DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG1494 and Abca2

DIOPT Version :9

Sequence 1:NP_001259763.1 Gene:CG1494 / 33102 FlyBaseID:FBgn0031169 Length:1695 Species:Drosophila melanogaster
Sequence 2:XP_006233707.2 Gene:Abca2 / 79248 RGDID:620238 Length:2435 Species:Rattus norvegicus


Alignment Length:1964 Identity:404/1964 - (20%)
Similarity:719/1964 - (36%) Gaps:562/1964 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   126 GFEDCEEMRESVIENGL----------FAGLCF----DGSPFVEDQVFEEDTLESYSNIQPMLNY 176
            ||.|    .||::...|          ||.:.|    |||                  :.|.::|
  Rat   582 GFPD----EESIVNYTLNQAYQDNVTVFASVIFQTRKDGS------------------LPPHVHY 624

  Fly   177 TILLPSELRMLDGDFRMANWMTLYNDDPNTFVLTRLNQPYEGGFVGYVREGFIRLQKSVSESFL- 240
            .|...|.......:.|.|.|    ...|||           ||.. |...||:.:|..:..:.: 
  Rat   625 KIRQNSSFTEKTNEIRRAYW----RPGPNT-----------GGRF-YFLYGFVWIQDMIERAIIN 673

  Fly   241 VLTSHKSL-PTIQIRRFPITGREQDPLMGNLNYGMPFIIIIGFLFPAQLFVWQVVSEKQSQVRQF 304
            ....|..: |...::.||.....:|..:..:.:.||..::|.:::...:.:..:|:||:.::::.
  Rat   674 TFVGHDVVEPGNYVQMFPYPCYTRDDFLFVIEHMMPLCMVISWVYSVAMTIQHIVAEKEHRLKEV 738

  Fly   305 LINMNIGNLIHFVSWYLKGLIYEMISSLIIAALLKIRWDQDHG-VLTQTPWYILILVLFCYNCAA 368
            :..|.:.|.:|:|:|::.|.:...||...:.|:||      :| ||..:...|:.|.|..|..|.
  Rat   739 MKTMGLNNAVHWVAWFITGFVQLSISVTALTAILK------YGQVLMHSHVLIIWLFLAVYAVAT 797

  Fly   369 VAFAIMVAAFFRNALNAVRVLTILWIMSYVPTFILSNNLEGNIHALRYVSY----ALPNVVATLV 429
            :.|..:|:..:..|..|.....|::.:||||...::...|        |::    |....:|:|:
  Rat   798 IMFCFLVSVLYSKAKLASACGGIIYFLSYVPYMYVAIREE--------VAHDKITAFEKCIASLM 854

  Fly   430 IEFLIERESIVHITWEDSGYRLNY--------DGGHITVTASSWIFMLNALVYCAIGLYVD---- 482
            ........|.....:|.:|..:.:        :|....:..:..:.|::.:||..:..|::    
  Rat   855 STTAFGLGSKYFALYEVAGVGIQWHTFSQSPVEGDDFNLLLAVTMLMVDTVVYGVLTWYIEAVHP 919

  Fly   483 ----------------MWRGGDRSGKKMKKPNTNASVQEDPY-HERGDSFTHQGQAIGVNS---- 526
                            .|.|..|         |.......|: |....|...:.||..:.|    
  Rat   920 GMYGLPRPWYFPLQKSYWLGSGR---------TETWEWSWPWAHAPRLSVMEEDQACAMESRHFE 975

  Fly   527 -TKIYEVEPSHRRFKLKIKKLCKRFATNDRPALNLFSWNVYENEVTVLMGHNGCGKSTLLKILAG 590
             |:..|.||:|....:.:.||.|.:..:.:.|||..|.|:|||:|...:||||.||:|.:.||.|
  Rat   976 ETRGMEEEPTHLPLVVCVDKLTKVYKNDKKLALNKLSLNLYENQVVSFLGHNGAGKTTTMSILTG 1040

  Fly   591 LVEPSRGTVMISSHNIQTERKAASMELGIAFGHDMLLTGFTVIDYLRFICRVKGLHNNIEIDGQS 655
            |..|:.|:..|..|:|:||.......||:...|::|....||.::|.|..|:|.:... ||..:.
  Rat  1041 LFPPTSGSATIYGHDIRTEMDEIRKNLGMCPQHNVLFDQLTVEEHLWFYSRLKSMAQE-EIRKEM 1104

  Fly   656 NYFLNVLQIGGLKTKRIRTLTDRDLCLVSICCAFVGNSPIILIDDVHSDLDKRTQSLVWNLINEE 720
            :..:..|::...:...::||:......:|:..||||.|..|::|:..:.:|...:..:|:||.:.
  Rat  1105 DKMIEDLELSNKRHSLVQTLSGGMKRKLSVAIAFVGGSRAIILDEPTAGVDPYARRAIWDLILKY 1169

  Fly   721 KSKRTIILVSNSPALAENIADRMAIMSNGELKCTGTKPFLKNMYGHGYRLTCVK----------- 774
            |..|||:|.::....|:.:.||:||:|:|:|||.|:..|||..||.|||||.||           
  Rat  1170 KPGRTILLSTHHMDEADLLGDRIAIISHGKLKCCGSPLFLKGAYGDGYRLTLVKRPAEPGTSQEP 1234

  Fly   775 -------GK----NYKRDELFGMMNSYMPNMSIERDIGYKVTFVLENKF--EDQFPMLIDDLEEN 826
                   |:    |....::...:..::.:..:..|...:::::|.::.  :..|..|...||.:
  Rat  1235 GMASSPSGRPQLSNCSEMQVSQFIRKHVASSLLVSDTSTELSYILPSEAVKKGAFERLFQQLEHS 1299

  Fly   827 MQQLGVVSFRIRDTSMEEIFLRFGCED----NDQSGAFQSHENA--------------------- 866
            :..|.:.||.:.||::||:||:...||    |.::...:|.::|                     
  Rat  1300 LDALHLSSFGLMDTTLEEVFLKVSEEDQSLENSEADVKESRKDALPGAEGLTAVESQAGNLARCS 1364

  Fly   867 --------------------------------------------QVLLEE-YYSTLAEANEKGRR 886
                                                        .|.|:| ....||...:..|:
  Rat  1365 ELAQSQASLQSASSVGSARGDEGAGYTDGYGDYRPLFDNLQDPDSVSLQEAEMEALARVGQGSRK 1429

  Fly   887 -TGW--KLFFLHGRAVIYKRWIAAHRHWIVLIFEVLAMAL---VAVCTFSSIFIYGKNYELEPLT 945
             .||  |:...||  ::.||:..|.|:...|..::|..|.   ||:....|:...|   :|.||.
  Rat  1430 LEGWWLKMRQFHG--LLVKRFHCARRNSKALCSQILLPAFFVCVAMTVALSVPEIG---DLPPLV 1489

  Fly   946 FNLSQLHTVDA----FVELFSEEE---------DVKDMHAYYT---------------------- 975
            .:.||.|....    |:...:||.         |........|                      
  Rat  1490 LSPSQYHNYTQPRGNFIPYANEERREYRLRLSPDASPQQLVSTFRLPSGVGATCVLKSPANGSLG 1554

  Fly   976 ------------------------------------------------------ELLYWYDA--- 983
                                                                  .||.|..:   
  Rat  1555 PMLNLSSGESRLLAARFFDSMCLESFTQGLPLSNFVPPPPSPAPSDSPLSPDEDSLLAWNTSLPP 1619

  Fly   984 ---------------------------------------------HVAT------LTKNRHNAYA 997
                                                         .|.|      :|.:..:.|.
  Rat  1620 TAGPETWTWAPSLPRLVHEPVRCTCSAQGTGFSCPSSVGGHPPQMRVVTGDILTDITGHNVSEYL 1684

  Fly   998 LLTQNQFTAHVNSRYIFGA-TFD-----------------------QKIVTAWFNNIPLHSAPYA 1038
            |.|.::|..|   ||  || ||.                       :::....:||...||.|..
  Rat  1685 LFTSDRFRLH---RY--GAITFGNIQKSIPAPIGTRTPLMVRKIAVRRVAQVLYNNKGYHSMPTY 1744

  Fly  1039 LNVVHNAVARHLFDEEA------TIDVTLAPLPFRTAINTFPPSSHTFGGCLAFGICFVLTFIWP 1097
            ||.::||:.|....:..      .|.||..|:...:|..:...........:|..|...::|:..
  Rat  1745 LNSLNNAILRANLPKSKGNPAAYGITVTNHPMNKTSASLSLDYLLQGTDVVIAIFIIVAMSFVPA 1809

  Fly  1098 AFAIYMITERGSLLKKQQFLAGVRVCSYWTFTVLYDLLFLLIFCACVVVMVALYENPNHD----- 1157
            :|.::::.|:.:..|..||::|.....||....::|:|..|:...|.::::.:::.|.:.     
  Rat  1810 SFVVFLVAEKSTKAKHLQFVSGCNPVIYWLANYVWDMLNYLVPATCCIIILFVFDLPAYTSPTNF 1874

  Fly  1158 ------VMLYGYISVTLML--GGFWVILLAYLMASLCRNPCYGFLWLCGIN-SIGLVCFSQFYRT 1213
                  .:|||: |:|.::  ..||..:           |...:::|..|| .||:..       
  Rat  1875 PAVLSLFLLYGW-SITPIMYPASFWFEV-----------PSSAYVFLIVINLFIGITA------- 1920

  Fly  1214 HPESMLLEPTFMAMYTVATVICKLFMIYEFKLICMDPVVNFTSVEVFKCNSIPNCCIKSNYGTF- 1277
                           ||||.:.:||                   |..|...:.|..:||.:..| 
  Rat  1921 ---------------TVATFLLQLF-------------------EHDKDLKVVNSYLKSCFLIFP 1951

  Fly  1278 TAGIYHDLVILTLLDIILLACLFVSEYHSILGFAD------------------------------ 1312
            ...:.|.|:.:...:       :::||::.:|..|                              
  Rat  1952 NYNLGHGLMEMAYNE-------YINEYYAKIGQFDKMKSPFEWDIVTRGLVAMTVEGFVGFFLTI 2009

  Fly  1313 -C---------RLDTRTNESPD----SNQESRAFPGILSNDTAALVDKEHTSRLNEEERSKYAAV 1363
             |         ||...|....|    :::..|...|...||   :|..|:.:::       |.:.
  Rat  2010 MCQYNFLRQPQRLPVSTKPVEDDVDVASERQRVLRGDADND---MVKIENLTKV-------YKSR 2064

  Fly  1364 GIGIVSKYRRNRVLRDLDFTLAKSECLSITGANNSGKTTLLKVVVNETKMNAGQLWIHDYSVNTH 1428
            .||.:....|      |...:...||..:.|.|.:|||:..|::..:.....|:.:::.:||...
  Rat  2065 KIGRILAVDR------LCLGVRPGECFGLLGVNGAGKTSTFKMLTGDESTTGGEAFVNGHSVLKD 2123

  Fly  1429 RVQCYRMVGYCPQKDSLPSEFTPRELLYIHAMLQGHRHRIGRELSEALLRLVGLTPCWNRSVRMC 1493
            .:|..:.:|||||.|:|..|.|.||.|.::..|:|...:...::....|..:.||.|.::.....
  Rat  2124 LLQVQQSLGYCPQFDALFDELTAREHLQLYTRLRGIPWKDEAQVVRWALEKLELTKCADKPAGSY 2188

  Fly  1494 TTGQIRRLYFAYAVLGSPDLICVDGVPAGLDPTGKRIILMMTSTMQAMGSSFLYTMLTGLDAERL 1558
            :.|..|:|..|.|::|.|..|.:|....|:||..:|.:..:...:...|.|.:.|..:..:.|.:
  Rat  2189 SGGNKRKLSTAIALIGYPAFIFLDEPTTGMDPKARRFLWNLILDLIKTGRSVVLTSHSMEECEAV 2253

  Fly  1559 SLRTPLLLEGQLWMIRPMDTETENYKSGYQLEVRFKRKVNPNVSMSRATWNLINHFPMSPNKKFS 1623
            ..|..:::.|:|..:..:......:..||.:.||.|...|.                    |...
  Rat  2254 CTRLAIMVNGRLRCLGSIQHLKNRFGDGYMITVRTKSSQNV--------------------KDVV 2298

  Fly  1624 AFMEIKFPDAVLTIERDDSMVFVLPLGTTTFSEIFLTLRKDAFEMNIEDYFITR----NMLVGF- 1683
            .|....||:|:|.......:.:.|.....:.:::|..:......:.||||.:::    |:.|.| 
  Rat  2299 RFFNRNFPEAMLKERHHTKVQYQLKSEHISLAQVFSKMEHVVGVLGIEDYSVSQTTLDNVFVNFA 2363

  Fly  1684 --QIFTYDQHQDNP 1695
              |....:|.:..|
  Rat  2364 KKQSDNVEQQEAEP 2377

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG1494NP_001259763.1 ABC2_membrane_3 <263..480 CDD:289468 47/229 (21%)
CcmA 541..848 CDD:224054 101/330 (31%)
ABC_subfamily_A 541..761 CDD:213230 74/219 (34%)
ABC2_membrane_3 911..>1189 CDD:289468 73/466 (16%)
ABC2_membrane <1080..>1188 CDD:304374 23/120 (19%)
ABC_subfamily_A 1370..1577 CDD:213230 52/206 (25%)
PRK14255 1371..1586 CDD:172743 52/214 (24%)
Abca2XP_006233707.2 rim_protein 1..2369 CDD:130324 402/1954 (21%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166342289
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0059
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D131191at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
43.750

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