DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1494 and Abca17

DIOPT Version :9

Sequence 1:	NP_001259763.1	Gene:	CG1494 / 33102	FlyBaseID:	FBgn0031169	Length:	1695	Species:	Drosophila melanogaster
Sequence 2:	NP_001026792.2	Gene:	Abca17 / 381072	MGIID:	3625331	Length:	1733	Species:	Mus musculus

Alignment Length:	1810	Identity:	413/1810 - (22%)
Similarity:	753/1810 - (41%)	Gaps:	285/1810 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 IRKFLLMNWKNHKLQLANPLELLVILLVPPLFTLVAVLMRFFIPVNHRSDTVYDPIDLDRSWMQM 71
            ::|..|:.|||..|:....|..|:.:|:|.||..:.:.:|.......:|.|.|..:|:....:..
Mouse     4 LKKLKLLLWKNFILKRRKTLITLLEMLMPLLFCAIVLYLRLNSMPRKKSSTNYPAVDVSLLPVYF 68

  Fly    72 VEKLEKARQVADTYNVKGNPFTPHLVIGWAPKRYGIFQAMMRRVQKQIEPMTSVGFEDCEEMRES 136
                         ||.   |......:.:.|.:    ...::.|.:.:|...:|.||
Mouse    69 -------------YNY---PLKSKFQLAYIPSK----SETLKAVTEVVEQTFAVDFE-------- 105

  Fly   137 VIENGLFAGLCFDGSPFVEDQ--------------VFEEDTLESYSNIQPMLNYTILLP------ 181
                    .|.|...|..||.              :|..|...|...:..::.|.:...
Mouse   106 --------VLGFPSVPLFEDYIIKDPKSFYILVGIIFHHDFNSSNEPLPLVVKYDLRFSYVQRNF 162

  Fly   182 -SELRMLDGDFRMANWMTLYNDDPNTFVLTRLNQPYEGGFVGYVREGFIRLQKSVSESFL----- 240
             |..|.|.....:..|.|.:...||.....|.....:||..||.:|||:.:|.:|.::.:
Mouse   163 VSPPRHLFFQEEIEGWCTAFLYPPNLSQAPREFSYADGGNPGYNKEGFLAIQHAVDKAIMRHHAP 227

  Fly   241 --VLTSHKSLPTIQIRRFPITGREQDPLMGNLNYGMPFIIIIGFLFPAQLFVWQVVSEKQSQVRQ 303
              .|...|.|..: ::|||.....|||.:..|....|.::::.|:....:....|:|||:.:.::
Mouse   228 KAALNMFKDLHVL-VQRFPFGPHIQDPFLVILQNEFPLLLMLSFICVELIITNSVLSEKERKQKE 291

  Fly   304 FLINMNIGNLIHFVSWYLKGLIYEMISSLIIAALLKIRWDQDHGVLTQTPWYILILVLFCYNCAA 368
            ::..|.:.:.:|:|:|::...|...|:..::..|...:.::........|..|.|. |.|:..|.
Mouse   292 YMSMMGVESWLHWVAWFITFFISVSITVSVMTVLFCTKINRVAVFRNSNPTLIFIF-LMCFAIAT 355

  Fly   369 VAFAIMVAAFFRNALNAVRVLTILWIMSYVPTFILSNNLEGNIHALRYVSYALPNVVATLVIEF- 432
            :.||.|::.||:.|.....:...::..:|:|...::.:.....:..:.:|....||.....:.|
Mouse   356 IFFAFMMSTFFQRAHVGTVIGGTVFFFTYLPYMYITFSYHQRTYTQKILSCLFSNVAMATGVRFI 420

  Fly   433 -LIERESIVHITWEDSGYRLNYDGGHITVTASSW----------IFMLNALVYCAIGLYVDMWRG 486
             |.|.|. ..|.|.:.|              |.|          :.:|::.:||.|...|:
Mouse   421 SLFEAEG-TGIQWRNIG--------------SVWGDFSFAQVLGMLLLDSFLYCLIAFLVE---- 466

  Fly   487 GDRSGKKM----------KKPNTNASVQEDPYHERGDSFTHQGQAIGVNSTKIYEVEPSHRRFKL 541
             ....:|.          |||     |.|.|      ...:.|.....:.....:.||:::...:
Mouse   467 -SLFPRKFGIPKSWYIFAKKP-----VPEIP------PLLNIGDPEKPSKGNFMQDEPTNQMNTI 519

  Fly   542 KIKKLCKRF--ATNDRPALNLFSWNVYENEVTVLMGHNGCGKSTLLKILAGLVEPSRGTVMISSH 604
            :|:.|.|.|  ..:.|.|:...|.|:|:.:||||:||||.||:|:..:|.||:.||:|...|...
Mouse   520 EIQHLYKVFYSGRSKRTAIRDLSMNLYKGQVTVLLGHNGAGKTTVCSVLTGLITPSKGHAYIHGC 584

  Fly   605 NIQTERKAASMELGIAFGHDMLLTGFTVIDYLRFICRVKGLHNNIEIDGQSNYFLNVLQIGGLKT 669
            .|..:.......||....||:|...|||.|:|.|..::|||... :...|:...|::|   |||.
Mouse   585 EISKDMVQIRKSLGWCPQHDILFDNFTVTDHLYFYGQLKGLSPQ-DCHEQTQEMLHLL---GLKD 645

  Fly   670 K---RIRTLTDRDLCLVSICCAFVGNSPIILIDDVHSDLDKRTQSLVWNLINEEKSKRTIILVSN 731
            |   |.:.|:......:||..|.:..|.::::|:..|.||..::..:|:|:.::|..||::|.::
Mouse   646 KWNSRSKFLSGGMKRKLSIGIALIAGSKVLILDEPTSGLDSPSRRAIWDLLQQQKGDRTVLLTTH 710

  Fly   732 SPALAENIADRMAIMSNGELKCTGTKPFLKNMYGHGYRLTCVKGKNYKRDELFGMMNSYMPNMSI 796
            ....|:.:.||:||::.|||:|.|:..|||..||.||.:|.:|.......:|..::..::||..:
Mouse   711 FMDEADLLGDRIAILAKGELQCCGSPSFLKQKYGAGYYMTIIKTPLCDTSKLSEVIYHHIPNAVL 775

  Fly   797 ERDIGYKVTFVLENKFEDQFPMLIDDLEENMQQLGVVSFRIRDTSMEEIFLRFGCEDNDQSGAFQ 861
            |.:||.::...|..|...:|..|.:|||....:||:.:|....|:|||:|:|. |:..|.|
Mouse   776 ESNIGEEMIVTLPKKTIHRFEALFNDLELRQTELGISTFATSVTTMEEVFIRV-CKLADPS---- 835

  Fly   862 SHENAQVLLEEYYS---------------------TLAEANEKGRR--TGWKLFFLHGRAVIYKR 903
                ..||.|:.:|                     |...:.|:..|  ||:.|......|::.|:
Mouse   836 ----TNVLTEKRHSLHPLPRHHRVPVDRIKCLHSGTFPVSTEQPMRLNTGFCLLCQQFYAMLLKK 896

  Fly   904 WIAAHRHWIVLIFEVLAMALVAVCTFSSIFIYGKNYELEPLTFNLSQLHTVDAFVELFSEEEDVK 968
            ...:.|:| :|:..|..:..:|:...|..|...|..:|:.:...|:........|..|..|....
Mouse   897 ITYSRRNW-MLVLSVQVLLPLAIIMLSLTFFNFKLRKLDNVPLELTLQTYGQTIVPFFIAENSHL 960

  Fly   969 D--MHAYYTELLYWYDAHVATLTKNRHNAYALLTQNQFTAHVNSRYIFGATFD----QKIVTAWF 1027
            |  :...:.::|. ....|....:.....:.|....:.....:..|:..|:|:    ...|.|.|
Mouse   961 DPQLSDDFVKMLV-AAGQVPLRIQGSVEDFLLKKAKEAPEGFDKLYVVAASFEDVNNHTTVKALF 1024

  Fly  1028 NNIPLHSAPYALNVVHNAVARHLFDEEATIDVTLAPLPFRTAINTFP------PSSHTFGGCLAF 1086
            ||...||...||.:|.|.:.:.|....|:|..|..|.| :|||....      |..|.......|
Mouse  1025 NNQAYHSPSLALTLVDNLLFKLLSGANASITTTNYPQP-QTAIEVSESILYQGPKGHYLVVNFLF 1088

  Fly  1087 GICFVLTFIWPAFAIYMITERGSLLKKQQFLAGVRVCSYWTFTVLYDLLFLLIFCACVVVMVALY 1151
            ||.|:.:    :|:|..:.|:....|..||::||....:|...:|:||:..|:....:|::...|
Mouse  1089 GIAFLSS----SFSILTVGEKSVKSKSLQFVSGVSTAVFWLSALLWDLISFLVPTLLLVLVFLWY 1149

  Fly  1152 EN---PNHDVMLYGYISVTLMLGGFWVILLAYLMASLCRNPCYGFLWLCGINSIGLVCFSQFYRT 1213
            :.   .:|:.:  ..:.:.:||.|:.||.|.|.::.....|        |...:.||....|...
Mouse  1150 KEEAFAHHESI--PAVVLIMMLYGWAVIPLVYTVSFSFNTP--------GSACVKLVVMLTFLSI 1204

  Fly  1214 HPESML----------------LEPTFMAM--YTVATVICKLFMIYEFKLICMDPVVNFTSVEVF 1260
            .|..::                |:..|:.:  :.:...:..|:..:|.|..|  ...|.:.::
Mouse  1205 SPVVLVTVTSEKDLGYTELSDSLDHIFLILPGHCLGMALSNLYYNFELKKFC--SAKNLSDID-- 1265

  Fly  1261 KCNSI-PNCCIKSN-YGTFTAGIYHDLVILTLLDIILLACLFVSEYHS-------ILGFADCRLD 1316
             ||.: ....::.| |...:.||...|..|.:|..:.:..||::|.::       :.||
Mouse  1266 -CNDVLEGYVVQENIYAWESLGIGKYLTALAVLGPVYITMLFLTEANAFYVLKSRLSGF------ 1323

  Fly  1317 TRTNESPDSNQESRAFPGILSNDTAALVD---KEHTSRLNEEERSK-YA-------AVGIGIVSK 1370
                           ||......:..:.|   .|....|.|.|..| |.       .:.:..|||
Mouse  1324 ---------------FPSFWKEKSGMIFDVAEPEDEDVLEEAETIKRYLETLVKKNPLVVKEVSK 1373

  Fly  1371 YRRNRV----LRDLDFTLAKSECLSITGANNSGKTTLLKVVVNETKMNAGQLWIHDYSVNTHRVQ 1431
            ..:::|    :..:.|.:.:.||..:.|.|.:|||::..::.:|..:.:|..::..:::.:...:
Mouse  1374 VYKDKVPLLAVNKVSFVVKEEECFGLLGLNGAGKTSIFNMLTSEQPITSGDAFVKGFNIKSDIAK 1438

  Fly  1432 CYRMVGYCPQKDSLPSEFTPRELLYIHAMLQG----HRHRIGRELSEALLRLVGLTPCWNRSVRM 1492
            ..:.:||||:.|:|.:..|.||:|.::|.::|    |.......:.|.||..|    |.::.|:.
Mouse  1439 VRQWIGYCPEFDALLNFMTGREMLVMYARIRGIPECHIKACVDLILENLLMCV----CADKLVKT 1499

  Fly  1493 CTTGQIRRLYFAYAVLGSPDLICVDGVPAGLDPTGKRIILMMTSTMQAMGSSFLYTMLTGLDAER 1557
            .:.|..|.|....|::|.|.:|.:|....|:||..:|::......::..|.:.:.|..:..:.|.
Mouse  1500 YSGGNKRMLSTGIALVGEPAVILLDEPSTGMDPVARRLLWDTVERVRESGKTIVITSHSMEECEA 1564

  Fly  1558 LSLRTPLLLEGQLWMIRPMDTETENYKSGYQLEVRFKRKVNPNVSMSRATWNLINHFPMSPNKKF 1622
            |..|..::::||...:.........:...|.|:.:.:||           |.      ....::|
Mouse  1565 LCTRLAIMVQGQFKCLGSPQHLKSKFGISYSLQAKVRRK-----------WQ------QQMLEEF 1612

  Fly  1623 SAFMEIKFPDAVLTIERDDSMVFVLPLGTTTFSEIFLTLRKDAFEMNIEDYFITR 1677
            .||:::.||.:.|..|..:.:.:.||....:::::|..:.:...:..:|||.|::
Mouse  1613 KAFVDLTFPGSNLEDEHQNMLQYYLPGPNLSWAKVFSIMEQAKKDYMLEDYSISQ 1667

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1494	NP_001259763.1	ABC2_membrane_3	<263..480	CDD:289468	47/228 (21%)
		CcmA	541..848	CDD:224054	105/311 (34%)
		ABC_subfamily_A	541..761	CDD:213230	76/224 (34%)
		ABC2_membrane_3	911..>1189	CDD:289468	68/292 (23%)
		ABC2_membrane	<1080..>1188	CDD:304374	27/110 (25%)
		ABC_subfamily_A	1370..1577	CDD:213230	50/214 (23%)
		PRK14255	1371..1586	CDD:172743	49/222 (22%)
Abca17	NP_001026792.2	rim_protein	<209..1684	CDD:130324	365/1569 (23%)
Abca17	NP_001026792.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1681..1733
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838413
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19229
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X215
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.850