DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1494 and abch1

DIOPT Version :9

Sequence 1:	NP_001259763.1	Gene:	CG1494 / 33102	FlyBaseID:	FBgn0031169	Length:	1695	Species:	Drosophila melanogaster
Sequence 2:	XP_021328839.1	Gene:	abch1 / 558667	ZFINID:	ZDB-GENE-050517-42	Length:	713	Species:	Danio rerio

Alignment Length:	738	Identity:	138/738 - (18%)
Similarity:	254/738 - (34%)	Gaps:	204/738 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   509 HERGDSFTHQGQAIGVNSTKIYEVEPSHRRFKLKIKKLCKRFATNDRPALNLFSWNVYENEVTVL 573
            ||.....|...|....:.|...::|.......:....:|:.:  .....||..:..:.:.::..|
Zfish     7 HEALSGSTEMEQRSLESGTMKTDLEAGSFSAAIHCHDVCRSY--GKLKVLNNLNLTLPQGQIYGL 69

  Fly   574 MGHNGCGKSTLLKILAGLVEPSRGTVMISSHNIQTERKAASMELG--IAF-GHDM---------- 625
            :|.:||||:||||.:.|.::.|||.:.:               ||  .|| ||::
Zfish    70 LGPSGCGKTTLLKCIVGTLKISRGHITV---------------LGKPPAFPGHEVPGKMVGYMPQ 119

  Fly   626 ---LLTGFTVIDYLRFICRVKGLHNNIEIDGQSNYFLNVLQIGGLKTKRIRTLTDRDLCLVSICC 687
               |...||:.:.|.|..|:.||.:. |.:.:.::.::.|.: ..|...::.|:......||:..
Zfish   120 DIALYNEFTISNTLWFFGRIHGLSSK-ETEARMSFLIDFLDL-PQKHSLVKNLSGGQRRRVSLGA 182

  Fly   688 AFVGNSPIILIDDVHSDLDKRTQSLVW-NLINEEKSKRTIILVSNSPALAENIADRMAIMSNGEL 751
            |.:.|..::::|:....:|...::.:| :|:...:..:..|:::.........|:.:.:|.||.|
Zfish   183 ALLQNPKLLILDEPTVGVDPVLRAKIWQHLVEIVRGGQVSIIITTHYIEEARQANTVGLMRNGRL 247

  Fly   752 KCTGTKPFLKNMYGHGYRLTCVKGKNYKRDELFGMMNSYMPNMSIERDIGYKVTFVLENKFEDQF 816
            ...|..                       |.:....|:
Zfish   248 LAEGPP-----------------------DAVMKQHNA--------------------------- 262

  Fly   817 PMLIDDLEENMQQLGVVSFRIRDTSMEEIFLRFGCEDNDQSGAFQSHENAQVLLEEYYSTLAEAN 881
                                   .::|..||:. |||:||||..||.:..  ||:...|..:..:
Zfish   263 -----------------------ATLETAFLQL-CEDSDQSGPKQSPQGR--LLDSSPSPDSMRD 301

  Fly   882 EKGR--------------RTGWKLFFLH-------GRAVIYKRWIAAHRHWIVLIFE----VLAM 921
            |...              :..||:...|       ..|::.|..:...|....|.|:    |:.:
Zfish   302 EIREPILRKSTSEEMPKCKADWKVRARHIIPKWSNIAALMIKTMVRMRRLPGSLCFQFLLPVIQI 366

  Fly   922 ALVAVCTF---SSIFIYGKNYELEPLTFNLSQLHTVDAFVELFSEEEDVKDMHAYYTELL----- 978
            .|:.:|..   .:|.:...|.|..|..|:.|.|.        |.:...:..:...:::..
Zfish   367 CLMCLCIGGDPKNIDVAVVNNESSPSAFSRSLLS--------FLDNTSINQVSLSHSDAFDGIRN 423

  Fly   979 --YWYDAHVATLTKNRHNAYALLTQNQFTAHVNSRYIFGATFDQKIVTAWFNNIPLHSAPYALNV 1041
              ||      .:.:...|..:.||:......|:...:.|.:     |.||.:......|......
Zfish   424 GEYW------GVIEFGENFTSYLTKRMLQPRVSREVVEGGS-----VHAWLDLTNRQIALMLQKK 477

  Fly  1042 VHNAVARHLFDEEATIDVTLA-PLPFRTAI----NTFPPSSHTFGGCLA--FGICFVLTFIWPAF 1099
            :|.|....:.....::...:| |:.|...|    ||...:..|.|..|:  |.:...||
Zfish   478 LHQAFEAFMEKRLGSMSYMVAVPIKFEEPIYGSKNTDFTTFVTPGAVLSITFYLAVGLT------ 536

  Fly  1100 AIYMITERGSLLKKQQFLAGVRVCSYWT---------FTVLYDLLFLLIFCACVVVMVALYENPN 1155
            |:..:.||...|..:.::||  |.|..|         |.:...::.||||...|      :..||
Zfish   537 ALSFVLERKEGLLDRCWVAG--VSSLETMLAHLFSQLFVISVQIILLLIFTLLV------FNIPN 593

  Fly  1156 HD--------VMLYGYISVTLML 1170
            ..        ::|.|...::..|
Zfish   594 EGSLALVISLIVLQGVTGISFGL 616

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1494	NP_001259763.1	ABC2_membrane_3	<263..480	CDD:289468
		CcmA	541..848	CDD:224054	54/323 (17%)
		ABC_subfamily_A	541..761	CDD:213230	50/236 (21%)
		ABC2_membrane_3	911..>1189	CDD:289468	58/298 (19%)
		ABC2_membrane	<1080..>1188	CDD:304374	25/110 (23%)
		ABC_subfamily_A	1370..1577	CDD:213230
		PRK14255	1371..1586	CDD:172743
abch1	XP_021328839.1	CcmA	38..>261	CDD:224054	51/264 (19%)
abch1	XP_021328839.1	ABC2_membrane_3	352..705	CDD:315386	58/298 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900