DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG1494 and abca1a

DIOPT Version :10

Sequence 1:NP_608444.2 Gene:CG1494 / 33102 FlyBaseID:FBgn0031169 Length:1695 Species:Drosophila melanogaster
Sequence 2:NP_001296394.1 Gene:abca1a / 558924 ZFINID:ZDB-GENE-031006-12 Length:2268 Species:Danio rerio


Alignment Length:2041 Identity:406/2041 - (19%)
Similarity:772/2041 - (37%) Gaps:539/2041 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    13 MNWKNHKLQLANPLELLVILLVPPLFTLVAVLMRFFIPVNHRSDTVYDPIDLDRSWMQMVEKLEK 77
            |.|:..|     ||.:..||..|.    .....|....||.....:....||...|.:|..|:..
Zfish   375 MIWRALK-----PLLMGKILYTPD----TPATQRIIHEVNKTFQELGVLRDLGGMWEEMRPKIWN 430

  Fly    78 ARQVADTYNVKGNPFTPHLVIGWAPKRYGIFQAMMRRVQKQIEPMTSVGFEDCEEMRESVIENGL 142
            ..:     |.:.......|:...|..|:  |.|.:...:.::|.::....:..|:.|.       
Zfish   431 FME-----NSEEMDLVRTLLQNNASARF--FNAKLSGTEWRVEDVSRFLSKSSEDTRP------- 481

  Fly   143 FAGLCFDGSPFVEDQVFEE-----DTLESY------SNIQPMLNYTILLPSELRMLDGDFRMANW 196
                  .|:.:...:||.|     .|:..:      ..::|:.|...|:...:|:|| |.:.  |
Zfish   482 ------HGTAYTWREVFNETDQAIQTISRFMECVNLDKLEPVANEERLVNKSMRLLD-DRKF--W 537

  Fly   197 MTLYNDD--PNTFVL---------------TRLNQ-------------PYEGGFVGYVREGFIRL 231
            ..:...|  .||..|               .|.|:             |:|.  :.|:..||..|
Zfish   538 AGIVFPDMQSNTSDLPLNVNYKIRMDIDNVERTNKIKDGYWDPGPRADPFED--LRYIWGGFTYL 600

  Fly   232 QKSVSESFL-VLTSHKSLPTIQIRRFPITGREQDPLMGNLNYGMPFIIIIGFLFPAQLFVWQVVS 295
            |..:....: .||..|....:.|::.|......|..:..::..||..:.:.:::...:.:..||.
Zfish   601 QDVIEHGIIRALTGSKEKTGVYIQQMPYPCYVDDIFLRVMSRSMPLFMTLAWMYSVAIIIKGVVY 665

  Fly   296 EKQSQVRQFLINMNIGNLIHFVSWYLKGLIYEMISSLIIAALLKIRWDQDHGVLTQTPWYILILV 360
            ||::::::.:..|.:.|.|.::||::..||..:||:.::..:||:     ..:|..:...::.|.
Zfish   666 EKEARLKETMRIMGLDNGILWLSWFISSLIPLLISAALLVLILKM-----GNLLPYSDPGVIYLF 725

  Fly   361 LFCYNCAAVAFAIMVAAFFRNALNAVRVLTILWIMSYVPTFILSNNLEGNIHALRYVSYALPNVV 425
            |..:....:....:::..|..|..|.....|::...|:| ::|.      :....||.:....||
Zfish   726 LSSFAVVTIMQCFLISTLFSRANLAAACGGIIYFTLYLP-YVLC------VAWQNYVGFGAKIVV 783

  Fly   426 ATL--------VIEFLIERESIVHITW---------EDSGYRLNYDGGHITVTASSWIFMLNALV 473
            :.|        ...|.:..|..|.|.|         ||| |.|         |.|..:.:.::::
Zfish   784 SLLSPVAFGFGCEYFALFEEQGVGIQWSNLLSSPMQEDS-YNL---------TTSICLMLFDSVL 838

  Fly   474 YCAIGLYVD--------------------MWRGGDRSG-----KKMKKPNTNA-SVQEDPYHERG 512
            |..:..|::                    .| .|::.|     ...:|.|..| .::|:|.|   
Zfish   839 YAVMTWYIEAVFPGQYGIPRPWYFPFTKSYW-CGEKCGWTTSVPSNRKENAEAVCIEEEPAH--- 899

  Fly   513 DSFTHQGQAIGVNSTKIYEVEPSHRRFKLKIKKLCKRFATNDRPALNLFSWNVYENEVTVLMGHN 577
                               ::|.     :.|:.|.|.: :|.:.|::..:...||.::|..:|||
Zfish   900 -------------------IDPG-----VYIENLMKIY-SNGKVAVDGLTLGFYEGQITSFLGHN 939

  Fly   578 GCGKSTLLKILAGLVEPSRGTVMISSHNIQTERKAASMELGIAFGHDMLLTGFTVIDYLRFICRV 642
            |.||:|.:.||.||..|:.||..|...:|:|:..|....||:...|::|.:..||.:::.|..|:
Zfish   940 GAGKTTTMSILTGLFPPTSGTAYIQGKDIRTDLNAIRQNLGVCPQHNVLFSMLTVEEHIWFYARL 1004

  Fly   643 KGLHNNIEIDGQSNYFLNVLQIGGLKTKRIRTLTDRDLCLVSICCAFVGNSPIILIDDVHSDLDK 707
            |||... ::..:....:..|.:...:|.|...|:......:|:..||||.|.::::|:..:.:|.
Zfish  1005 KGLSAE-KVKSEMEQIVMDLGLPHKRTSRSNQLSGGMQRKLSVALAFVGGSKVVILDEPTAGVDP 1068

  Fly   708 RTQSLVWNLINEEKSKRTIILVSNSPALAENIADRMAIMSNGELKCTGTKPFLKNMYGHGYRLTC 772
            ..:..:|:|:.:.:..|||||.::....|:.:.||:||:|:|:|.|.|:..|||...|.||.||.
Zfish  1069 YARRGIWDLLLKYRQGRTIILSTHHMDEADILGDRIAIISHGKLCCVGSSLFLKTQLGTGYYLTL 1133

  Fly   773 VKGKNY---------------------KRDE--------------------------LFGMMNSY 790
            || |::                     |:|:                          :..::..:
Zfish  1134 VK-KDFDLSASSCRTSSSTVSYSKGSLKKDDSVSESSSDAGLGSDHESETTTIDISLISNVIFKH 1197

  Fly   791 MPNMSIERDIGYKVTFVL--ENKFEDQFPMLIDDLEENMQQLGVVSFRIRDTSMEEIFLRF---- 849
            :|...:..|:|:::|:||  |:..:..|..|..::::.:..|.:.|:.|.||::|||||:.    
Zfish  1198 VPTARLVEDLGHEITYVLPYESAKDGAFVELFHEIDDRLTDLSISSYGISDTTLEEIFLKVAEDC 1262

  Fly   850 GCEDNDQSGAFQSHENAQVLLEEYYSTL------------AEANEKGRRT--------------- 887
            |.:.....|...:..|.:....::.|.|            :|.:.:.|.|               
Zfish  1263 GVDAETSDGTLPARRNRRHAFGDHQSCLKPFTEDDFDFNDSEGDPESRETDWLDGADGKGSYQVK 1327

  Fly   888 GWKLFFLHGRAVIYKRWIAAHRH---------------WIVLIFEVL------------------ 919
            ||.|......|:::||.:.|.|.               .|.|:|.::                  
Zfish  1328 GWSLKRQQFVALLWKRLLYARRSRKGFFAQIVLPAVFVCIALVFSLIVPPFGKYPSLALEPSMYE 1392

  Fly   920 -------------------------AMALVAVCT-------------------------FSSIFI 934
                                     :.|....||                         ..:||:
Zfish  1393 EQFTFISNDAPEDRHTNRLLDALKDSPAYTDQCTDGKNTASRSCPIKDGEWLVPEVTESIEAIFL 1457

  Fly   935 YGKNYELE---PL----------------------------------TFNLSQLHTVDAFVELFS 962
            .| |:.:|   ||                                  ..|||..:..|..|:.::
Zfish  1458 NG-NWSMENPSPLCECSCEGRKKMLPECPPGAGGLPPPQIKVTHDETLQNLSGRNISDYLVKTYA 1521

  Fly   963 E--EEDVKDMHAYYTELLYWYDAHVATLTKNRHNAYALLTQNQFT---AHVNSRYIF--GATFDQ 1020
            :  .:.:|: ..:..|..|      ...:....|..||...::.|   :|:.||:..  |...|:
Zfish  1522 QIIGKSLKN-KLWVNEFRY------GGFSLGARNTQALPPGDELTDAISHIRSRFSLESGTAADR 1579

  Fly  1021 KI---------------VTAWFNNIPLHSAPYALNVVHNAVARHLFDEEATIDVTLAPLP----- 1065
            .:               |..||||...||....|||::|||.|             |.||     
Zfish  1580 FLGSLSTFIRGLDTNNNVKIWFNNKGWHSIGSFLNVMNNAVLR-------------ANLPPGLDR 1631

  Fly  1066 FRTAINTF--------PPSSH----TFGGCLAFGIC--FVLTFIWPAFAIYMITERGSLLKKQQF 1116
            .:..||.|        ...||    |....:...||  |.::|:..:|.:::|.||.:..|..||
Zfish  1632 SKFGINAFNHPLNLTKEQLSHVALMTTSVDVLVSICVIFAMSFVPASFVVFLIQERVNKAKHMQF 1696

  Fly  1117 LAGVRVCSYWTFTVLYDLLFLLIFCACVVVMVALYENPNHDVMLYGYISVT--------LMLGGF 1173
            ::||:...||....::|:...::....|:::...::..       .|:|.|        |:|.|:
Zfish  1697 ISGVQPFLYWLANFVWDMCNYIVPATLVIIIFVCFQQE-------AYVSSTNLPVLALLLLLYGW 1754

  Fly  1174 WVILLAYLMASLCRNPCYGFLWLCGIN-SIGLVCFSQFYRTHPESMLLEPTFMAMYTVATVICKL 1237
            .:..|.|..:...:.|...::.|..:| .||:                      ..:|:|.:.:|
Zfish  1755 SITPLMYPASFFFKIPSTAYVVLTSVNILIGI----------------------NGSVSTFVLEL 1797

  Fly  1238 FMIYE--------------FKLICMDPVVNFTSVEVFKCNSIPNCCIKSNYGTFTAGIYHDLVIL 1288
            |...|              |...|:...:    :::.|..::.:...:.....|.:.:..|:|..
Zfish  1798 FGSNEIGGINDILKNVFLIFPHFCLGRGL----IDMVKNQAMADALERFGENRFRSPLAWDMVGK 1858

  Fly  1289 TLLDIILLACLFVSEYHSILGFADC----RLDTRT----NESPD-SNQESRAFPGILSNDTAALV 1344
            .|..:.:...:|.| ...::.:..|    .|.|:.    .|..| :.:..|...|  ...|..|.
Zfish  1859 NLFAMAIEGVIFFS-ITVLIQYRFCIKARSLSTKLKPIGEEDEDVARERQRILGG--GGQTDILE 1920

  Fly  1345 DKEHTSRLNEEERSKYAAVGIGIVSKYRRNRVLRDLDFTLAKSECLSITGANNSGKTTLLKVVVN 1409
            .::.|.....:::.....:.:||                 ...||..:.|.|.:|||:..|::..
Zfish  1921 LRQLTKVYKRKQKPAVDRLCVGI-----------------PPGECFGLLGVNGAGKTSTFKMLTG 1968

  Fly  1410 ETKMNAGQLWIHDYSVNTHRVQCYRMVGYCPQKDSLPSEFTPRELLYIHAMLQGHRHRIGRELSE 1474
            ::.:.:|:.::...||.|...:.::.:|||||.|::....|.||.|..:|:|:|...:...::::
Zfish  1969 DSVVTSGEAYLAGNSVLTEIDEVHQNMGYCPQFDAINDLLTGREHLEFYAILRGVPEKEVCKVAD 2033

  Fly  1475 ALLRLVGLTPCWNRSVRMCTTGQIRRLYFAYAVLGSPDLICVDGVPAGLDPTGKRIILMMTSTMQ 1539
            ..:|.:||....:::....:.|.:|:|..|.|::|.|.::.:|....|:||..:|.:.....::.
Zfish  2034 WGIRKLGLMKYVDKAAGSYSGGNMRKLSTAMALIGGPPVVFLDEPTTGMDPKARRALWNCILSII 2098

  Fly  1540 AMGSSFLYTMLTGLDAERLSLRTPLLLEGQLWMIRPMDTETENYKSGYQLEVRFKRKVNPNVSMS 1604
            ..|.|.:.|..:..:.|.|..|..:::.|:...:..:......:..||.:.:|. ...:|.:   
Zfish  2099 KEGRSVVLTSHSMEECEALCTRMAIMVNGRFRCLGSVQHLKNKFGDGYTIILRV-AGADPRL--- 2159

  Fly  1605 RATWNLINHFPMSPNKKFSAFMEIKFPDAVLTIERDDSMVFVLPLGTTTFSEIFLTLRKDAFEMN 1669
                           :....|:|.:.|.:.|..:..:.:.:.|....|:.:.||..|.|:..:::
Zfish  2160 ---------------EPVMEFIERELPGSTLKEKHRNMLQYQLSSSLTSLARIFNILSKNKEQLH 2209

  Fly  1670 IEDYFITRNML-VGFQIFTYDQHQDN 1694
            ||||.:::..| ..|..|..||..::
Zfish  2210 IEDYSVSQTTLDQVFVNFAKDQSDED 2235

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG1494NP_608444.2 rim_protein <223..1689 CDD:130324 358/1783 (20%)
ABC_subfamily_A 541..761 CDD:213230 67/219 (31%)
abca1aNP_001296394.1 rim_protein 1..2233 CDD:130324 406/2037 (20%)

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