DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1494 and snu

DIOPT Version :9

Sequence 1:	NP_001259763.1	Gene:	CG1494 / 33102	FlyBaseID:	FBgn0031169	Length:	1695	Species:	Drosophila melanogaster
Sequence 2:	NP_651628.1	Gene:	snu / 43391	FlyBaseID:	FBgn0039594	Length:	808	Species:	Drosophila melanogaster

Alignment Length:	876	Identity:	164/876 - (18%)
Similarity:	305/876 - (34%)	Gaps:	272/876 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   441 HITWEDSGYRL---------NYDGGHITVTASSWIFMLNALVYCAIGLYVDMWRGGDRSGKKMKK 496
            |.:|.|....:         |.|||......::|                    |...:|.:
  Fly    27 HFSWSDPSAIISTDSAMAATNNDGGTQPNAVAAW--------------------GAPANGPR--- 68

  Fly   497 PNTNASVQEDPYHERGDSFTHQGQAIGVNSTKIYEVEPSHRRFKLKIKKLCKRFATNDRPALNLF 561
             ||.|:|          |..|..:|.|                    ||      .|....||..
  Fly    69 -NTQAAV----------SVRHAFKAYG--------------------KK------KNANQVLNNL 96

  Fly   562 SWNVYENEVTVLMGHNGCGKSTLLKILAGLVEPSRGTVMISSHNIQTE------RKAASMELGIA 620
            :..|.:..:..|:|.:||||:|||..:.|......|.:.:......|.      ::...|...||
  Fly    97 NMTVPKGTIYGLLGASGCGKTTLLSCIVGRRYMDAGEIFVLGGKPGTRGSGVPGKRVGYMPQEIA 161

  Fly   621 FGHDMLLTGFTVIDYLRFICRVKGLHNNIEIDGQSNYFLNVLQIGGLKTKRIRTLTDRDLCLVSI 685
                 |...|::.:.:.:...:.|:... ||..:..:.||.|.:...| :.::.|:......||.
  Fly   162 -----LYGEFSIQETMMYFGWIFGMDTK-EILERLQFLLNFLDLPSEK-RLVKNLSGGQQRRVSF 219

  Fly   686 CCAFVGNSPIILIDDVHSDLDKRTQSLVWN-LINEEKS-KRTIILVSNSPALAENIADRMAIMSN 748
            ..|.:.:..::::|:....:|...:..:|| |::..|: ::|:|:.::....|.. |..:.:|.:
  Fly   220 AVALMHDPELLILDEPTVGVDPLLRQSIWNHLVHITKAGQKTVIITTHYIEEARQ-AHTIGLMRS 283

  Fly   749 GELKCTGTKPFLKNMYGHGYRLTCVKGKNYKRDELFGMMN------------SYMPNMSIE-RDI 800
            |.|....:...|.::|      .|:     ..:|:|..::            ::..|:|:. ...
  Fly   284 GHLLAEESPSVLLSIY------KCI-----SLEEVFLKLSRIQSQKGDVTHVNFSNNISLHAMAF 337

  Fly   801 GYKVTFVLENKFEDQFPMLIDDLEENMQQLGVVSFRIRDTSMEEIFLRFGCEDNDQSGAF----- 860
            |.|:                 |...:.|:.|||......:  :|:.:      ||.:|:.
  Fly   338 GSKM-----------------DKPSSSQEGGVVGLNFHQS--KEVLI------NDSNGSIYTLNQ 377

  Fly   861 ----------QSHENAQVLLEEYYSTLAEANEKGRRTGWKLFFLHGRAVIYKRWIAAHRHWIVLI 915
                      .::.|.:...::.||.|.:...||:.          ||::.|..:...|:..|::
  Fly   378 EPYSPPPSRRNNNPNDEESCQDCYSNLCKITSKGKI----------RALLTKNMLRMWRNVGVML 432

  Fly   916 FEVLAMALVAVCTFSSIFIYGKNYELEPLTFNLSQLHTVDAFVELFSEEEDVKDMHAYYTELLYW 980
            | :.|:.::.|..|  ....|:    :|...||:.::               .:|:....|..||
  Fly   433 F-IFALPVMQVILF--CLAIGR----DPQGLNLAIVN---------------GEMNDTVRENCYW 475

  Fly   981 YDA---------HVATLTKNRHNAY------------------ALLTQNQFTAHVNSRYIFG--- 1015
            .|.         :::.|..:....|                  |:.....||....:|...|
  Fly   476 EDGCHFKNLGCRYLSHLNTSVVKTYYEDLDDAKEAVRKGTAWGAVYISENFTDAFIARANLGRDS 540

  Fly  1016 --ATFDQKIVTAWFN------------NIPLHSAPYALNVVHNAVARHLFDEEATIDVTLAPLPF 1066
              .|.|...|..|.:            :|.|....:|:.::....:.....:        .|:.|
  Fly   541 DDETIDSSEVKVWLDMSNQQIGVMLNRDIQLAFRDFAMGLLGQCGSNPKLGD--------VPIQF 597

  Fly  1067 RTAI-NTFPPSSHTFGGCLAFGICFVLTFIWPAFAI---YMITERGSLLKKQQFLAGVRVCSYWT 1127
            |..| .|..||   |...:|.|:...:.| :.|.|:   .:|.||...|..:.::|||.     .
  Fly   598 RDPIYGTMNPS---FTDFVAPGVILTIVF-FLAVALTSSALIIERTEGLLDRSWVAGVS-----P 653

  Fly  1128 FTVLYDLLFLLIFCAC------VVVMVALYENPNHDVMLYGYISVTLMLGGFWVILLAYLMASLC 1186
            |.:|:..:.......|      ::.|:.::...|:..:             ||||:|. |:..:|
  Fly   654 FEILFSHVITQFVVMCGQTTLVLIFMLVVFGVTNNGDL-------------FWVIVLT-LLQGMC 704

  Fly  1187 RNPCYGFL--WLCGI--NSIGLVCFSQFYRT 1213
             ..|:|||  .:|.:  |:|.| ....||.|
  Fly   705 -GMCFGFLISSVCELERNAIQL-ALGSFYPT 733

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1494	NP_001259763.1	ABC2_membrane_3	<263..480	CDD:289468	8/47 (17%)
		CcmA	541..848	CDD:224054	62/327 (19%)
		ABC_subfamily_A	541..761	CDD:213230	47/227 (21%)
		ABC2_membrane_3	911..>1189	CDD:289468	60/331 (18%)
		ABC2_membrane	<1080..>1188	CDD:304374	25/116 (22%)
		ABC_subfamily_A	1370..1577	CDD:213230
		PRK14255	1371..1586	CDD:172743
snu	NP_651628.1	LolD	73..290	CDD:224059	52/260 (20%)
		ABC_DR_subfamily_A	74..286	CDD:213197	51/255 (20%)
		pip_yhgE_Nterm	427..>474	CDD:276270	11/68 (16%)
		ABC2_membrane_3	429..801	CDD:289468	71/360 (20%)
		ABC2_membrane	601..769	CDD:279410	40/158 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810