genomics Resources

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Protein Alignment Abca3 and abca1

DIOPT Version :10

Sequence 1:NP_608445.2 Gene:Abca3 / 33103 FlyBaseID:FBgn0031170 Length:1714 Species:Drosophila melanogaster
Sequence 2:XP_004910916.1 Gene:abca1 / 100491942 XenbaseID:XB-GENE-1001143 Length:2311 Species:Xenopus tropicalis


Alignment Length:1977 Identity:630/1977 - (31%)
Similarity:982/1977 - (49%) Gaps:417/1977 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    31 ELVLPAIFSLL-----LVLVRTLVDTEQKGVRYYNEQNLTDLNLLQHSLHRSSYLGKLIALIAPN 90
            |.|.|.|.:.:     :.|:|||:  ..||.:.:.:|.|........::.|  :|.|..|.:   
 Frog   421 EEVRPQIKNFMESSQEMDLIRTLL--TNKGSKTFLDQQLNSTGWTTENISR--FLAKETADV--- 478

  Fly    91 RRRKNGGF-----------------SKFEFILCYSPVNPVL--KKLVEEAWQSLGKNKICESENA 136
             ..:||.|                 |:|...:....:.||.  :.|::::.:.|.:.|.      
 Frog   479 -ETENGPFYSWREALNETDRVVLTLSRFMECVNLDKLEPVATEEMLIDKSMELLNERKF------ 536

  Fly   137 TQLELDTVSKNAFAGVQFDDAWANLTENDPLPNDFHFALRFPAELRTATIAIANTWLTMRLFPTI 201
                        :||:.|.|.....||   ||:...:.:|         :.|.|...|.::....
 Frog   537 ------------WAGIVFMDMPEEETE---LPHHVKYKIR---------MDIDNVERTNKIKDGY 577

  Fly   202 DLTGPRNEGDDDGGIPPGYLREGFLPLQHSLSMAYLRQKSGEQDLPNVVMKRYPFPAYIFDPLLE 266
            ...|||.:..:|    ..|:..||..||..:..|.:|.::|.:....:.:::.|:|.|:.|..|.
 Frog   578 WDPGPRADPFED----MRYIWGGFSYLQDVVEQAIIRVQTGVEKRTGIYVQQMPYPCYVDDIFLR 638

  Fly   267 GMSSIMSLIILLSFIYPCTYITKYITAEKEKQLKEVMKIMGLSNWLHWTAWFVKSFIMLTISAIL 331
            .||..|.|.:.|::||....|.|.|..|||.:|||.|:||||.|.:.|.:||:.|.|.|.:||.|
 Frog   639 VMSRSMPLFMTLAWIYSVAVIIKGIVYEKEARLKETMRIMGLDNGILWLSWFISSLIPLLMSAAL 703

  Fly   332 IAILVKINWSEDVAVLTHANFTALVFFLIIYIVSSICFCFMMATFFSRASTAAAVTGLIWFIAYI 396
            :.:::|..     .:|.:::.:.:..||.::.|.:|..||:::|.||||:.|||..|:|:|..|:
 Frog   704 LVLILKTG-----NLLPYSDPSVVFVFLSVFAVVTISQCFLISTIFSRANLAAACGGIIYFTLYL 763

  Fly   397 PYSFTINSYDDLSLSSKLGWSLISNTAMGFGIKLILGFEGTGEGLQWSNFFTPVSVDDTLTLGAV 461
            ||...:...|.:..:.|:..|.:|..|.|||.::....|..|.|:||.|.......::...:...
 Frog   764 PYVLCVAWQDYVGYTLKIFASFLSPVAFGFGCEVFALLEEQGVGVQWDNLLESPLEENGYNITTS 828

  Fly   462 MIMMLVSCVIYMIICLYVEQVMPGSFGVPRPWNFPFTREFWCGE--REYTGVEDIPNGHVEQRDP 524
            ..|||...::|.|:..|:|.|.||.:|:||||.||||:.:||||  :||.....:..|..|    
 Frog   829 GFMMLFDTLLYGIMTWYIEAVFPGQYGIPRPWYFPFTKSYWCGEECKEYNQPHTVQKGSSE---- 889

  Fly   525 KAFETEPEGKHIGLQMRHLKK--RFGNKMVVKGLSMNMFEDEITVLLGHNGAGKTTTISMLTGMF 587
            ...|.||....:|:.:::|.|  |.|.|:.|.||::|.:|.:||..|||||||||||:|:|||:|
 Frog   890 VCMEEEPSHLPLGVSIQNLVKIYRNGKKVAVDGLTLNFYEGQITSFLGHNGAGKTTTMSILTGLF 954

  Fly   588 PPTSGTAIINGSDIRTNIEGARMSLGICPQHNVLFDEMSVSNHIRFFSRMKGLRGKAVEQEVAKY 652
            |||:|||.|...||||.:...|.:||:|||||||||.::|..||.|::|:|||..:.|:.|:.:.
 Frog   955 PPTTGTAYIMKKDIRTELNSIRQNLGVCPQHNVLFDALTVEEHIWFYARLKGLSEEKVKAEMEQM 1019

  Fly   653 LKMIELEDKANVASSKLSGGMKRKLSVCCALCGDTKVVLCDEPSSGMDPSARRQLWDLLQQEKVG 717
            :..:.|..|....:|:|||||:|||||..|..|.:|||:.|||::|:||.:||.:|:||.:.:.|
 Frog  1020 VNDVGLPHKKKYKTSQLSGGMQRKLSVALAFVGGSKVVILDEPTAGVDPYSRRGIWELLIKYRQG 1084

  Fly   718 RTLLLTTHFMDEADVLGDRIAIMCDGELKCQGTSFFLKKQYGSGYRLICVKRDD------C---- 772
            ||::|:||.|||||:|||||||:..|:|.|.|:|.|||.|.|:||.|..||||:      |    
 Frog  1085 RTIILSTHHMDEADILGDRIAIISHGKLCCVGSSLFLKNQLGTGYYLTLVKRDNDSSLSSCRNSS 1149

  Fly   773 --------ETNEVTA-------------------------------------------------- 779
                    |:::.||                                                  
 Frog  1150 STMSYLKKESSKQTACKQHPSPMIAAPSASGTTAAVITKHSKHTAGQKKEAKDREDSVSQSSSDA 1214

  Fly   780 -----------------------LLNKYIPGLKPECDIGAELSYQLPDSASAK--FEEMFGQLEE 819
                                   |:||::|..:...|||.||:|.||..|:.:  |.|:|.::::
 Frog  1215 GLGSDHESDTMTIGLTDVSAISNLINKHVPEARLVEDIGHELTYVLPYEAAKEGAFVELFHEIDD 1279

  Fly   820 QSDELHLNGYGVGITSMEEVFMKVGAEKDNTGNIKDQHEIMNG---------------------- 862
            :..:|.::.||:..|::||:|:||.   |:||   ...|..:|                      
 Frog  1280 RLSDLGISSYGIADTTLEEIFLKVA---DDTG---VDAETSDGTLPARRKRYAFGDHQSCLRPFT 1338

  Fly   863 -GSGFRGED---DNESVQSD---GIFSENRRLLQGLQLLSNQWKAMLLKKFLYTWRNKLLLLIQN 920
             ...|...|   |.||.::|   ||..:....|:...|:..|:.|:|.|:.||..|::.....|.
 Frog  1339 EDDAFDTNDSDMDPESRETDYLSGIDGKGSYQLKSWNLMRQQFTALLWKRLLYAKRSRKGFFAQI 1403

  Fly   921 IMPVFFVVVTI---LIIKTQGTFQ--ELKP------ITISLTQYP-------LAVTVLDRSNVQN 967
            ::|..||::.:   ||:...|.:.  ||:|      .|......|       |...::|:...  
 Frog  1404 VLPAVFVLIALVFSLIVPPFGKYPSLELEPWMYDEQYTFFSNDAPDDQGTQALLKALIDKPGF-- 1466

  Fly   968 GT----GYEI-----ANKYEDLARSYGS----------NYGLE---------------------- 991
            ||    |:.:     :.:.|:.:..:.|          |:.:|                      
 Frog  1467 GTACMEGHSVMKVSCSGEEEEWSTQFVSQSVMDLFLNGNWTMENPSPSCECSSDKRKKMLPICPP 1531

  Fly   992 --------------------LTGTQGFEDYILD-----LGKTIQVRI---------------NSR 1016
                                ||| :...||::.     :.|:::.:|               ||.
 Frog  1532 GAGGLPPFQRRQNTSDILQNLTG-RNISDYLVKTYSQIIEKSLKNKIWVNEFRYGGFSLGASNSP 1595

  Fly  1017 YL-----VAATI------------------------------TESKITAWLNNQALHTAPLTVNM 1046
            .|     |.|:|                              |:..:..|.||:..|.....:|:
 Frog  1596 ALPPNEEVVASINHIKKRLELPQNGAANRFLDSFGAFMKGLDTKDNVKVWFNNKGWHAVGAFLNV 1660

  Fly  1047 VHNAI-ADKL----FGSSVKIQVTNAPLPYTTSTLLSQLSTGNNLGTQLASNLCFCMCFVSSIYI 1106
            ::||| ..||    ..:|..|...|.||..|...|........::...::..:.|.|.||.:.::
 Frog  1661 MNNAILRSKLREGEDPASYGITAFNHPLNLTKEQLSEVALMTTSVDVLVSICVIFAMSFVPASFV 1725

  Fly  1107 LFLIKERESRAKLLQFVGGVKVWTFWLSQFICDFASYIVTALIVVITIVCFQETGLSTFGELGRY 1171
            :|||:||.|:||.:|.:.|||...:||:.|:.|..:|:|.|.:|:|..:|||:....:...|...
 Frog  1726 VFLIQERVSKAKHMQCISGVKPVIYWLANFVWDMCNYVVPATLVIIIFICFQQDSYVSSSNLPVL 1790

  Fly  1172 YLLLLLFGFAVLPFIYIMSLFFREPATGFARVSIVNIFCG----MALFIVVVVMSSELFDTKDTA 1232
            .|||||:|:::.|.:|..|..|:.|:|.:..::.||:|.|    :|.|::.:..:::|   .:..
 Frog  1791 ALLLLLYGWSITPLMYPASFIFKIPSTAYVVLTSVNLFIGINGSVATFVLELFTNNKL---SNIN 1852

  Fly  1233 DILGWIFRIFPHFSLAMSLNKVYTNTATRNACAKAGA---LPPILLCELVPQCCNLKPYFAWEEP 1294
            :||..:..|||||.|...|..:..|.|..:|..:.|.   :.|:                :|:..
 Frog  1853 EILKSVLLIFPHFCLGRGLIDMVKNQAMADALERFGENRFVSPM----------------SWDLV 1901

  Fly  1295 GVLPETVYMAVTGVVFFLIIIVLEFRLINELMFKIRQLISKPPPPPTEGQLDDDVANERERILQM 1359
            |  .....|||.|||||.|.:::::|    ...|.|.:.:|.||...|   |:|||.||:||.:.
 Frog  1902 G--RNLFAMAVEGVVFFAITLMIQYR----FFIKPRPVNAKLPPVVDE---DEDVARERQRINEG 1957

  Fly  1360 SSNELATKNLVLDRVTKYY--GQFMAVNQVSLCVQEVECFGLLGVNGAGKTTTFKMMTGDERISS 1422
            ..|::    |.|..:||.|  .:..||:::.:.:...|||||||||||||||||||:|||..:::
 Frog  1958 GRNDI----LELKGLTKIYRMKRKPAVDRLCVGIPPGECFGLLGVNGAGKTTTFKMLTGDTDVTA 2018

  Fly  1423 GAAYVQGLSLESNMNSIYKMIGYCPQFDALLDDLTGREVLRIFCMLRGVQESRIRQLSEDLAKSF 1487
            |.|:::..|:..|::.:::.:||||||||:.:.|||||.|.::.:||||.|..:.:::|...:..
 Frog  2019 GEAFLKNHSILRNIHEVHQNMGYCPQFDAINELLTGREHLELYALLRGVPEKEVCKVAEWAIRKL 2083

  Fly  1488 GFMKHIDKQTHAYSGGNKRKLSTAIAVIGSPSVIYLDEPTTGMDPAARRQLWNMVCRIRDSGKSI 1552
            |.:|:.:|....||||||||||||||:||.|.|::||||||||||.|||.|||....:...|:|:
 Frog  2084 GLVKYSEKHAGNYSGGNKRKLSTAIALIGGPPVVFLDEPTTGMDPKARRFLWNCALSVIKEGRSV 2148

  Fly  1553 VLTSHSMEECEALCTRLAIMVNGEFKCIGSTQHLKNKFSKGLILKIKVRRNLEALRQARLSGGYA 1617
            ||||||||||||||||:||||||.|||:||.|||||:|..|..:.:            |::|.  
 Frog  2149 VLTSHSMEECEALCTRMAIMVNGRFKCLGSVQHLKNRFGDGYTIIV------------RIAGS-- 2199

  Fly  1618 RNPDEQTVPAQMSQRDIDAVKEFVETEYPNSILQEEYQGILTFYIPLTGVKWSRIFGLMESNRDQ 1682
             ||            |:..|:||....:|.|:|:|:::.:|.:.:..:....:|||.::..|:.:
 Frog  2200 -NP------------DLKPVEEFFSHAFPGSVLKEKHRSMLQYQLRSSQSSLARIFSILSKNKKR 2251

  Fly  1683 LNVEDYSVSQTTLEEIFLEFAKYQRED 1709
            |::||||||||||:::|:.|||.|.:|
 Frog  2252 LHIEDYSVSQTTLDQVFVNFAKDQSDD 2278

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Abca3NP_608445.2 rim_protein <137..1708 CDD:130324 603/1844 (33%)
abca1XP_004910916.1 rim_protein 1..2272 CDD:130324 625/1969 (32%)

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