DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1494 and AgaP_AGAP006380

DIOPT Version :9

Sequence 1:	NP_001259763.1	Gene:	CG1494 / 33102	FlyBaseID:	FBgn0031169	Length:	1695	Species:	Drosophila melanogaster
Sequence 2:	XP_001688862.1	Gene:	AgaP_AGAP006380 / 5666864	VectorBaseID:	AGAP006380	Length:	1652	Species:	Anopheles gambiae

Alignment Length:	1763	Identity:	441/1763 - (25%)
Similarity:	815/1763 - (46%)	Gaps:	210/1763 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 KFLLMNWKNHKLQLANPLELLVILLVPPLFTLVAVLMRFFI-PVNHRSDTVYDPIDLDRSWMQMV 72
            ||:|:.|||..||..:.::.|..:|:|.|...:.:|:|..: |....|::.:.|:::||  :..:
Mosquito     8 KFVLLLWKNWILQKRHYIQTLFEILIPVLCCSILLLVRGLVDPEFIDSNSEFKPLEIDR--LTHL 70

  Fly    73 EKLEKARQVADTYNVKGNPFTPHLVIGWAPKRYGIFQAMMRRVQKQI---EP---MTSVGFEDCE 131
            |||.:|:    .:..|         |.::| |..:.:|:::...:.:   :|   :|...|.|..
Mosquito    71 EKLAEAK----NFEFK---------IAYSP-RNDLLEAVVQEAVRALNANDPKARLTYASFADAR 121

  Fly   132 EMRESVIENGLFAGLCFDGSPFVEDQVFEEDTLESY--SNIQPM--LNYTILLPSELRMLDGDFR 192
            ||...:.|:...||:.||            |:..|:  :|..|.  |.:.:..|:|||  |.:|:
Mosquito   122 EMESVLAESSFLAGVEFD------------DSWASWTAANGVPTDNLTFAVRYPAELR--DDEFQ 172

  Fly   193 MANWMTLYNDDPNTFVL---TRLNQPY--EGGFVGYVREGFIRLQKSVSESFLVLTSHK----SL 248
            .:||:|      |..|:   .||..|.  :||...|..|||:.:|.::|.:.|   ..:    .|
Mosquito   173 FSNWVT------NLLVVPFSPRLRNPLLDDGGSPSYYSEGFLGIQGAISRALL---GRRLPGVDL 228

  Fly   249 PTIQIRRFPITGREQDPLMGNLNYGMPFIIIIGFLFPAQLFVWQVVSEKQSQVRQFLINMNIGNL 313
            ||:.::|:|......|.::..|...:..||:|.|.:.....|..:..||:.|:::.:..|.:.|.
Mosquito   229 PTVHVQRYPYPPYYDDAILEALQQLLALIIVISFFYTCINTVKYITIEKEKQLKEAMKIMGLSNW 293

  Fly   314 IHFVSWYLKGLIYEMISSLIIAALLKIRWDQDHGVLTQTPWYILILVLFCYNCAAVAFAIMVAAF 378
            :|:.:|::|.||...:|..:|..||.:.: ....:...:.|.::.:..|.|:.:.:.|..|::.|
Mosquito   294 LHWSAWFVKCLILLTVSLSLITILLCVPF-SSAAIFENSDWTLIWVFFFVYSISTICFCFMISVF 357

  Fly   379 FRNALNAVRVLTILWIMSYVPTFILSNNLEGNIHALRYVSYALPNVVATLVIEFLIERE-SIVHI 442
            |..|..|..:..:||.::.:|..:...|.:......:.....|.|...:|.:...:..| :.|.:
Mosquito   358 FSKANTAAGIAGLLWFVTQLPFNVSQQNYDEMGTGAKLGMCLLSNSGMSLAMFLTVRLEATAVGL 422

  Fly   443 TWE--------DSGYRLNYDGGHITVTASSWIFMLNALVYCAIGLYVDMWRGGDRS-GKKMKKPN 498
            .|.        |.|:.:    |.|.:     :.:::|::|..|.||::....|:.. .:....|.
Mosquito   423 RWSNLFEPATIDDGFNV----GLIII-----MLLVDAVIYLLIALYIEQIMPGEFGIARPWYFPF 478

  Fly   499 TNASVQEDPYHERGDSFTHQGQAIGVNSTKIYEVEPSHRRFKLKIKKLCKRFATNDRPALNLFSW 563
            |...........|...|    ||.|...::..|.:|:... .::||:|.|.:..| :.|::..:.
Mosquito   479 TKEFWVRTQTPSRDTLF----QANGSTESRYIEQDPAGYA-GVEIKQLRKVYKGN-KAAVDGLNL 537

  Fly   564 NVYENEVTVLMGHNGCGKSTLLKILAGLVEPSRGTVMISSHNIQTERKAASMELGIAFGHDMLLT 628
            .:|||:::||:||||.||:|.:.:|.|:..|:.||.:|:.|:|:|:.......||:...|::|..
Mosquito   538 RMYENQISVLLGHNGAGKTTTMSMLTGVFAPTSGTALINGHDIRTDIDGVRSSLGLCPQHNVLFD 602

  Fly   629 GFTVIDYLRFICRVKGLHNNIEIDGQSNYFLNVLQIGGLKTKRIRTLTDRDLCLVSICCAFVGNS 693
            ..||.::|:|..|:||:... .:.|:.:.:|.:|::...:..:.:||:......:::..|..|.|
Mosquito   603 EMTVDEHLKFFSRLKGVPTE-AVSGEIDRYLKLLELTDKRDAQSQTLSGGMKRKLAVGMALCGGS 666

  Fly   694 PIILIDDVHSDLDKRTQSLVWNLINEEKSKRTIILVSNSPALAENIADRMAIMSNGELKCTGTKP 758
            .::|:|:..|.:|...:..:|||:.:||..||::|.::....|:.:.||:|||:.|:||..|:..
Mosquito   667 KVVLLDEPTSGMDPSARRALWNLLQKEKQNRTMLLSTHFMDEADVLGDRIAIMAEGKLKAVGSPF 731

  Fly   759 FLKNMYGHGYRLTCVKGKNYKRDELFGMMNSYMPNMSIERDIGYKVTFVLENKFEDQFPMLIDDL 823
            |||..:|.||||.|||.....:..|.|::..|:|:::|:.|||.:::|:|:..:.|.|..|::|:
Mosquito   732 FLKKTFGVGYRLICVKDARCDKQRLLGILRKYIPDVTIDTDIGSELSFILKEDYLDVFQRLLEDI 796

  Fly   824 EENMQQLGVVSFRIRDTSMEEIFLRFGCEDNDQSGAFQSHENAQVLLEEYYSTLAEANEKGRRTG 888
            |:.|...|:.|:.|..|:|||:||:.|.:..|::|   :|.|..|:  |..|:....:.....||
Mosquito   797 EQQMVSCGITSYGISLTTMEEVFLKAGSDSFDETG---THTNGTVV--ETGSSEYALDRLHLLTG 856

  Fly   889 WKLFFLHGRAVIYKRWIAAHRHWIVLIFEVLAMALVAVC-TF--SSIFIYGKNYELEPLTFNL-- 948
            .:|.|...:|.:.|:::::.|.|:.|:. :..:.:..|| ||  :.....||:.....:|.:.
Mosquito   857 KELLFNQIQAQLLKKYLSSIRAWVQLVM-MFVIPIFFVCMTFIITRSISAGKDLPALEITIDSYE 920

  Fly   949 ----------SQLHTVDAFVELFSEEEDVKDMHAYYTELLYWYDAHVATLTKNRHNAYALLTQNQ 1003
                      .:...|:||..:|::..::..:....||                   |.:....:
Mosquito   921 KAITVLERAGGETARVEAFQNMFTDRGELVTIDEDMTE-------------------YIVRKSIE 966

  Fly  1004 FTAHVNSRYIFGATFDQKI-VTAWFNNIPLHSAPYALNVVHNAVARHLFDEEATIDVTLAPLPFR 1067
            ..|.||:||..|||..... ...||||...|:||.|||:|::|:.:... .|..:.|...|||:|
Mosquito   967 DIAAVNTRYFVGATIRSGAPYVGWFNNKAFHTAPLALNLVYSAILQAQC-TECQLHVINKPLPYR 1030

  Fly  1068 ---------TAINTFPPSSHTFGGCLAFGICFVLTFIWPAFAIYMITERGSLLKKQQFLAGVRVC 1123
                     |.:|.        |..|||...|.:.|:...:.::.|.||.|..|..||::|..|.
Mosquito  1031 LDTQLKKLNTGLNA--------GFQLAFNTGFAMAFVAALYIMFYIKERTSRAKLLQFVSGTNVT 1087

  Fly  1124 SYWTFTVLYDLLFLLIFCACVVVMVALYENPNHDVM-LYGYISVTLMLGGFWVILLAYLMASLCR 1187
            .:|....::|....::.....:..||:::....... ..|...:.|:..|:..:.:.||.:.|..
Mosquito  1088 MFWLLAFMWDFTLFVLNSLVYIATVAIFQEEGWSTFEELGRAFLLLLFFGYATLPVTYLFSFLFS 1152

  Fly  1188 NPCYGFLWLCGINSI-GLVCFS-----------------------QFYRTHPESMLLEPTFMAMY 1228
            ....||:.:..:|.: |.:.|:                       .|:.....|..|.....|..
Mosquito  1153 VSATGFVRMMFVNVLSGAIFFTAVNVLKFDGIDLVEVAEGLEWVFMFFPNFVLSHGLNNLNAASS 1217

  Fly  1229 TVATVICKLFMIYEFKLICMDPVVNFTSVEVFKCNSIPNCCIKSNYGTFTAGIYHDLVILTLLDI 1293
            |.::  ||.|.    .|:....||:..      |:....||....:.....||..:|:...|:..
Mosquito  1218 TASS--CKKFC----DLLGAQCVVDDL------CSVDARCCDLEVFSFGNVGIIRNLLFCVLIGT 1270

  Fly  1294 ILLACLFVSEYHSILGFADCRLDTRTNESPDSNQESRAFPGILSN--DTAALVDKEHTSRLNEEE 1356
            :..:.||:.||..:.     ||..|   .|..:.......|.:.:  |:..|.:|...:.|:..:
Mosquito  1271 VSFSLLFMLEYGVLQ-----RLFQR---KPKGSASPAGPQGTVGSEQDSDVLEEKRRIANLSRTD 1327

  Fly  1357 RSKYAAVGIGIVSKYRRN-RVLRDLDFTLAKSECLSITGANNSGKTTLLKVVVNETKMNAGQLWI 1420
            ...:..: :..|:||..| :.:.:|...:..|||..:.|.|.:||||..|::..:.::::|..|:
Mosquito  1328 IDGHNLL-LRDVTKYYGNFQAVNNLSIGINHSECFGLLGINGAGKTTTFKMMTGDEEISSGNAWV 1391

  Fly  1421 HDYSVNTHRVQCYRMVGYCPQKDSLPSEFTPRELLYIHAMLQGHRHRIGRELSEALLRLVGLTPC 1485
            ...|:.....:.:|.:|||||.|:|..:.|.||.|.|.|:|:|.|.:..:.:|..|...:..|..
Mosquito  1392 KGISLREDMNRAHRQIGYCPQFDALLEDLTGRETLRIFALLRGVRKQEVKNVSYILAEELNFTKH 1456

  Fly  1486 WNRSVRMCTTGQIRRLYFAYAVLGSPDLICVDGVPAGLDPTGKRIILMMTSTMQAMGSSFLYTML 1550
            .::..:..:.|..|:|..|.|:||:|.::.:|....|:||..||....:...:::.|.|.:.|..
Mosquito  1457 LDKRTKAYSGGNKRKLSTALALLGNPSVVYLDEPTTGMDPGAKRQFWDVICKVRSTGKSIVLTSH 1521

  Fly  1551 TGLDAERLSLRTPLLLEGQLWMIRPMDTETENYKSGYQLEVRFKRKVNPNVSMSRATWNLINHFP 1615
            :..:.|.|..|..:::.|:...:.........:..|:.|.|:..|. :.:....|...  :..|.
Mosquito  1522 SMEECEALCTRLAIMVNGEFKCLGSTQHLKNKFSKGFLLTVKVARG-STDAQQKRVAG--VKDFV 1583

  Fly  1616 MSPNKKFSAFMEIKFPDAVLTIERDDSMVFVLPLGTTTFSEIFLTLRKDAFEMNIEDYFITRNML 1680
            ||           :|..|||..|.:||:.|.:|:....:|::|..:.....|:.||||.:.:..|
Mosquito  1584 MS-----------RFSGAVLKEEYEDSLTFHIPVTDLKWSQMFGLMESSKQELEIEDYALGQTSL 1637

  Fly  1681 VGFQIFTY 1688
            .  |:|.:
Mosquito  1638 E--QVFLF 1643

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1494	NP_001259763.1	ABC2_membrane_3	<263..480	CDD:289468	47/225 (21%)
		CcmA	541..848	CDD:224054	103/306 (34%)
		ABC_subfamily_A	541..761	CDD:213230	69/219 (32%)
		ABC2_membrane_3	911..>1189	CDD:289468	69/303 (23%)
		ABC2_membrane	<1080..>1188	CDD:304374	25/108 (23%)
		ABC_subfamily_A	1370..1577	CDD:213230	58/207 (28%)
		PRK14255	1371..1586	CDD:172743	57/215 (27%)
AgaP_AGAP006380	XP_001688862.1	ABC2_membrane_3	<257..459	CDD:289468	45/211 (21%)
		CcmA	516..796	CDD:224054	92/281 (33%)
		ABC_subfamily_A	516..734	CDD:213230	69/219 (32%)
		ABC2_membrane_3	879..1213	CDD:289468	77/362 (21%)
		ABC_subfamily_A	1333..1551	CDD:213230	59/218 (27%)
		drrA	1340..1645	CDD:130256	85/320 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19229
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X215
TreeFam	0	0.000	Not matched by this tool.
	6	5.920