DRSC/TRiP Functional Genomics Resources

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Protein Alignment Abca3 and abca1b

DIOPT Version :10

Sequence 1:NP_608445.2 Gene:Abca3 / 33103 FlyBaseID:FBgn0031170 Length:1714 Species:Drosophila melanogaster
Sequence 2:XP_005173137.1 Gene:abca1b / 100136868 ZFINID:ZDB-GENE-030131-9826 Length:2282 Species:Danio rerio


Alignment Length:1850 Identity:613/1850 - (33%)
Similarity:933/1850 - (50%) Gaps:343/1850 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    99 SKFEFILCYSPVNPVL--KKLVEEAWQSLGKNKICESENATQLELDTVSKNAFAGVQFDDAWANL 161
            |:|...:....:.||.  :|||.|:...|...|.                  :||:.|.|..:|.
Zfish   502 SRFMECVNLDKLEPVSTEEKLVNESMSLLDNRKF------------------WAGIVFLDIPSNS 548

  Fly   162 TENDPLPNDFHFALRFPAELRTATIAIANTWLTMRLFPTIDLTGPRNEGDDDGGIPPGYLREGFL 226
            :|   ||.:.::.:|         :.|.|...|.::.......|||.:..:|    ..|:..||.
Zfish   549 SE---LPPNVNYKIR---------MDIDNVERTNKIKDGYWDPGPRADPFED----LRYIWGGFS 597

  Fly   227 PLQHSLSMAYLRQKSGEQDLPNVVMKRYPFPAYIFDPLLEGMSSIMSLIILLSFIYPCTYITKYI 291
            .||..:..:.:|..:|.::...|.:::.|:|.|:.|..|..||..|.|.:.|:::|....|.|.:
Zfish   598 YLQDVVEHSIIRAVTGSKEKTGVYIQQMPYPCYVDDIFLRIMSRSMPLFMTLAWMYSVAIIIKGV 662

  Fly   292 TAEKEKQLKEVMKIMGLSNWLHWTAWFVKSFIMLTISAILIAILVKINWSEDVAVLTHANFTALV 356
            ..|||.:|||.|:||||.|.:.|.:||:.|.|.|.|||.|:.:|:|:.     .:|.:::...:.
Zfish   663 VYEKEARLKETMRIMGLDNGILWFSWFISSLIPLLISAGLLVLLLKMG-----NLLPYSDPGVVF 722

  Fly   357 FFLIIYIVSSICFCFMMATFFSRASTAAAVTGLIWFIAYIPYSFTINSYDDLSLSSKLGWSLISN 421
            .||..:.|.:|..||:::|.|:||:.|||..|:|:|..|:||...:...|.:..::|:..||:|.
Zfish   723 LFLGSFAVVTIMQCFLISTAFARANLAAACGGIIYFTLYLPYVLCVAWQDYVGFAAKVIASLLSP 787

  Fly   422 TAMGFGIKLILGFEGTGEGLQWSNFF-TPVSVDDTLTLGAVMIMMLVSCVIYMIICLYVEQVMPG 485
            .|.|||.:....||..|.|:||:|.| :||..|| ..|...:|:|.....:|.::..|:|.|.||
Zfish   788 VAFGFGCEYFALFEEQGVGIQWNNLFSSPVEEDD-YNLTTCLILMYFDAFLYGVMTWYIETVFPG 851

  Fly   486 SFGVPRPWNFPFTREFWCGER--EYTGVEDIPNGHVEQRDPKAFETEPEGKHIGLQMRHLKK--R 546
            .:|:||||.||||:.:|.||.  ..|.:    :|..........|.||....:|:.:.:|.|  |
Zfish   852 QYGIPRPWYFPFTKSYWFGENSTNNTAI----HGKKSNAGAVCIEEEPTHLKLGVYIENLVKVYR 912

  Fly   547 FGNKMVVKGLSMNMFEDEITVLLGHNGAGKTTTISMLTGMFPPTSGTAIINGSDIRTNIEGARMS 611
            .|.|:.|.||::...|.:||..|||||||||||:|:|||:||||||||.|.|.|||:.:...|.|
Zfish   913 HGKKLAVDGLTLGFHEGQITSFLGHNGAGKTTTMSILTGLFPPTSGTAYIMGKDIRSELSSIRQS 977

  Fly   612 LGICPQHNVLFDEMSVSNHIRFFSRMKGLRGKAVEQEVAKYLKMIELEDKANVASSKLSGGMKRK 676
            ||:||||||||..::|..||.|::|:|||..:.|:.|:.:.|....|..|....:|:|||||:||
Zfish   978 LGVCPQHNVLFSMLTVEEHIWFYARLKGLSEEEVKAEMEQILSDTGLPHKRKSRTSQLSGGMQRK 1042

  Fly   677 LSVCCALCGDTKVVLCDEPSSGMDPSARRQLWDLLQQEKVGRTLLLTTHFMDEADVLGDRIAIMC 741
            |||..|..|.:|||:.|||::|:||.|||.:||||.:.:.|||:||:||.|||||:|||||||:.
Zfish  1043 LSVALAFVGGSKVVILDEPTAGVDPYARRGIWDLLLKYRAGRTILLSTHHMDEADILGDRIAIIS 1107

  Fly   742 DGELKCQGTSFFLKKQYGSGYRLICVKRD-----------------------------------D 771
            .|:|.|.|:|.|||.|.|:||.|..||::                                   |
Zfish  1108 HGKLCCVGSSLFLKTQLGTGYYLTLVKKNTEPSLSSCRNSSSTVSFVKKDDNASESSSDAGLGSD 1172

  Fly   772 CETNEVTA--------------------LLNKYIPGLKPECDIGAELSYQLP-DSA-SAKFEEMF 814
            .|:...||                    |:.|::|..:...|.|.|::|.|| :|| :..|.|:|
Zfish  1173 QESEAATAIGTSWPESPVVPVDVTIISRLILKHVPAARMVEDQGHEITYVLPYESAKNGAFVELF 1237

  Fly   815 GQLEEQSDELHLNGYGVGITSMEEVFMKVGAE--------KDNTGNIKDQHEIMNGG-------- 863
            ..|:::..:|.::.|||..|::||:|:||..:        .|.|..::.|.....|.        
Zfish  1238 HDLDDRLADLGISSYGVSDTTLEEIFLKVAEDSGVDTEMLSDGTLPVRRQRRHAFGADHQSCLKP 1302

  Fly   864 ----SGF---RGEDDNESVQSD---GIFSENRRLLQGLQLLSNQWKAMLLKKFLYTWRNKLLLLI 918
                ..|   ..|.|.||.::|   |...:....::|..|...|:.|:|.|:.||..|::.....
Zfish  1303 LTEDDSFDCNESEGDPESKETDYLSGSDGKGSYQVKGWSLKRQQFVALLWKRLLYARRSRKGFFA 1367

  Fly   919 QNIMPVFFVVVTI---LIIKTQGTFQEL------------------------------------- 943
            |.::|..||.:.:   ||:...|.:..|                                     
Zfish  1368 QIVLPAVFVCIALVFSLIVPPFGKYPSLALNPWMYEEQFMFFSEDAPYDVSTHKLLRALFDDPGF 1432

  Fly   944 ------------KPITISLTQY------------------------------------------- 953
                        .|.|:...::                                           
Zfish  1433 GTRCMKGESIPDAPCTMGDEEWSTPEVPESIIEILTTRNWTMNDPSPACECSCNGKKKMLPECPA 1497

  Fly   954 ------PLAVTVLDRSNVQNGTGYEIANKYEDLARSYGSNYGLELTG------------------ 994
                  |..:.:.:...:||.||..|:   :.|.::|....|..|..                  
Zfish  1498 GAGGLPPPQIKISETETLQNLTGRNIS---DYLVKTYAQIIGKSLKNKIWVNEFRYGGFSLGARS 1559

  Fly   995 ------TQGFEDYILDLGKTIQVRINS-----RYL--VAATI----TESKITAWLNNQALHTAPL 1042
                  .:..:|.|..:.:..|:..:|     |:|  ::|.|    |::.:..|.||:..|:...
Zfish  1560 TQVLPPAEEIDDAISRVREIFQLGKDSGSAADRFLKSLSAFINGLDTKNNVKIWFNNKGWHSIGA 1624

  Fly  1043 TVNMVHNAI--ADKLFG---SSVKIQVTNAPLPYTTSTLLSQLSTGNNLGTQLASNLC--FCMCF 1100
            .:|:::|.|  |:...|   |...|...|.||..|... |||::........|.| :|  |.|.|
Zfish  1625 FLNVMNNGILRANLPPGKDPSEFGITAYNHPLNLTKEQ-LSQVALMTTSVDVLVS-ICVIFAMSF 1687

  Fly  1101 VSSIYILFLIKERESRAKLLQFVGGVKVWTFWLSQFICDFASYIVTALIVVITIVCFQETGLSTF 1165
            |.:.:::|||:||.::||.:||:.||:.:.:||:.|:.|..:|:|.|.:|::..||||:....:.
Zfish  1688 VPASFVVFLIQERVNKAKHMQFISGVQPYLYWLANFLWDMCNYVVPATLVILIFVCFQQKAYVSA 1752

  Fly  1166 GELGRYYLLLLLFGFAVLPFIYIMSLFFREPATGFARVSIVNIFCGMALFIVVVVMSSELFDTKD 1230
            ..|....|||||:|:::.|.:|..|..|:.|:|.:..::.|||..|:...|...||  |||...:
Zfish  1753 TNLPVLALLLLLYGWSITPLMYPASFLFKIPSTAYVVLTSVNILIGINGSISTFVM--ELFGNHE 1815

  Fly  1231 TA---DILGWIFRIFPHFSLAMSLNKVYTNTATRNACAKAGALPPILLCELVPQCCNLKPYFAWE 1292
            ..   |||..:..|||||.|...|..:..|.|..:|..:.|.             ...:....|:
Zfish  1816 IGGINDILKNVLLIFPHFCLGRGLIDMVKNQAMADALERFGE-------------NRFRSPLEWD 1867

  Fly  1293 EPGVLPETVYMAVTGVVFFLIIIVLEFRLINELMFKIRQLISKPPPPPTEGQLDDDVANERERIL 1357
            ..|  .....|||.|||||:|.:::::|    ..|:.:.|..|..|   .|:.|:|||.||:||:
Zfish  1868 MVG--KNLFAMAVEGVVFFIITVLIQYR----FFFEPKSLCPKLSP---IGEEDEDVARERQRIM 1923

  Fly  1358 Q-MSSNELATKNLVLDRVTKYY--GQFMAVNQVSLCVQEVECFGLLGVNGAGKTTTFKMMTGDER 1419
            . ....::    |.|.::||.|  .|..||:::.:.:...||||||||||||||:||||:|||..
Zfish  1924 SGAGQGDI----LELRQLTKVYKRKQKPAVDRLCVGIPPGECFGLLGVNGAGKTSTFKMLTGDSV 1984

  Fly  1420 ISSGAAYVQGLSLESNMNSIYKMIGYCPQFDALLDDLTGREVLRIFCMLRGVQESRIRQLSEDLA 1484
            ::.|.|::.|.|:...::.:::.:||||||||:.|.|||||.|..:.:||||.|:.:..::|...
Zfish  1985 VTKGEAFIAGKSILREIDEVHQNMGYCPQFDAINDLLTGREHLEFYAILRGVPENEVCAVAEWGI 2049

  Fly  1485 KSFGFMKHIDKQTHAYSGGNKRKLSTAIAVIGSPSVIYLDEPTTGMDPAARRQLWNMVCRIRDSG 1549
            :..|.:|::||...:|||||.|||||||::||:|.|::||||||||||.|||.|||.:..:...|
Zfish  2050 RKLGLVKYVDKNAGSYSGGNMRKLSTAISLIGAPPVVFLDEPTTGMDPKARRALWNCIHSVIKEG 2114

  Fly  1550 KSIVLTSHSMEECEALCTRLAIMVNGEFKCIGSTQHLKNKFSKGLILKIKVRRNLEALRQARLSG 1614
            :|:||||||||||||||||:||||||.|:|:||.|||||:|..|..:.::|              
Zfish  2115 RSVVLTSHSMEECEALCTRMAIMVNGRFRCLGSVQHLKNRFGDGYTIILRV-------------- 2165

  Fly  1615 GYARNPDEQTVPAQMSQRDIDAVKEFVETEYPNSILQEEYQGILTFYIPLTGVKWSRIFGLMESN 1679
               ..||.          |:..|.:|:|:|.|.|.|:|:::.:|.:.:|.:....:.||.::..|
Zfish  2166 ---AGPDP----------DLQPVMKFIESELPGSTLKEKHRNMLQYQLPSSLTSLAHIFSILAKN 2217

  Fly  1680 RDQLNVEDYSVSQTTLEEIFLEFAKYQRED 1709
            ::.|.:||||||||||:::|:.|||.|.:|
Zfish  2218 KEFLRIEDYSVSQTTLDQVFVNFAKDQSDD 2247

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Abca3NP_608445.2 rim_protein <137..1708 CDD:130324 602/1807 (33%)
abca1bXP_005173137.1 rim_protein 1..2242 CDD:130324 609/1843 (33%)

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