DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1494 and ABCA2

DIOPT Version :9

Sequence 1:	NP_001259763.1	Gene:	CG1494 / 33102	FlyBaseID:	FBgn0031169	Length:	1695	Species:	Drosophila melanogaster
Sequence 2:	NP_190357.2	Gene:	ABCA2 / 823927	AraportID:	AT3G47730	Length:	983	Species:	Arabidopsis thaliana

Alignment Length:	962	Identity:	186/962 - (19%)
Similarity:	376/962 - (39%)	Gaps:	233/962 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 RKFLLMNWKNHK---LQLANPLELLVILLVPPLFTLVAVLMRFFIPVNHRSDTVYDPIDL----- 64
            :|.||::|::.:   |||.  .....|||:   |.:.|.:.:.|.. :....||.||..|
plant    19 KKNLLLSWRSKRATFLQLF--ASFFFILLI---FCIQAAMEKSFAS-STALKTVTDPTALISPPI 77

  Fly    65 ----DRSWMQMV--------EKLEKARQVADTYNVKGNP------------FTPHLVIGWAPKRY 105
                |:.::.:.        .:..|..|:.:.. :|.||            ..|..|..|.
plant    78 PPCEDKFFVNLPCYDFVWSGNRSSKVTQIVNAI-MKNNPGRSIPIEKVRSFVDPEAVDTWL---- 137

  Fly   106 GIFQAMMRRVQKQIEPMTSVGFEDCEEMRESVIENGLFAGLCFDGSPFVEDQVFEEDTLESYSNI 170
                        ...|:...|.....|...:||..|:..    :.:|.:....||:.|.:....:
plant   138 ------------MANPLLVPGALHFIERNATVISYGIQT----NSTPEMNRGRFEDPTFKFQIPL 186

  Fly   171 QPMLNYTILLPSEL-RMLDGDFRMANWMTLYNDDPNTFVLTRLNQPYEGGFVGYVREGFIRLQKS 234
            |      |....|: |.|.||... ||:..:.:.|:..:                 |..:.|. :
plant   187 Q------IAAEREIARSLIGDPNF-NWVVGFKEFPHPTI-----------------EAIVALD-T 226

  Fly   235 VSESFLVLTSHKSLPTIQIRRFPITGREQDPLMGNLNYGMPFIIIIGFLFPAQLFVWQVVSEKQS 299
            :..:|.:.                                  :.:.||:    |.:..:::||:.
plant   227 IGPTFFLA----------------------------------VAMFGFV----LQISSLITEKEL 253

  Fly   300 QVRQFLINMNIGNLIHFVSWYLKGLIYEMISSLIIAALLKIRWDQDHGVLTQTPWYILILVLFCY 364
            ::||.:..|.:.:..:::||.....|...||:| :..|..:.:..|..:....|...|:.:||.:
plant   254 KLRQAMTMMGVFDTAYWLSWLTWEGILTAISAL-LTVLFGMMFQFDFFLKNSFPVVFLLFMLFQF 317

  Fly   365 NCAAVAFAIMVAAFFRNALNAVRVLTILWIMSYVPTFILSNNLEGNIHALRYV-------SYALP 422
            |...:||  |::||...:.:|..|...::::.:|.....|:   |..:|.:|.       |...|
plant   318 NLIGLAF--MLSAFISKSTSATTVGFFVFLVGFVTQLATSS---GFPYAKKYSRMIRALWSLFPP 377

  Fly   423 NVVATLVIEFLIERESIVHITWEDSGYRL--------NYDGGHITVTASSWIFMLNA-LVYCAIG 478
            |..:. .::.|.:..|    |.:|.|...        |.|.|.:......::::|.. .::..:.
plant   378 NTFSQ-GLKLLADATS----TPQDPGISWSKRAECGPNDDTGCVLTINDIYLWLLGTFFLWFVLA 437

  Fly   479 LYVD--------------------MWRGGDRSGKKMKKPNTNASVQEDPYHERGDSFTHQGQAIG 523
            ||.|                    .|.|  :.|.::::....:.:...|   ..|..|...:.:.
plant   438 LYFDNITPNASGVRKSIFYFLKPGYWTG--KGGNRVEEGGICSCIGSVP---PVDHITPDDEDVL 497

  Fly   524 VNSTKIYE------VEPSHRRFKLKIKKL------------CKRFATNDRPALNLFSWNVYENEV 570
            ...|.:.:      |:|:   ..::|:.|            ||...|:...||.....|:.::::
plant   498 EEETLVKQHSMEGLVDPN---VAVQIRGLAKTYPGTTKFGCCKCKKTSPFHALKGLWMNIAKDQL 559

  Fly   571 TVLMGHNGCGKSTLLKILAGLVEPSRGTVMISSHNIQTERKAASME--LGIAFGHDMLLTGFTVI 633
            ..|:|.||.||:|.:..|.||...:.|..:|..::|::....:::.  :|:....|:|....:..
plant   560 FCLLGPNGAGKTTTINCLTGLFPVTGGDALIYGNSIRSSVGMSNIRKMIGVCPQFDILWDALSGE 624

  Fly   634 DYLRFICRVKGLHNNIEIDGQSNYFLNVLQI------------GGLKTKRIRTLTDRDLCLVSIC 686
            ::|:....:|||..: .|:......|..:::            ||:|.:            :|:.
plant   625 EHLKLFASIKGLPPS-SINSMVEKSLAEVKLTEAGKIRAGSYSGGMKRR------------LSVA 676

  Fly   687 CAFVGNSPIILIDDVHSDLDKRTQSLVWNLINEEKSKRTIILVSNSPALAENIADRMAIMSNGEL 751
            .:.:|:..::.:|:..:.:|..|:..||::|.|.|..|.|||.::|...|:.::||:.||:.|.|
plant   677 VSLIGDPKLVFLDEPTTGMDPITRRHVWDIIQETKKGRAIILTTHSMEEADILSDRIGIMAKGRL 741

  Fly   752 KCTGTKPFLKNMYGHGY--RLTCVKGKNY-------KRDELFGMMNSYMPNMSIERDIGYKVTFV 807
            :|.||...||:.:|.|:  .::.|:..|:       .|:.:......::....||.:..: :|||
plant   742 RCIGTSIRLKSRFGTGFIANISFVESNNHNGEAGSDSREPVKKFFKDHLKVKPIEENKAF-MTFV 805

  Fly   808 LENKFEDQFPMLIDDLEENMQQLGVVSFRIRDTSMEEIFLRFGCEDNDQSGA 859
            :.:..|:.......:|::..::.|:...::...::||:||....:...:|.|
plant   806 IPHDKENLLTSFFAELQDREEEFGISDIQLGLATLEEVFLNIARKAELESAA 857

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1494	NP_001259763.1	ABC2_membrane_3	<263..480	CDD:289468	45/232 (19%)
		CcmA	541..848	CDD:224054	76/341 (22%)
		ABC_subfamily_A	541..761	CDD:213230	58/245 (24%)
		ABC2_membrane_3	911..>1189	CDD:289468
		ABC2_membrane	<1080..>1188	CDD:304374
		ABC_subfamily_A	1370..1577	CDD:213230
		PRK14255	1371..1586	CDD:172743
ABCA2	NP_190357.2	rim_protein	<186..>861	CDD:130324	149/768 (19%)
ABCA2	NP_190357.2	ABC_subfamily_A	518..751	CDD:213230	58/245 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19229
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.920