Protein Alignment CG1494 and Abca6

DIOPT Version :9

• Sequence 1: NP_001259763.1
• Gene: CG1494 / 33102
• FlyBaseID: FBgn0031169
• Length: 1695
• Species: Drosophila melanogaster
• Sequence 2: XP_006247716.1
• Gene: Abca6 / 303639
• RGDID: 1308998
• Length: 1630
• Species: Rattus norvegicus
• Alignment Length: 1845
• Identity: 384/1845 - (20%)
• Similarity: 725/1845 - (39%)
• Gaps: 440/1845 - (23%)

  Fly     4 RSYIRKFLLMNWKNHKLQLANPLELLVILLVPPLFTLVAVLMRFFIPVNHRSDTVYDPIDLDRSW 68
            |..:.|.||..|:..:       |.|:...:|.:..|...|..:|...|...:.  .|.||..
  Rat    17 RVLLHKNLLKKWRMKR-------ESLLEWSIPVVIGLYMGLFSYFKENNQVPEV--PPQDLGS-- 70

  Fly    69 MQMVEKLEKARQVADTYNVKGNPFTPHLVIGWAPKRYGIFQAMMRRVQKQIEPMTS-----VGFE 128
                         .|.:|...      :::.:.|    |.....:.:.|.|...|.     ||..
  Rat    71 -------------IDEFNGSS------IMVVYTP----ISNVTQQIMNKTITAPTMKGTRIVGVP 112

  Fly   129 DCEEMRESVIENGLFA-GLCFDGSPFVEDQVFEEDTLESYSNIQPMLNYTILLPSELRMLDGDFR 192
            ..:::.|.::::...| |:.|:.:.|.:.:|:     ..|.|  |.|...:|...
  Rat   113 SEKDLDEMLLDHVPRAFGIVFNDTFFYKLKVY-----LMYGN--PFLKEDLLAHC---------- 160

  Fly   193 MANWMTLYNDDPNTFV-LTRLNQPYEGGFVGYVREGFIRLQKSVSESFL-VLTSH------KSLP 249
               |.|.    |:.|. |||           |.:.||:.||.:::.:.: |.|.|      .|:.
  Rat   161 ---WDTY----PHVFCSLTR-----------YWKRGFVALQTAINAAIIEVTTKHPVMEELMSVN 207

  Fly   250 TIQIRRFPITGREQDPLMGNLNYGMPFIIIIGFLFPAQL-FVWQVVSEKQSQVRQFLINMNIGNL 313
            ...::..|...::      ...|.: ||:.....|.:.: |..:.|::::...::|:..|.:.:.
  Rat   208 AFNMKTLPFISKD------IFQYEI-FILFCLLYFSSFIYFASRSVTKERKHSKEFMKVMGLQDS 265

  Fly   314 IHFVSWYLKGLIYE---MISSLIIAALLKIRWDQDHGVLTQTPWYILILVLFCYNCAAVAFAIMV 375
            ..::||   ||||.   .|.|:.||.::     ....::..|.:.::..:.|.|..:.:|...::
  Rat   266 AFWLSW---GLIYVGFIFIFSVFIAVII-----TSTRIIVMTGFLVIFTLFFLYGLSVIAVTFLM 322

  Fly   376 AAFFRNAL--NAVRVL----------TIL---------WIMSYVPTFILSNNLEGNIHALRYVSY 419
            |...:.|:  |....|          |:|         |::|....|..::.:...|    ::.|
  Rat   323 AVLLQKAIITNLFVFLFNLFWGCVGFTVLHKELPSSLEWVLSICSPFAFTSGMTKII----FLEY 383

  Fly   420 ALPNVVATLVIEFLIERESIVHITWEDSGYRLNYDGGHITVTASSWIFMLNALVYCAIGLYVD-- 482
            .|..||                  :.|.      .|....:.|..:|...:.|:|..:.||.|
  Rat   384 NLNGVV------------------FPDP------SGESYVMIAVFFILAFDGLLYLVLALYFDKI 424

  Fly   483 MWRGGDR------------------SGKKMKKPNTNASVQEDPYHERGDSFTHQG-QAIGVNSTK 528
            :..|.||                  |..|:.:.:.:..:..|.|.|..|. .:|| :||.:.:.:
  Rat   425 LPCGADRRAAPLFFLNPVSCFRKRTSRNKVTERDIDPELPSDEYFEPVDP-EYQGKEAIRIRNIR 488

  Fly   529 IYEVEPSHRRFKLKIKKLCKRFATNDRPALNLFSWNVYENEVTVLMGHNGCGKSTLLKILAGLVE 593
                    :.:|.|..|:         .||....::|||:::|.::||.|.|||:||.||.||..
  Rat   489 --------KEYKGKSGKV---------EALKGLFFDVYESQITAVLGHGGAGKSSLLNILNGLSV 536

  Fly   594 PSRGTVMISSHNI--QTERKAASMELGIAFGHDMLLTGFTVIDYLRFICRVKGLHNNIEIDGQSN 656
            |:.|...:.:.|:  ..:.|.....:|:...|::.....||.:.|.....:||:... .:..:..
  Rat   537 PTSGLATVYNKNLSEMQDLKEIRKMIGVCPQHNVQFDALTVKENLTLFANIKGIVPQ-SVAQEVQ 600

  Fly   657 YFLNVLQIGGLKTKRIRTLTDRDLCLVSICCAFVGNSPIILIDDVHSDLDKRTQSLVWNLINEEK 721
            ..|:.|.:..::.:....|::.....::...|.:|:..|:|:|:..:.||..::..||..:.|.:
  Rat   601 QILSELDMQTIQDELAEHLSEGQKRKLTFGVAILGDPRILLLDEPTAGLDPFSRQRVWGFLKERR 665

  Fly   722 SKRTIILVSNSPALAENIADRMAIMSNGELKCTGTKPFLKNMYGHGYRLTCVKGKNYKRDELFGM 786
            :.|.|:..:.....|:.:|||..|:|||.|||||:..|||..:|.||.|:....:....::|...
  Rat   666 ADRVILFSTQFTDEADILADRKVILSNGALKCTGSSVFLKRKWGLGYHLSLFMNETCDSEQLTSF 730

  Fly   787 MNSYMPNMSIERDIGYKVTFVLENKFEDQFPMLIDDLEENMQQLGVVSFRIRDTSMEEIFLRFGC 851
            :|.::|...::.....|:.:.|..:...:||....||::...| |::::.:..:::.|:|:..
  Rat   731 INHHIPGAKLKAKTKEKLVYTLPLEKTSKFPEFFSDLDKYSGQ-GLMNYEVSMSTLNEVFMNL-- 792

  Fly   852 EDNDQSGAFQSHENAQVLLEEYYSTLAEAN------EKGRRT--GWKLFFLHGRAVIYKRWIAAH 908
              ..:....|..|..:.|.:.  .:|.|..      .|.::|  ...|:.:...|:...|.:...
  Rat   793 --EGEPSTTQDFEKGETLTDS--DSLNEMEVAPPSLSKAQKTMSAMSLWRMQVCAIARLRVLKLR 853

  Fly   909 RH--------------WIVLIFEVLAMALVAVCTFSSIFIYGKNYELEPLTFNLS--QL------ 951
            |.              .|.||.|.:|.||:.|.|         |:|.:...:.||  ||
  Rat   854 RERKAFLTFLPLLGISLIPLITEYMANALIEVKT---------NWEFKTDLYFLSPGQLPQGLRT 909

  Fly   952 ---------HTVDAFVE------LFSEEEDVKDMHAYYTELLYWYDAHVATLTKNRHNAYALLTQ 1001
                     ..::.||:      :..|.:|.::.:|  ||.|.:   :.|.:...|...|
  Rat   910 SLLVINNTESNIEDFVQSLKHQNIVLEVDDFENRNA--TESLSY---NGAIIVSGRQKDY----- 964

  Fly  1002 NQFTAHVNSRYIFGATFDQKIVTAWFNNIPLHSAPYALNVVHNAVAR------HLFDEEATIDVT 1060
             :|:|..|::                   .||..|..:||:.|.:.|      |:..||..:...
  Rat   965 -RFSAVCNTK-------------------RLHCFPILMNVISNGILRMLNHTQHIRLEEDVLSSG 1009

  Fly  1061 LAPLPFRTAINTFPPSSHTFGGCL--AFGICFVLTFIWPAFAIYMITERGSLLKKQQFLAGVRVC 1123
            :..:.|               |.|  :..|.|::..:.|..|:..|::.......|.:::|:...
  Rat  1010 IVVVWF---------------GILEASLSILFIVCSVSPHIAMSSISDFKKKADSQLWISGLYPS 1059

  Fly  1124 SYWTFTVLYDLLFLLIFCACVVVMVALYENPNHDVMLYGYISVTLMLGGFW----VILLAYLMAS 1184
            :||....|.|:  .|:....:...:.||......:.|.|.|.::::|..|.    ::.|.|:::
  Rat  1060 AYWCGQALVDI--TLLSGILLTGYITLYTTKLMHIYLTGEIVLSIVLLAFGCAASLVFLTYVIS- 1121

  Fly  1185 LCRNPCYGFLWLCGINSIGL--VCFSQFYRTHPESMLLEPTFMAMYTVATVICKLFMIYEFKLIC 1247
                    |::.....:.||  :||........:::|::|     :..|.:|..:.::..|.|..
  Rat  1122 --------FVFGKKRKNSGLWSICFFIVITIMFDTVLMDP-----FNEALLISAMMLVPSFSLNA 1173

  Fly  1248 MDPVVNFTSVEVFKCNSIPNCCIKSNYGTFTAGIYHDLVIL------TLLDIILLACL------F 1300
            :..|:...:.:.::...      :|.||  .:|:  ||::.      |||.|.:|.||      .
  Rat  1174 LLIVLEMRAYQYYREFG------ESKYG--LSGV--DLLLCLIPYFHTLLFIFVLRCLELKYGKN 1228

  Fly  1301 VSEYHSILGFADCRLDTRTN-ESP-DSNQESRA----------------FPGILSNDTAALVDKE 1347
            |.....:...|...|..:.| |.| |.:::.:|                .|.|:    |:.:.||
  Rat  1229 VVRKDPLFRIAPQSLHVQPNPEEPVDEDEDVQAERMRTSDALSTVNLDEKPAII----ASCLHKE 1289

  Fly  1348 HTSRLNEEERSKYAAVGIGIVSKYRRNRVLRDLDFTLAKSECLSITGANNSGKTTLLKVVVNETK 1412
            :|.      :.|:..      ||.|:...:|::.|.:.|.|.|.:.|...:||::.|:::....|
  Rat  1290 YTG------QKKWCC------SKRRKKIAVRNISFCVNKGEILGLLGPEGAGKSSSLRMIAGIMK 1342

  Fly  1413 MNAGQLWIHDY-SVNTHRVQCY--RMVGYCPQKDSLPSEFTPRELLYIHAMLQGHRHRIGRELSE 1474
            ..||::.:.:. |...|:.:.:  ..:|||||::.|....|.:|.|.::|.::|.|.   ::...
  Rat  1343 PTAGEVELKELSSAVAHQGEGHGAAKLGYCPQENVLWPILTVKEHLEVYAAVKGLRK---KDAVI 1404

  Fly  1475 ALLRLVG---LTPCWNRSVRMCTTGQIRRLYFAYAVLGSPDLICVDGVPAGLDPTGKRIILMMTS 1536
            |:.|||.   |....|...|....|..|:|.||.::||:..::.:|....|||.:||:   .|..
  Rat  1405 AISRLVNAFKLHDQLNVQARNLVVGLTRKLCFALSILGNSPVLILDEPSTGLDVSGKQ---QMWQ 1466

  Fly  1537 TMQAM----GSSFLYTMLTGLDAERLSLRTPLLLEGQLWMIRPMDTETENYKSGYQLEVRFKR-- 1595
            .:||.    ....|.:.....:||.|..|..:::.|:|.:|..:......:...|.||:|.|.
  Rat  1467 AIQAAVKDNKKGVLLSTHDLAEAEALCDRAAIMVSGRLRLIGSIQHLKRRFGKDYILELRVKEIS 1531

  Fly  1596 ----------KVNPNVSMSRATWNLINH-------FPMSPNKKFSAFMEIKFPDAVLTIER---- 1639
                      ::.|..:.....::|:.:       .|:|     .||.:::      .::|
  Rat  1532 QEPLVHKEILRLFPQAARQDRCFSLLTYKLPVTDVHPLS-----QAFHKLE------AVKRGFNL 1585

  Fly  1640 DDSMVFVLPLGTTTFSEIFLTLRKD 1664
            ||     ..|...|...:||.|.|:
  Rat  1586 DD-----YSLSQCTLDRVFLELSKE 1605

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG1494	NP_001259763.1	ABC2_membrane_3	<263..480	CDD:289468	42/241 (17%)
		CcmA	541..848	CDD:224054	79/308 (26%)
		ABC_subfamily_A	541..761	CDD:213230	60/221 (27%)
		ABC2_membrane_3	911..>1189	CDD:289468	63/312 (20%)
		ABC2_membrane	<1080..>1188	CDD:304374	23/113 (20%)
		ABC_subfamily_A	1370..1577	CDD:213230	59/216 (27%)
		PRK14255	1371..1586	CDD:172743	58/224 (26%)
Abca6	XP_006247716.1	ABC2_membrane_3	35..420	CDD:289468	88/489 (18%)
		ABC2_membrane_4	220..409	CDD:289500	40/231 (17%)
		CcmA	480..795	CDD:224054	82/337 (24%)
		ABC_subfamily_A	482..705	CDD:213230	62/240 (26%)
		ABC2_membrane_3	859..1171	CDD:289468	73/381 (19%)
		ABC2_membrane_4	1007..1178	CDD:289500	35/201 (17%)
		CcmA	1279..1605	CDD:224054	86/363 (24%)
		ABC_subfamily_A	1300..1514	CDD:213230	59/219 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166342235
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.750