DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ABCA and abca2

DIOPT Version :9

Sequence 1:NP_608445.2 Gene:ABCA / 33103 FlyBaseID:FBgn0031170 Length:1714 Species:Drosophila melanogaster
Sequence 2:XP_005165286.1 Gene:abca2 / 100006090 ZFINID:ZDB-GENE-050517-1 Length:2504 Species:Danio rerio


Alignment Length:2046 Identity:607/2046 - (29%)
Similarity:934/2046 - (45%) Gaps:526/2046 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    80 LGKLIALIAPNRRRKNGGFSKFEFILCYSPVNPVLKKLVEEAWQSLGKNKICESENATQLELDTV 144
            ||.|:.|:..|.:            :.|||::..:.|::::|.::.                   
Zfish   500 LGLLVHLMTTNPK------------ILYSPIDSEVDKVIQKANETF------------------- 533

  Fly   145 SKNAFAG--VQFDDAWANLT-------ENDPLPNDFHFALRFPAELR------------------ 182
               ||.|  ..:...|.|::       |...|.|...:..:|..:|:                  
Zfish   534 ---AFVGNVTHYARVWLNISAELRAFLEEGKLQNHLMWLQQFITDLKRHHELLNVSDSELMNSLL 595

  Fly   183 TATIAIANTWLTMRLFPTIDLTG------------------PRNEG------------------- 210
            .....:.||...:....|||...                  |..|.                   
Zfish   596 EENFTLPNTTTLLEQLHTIDNAACGWTNFMSKVSVDIFRGFPDEESIVNYTLNQAYHDNVSVFAS 660

  Fly   211 -----DDDGGIPPG---------------------------------YLREGFLPLQHSLSMAYL 237
                 :.||.:||.                                 |...||:.:|..:..|.:
Zfish   661 VIFQTNKDGSLPPHVMYKIRQNSSFTEKTNEIRRAYWRPGPNTGGKFYFLYGFVWIQDMIERAII 725

  Fly   238 RQKSGEQDL-PNVVMKRYPFPAYIFDPLLEGMSSIMSLIILLSFIYPCTYITKYITAEKEKQLKE 301
            ....|...: |...::.:|:|.|..|..|..:..:|.|.:::|::|....:.::|.||||::|||
Zfish   726 NTFVGHDVVEPGNYVQMFPYPCYTRDDFLFVIEHMMPLCMVISWVYSVAMMIQHIVAEKEQRLKE 790

  Fly   302 VMKIMGLSNWLHWTAWFVKSFIMLTISAILIAILVKINWSEDVAVLTHANFTALVFFLIIYIVSS 366
            |||:|||:|.:||.|||:..|:.|:||...:..::|..     .||.|::...:..||.||.|::
Zfish   791 VMKMMGLNNAVHWVAWFITGFVQLSISVTALTAILKYG-----KVLLHSDPFIIWLFLTIYAVAT 850

  Fly   367 ICFCFMMATFFSRASTAAAVTGLIWFIAYIPYSFTI----NSYDDLSLSSKLGWSLISNTAMGFG 427
            |.|||:::..:|:|..|:|..|:|:|::|:||.:..    .::|.::...|...||:|.||.|.|
Zfish   851 IMFCFLVSVLYSKAKLASACGGIIYFLSYVPYMYVAIREEVAHDKITAFEKCIASLMSTTAFGLG 915

  Fly   428 IKLILGFEGTGEGLQWSNF-FTPVSVDDTLTLGAVMIMMLVSCVIYMIICLYVEQVMPGSFGVPR 491
            .|....:|..|.|:||... .:||..|| ..|...|:|:.:..::|.::..|:|.|.||.:|:||
Zfish   916 SKYFALYEVAGVGIQWRTINQSPVEGDD-FNLLLSMVMLTIDAIVYGVLTWYIEAVHPGMYGLPR 979

  Fly   492 PWNFPFTREFWCG---------------------EREYTGVEDIPNGHVEQRDPKAFETEPEGKH 535
            ||.||..:.:|.|                     |.:...:|     |....:.:..|.||....
Zfish   980 PWYFPLQKSYWLGSGRIETWEWPWGGGTRLSVMEEDQACAME-----HRRSEETRGIEEEPNHLP 1039

  Fly   536 IGLQMRHLKK--RFGNKMVVKGLSMNMFEDEITVLLGHNGAGKTTTISMLTGMFPPTSGTAIING 598
            :.:.:..|.|  :.|:|:.:..||:|:.|:::...|||||||||||:|:|||:||||||:|.|.|
Zfish  1040 LVVCIDKLTKVYKTGSKLALNKLSLNLHENQVVSFLGHNGAGKTTTMSILTGLFPPTSGSATIYG 1104

  Fly   599 SDIRTNIEGARMSLGICPQHNVLFDEMSVSNHIRFFSRMKGLRGKAVEQEVAKYLKMIELEDKAN 663
            .||||.:|..|.:||:|||||||||::||..|:.|:||:||:..:.:.:|:.|.::.:||.:|.:
Zfish  1105 HDIRTEMERIRQNLGMCPQHNVLFDKLSVEEHLWFYSRLKGMAEEDIRKEMDKMIEDLELSNKRH 1169

  Fly   664 VASSKLSGGMKRKLSVCCALCGDTKVVLCDEPSSGMDPSARRQLWDLLQQEKVGRTLLLTTHFMD 728
            .....|||||||||||..|..|.::.|:.|||::|:||.|||.:|||:.:.|.|||:||:||.||
Zfish  1170 SLVQTLSGGMKRKLSVAIAFVGGSRAVILDEPTAGVDPYARRAIWDLILKYKQGRTILLSTHHMD 1234

  Fly   729 EADVLGDRIAIMCDGELKCQGTSFFLKKQYGSGYRLICVKRDD------------------CETN 775
            |||:|||||||:..|:|||.|:..|||..||.||:|..||:..                  |..|
Zfish  1235 EADLLGDRIAIISHGKLKCCGSPLFLKSTYGDGYKLTLVKKQSDSHTADQSSQSPSSSISPCSEN 1299

  Fly   776 EVTALLNKYIPGLKPECDIGAELSYQLPDSASAK--FEEMFGQLEEQSDELHLNGYGVGITSMEE 838
            .||..:.:|:.......|...||||.||..|..|  ||.:|..||:..|.|.|..:||..|::||
Zfish  1300 RVTQFIRQYVASCLLVSDSNTELSYVLPSEAVKKGCFERLFQALEQSLDSLALTSFGVMDTTLEE 1364

  Fly   839 VFMKVGAE-----------KDNTGN-----------------------IKDQHEIMN-------- 861
            ||:||..|           ||:.|.                       ::.:.|:.|        
Zfish  1365 VFLKVSEEDLSLENSDADMKDSPGGASAGKPSGLLGGPQCEGAPAAAVMRPEVELSNLMMCSRLS 1429

  Fly   862 -------------------GG--SGFRGE-----------------DDNESVQSDGIFSENRRLL 888
                               ||  |.|.|:                 |:..|.|...:..:....|
Zfish  1430 PSQASLQSGSSLGSVRGDEGGPYSEFYGDYCPLFDNGQDLDSASLRDEESSPQPTVLEGQGSFKL 1494

  Fly   889 QGLQLLSNQWKAMLLKKFLYTWRNKLLLLIQNIMPVFFVVVTILIIKTQGTFQELKPITISLTQY 953
            .|..|...|:..:::|:|....||...:..|.::|.|||.|.:.:..:.....:|.|:.:|.:||
Zfish  1495 DGWWLKLRQFHGLIVKRFHCAKRNTKGIFSQILLPAFFVCVAMTVALSVPEIGDLPPLILSPSQY 1559

  Fly   954 -----------PLAVTVLDRSNVQ--------------------------------NGTGYEIA- 974
                       |.|..  |||..:                                |.|..::| 
Zfish  1560 HNYTQPRGNFIPYANE--DRSQYRTKFSPDAGPQRIVNTLRLPSGVGATCILKTPFNSTLDQLAQ 1622

  Fly   975 --NKYEDLARSYGSNY-------------------------------------GL---------- 990
              |.|.:.:::..:.|                                     ||          
Zfish  1623 TLNPYANNSKTLAARYFDSMCLDSFTQGVPLSNFVPPPPSPAPSDDPEAHFEDGLWNYTAAPTTV 1687

  Fly   991 ----------------------ELTGTQGFE-----------------DYILDL-GKTI------ 1009
                                  .:.|| ||.                 |.::|: |:.:      
Zfish  1688 REMATSPPTLPLSIHEPVRCICSMQGT-GFSCPSGVGGRPPLMKVVTGDILVDITGRNVSEYLLY 1751

  Fly  1010 ---QVRINSRY----------------------LVAATITESKITAWLNNQALHTAPLTVNMVHN 1049
               ::|:: ||                      :|.............||:..|:.|..:|:::|
Zfish  1752 TSDRLRLH-RYGGFTVGNIQKSVPASFGRKTPPMVRKIAVRRSSQVLYNNKGYHSMPTYLNVLNN 1815

  Fly  1050 AI------ADKLFGSSVKIQVTNAPLPYTTSTL-LSQLSTGNNLGTQLASNLCFCMCFVSSIYIL 1107
            ||      :.|...|:..|.|||.|:..|:::| |..|..|.::  .:|..:...|.||.:.:::
Zfish  1816 AILRANLPSSKGNPSAYGITVTNHPMNRTSASLSLDYLLQGTDV--VIAIFIIVAMSFVPASFVV 1878

  Fly  1108 FLIKERESRAKLLQFVGGVKVWTFWLSQFICDFASYIVTALIVVITIVCFQETGLSTFGELGRYY 1172
            ||:.|:.::||.||||.|....|:||:.:|.|..:|:|.|...|:.:..|.....::........
Zfish  1879 FLVAEKSTKAKHLQFVSGCDPVTYWLANYIWDMLNYLVPATCCVLILFVFDLPAYTSPTNFPAVL 1943

  Fly  1173 LLLLLFGFAVLPFIYIMSLFFREPATGFARVSIVNIFCGMALFIVVVVMSSELF----DTKDTAD 1233
            .|.||:|:::.|.:|..|.:|..|:|.:..:.::|:|.|:...:...::  :||    |.|....
Zfish  1944 SLFLLYGWSITPIMYPASFWFEVPSTAYVFLIVINLFIGITATVATFLL--QLFERDKDLKLVNS 2006

  Fly  1234 ILGWIFRIFPHFSLAMSLNKVYTNTATRNACAKAGALPPILLCELVPQCCNLKPYFAWEEPGVLP 1298
            .|...|.|||:::|...|.::..|.......||.|            |...:|..|.|:.  |..
Zfish  2007 YLKSCFLIFPNYNLGHGLMEMAYNEYINEYYAKIG------------QFDKVKSPFEWDI--VTR 2057

  Fly  1299 ETVYMAVTGVVFFLIIIVLEFRLINELMFKIRQLISKPPPPPTEGQLDDDVANERERILQ-MSSN 1362
            ..|.|.:.|.|.|||.|:.::..:.    |.:::.....|...:   |.|||.||.|:|: .:.|
Zfish  2058 GLVAMTIEGFVGFLITILCQYNFLR----KAQRVPVNSQPVEDD---DVDVACERRRVLRGDADN 2115

  Fly  1363 ELATKNLVLDRVTKYY-----GQFMAVNQVSLCVQEVECFGLLGVNGAGKTTTFKMMTGDERISS 1422
            ::    |.:|.:||.|     |:.:||:::.|.|:..|||||||||||||||||||:||||..:.
Zfish  2116 DM----LKIDNLTKVYKSRKMGRILAVDRLCLGVRPGECFGLLGVNGAGKTTTFKMLTGDESTTG 2176

  Fly  1423 GAAYVQGLSLESNMNSIYKMIGYCPQFDALLDDLTGREVLRIFCMLRGV---QESRIRQLS-EDL 1483
            |.|::|..|:...:..:.:.||||||||||.||||.||.|.::..|||:   .|.|:.|.: |.|
Zfish  2177 GEAFIQEHSILRELLRVQQSIGYCPQFDALFDDLTAREHLELYTRLRGIPWKDEERVVQWALEKL 2241

  Fly  1484 AKSFGFMKHIDKQTHAYSGGNKRKLSTAIAVIGSPSVIYLDEPTTGMDPAARRQLWNMVCRIRDS 1548
            ..|    |:.||....||||||||||||||:||.||:|:||||||||||.|||.|||::..|..:
Zfish  2242 ELS----KYADKPAGTYSGGNKRKLSTAIALIGYPSLIFLDEPTTGMDPKARRFLWNLILDIIKT 2302

  Fly  1549 GKSIVLTSHSMEECEALCTRLAIMVNGEFKCIGSTQHLKNKFSKGLILKIKVRRNLEALRQARLS 1613
            |:|:|||||||||||||||||.|||||.|||:||.|||||:|..|.::.::.:            
Zfish  2303 GRSVVLTSHSMEECEALCTRLGIMVNGRFKCLGSIQHLKNRFGDGYMITVRTK------------ 2355

  Fly  1614 GGYARNPDEQTVPAQMSQRDIDAVKEFVETEYPNSILQEEYQGILTFYIPLTGVKWSRIFGLMES 1678
                            :...:..|..|....:|.:||:|.:...:.:.:....:..:::|..||.
Zfish  2356 ----------------TTASVKEVIRFFNRNFPEAILKERHHTKIQYQLKSENISLAQVFSKMEQ 2404

  Fly  1679 NRDQLNVEDYSVSQTTLEEIFLEFAKYQRED 1709
            ..:.|::||||||||||:.:|:.|||.|.::
Zfish  2405 VVEVLSIEDYSVSQTTLDNVFVNFAKKQSDN 2435

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ABCANP_608445.2 ABC2_membrane_4 254..434 CDD:289500 66/183 (36%)
ABC2_membrane_3 <269..475 CDD:289468 74/210 (35%)
CcmA 538..843 CDD:224054 152/326 (47%)
ABC_subfamily_A 538..755 CDD:213230 114/218 (52%)
ABC2_membrane_3 913..1316 CDD:289468 119/577 (21%)
ABC_subfamily_A 1369..1587 CDD:213230 133/226 (59%)
drrA 1376..1702 CDD:130256 156/334 (47%)
abca2XP_005165286.1 rim_protein 1..2435 CDD:130324 607/2044 (30%)
ABC_subfamily_A 1042..1261 CDD:213230 114/218 (52%)
ABC_subfamily_A 2118..2341 CDD:213230 133/226 (59%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170582275
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D131191at2759
OrthoFinder 1 1.000 - - FOG0000051
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
43.940

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