DRSC/TRiP Functional Genomics Resources

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Protein Alignment Abca3 and abca2

DIOPT Version :10

Sequence 1:NP_608445.2 Gene:Abca3 / 33103 FlyBaseID:FBgn0031170 Length:1714 Species:Drosophila melanogaster
Sequence 2:XP_005165287.2 Gene:abca2 / 100006090 ZFINID:ZDB-GENE-050517-1 Length:2503 Species:Danio rerio


Alignment Length:2046 Identity:607/2046 - (29%)
Similarity:934/2046 - (45%) Gaps:526/2046 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    80 LGKLIALIAPNRRRKNGGFSKFEFILCYSPVNPVLKKLVEEAWQSLGKNKICESENATQLELDTV 144
            ||.|:.|:..|.:            :.|||::..:.|::::|.::.                   
Zfish   499 LGLLVHLMTTNPK------------ILYSPIDSEVDKVIQKANETF------------------- 532

  Fly   145 SKNAFAG--VQFDDAWANLT-------ENDPLPNDFHFALRFPAELR------------------ 182
               ||.|  ..:...|.|::       |...|.|...:..:|..:|:                  
Zfish   533 ---AFVGNVTHYARVWLNISAELRAFLEEGKLQNHLMWLQQFITDLKRHHELLNVSDSELMNSLL 594

  Fly   183 TATIAIANTWLTMRLFPTIDLTG------------------PRNEG------------------- 210
            .....:.||...:....|||...                  |..|.                   
Zfish   595 EENFTLPNTTTLLEQLHTIDNAACGWTNFMSKVSVDIFRGFPDEESIVNYTLNQAYHDNVSVFAS 659

  Fly   211 -----DDDGGIPPG---------------------------------YLREGFLPLQHSLSMAYL 237
                 :.||.:||.                                 |...||:.:|..:..|.:
Zfish   660 VIFQTNKDGSLPPHVMYKIRQNSSFTEKTNEIRRAYWRPGPNTGGKFYFLYGFVWIQDMIERAII 724

  Fly   238 RQKSGEQDL-PNVVMKRYPFPAYIFDPLLEGMSSIMSLIILLSFIYPCTYITKYITAEKEKQLKE 301
            ....|...: |...::.:|:|.|..|..|..:..:|.|.:::|::|....:.::|.||||::|||
Zfish   725 NTFVGHDVVEPGNYVQMFPYPCYTRDDFLFVIEHMMPLCMVISWVYSVAMMIQHIVAEKEQRLKE 789

  Fly   302 VMKIMGLSNWLHWTAWFVKSFIMLTISAILIAILVKINWSEDVAVLTHANFTALVFFLIIYIVSS 366
            |||:|||:|.:||.|||:..|:.|:||...:..::|..     .||.|::...:..||.||.|::
Zfish   790 VMKMMGLNNAVHWVAWFITGFVQLSISVTALTAILKYG-----KVLLHSDPFIIWLFLTIYAVAT 849

  Fly   367 ICFCFMMATFFSRASTAAAVTGLIWFIAYIPYSFTI----NSYDDLSLSSKLGWSLISNTAMGFG 427
            |.|||:::..:|:|..|:|..|:|:|::|:||.:..    .::|.::...|...||:|.||.|.|
Zfish   850 IMFCFLVSVLYSKAKLASACGGIIYFLSYVPYMYVAIREEVAHDKITAFEKCIASLMSTTAFGLG 914

  Fly   428 IKLILGFEGTGEGLQWSNF-FTPVSVDDTLTLGAVMIMMLVSCVIYMIICLYVEQVMPGSFGVPR 491
            .|....:|..|.|:||... .:||..|| ..|...|:|:.:..::|.::..|:|.|.||.:|:||
Zfish   915 SKYFALYEVAGVGIQWRTINQSPVEGDD-FNLLLSMVMLTIDAIVYGVLTWYIEAVHPGMYGLPR 978

  Fly   492 PWNFPFTREFWCG---------------------EREYTGVEDIPNGHVEQRDPKAFETEPEGKH 535
            ||.||..:.:|.|                     |.:...:|     |....:.:..|.||....
Zfish   979 PWYFPLQKSYWLGSGRIETWEWPWGGGTRLSVMEEDQACAME-----HRRSEETRGIEEEPNHLP 1038

  Fly   536 IGLQMRHLKK--RFGNKMVVKGLSMNMFEDEITVLLGHNGAGKTTTISMLTGMFPPTSGTAIING 598
            :.:.:..|.|  :.|:|:.:..||:|:.|:::...|||||||||||:|:|||:||||||:|.|.|
Zfish  1039 LVVCIDKLTKVYKTGSKLALNKLSLNLHENQVVSFLGHNGAGKTTTMSILTGLFPPTSGSATIYG 1103

  Fly   599 SDIRTNIEGARMSLGICPQHNVLFDEMSVSNHIRFFSRMKGLRGKAVEQEVAKYLKMIELEDKAN 663
            .||||.:|..|.:||:|||||||||::||..|:.|:||:||:..:.:.:|:.|.::.:||.:|.:
Zfish  1104 HDIRTEMERIRQNLGMCPQHNVLFDKLSVEEHLWFYSRLKGMAEEDIRKEMDKMIEDLELSNKRH 1168

  Fly   664 VASSKLSGGMKRKLSVCCALCGDTKVVLCDEPSSGMDPSARRQLWDLLQQEKVGRTLLLTTHFMD 728
            .....|||||||||||..|..|.::.|:.|||::|:||.|||.:|||:.:.|.|||:||:||.||
Zfish  1169 SLVQTLSGGMKRKLSVAIAFVGGSRAVILDEPTAGVDPYARRAIWDLILKYKQGRTILLSTHHMD 1233

  Fly   729 EADVLGDRIAIMCDGELKCQGTSFFLKKQYGSGYRLICVKRDD------------------CETN 775
            |||:|||||||:..|:|||.|:..|||..||.||:|..||:..                  |..|
Zfish  1234 EADLLGDRIAIISHGKLKCCGSPLFLKSTYGDGYKLTLVKKQSDSHTADQSSQSPSSSISPCSEN 1298

  Fly   776 EVTALLNKYIPGLKPECDIGAELSYQLPDSASAK--FEEMFGQLEEQSDELHLNGYGVGITSMEE 838
            .||..:.:|:.......|...||||.||..|..|  ||.:|..||:..|.|.|..:||..|::||
Zfish  1299 RVTQFIRQYVASCLLVSDSNTELSYVLPSEAVKKGCFERLFQALEQSLDSLALTSFGVMDTTLEE 1363

  Fly   839 VFMKVGAE-----------KDNTGN-----------------------IKDQHEIMN-------- 861
            ||:||..|           ||:.|.                       ::.:.|:.|        
Zfish  1364 VFLKVSEEDLSLENSDADMKDSPGGASAGKPSGLLGGPQCEGAPAAAVMRPEVELSNLMMCSRLS 1428

  Fly   862 -------------------GG--SGFRGE-----------------DDNESVQSDGIFSENRRLL 888
                               ||  |.|.|:                 |:..|.|...:..:....|
Zfish  1429 PSQASLQSGSSLGSVRGDEGGPYSEFYGDYCPLFDNGQDLDSASLRDEESSPQPTVLEGQGSFKL 1493

  Fly   889 QGLQLLSNQWKAMLLKKFLYTWRNKLLLLIQNIMPVFFVVVTILIIKTQGTFQELKPITISLTQY 953
            .|..|...|:..:::|:|....||...:..|.::|.|||.|.:.:..:.....:|.|:.:|.:||
Zfish  1494 DGWWLKLRQFHGLIVKRFHCAKRNTKGIFSQILLPAFFVCVAMTVALSVPEIGDLPPLILSPSQY 1558

  Fly   954 -----------PLAVTVLDRSNVQ--------------------------------NGTGYEIA- 974
                       |.|..  |||..:                                |.|..::| 
Zfish  1559 HNYTQPRGNFIPYANE--DRSQYRTKFSPDAGPQRIVNTLRLPSGVGATCILKTPFNSTLDQLAQ 1621

  Fly   975 --NKYEDLARSYGSNY-------------------------------------GL---------- 990
              |.|.:.:::..:.|                                     ||          
Zfish  1622 TLNPYANNSKTLAARYFDSMCLDSFTQGVPLSNFVPPPPSPAPSDDPEAHFEDGLWNYTAAPTTV 1686

  Fly   991 ----------------------ELTGTQGFE-----------------DYILDL-GKTI------ 1009
                                  .:.|| ||.                 |.::|: |:.:      
Zfish  1687 REMATSPPTLPLSIHEPVRCICSMQGT-GFSCPSGVGGRPPLMKVVTGDILVDITGRNVSEYLLY 1750

  Fly  1010 ---QVRINSRY----------------------LVAATITESKITAWLNNQALHTAPLTVNMVHN 1049
               ::|:: ||                      :|.............||:..|:.|..:|:::|
Zfish  1751 TSDRLRLH-RYGGFTVGNIQKSVPASFGRKTPPMVRKIAVRRSSQVLYNNKGYHSMPTYLNVLNN 1814

  Fly  1050 AI------ADKLFGSSVKIQVTNAPLPYTTSTL-LSQLSTGNNLGTQLASNLCFCMCFVSSIYIL 1107
            ||      :.|...|:..|.|||.|:..|:::| |..|..|.::  .:|..:...|.||.:.:::
Zfish  1815 AILRANLPSSKGNPSAYGITVTNHPMNRTSASLSLDYLLQGTDV--VIAIFIIVAMSFVPASFVV 1877

  Fly  1108 FLIKERESRAKLLQFVGGVKVWTFWLSQFICDFASYIVTALIVVITIVCFQETGLSTFGELGRYY 1172
            ||:.|:.::||.||||.|....|:||:.:|.|..:|:|.|...|:.:..|.....::........
Zfish  1878 FLVAEKSTKAKHLQFVSGCDPVTYWLANYIWDMLNYLVPATCCVLILFVFDLPAYTSPTNFPAVL 1942

  Fly  1173 LLLLLFGFAVLPFIYIMSLFFREPATGFARVSIVNIFCGMALFIVVVVMSSELF----DTKDTAD 1233
            .|.||:|:::.|.:|..|.:|..|:|.:..:.::|:|.|:...:...::  :||    |.|....
Zfish  1943 SLFLLYGWSITPIMYPASFWFEVPSTAYVFLIVINLFIGITATVATFLL--QLFERDKDLKLVNS 2005

  Fly  1234 ILGWIFRIFPHFSLAMSLNKVYTNTATRNACAKAGALPPILLCELVPQCCNLKPYFAWEEPGVLP 1298
            .|...|.|||:::|...|.::..|.......||.|            |...:|..|.|:.  |..
Zfish  2006 YLKSCFLIFPNYNLGHGLMEMAYNEYINEYYAKIG------------QFDKVKSPFEWDI--VTR 2056

  Fly  1299 ETVYMAVTGVVFFLIIIVLEFRLINELMFKIRQLISKPPPPPTEGQLDDDVANERERILQ-MSSN 1362
            ..|.|.:.|.|.|||.|:.::..:.    |.:::.....|...:   |.|||.||.|:|: .:.|
Zfish  2057 GLVAMTIEGFVGFLITILCQYNFLR----KAQRVPVNSQPVEDD---DVDVACERRRVLRGDADN 2114

  Fly  1363 ELATKNLVLDRVTKYY-----GQFMAVNQVSLCVQEVECFGLLGVNGAGKTTTFKMMTGDERISS 1422
            ::    |.:|.:||.|     |:.:||:::.|.|:..|||||||||||||||||||:||||..:.
Zfish  2115 DM----LKIDNLTKVYKSRKMGRILAVDRLCLGVRPGECFGLLGVNGAGKTTTFKMLTGDESTTG 2175

  Fly  1423 GAAYVQGLSLESNMNSIYKMIGYCPQFDALLDDLTGREVLRIFCMLRGV---QESRIRQLS-EDL 1483
            |.|::|..|:...:..:.:.||||||||||.||||.||.|.::..|||:   .|.|:.|.: |.|
Zfish  2176 GEAFIQEHSILRELLRVQQSIGYCPQFDALFDDLTAREHLELYTRLRGIPWKDEERVVQWALEKL 2240

  Fly  1484 AKSFGFMKHIDKQTHAYSGGNKRKLSTAIAVIGSPSVIYLDEPTTGMDPAARRQLWNMVCRIRDS 1548
            ..|    |:.||....||||||||||||||:||.||:|:||||||||||.|||.|||::..|..:
Zfish  2241 ELS----KYADKPAGTYSGGNKRKLSTAIALIGYPSLIFLDEPTTGMDPKARRFLWNLILDIIKT 2301

  Fly  1549 GKSIVLTSHSMEECEALCTRLAIMVNGEFKCIGSTQHLKNKFSKGLILKIKVRRNLEALRQARLS 1613
            |:|:|||||||||||||||||.|||||.|||:||.|||||:|..|.::.::.:            
Zfish  2302 GRSVVLTSHSMEECEALCTRLGIMVNGRFKCLGSIQHLKNRFGDGYMITVRTK------------ 2354

  Fly  1614 GGYARNPDEQTVPAQMSQRDIDAVKEFVETEYPNSILQEEYQGILTFYIPLTGVKWSRIFGLMES 1678
                            :...:..|..|....:|.:||:|.:...:.:.:....:..:::|..||.
Zfish  2355 ----------------TTASVKEVIRFFNRNFPEAILKERHHTKIQYQLKSENISLAQVFSKMEQ 2403

  Fly  1679 NRDQLNVEDYSVSQTTLEEIFLEFAKYQRED 1709
            ..:.|::||||||||||:.:|:.|||.|.::
Zfish  2404 VVEVLSIEDYSVSQTTLDNVFVNFAKKQSDN 2434

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Abca3NP_608445.2 rim_protein <137..1708 CDD:130324 597/1986 (30%)
abca2XP_005165287.2 None

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