Protein Alignment ABCA and abca3

DIOPT Version :9

• Sequence 1: NP_608445.2
• Gene: ABCA / 33103
• FlyBaseID: FBgn0031170
• Length: 1714
• Species: Drosophila melanogaster
• Sequence 2: XP_004918068.1
• Gene: abca3 / 100490925
• XenbaseID: XB-GENE-1010698
• Length: 1720
• Species: Xenopus tropicalis
• Alignment Length: 1774
• Identity: 663/1774 - (37%)
• Similarity: 979/1774 - (55%)
• Gaps: 163/1774 - (9%)

  Fly    12 LLLWKNWTLQWNHKWQMVIELVLPAIFSLLLVLVRTLVDTEQKGVRYYNEQNLTDLNLLQHSLHR 76
            ||||||:.||.......||||.||.:||.:|:.:|..|.:    |.|.|.           :|:|
 Frog    25 LLLWKNYILQKRQVLVTVIELALPLLFSAILIALRHRVPS----VTYPNA-----------TLYR 74

  Fly    77 SSYLGKLIALIAPNRRRKNGGFSKFEFILCYSPVNPVLKKLVEEAWQSLGKNKI----------- 130
            ......|..:..|.           .:.|.|.|.:   .|........:|.:..
 Frog    75 EMPFPNLPFIPGPR-----------PWELAYVPSH---SKAAHSIILDVGNHLFPYYFANQSARG 125

  Fly   131 --CESENATQLELDTVSKNAFAGVQFDDAWANLTENDPLPNDFHFALRFPAELRTATIA------ 187
              .|.:....:..:..|....|.|.|:..:.:  ..||||....:.|||....|.|.::
 Frog   126 FPTEEDFEDYIRHNNHSSKILAAVVFEHNFNH--SGDPLPLQVRYRLRFKYSPRNAPMSEQTGLN 188

  Fly   188 --IANTWLTMRLFPTIDLTGPRNEGDDDGGIPPGYLREGFLPLQHSLSMAYLRQKSGEQ-----D 245
              :...|.|..|:|...:.|||..||..|| .|||.|||||.:||.:..|.:|..:.|.     |
 Frog   189 PNVDRNWHTRYLYPLFQMPGPREAGDKTGG-TPGYQREGFLAMQHEVDRAIMRYHANESGRLLLD 252

  Fly   246 LPNVVMKRYPFPAYIFDPLLEGMSSIMSLIILLSFIYPCTYITKYITAEKEKQLKEVMKIMGLSN 310
            ..:|.::|:|:|.|:.|..:..:.:.:.|:::|||.|....|.:.:..|||::|||.|::||||:
 Frog   253 NIDVAIRRFPYPPYVNDLFILAIQNQLPLLLMLSFTYTSLSIVRALVLEKERKLKEYMRVMGLSS 317

  Fly   311 WLHWTAWFVKSFIMLTISAILIAILVKINWSEDVAVLTHANFTALVFFLIIYIVSSICFCFMMAT 375
            |||.||||:..|::|.:|...:.:|:.|..|.:.||||.::.:.:..:::::.||:|.|.||:::
 Frog   318 WLHSTAWFIHFFLLLLVSVFFVTLLLCIQVSSEGAVLTRSDPSLVFVYILVFSVSTISFSFMISS 382

  Fly   376 FFSRASTAAAVTGLIWFIAYIPYSFTINSYDDLSLSSKLGWSLISNTAMGFGIKLILGFEGTGEG 440
            |||||:.|||..|.::|::||||.|....||:|:..:|:...|.||..|..|.:||..|||.|.|
 Frog   383 FFSRANMAAAAGGFLYFLSYIPYFFISPWYDELNHGAKVSSCLFSNVGMAMGAQLIGMFEGKGTG 447

  Fly   441 LQWSNFFTPVSVDDTLTLGAVMIMMLVSCVIYMIICLYVEQVMPGSFGVPRPWNFPFTREFWCG- 504
            .||||.||||||||..|||.|:.|:::.||:|.::..|||.||||.:|||:||.|.|...:|||
 Frog   448 AQWSNLFTPVSVDDNFTLGQVLQMLMLDCVLYFLVGWYVESVMPGDYGVPQPWYFCFLPSYWCGT 512

  Fly   505 EREYTGVEDIPNGHVEQRDPKA------FETEPEGKHIGLQMRHLKKRF---GNKMV-VKGLSMN 559
            .|...|:|     ..:..||:.      .|.||.....|::::||.|.:   |.|.: |:.|::|
 Frog   513 PRLVEGLE-----KEDDEDPEKALKGEYLEEEPSDLVPGIRIKHLTKVYHASGKKRIAVRDLTLN 572

  Fly   560 MFEDEITVLLGHNGAGKTTTISMLTGMFPPTSGTAIINGSDIRTNIEGARMSLGICPQHNVLFDE 624
            |:|.::|||||||||||:||:|||||:.||:||...|.|.:|..:....|.|||:||||:|||..
 Frog   573 MYEGQVTVLLGHNGAGKSTTLSMLTGLSPPSSGECYIGGYEITRDTALIRRSLGLCPQHDVLFQG 637

  Fly   625 MSVSNHIRFFSRMKGLRGKAVEQEVAKYLKMIELEDKANVASSKLSGGMKRKLSVCCALCGDTKV 689
            ::|..|:.|::.:||.......:||.|.|:::.||:|.|..|::||||..||||:..||.|.:||
 Frog   638 LTVEEHLYFYAGLKGCPRWCCPEEVEKILQILRLEEKRNALSTQLSGGTCRKLSIGIALIGGSKV 702

  Fly   690 VLCDEPSSGMDPSARRQLWDLLQQEKVGRTLLLTTHFMDEADVLGDRIAIMCDGELKCQGTSFFL 754
            |:.|||:|||||::||..|:||:|.|..||||||||||||||:|||||||:..|:|:|.|:..||
 Frog   703 VMLDEPTSGMDPASRRDTWELLRQHKHDRTLLLTTHFMDEADILGDRIAILAQGQLQCCGSPLFL 767

  Fly   755 KKQYGSGYRLICVKRDDCETNEVTALLNKYIPGLKPECDIGAELSYQLPDSASAKFEEMFGQLEE 819
            |.:||:||.::.||...|:..::|.|:..|:|....|.:.||||||.||..::.:||.:|.:||.
 Frog   768 KCKYGAGYHMVMVKEPHCQVEDITHLITSYVPNATLESNAGAELSYILPKESTHRFEPLFSELEL 832

  Fly   820 QSDELHLNGYGVGITSMEEVFMKVGAEKDNTGNIKD--------QHEIMNGGSGFR--------G 868
            :.:||.:..||..:|:|||||::||...|.:.:|:.        |||......|..        .
 Frog   833 RREELGIASYGASVTTMEEVFLRVGKLVDTSLDIQAIQLPPLQYQHERRANDWGTEESCSMSDCT 897

  Fly   869 EDDNESVQSDGIFSENRRLLQGLQLLSNQWKAMLLKKFLYTWRNKLLLLIQNIMPVFFVVVTILI 933
            ||....:..|   ..|.:|.....|...|:.|:.:|:..|:|||..:::.|.::|:.|..:.:::
 Frog   898 EDSGTLITED---CSNIKLNGKCTLWCQQFYALFVKRAAYSWRNWKMVVGQFLVPLVFTTLALVV 959

  Fly   934 IKTQGTFQELKPITISLTQYPLAVTVLDRSNVQNGTGYEIANKYEDLARSYGSNYGLELTGTQ-- 996
            .||....|:..|:.:||..|...|           ..|.:......|.:|...|:..:.:|.|
 Frog   960 GKTFPGPQDSPPLDLSLVPYGYTV-----------VPYSLPPNASTLLQSLADNFRDQFSGQQME 1013

  Fly   997 ------GFEDYILDLGKTIQVRINSRYLVAATI----TESKITAWLNNQALHTAPLTVNMVHNAI 1051
                  ..::|:|............|.|.||.|    :..|:||..||||.|.....:.:|.||:
 Frog  1014 PQEVLDDLDNYLLTRASDEGALFAERCLCAADIQNLGSRIKVTARFNNQAYHAVASALALVDNAL 1078

  Fly  1052 ADKLFGSSVKIQVTNAPLP-YTTSTLLSQLSTGNNLGTQLASNLCFCMCFVSSIYILFLIKERES 1115
            ...:.|....|.|||.|.| .||.|...||..| ..|..:|.||.:.|..::|.:.|.|:.||..
 Frog  1079 FKLIAGPEASISVTNYPQPRNTTETAQDQLLEG-QAGFAIAINLLYGMASLASTFSLLLVGERAV 1142

  Fly  1116 RAKLLQFVGGVKVWTFWLSQFICDFASYIVTALIVVITIVCFQETGLSTFGELGRYYLLLLLFGF 1180
            ::|.:|||.|....::|||....|..::::....::.....|.....:....|....|:|||:|:
 Frog  1143 KSKHVQFVSGASALSYWLSALTWDLLNFLIPCTFMLAVFQAFDVRAYTEEHHLVDVILMLLLYGW 1207

  Fly  1181 AVLPFIYIMSLFFREPATGFARVSIVNIFCGMALFIVVVVMSSELFDTKDTADILGWIFRIFPHF 1245
            ||:|.:|:.|..|...||.:.|::|.||..|.|.|:.|.:||.......|.:.||..:|.:.|::
 Frog  1208 AVIPLMYLFSFLFTSTATAYTRLTIFNILSGTASFLSVTIMSIPALGLVDLSHILDQVFLVLPNY 1272

  Fly  1246 SLAMSLNKVYTNTATRNACAKAGALPPILLCELVPQCCNLKPYFAWEEPGVLPETVYMAVTGVVF 1310
            .|..|.:..|.|......|..:..  ..::|:.....|. ..||:|..|||......|||.|..|
 Frog  1273 CLGRSFSDFYQNYHLLKFCRSSPR--SAIICQAFNITCQ-DNYFSWSSPGVGRYLTAMAVQGSAF 1334

  Fly  1311 FLIIIVLEFRLINEL-----MFKIRQLISKPPPP--PTEGQLDDDVANERERILQMSSNELA--T 1366
            ..::.::|.::...|     .:|..:..|.|..|  |.|   |.|||:||:::|:....:|:  :
 Frog  1335 LCLLFIIESQIFCRLYNLCRSYKEHRWASLPESPVSPPE---DRDVADERKKVLESPLEQLSALS 1396

  Fly  1367 KNLVLDRVTKYYGQ---FMAVNQVSLCVQEVECFGLLGVNGAGKTTTFKMMTGDERISSGAAYVQ 1428
            ..||:..::|.||:   .:||:::||.|...|||||||.|||||||||:|:||||.:|||.||:.
 Frog  1397 SPLVIRELSKVYGRRALVLAVDRISLAVGRGECFGLLGFNGAGKTTTFRMLTGDETVSSGDAYID 1461

  Fly  1429 GLSLESNMNSIYKMIGYCPQFDALLDDLTGREVLRIFCMLRGVQESRIRQLSEDLAKSFGFMKHI 1493
            |.|:..::..:.:.||||||||.|||.:||||.|.::..||||.|..|....|::.:......|.
 Frog  1462 GYSILRHIKKVQQRIGYCPQFDPLLDHMTGRETLCMYARLRGVPEGYINSCVENMLRGLLLEAHA 1526

  Fly  1494 DKQTHAYSGGNKRKLSTAIAVIGSPSVIYLDEPTTGMDPAARRQLWNMVCRIRDSGKSIVLTSHS 1558
            :|....||||||||||..||:||.||||::|||:|||||.|||.||:.|.|.|::||::::||||
 Frog  1527 NKLVRTYSGGNKRKLSAGIALIGGPSVIFMDEPSTGMDPVARRLLWDAVTRTRENGKAVIITSHS 1591

  Fly  1559 MEECEALCTRLAIMVNGEFKCIGSTQHLKNKFSKGLILKIKVRRNLEALRQARLSGGYARNPDEQ 1623
            |||||||||||||||||:.||:||.|||||||..|..|..|..|..|.|.
 Frog  1592 MEECEALCTRLAIMVNGQLKCLGSPQHLKNKFGSGYTLLAKTSRGAEELM--------------- 1641

  Fly  1624 TVPAQMSQRDIDAVKEFVETEYPNSILQEEYQGILTFYIPLTGVKWSRIFGLMESNRDQLNVEDY 1688
                        |.|:||||.:|.|:|:.|:||::.::|....:.|:::||.:|..:::.::|||
 Frog  1642 ------------AFKDFVETIFPGSVLKHEHQGMVHYHITSQELSWAQVFGTLEKAKEKFDLEDY 1694

  Fly  1689 SVSQTTLEEIFLEFAKYQR 1707
            .|||.:||::||.|:.:|:
 Frog  1695 CVSQISLEQVFLSFSHFQQ 1713

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ABCA	NP_608445.2	ABC2_membrane_4	254..434	CDD:289500	70/179 (39%)
		ABC2_membrane_3	<269..475	CDD:289468	91/205 (44%)
		CcmA	538..843	CDD:224054	152/308 (49%)
		ABC_subfamily_A	538..755	CDD:213230	115/220 (52%)
		ABC2_membrane_3	913..1316	CDD:289468	115/415 (28%)
		ABC_subfamily_A	1369..1587	CDD:213230	126/220 (57%)
		drrA	1376..1702	CDD:130256	162/328 (49%)
abca3	XP_004918068.1	ABC2_membrane_3	<279..485	CDD:289468	91/205 (44%)
		CcmA	547..830	CDD:224054	140/282 (50%)
		ABC_subfamily_A	547..768	CDD:213230	115/220 (52%)
		ABC2_membrane_3	939..1287	CDD:289468	101/359 (28%)
		NatA	1399..1625	CDD:226927	131/225 (58%)
		ABC_subfamily_A	1399..1620	CDD:213230	126/220 (57%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	195	1.000	Domainoid score	I3096
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H37437
Inparanoid	1	1.050	1123	1.000	Inparanoid score	I228
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	1	1.000	-	-		otm47667
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X215
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.060