DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1494 and rbbA

DIOPT Version :9

Sequence 1:	NP_001259763.1	Gene:	CG1494 / 33102	FlyBaseID:	FBgn0031169	Length:	1695	Species:	Drosophila melanogaster
Sequence 2:	YP_026225.1	Gene:	rbbA / 947998	ECOCYCID:	EG12223	Length:	911	Species:	Escherichia coli

Alignment Length:	789	Identity:	141/789 - (17%)
Similarity:	256/789 - (32%)	Gaps:	234/789 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   465 WIFMLNALVYCAIGLYVDMWRGGDRSGKKMKKPNTNASVQEDPYHERGDSFTH---QGQAIGVNS 526
            |:..:||....|.|           |.:::::...:|:::|        :|.:   |.|.....:
E. coli   217 WLVAMNAGEVLATG-----------SAEELRQQTQSATLEE--------AFINLLPQAQRQAHQA 262

  Fly   527 TKIYEVEPSHRRFKLKIKKLCKRFATNDRPALNLFSWNVYENEVTVLMGHNGCGKSTLLKILAGL 591
            ..|...:|.:....::.:.|..||.:  ..|::..::.:...|:...:|.|||||||.:|:|.||
E. coli   263 VVIPPYQPENAEIAIEARDLTMRFGS--FVAVDHVNFRIPRGEIFGFLGSNGCGKSTTMKMLTGL 325

  Fly   592 VEPSRGTVM-----ISSHNIQTERKAASMELGIAFGHDMLLTGFTV------------IDYLRFI 639
            :..|.|...     :...:|.|.|:...|....:..:::     ||            |......
E. coli   326 LPASEGEAWLFGQPVDPKDIDTRRRVGYMSQAFSLYNEL-----TVRQNLELHARLFHIPEAEIP 385

  Fly   640 CRVKGLHNNIEIDGQSNYFLNVLQIGGLKTKRIRTLTDRDLCLVSICCAFVGNSPIILIDDVHSD 704
            .||..:....:::...:.....|.:|      ||.       .:|:..|.:....::::|:..|.
E. coli   386 ARVAEMSERFKLNDVEDILPESLPLG------IRQ-------RLSLAVAVIHRPEMLILDEPTSG 437

  Fly   705 LDKRTQSLVWNLINE--EKSKRTIILVSNSPALAENIADRMAIMSNGELKCTGTKPFLKNMYGHG 767
            :|...:.:.|.|:.:  .:.|.||.:.::....||. .||:::|..|::..:||...|....|..
E. coli   438 VDPVARDMFWQLMVDLSRQDKVTIFISTHFMNEAER-CDRISLMHAGKVLASGTPQELVEKRGAA 501

  Fly   768 YRLTCVKGKNYKRDELF--------GMMN-----------SYMP--NMSIERDIGYKVTFVLENK 811
                       ..:|.|        |..|           ::.|  ..|:.|...|.....||
E. coli   502 -----------SLEEAFIAYLQEAAGQSNEAEAPPVVHDTTHAPRQGFSLRRLFSYSRREALE-- 553

  Fly   812 FEDQFPMLIDDLEENMQQLGVVSFRI---RDTSMEEIFLRFGCEDNDQSGAFQSH----ENAQVL 869
                  :..|.:...:..:|.|...:   ...||:...|||...|.||:.:.|:.    ..::..
E. coli   554 ------LRRDPVRSTLALMGTVILMLIMGYGISMDVENLRFAVLDRDQTVSSQAWTLNLSGSRYF 612

  Fly   870 LEEYYSTLAEANEKGRRTG--------------------------WKLFFLHGRAVIYKRWI-AA 907
            :|:...|..:..::..|.|                          |....:..||...|.:: |.
E. coli   613 IEQPPLTSYDELDRRMRAGDITVAIEIPPNFGRDIARGTPVELGVWIDGAMPSRAETVKGYVQAM 677

  Fly   908 HRHWIVLIFEVLAMALVAVCTFSSIFIYGKNYELEPLTFNLSQLHTVDAFVELFSEEEDVKDMHA 972
            |:.|:    :.:|.......:.|.:......|...|                      |||.:.|
E. coli   678 HQSWL----QDVASRQSTPASQSGLMNIETRYRYNP----------------------DVKSLPA 716

  Fly   973 YYTE----LLYWYDAHVATLTKNRHNAYALLTQNQFTAHVNSRYIFGATFDQKIVTAWFNNIPLH 1033
            ....    ||....:.::.|:..|......:.....|....|.::.|..... |.....|...|.
E. coli   717 IVPAVIPLLLMMIPSMLSALSVVREKELGSIINLYVTPTTRSEFLLGKQLPY-IALGMLNFFLLC 780

  Fly  1034 S-APYALNVVHNAVARHLFDEEATIDVTLAPL-----------------------PFRTAINTFP 1074
            . :.:...|.|..         :.:.:|||.|                       .|.|||.|..
E. coli   781 GLSVFVFGVPHKG---------SFLTLTLAALLYIIIATGMGLLISTFMKSQIAAIFGTAIITLI 836

  Fly  1075 PSSHTFGGCL----------------------------AFGICFVLTFIWPAF-----AIYMITE 1106
            |::. |.|.:                            .|.....||.:|..|     ||.::..
E. coli   837 PATQ-FSGMIDPVASLEGPGRWIGEVYPTSHFLTIARGTFSKALDLTDLWQLFIPLLIAIPLVMG 900

  Fly  1107 RGSLLKKQQ 1115
            ...||.|:|
E. coli   901 LSILLLKKQ 909

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1494	NP_001259763.1	ABC2_membrane_3	<263..480	CDD:289468	5/14 (36%)
		CcmA	541..848	CDD:224054	67/349 (19%)
		ABC_subfamily_A	541..761	CDD:213230	50/238 (21%)
		ABC2_membrane_3	911..>1189	CDD:289468	44/266 (17%)
		ABC2_membrane	<1080..>1188	CDD:304374	13/69 (19%)
		ABC_subfamily_A	1370..1577	CDD:213230
		PRK14255	1371..1586	CDD:172743
rbbA	YP_026225.1	ABC2_perm_RbbA	12..910	CDD:411426	141/789 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	228	1.000	Inparanoid score	I138
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
	1	1.050