DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1494 and ABCC12

DIOPT Version :9

Sequence 1:	NP_001259763.1	Gene:	CG1494 / 33102	FlyBaseID:	FBgn0031169	Length:	1695	Species:	Drosophila melanogaster
Sequence 2:	NP_001319111.1	Gene:	ABCC12 / 839921	AraportID:	AT1G30410	Length:	1498	Species:	Arabidopsis thaliana

Alignment Length:	1519	Identity:	277/1519 - (18%)
Similarity:	511/1519 - (33%)	Gaps:	436/1519 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   120 EPMTSVGFED-------CEEMRESVIEN---GLFAGLCFDG--SPFVEDQVFEEDTLESYSNIQP 172
            ||:.:|.::.       |.|...|:...   |....|...|  .|..|..|::   |:.:...:.
plant   210 EPLDNVEYDALRGGEHICPERHASIFSRIYFGWITPLMQLGYRKPITEKDVWQ---LDKWDQTET 271

  Fly   173 MLNYTILLPSELRMLDGDFRMANWMTLYNDDPNTFVLTRLNQPYEGGF--VGYVREGFIRLQKSV 235
            ::.                |.....|..:..|..::|..||....|.|  .|..:  ..|:...:
plant   272 LIK----------------RFQRCWTEESRRPKPWLLRALNNSLGGRFWLAGIFK--VTRIGNDL 318

  Fly   236 SESFL--VLTSH--KSLPTIQIRRFPITGREQDPLMGNLNYGMPFIIII----GFLFPAQLF--V 290
            |: |:  |:.||  :|:            :|.||..  :.|...|||.:    |.|..||.|  |
plant   319 SQ-FVGPVILSHLLRSM------------QEGDPAW--VGYVYAFIIFVGVTLGVLCEAQYFQNV 368

  Fly   291 WQVVSEKQSQVRQFLINMNIGNLIH-----FVSWYLKGLIYEMISSLIIAALLKIRWDQDHGVLT 350
            |:|....:|.:...:.:.:: .|.|     |.|    |.:..||:: ...||.:|. .|.|| |.
plant   369 WRVGFRLRSTLVAAIFHKSL-RLTHEARKNFAS----GKVTNMITT-DANALQQIS-QQLHG-LW 425

  Fly   351 QTPWYILILVLFCYNCAAVAFAIMVAAFFRNALNAVRVLTILWIMSYVPTFILSNNLEGNIHALR 415
            ..|:.|::.::..|.      .:.||:.|.:        .||:::..:.|.|:|...:.....|:
plant   426 SAPFRIIVSMILLYQ------QLGVASLFGS--------LILFLLIPLQTLIISKMRKLTKEGLQ 476

  Fly   416 YVSYALPNVVATLVIEFLIERESIVHITWEDSGYRLNYDGGHITVTASSWI-----------FML 469
            :....:     .:..|.|...:::....||.| :.....|  |.....||.           |:|
plant   477 WTDKRV-----GITNEILSSMDTVKCYAWEKS-FESRIQG--IRNEELSWFRKAQLLSAFNSFIL 533

  Fly   470 NAL--VYCAIGLYVDMWRGGDRSGKKMKKPNTNASVQEDPYHERGDSFTHQGQAIGVNST--KIY 530
            |::  |...:...|.:..|||.:..:.....:..:|...|.:...:..:   |.:..|.:  :|.
plant   534 NSIPVVVTVVSFGVFVLLGGDLTPARAFTSLSLFAVLRFPLNMLPNLLS---QVVNANVSLQRIE 595

  Fly   531 EVEPSHRRFKLKIKKLCKRFATN-----DRPALNL----FSWNVYENEVTV-------------- 572
            |:..|..|.          .|.|     ..||:::    |||:....:.|:
plant   596 ELLLSEERI----------LAQNPPLQPGTPAISIKNGYFSWDSKTTKPTLSDINLEIPVGTLVA 650

  Fly   573 LMGHNGCGKSTLLKILAGLVEPSRGTVMISSHNIQTERKA-----ASMELGIAFGHDMLLTGFTV 632
            ::|..|.||::|:..:.|.:..:..|.::...::....:.     |::...|.||.|     |..
plant   651 IVGGTGEGKTSLISAMLGELSHAETTSVVIRGSVAYVPQVSWIFNATVRENILFGSD-----FES 710

  Fly   633 IDYLRFICRVKGLHNNIEIDGQSNYFLNVLQI--------GGLKTKRIRTLTDRDLCLVSICCAF 689
            ..|.|.|......|:...:.|:     ::.:|        ||.|.:            ||:..|.
plant   711 ERYWRAIDATALQHDLDLLPGR-----DLTEIGERGVNISGGQKQR------------VSMARAV 758

  Fly   690 VGNSPIILIDDVHSDLDKRTQSLVW-NLINEEKSKRTIILVSNS----PALAENIADRMAIMSNG 749
            ..||.:.:.||..|.||......|: :.:.:|...:|.:||:|.    |     :.|::.::|.|
plant   759 YSNSDVYIFDDPLSALDAHVAHQVFDSCMKDELRGKTRVLVTNQLHFLP-----LMDKIILVSEG 818

  Fly   750 ELKCTGTKPFLKNMYGHGYRLTCVKGKNYKRDELFGMMNSYMPNMSIERDIGYKVTFVLENKFED 814
            .:|..||...|..           .|..:|:                          ::||..:.
plant   819 MIKEEGTFVELSK-----------SGILFKK--------------------------LMENAGKM 846

  Fly   815 QFPMLIDDLEENMQQLG-VVSFRIRDTSMEEIFLRFGCEDNDQSGAFQSHENAQVLLEEYYSTLA 878
            .....::..:||:.:|| .|:..:.:.::              ....|......||::
plant   847 DATQEVNTNDENILKLGPTVTVDVSERNL--------------GSTKQGKRRRSVLIK------- 890

  Fly   879 EANEKGRRTG---WKLFFLHGRAVIYKRWIAAHRHWIVLIFEVLAMALVAVCTFSSIFIYGKNYE 940
               ::.|.||   |.:...:..||        ...|:|:|.....:|...:...||
plant   891 ---QEERETGIISWNVLMRYKEAV--------GGLWVVMILLACYLATEVLRVSSS--------- 935

  Fly   941 LEPLTFNLSQLHTVDAFVELFSEEEDVKDMHAYYTELLYWYDAHVATLTKNRHNAYALLTQNQFT 1005
                           .::.:::::...|:    |:...|..             .||||...|
plant   936 ---------------TWLSIWTDQSTSKN----YSPGFYIV-------------VYALLGFGQ-- 966

  Fly  1006 AHVNSRYIFGATFDQKIVTAWFNNIPLHSAPYALNVVHNAVARHLFDEEATIDVTLAPL------ 1064
                    ...||....   |.....||:            ||.|.|...: .:..||:
plant   967 --------VAVTFTNSF---WLITSSLHA------------ARRLHDAMLS-SILRAPMLFFHTN 1007

  Fly  1065 PFRTAINTFPPSSHTFGGCLAFGICFVLTFIWPAFAIYMITERGSLLKKQQFLAGVRVCSYWTFT 1129
            |....||.|..........:|..:...:..:|            .||.....:..|...|.|...
plant  1008 PTGRVINRFSKDIGDIDRNVANLMNMFMNQLW------------QLLSTFALIGTVSTISLWAIM 1060

  Fly  1130 VLYDLLFLLIFCACVVVMVALYENPNHDVMLYGYISVTLMLGGFWVILLAYLMASLCRNPCYGFL 1194
            .|     |::|.|..:    .|::.:.:|.                     .:.|:.|:|.|...
plant  1061 PL-----LILFYAAYL----YYQSTSREVR---------------------RLDSVTRSPIYAQF 1095

  Fly  1195 W--LCGINSIGLVCFSQFYRTHPESMLLEPTFM---AMYTVATVICKLFMIYEFKLICMDPVVNF 1254
            .  |.|::||      :.|:.:.....:....|   ..:|:|......::....:.: ...::..
plant  1096 GEALNGLSSI------RAYKAYDRMAKINGKSMDNNIRFTLANTSSNRWLTIRLETL-GGVMIWL 1153

  Fly  1255 TSVEVFKCNSIPNCCIKSNYGTF--TAGIY--HDLVILTLLDIILLACLFVSEYHSILGFADCRL 1315
            |:......|...|     |...|  |.|:.  :.|.|.:||..:|                  |.
plant  1154 TATFAVLQNGNTN-----NQAGFASTMGLLLSYTLNITSLLSGVL------------------RQ 1195

  Fly  1316 DTRTNESPDSNQESRAFPGILSNDTAALVDKEHTSRLNEEERSKYAAVGIGIVSKYRRN--RVLR 1378
            .:|...|.:|.:....:..:.|..|..:.:.............|:..|.:    :||..  .||.
plant  1196 ASRAENSLNSVERVGNYIDLPSEATDIIENNRPVCGWPSGGSIKFEDVHL----RYRPGLPPVLH 1256

  Fly  1379 DLDFTLAKSECLSITGANNSGKTTLLKVVVNETKMNAGQLWIHDYSVNTHRV-QCYRMVGYCPQK 1442
            .|.|.::.||.:.:.|...:||:::|..:....::..|::.|.|..|....: ...|::...||.
plant  1257 GLTFFVSPSEKVGVVGRTGAGKSSMLNALFRIVEVEKGRIMIDDCDVAKFGLTDVRRVLSIIPQS 1321

  Fly  1443 DSLPSEFTPRELLYIHAMLQGHRHRIGRELSEALLR-LVGLTPCWNRSVRMC------TTGQIRR 1500
               |..|:......|....:.:...:...|..|.:: ::...| :.....:|      :.||.:.
plant  1322 ---PVLFSGTVRFNIDPFSEHNDAGLWEALHRAHIKDVISRNP-FGLDAEVCEGGENFSVGQRQL 1382

  Fly  1501 LYFAYAVLGSPDLICVDGVPAGLD 1524
            |..|.|:|....::.:|...|.:|
plant  1383 LSLARALLRRSKILVLDEATASVD 1406

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1494	NP_001259763.1	ABC2_membrane_3	<263..480	CDD:289468	54/240 (23%)
		CcmA	541..848	CDD:224054	63/348 (18%)
		ABC_subfamily_A	541..761	CDD:213230	53/260 (20%)
		ABC2_membrane_3	911..>1189	CDD:289468	44/283 (16%)
		ABC2_membrane	<1080..>1188	CDD:304374	14/107 (13%)
		ABC_subfamily_A	1370..1577	CDD:213230	35/165 (21%)
		PRK14255	1371..1586	CDD:172743	35/164 (21%)
ABCC12	NP_001319111.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910