Protein Alignment CG1494 and Abca7

DIOPT Version :10

• Sequence 1: NP_608444.2
• Gene: CG1494 / 33102
• FlyBaseID: FBgn0031169
• Length: 1695
• Species: Drosophila melanogaster
• Sequence 2: NP_997481.2
• Gene: Abca7 / 299609
• RGDID: 1303134
• Length: 2170
• Species: Rattus norvegicus
• Alignment Length: 2028
• Identity: 408/2028 - (20%)
• Similarity: 752/2028 - (37%)
• Gaps: 533/2028 - (26%)

  Fly     5 SYIRKFLL-MNWKNHKLQLANPLELLVILLVPPLF------TLVAVLMRFFIPVNHRSDTVYDPI 62
            ::.||.:. :|....:|.|...|..|..:|.|.:|      |.||:|.:.              :
  Rat   299 NFTRKLMAQVNQTFEELALLRDLHELWGVLGPQIFNFMNDSTNVAMLQKL--------------L 349

  Fly    63 DLD-RSWMQMVEK----LEKARQVADTYNVKGNPFTPHLVIGWAPKRYG-IFQAMMRRVQKQIEP 121
            |:: ..|.|...|    ||..|...|....:.|....|..:|...:..| |.:.:      .::.
  Rat   350 DVEGTGWQQQTPKGQKQLEAIRDFLDPSRGRYNWQEAHADMGRLAEILGQILECV------SLDK 408

  Fly   122 MTSVGFEDCEEMR--ESVIENGLFAGLCFDGSPFVEDQVFEEDTLESYSNIQPMLNYTILLPSEL 184
            :.:|..|:....|  |.:.|..|:||:.|         :..|..|:|.....|.......|..::
  Rat   409 LEAVPSEEALVSRALELLGERRLWAGIVF---------LSPEHPLDSSEPPSPTTTGPGHLRVKI 464

  Fly   185 RMLDGDFRMANWM--TLYNDDPNTFVLTRLNQPYEGGFVGYVREGFIRLQKSVSESFL-VLTSHK 246
            ||...|....|.:  ..::..|:...|..|.         ||..||:.||..:.::.: ||:...
  Rat   465 RMDIDDVTRTNKIRDKFWDPGPSADPLMDLR---------YVWGGFVYLQDLLEQAAVRVLSGRD 520

  Fly   247 SLPTIQIRRFPITGREQDPLMGNLNYGMPFIIIIGFLFPAQLFVWQVVSEKQSQVRQFLINMNIG 311
            |...:.:::.|......|..:..|:..:|..:.:.:::...|.|..||.||::::|:.:..|.:.
  Rat   521 SRAGLYLQQMPHPCYVDDVFLRVLSRSLPLFLTLAWIYSVALTVKAVVREKETRLRETMRAMGLS 585

  Fly   312 NLIHFVSWYLKGLIYEMISSLIIAALLKIRWDQDHGVLTQTPWYILILVLFCYNCAAVAFAIMVA 376
            ..:.::.|:|..|...::|:.::..:||:     ..:|..:...::.|.|..:..|.||.:.:::
  Rat   586 RAVLWLGWFLSCLGPFLVSAALLVLVLKL-----GNILPYSHPVVVFLFLAAFAVATVAQSFLLS 645

  Fly   377 AFFRNALNAVRVLTILWIMSYVPTFILSNNLEGNIHALRYVSYALPNVVAT-----------LVI 430
            |||..|                       ||......|.|.:..||.|:..           |.:
  Rat   646 AFFSRA-----------------------NLAAACGGLAYFALYLPYVLCVAWRERLPLGGLLAV 687

  Fly   431 EFL------IERESIVHITWEDSGYRLNYDGGH------------ITVTASSWIFMLNALVYCAI 477
            ..|      ...||:..:  |:.|     ||..            .::...|...:|:|::|...
  Rat   688 SLLSPVAFGFGCESLALL--EEQG-----DGAQWHNLGTGPAEDVFSLAQVSAFLLLDAVIYGLA 745

  Fly   478 GLYVDM-----------W----RGGDRSGKKMKKPNTNASVQEDPYHERGDSFTHQGQAIGVNST 527
            ..|::.           |    |.....|....|.:..|...:||
  Rat   746 LWYLEAVCPGQYGIPEPWNFPFRRSYWCGPGPPKSSVLAPAPQDP-------------------- 790

  Fly   528 KIYEVEPSHRRFK-LKIKKLCKRFATNDRPALNLFSWNVYENEVTVLMGHNGCGKSTLLKILAGL 591
            |:...||...... :.|:.|.|.|..:.:|||...:.:.||..:|..:||||.||:|.|.||:||
  Rat   791 KVLVEEPPPGLVPGVSIRGLKKHFRGSPQPALRGLNLDFYEGHITAFLGHNGAGKTTTLSILSGL 855

  Fly   592 VEPSRGTVMISSHNIQTERKAASMELGIAFGHDMLLTGFTVIDYLRFICRVKGLHNNIEIDGQSN 656
            ..||.|:..|..|::||...|....|||...:::|....||.:::.|..|:||: :...||.:..
  Rat   856 FPPSSGSASILGHDVQTNMAAIRPHLGICPQYNVLFDMLTVEEHVWFYGRLKGV-SAAAIDSEQE 919

  Fly   657 YFLNVLQIGGLKTKR---IRTLTDRDLCLVSICCAFVGNSPIILIDDVHSDLDKRTQSLVWNLIN 718
            :.:..:   ||..||   .|.|:......:|:..||||.|.::::|:..:.:|..::..:|.|:.
  Rat   920 HLIRDV---GLIPKRDTQTRHLSGGMQRKLSVAIAFVGGSRVVIMDEPTAGVDPASRRGIWELLL 981

  Fly   719 EEKSKRTIILVSNSPALAENIADRMAIMSNGELKCTGTKPFLKNMYGHGYRLTCVKG-------- 775
            :.:..||:||.::....||.:.||:|::::|.|.|.|:..||:...|.||.||.||.
  Rat   982 KYREGRTLILSTHHLDEAELLGDRVAMVASGSLCCCGSPLFLRRHLGCGYYLTLVKSSQSLVTHD 1046

  Fly   776 -----KNYKRDELFG--------------------------------------MMNSYMPNMSIE 797
                 ::.:|::..|                                      ::..::|...:.
  Rat  1047 LKGDTEDPRREKKSGSEGKTADTVLTRDGPHRSSQAPAPDAVPVTPSAALILELVQRHVPGAQLV 1111

  Fly   798 RDIGYKVTFVL--ENKFEDQFPMLIDDLEENMQQLGVVSFRIRDTSMEEIFLRF---------GC 851
            .::.:::...|  ....:..|..:..:|::.:::||:..:.|.||::|||||:.         |.
  Rat  1112 EELPHELVLALPYAGALDGSFATVFQELDQQLERLGLTGYGISDTNLEEIFLKVVEEAHAHGEGG 1176

  Fly   852 EDNDQ---------------SGAFQSHENAQVLLEEYYSTLAEANEKGRRTGWKLFFLHGRAVIY 901
            :...|               :...::.|.|:::|:. .:....|....:..||.|.....||:::
  Rat  1177 DPRQQQHLLTATPQPHTGPEASVLENGELAKLVLDP-QAPKGSAPTTAQVQGWTLTCQQLRALLH 1240

  Fly   902 KRWIAAHRHWIVLIFEVLAMAL-VAVCTFSSIFI--YGK--NYELEPLTFNLSQLHTVDAFVELF 961
            ||::.|.|....|..:::..|| |.:..|.::.:  :|:  ..:|.|..:...        |..|
  Rat  1241 KRFLLARRSRRGLFAQIVLPALFVGLALFFTLIVPPFGQYPPLQLSPAMYGPQ--------VSFF 1297

  Fly   962 SEE---------------------------------EDVKDMHAYYT------------------ 975
            ||:                                 |....:..|:|
  Rat  1298 SEDAPADPNRMKLLEALLGEAGLQDPSVQGKGSRGSECTHSLACYFTVPEVPPDVASILASGNWT 1362

  Fly   976 --------------------------------ELLYWYDAHVATLT-KN---------------- 991
                                            :.:..:...|..|| :|
  Rat  1363 PDSPSPACQCSQPGARRLLPDCPAGAGGPPPPQAMAGFGEVVQNLTGRNVSDFLVKTYPSLVRRG 1427

  Fly   992 ----------RHNAYAL--------------LTQNQFTAHVNSRYIFGATFDQKI---------- 1022
                      |:..::|              .|..:..|.::.:.  |.|.|:.:
  Rat  1428 LKTKKWVDEVRYGGFSLGGRDPDLPSGREVVRTVAEMRALLSPQP--GNTLDRILNNLTQWALGL 1490

  Fly  1023 -----VTAWFNNIPLHSAPYALNVVHNAVARHLFDEEAT------------IDVTLAPLPFRTAI 1070
                 :..||||...|:....:|..:|.:.|......:.            :::|...|...|.|
  Rat  1491 DARNSLKIWFNNKGWHAMVAFVNRANNGLLRAFLPSGSVRHAHSITTLNHPLNLTKEQLSEATLI 1555

  Fly  1071 NTFPPSSHTFGGCLAFGICFVLTFIWPAFAIYMITERGSLLKKQQFLAGVRVCSYWTFTVLYDLL 1135
                  :.:....::..:.|.::|:..:|.:.:|.||.:..|..|.::|:....||....|:|:.
  Rat  1556 ------ASSVDVLVSICVVFAMSFVPASFTLVLIEERITRAKHLQLVSGLPQTLYWLGNFLWDMC 1614

  Fly  1136 FLLIFCACVVVMVAL------YENPNH------DVMLYGYISVTLMLGG---FWVILLAYLMASL 1185
            ..|: ..|:||::.|      |..|.:      .::|||:....||...   |.|...||::.:
  Rat  1615 NYLV-AVCIVVLIFLAFQQKAYVAPENLPALLLLLLLYGWSITPLMYPASFFFSVPSTAYVVLT- 1677

  Fly  1186 CRNPCYGFLWLCGINSIGLVCFSQFYRTHPESMLLEPTFMA-------MYTVATVICKLFMIYEF 1243
            |.|     |:: ||||               ||   .||:.       :..|:.::.::|:|  |
  Rat  1678 CIN-----LFI-GINS---------------SM---ATFVLELLSDQNLQEVSRILKQVFLI--F 1716

  Fly  1244 KLICM-----DPVVNFTSVEVFKCNSIPNCCIKSNYGTFTAGIYHDLVILTLLDII------LLA 1297
            ...|:     |.|.|....:.|:         :.....|.:.:..|::...||.::      ||.
  Rat  1717 PHFCLGRGLIDMVRNQAMADAFE---------RLGDKQFQSPLRWDIIGKNLLAMVAQGPLFLLI 1772

  Fly  1298 CLFVSEYHSILGFADCRLDTRTNESPDS--NQESRAFPGILSNDTAALVDKEHTSRLNEEERSKY 1360
            .|.:...:.:|.....||.....|..:.  .:..|...|....|...|.|
  Rat  1773 TLLLQHRNRLLPQPKSRLPPPLGEEDEDVVRERERVTKGATQGDVLVLRD--------------- 1822

  Fly  1361 AAVGIGIVSKYR--RNRVLRDLDFTLAKSECLSITGANNSGKTTLLKVVVNETKMNAGQLWIHDY 1423
                  :...||  |:..:..|...:...||..:.|.|.:|||:..::|..:|..::|:..:..:
  Rat  1823 ------LTKVYRGQRSPAVDHLCLGIPPGECFGLLGVNGAGKTSTFRMVTGDTLPSSGEAVLAGH 1881

  Fly  1424 SVNTHRVQCYRMVGYCPQKDSLPSEFTPRELLYIHAMLQG-HRHRIGRELSEALLRLVGLTPCWN 1487
            :|.......:|.:|||||.|::....|.||.|.:.|.|:| ...::.:.....|:|| ||....:
  Rat  1882 NVAQEPSAAHRSMGYCPQSDAIFDLLTGREHLELFARLRGVPEAQVAQTALSGLVRL-GLPSYAD 1945

  Fly  1488 RSVRMCTTGQIRRLYFAYAVLGSPDLICVDGVPAGLDPTGKRIILMMTSTMQAMGSSFLYTMLTG 1552
            |.....:.|..|:|..|.|::|.|.::.:|....|:||:.:|.:.....::...|.|.:.|..:.
  Rat  1946 RPAGTYSGGNKRKLATALALVGDPAVVFLDEPTTGMDPSARRFLWNNLLSVVREGRSVVLTSHSM 2010

  Fly  1553 LDAERLSLRTPLLLEGQLWMIRPMDTETENYKSGYQLEVRFKRKVNPNVSMSRATWNLINHFPMS 1617
            .:.|.|..|..:::.|:...:.........:.:|:.|.:|..                    |..
  Rat  2011 EECEALCTRLAIMVNGRFRCLGSAQHLKSRFGAGHTLTLRVP--------------------PDQ 2055

  Fly  1618 PNKKFSAFMEIKFPDAVLTIERDDSMVFVLPL-GTTTFSEIFLTLRKDAFEMNIEDYFITRNMLV 1681
            |.... ||:...||||.|.......:.|.||. |....:.:|..|........:||:.:::..|.
  Rat  2056 PEPAI-AFIVTTFPDAELREVHGSRLRFQLPPGGGCKLARVFRELAAQGKAHGVEDFSVSQTTLE 2119

  Fly  1682 G-FQIFTYDQHQD 1693
            . |..|:.||.::
  Rat  2120 EVFLYFSKDQGEE 2132

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG1494	NP_608444.2	rim_protein	<223..1689	CDD:130324	358/1787 (20%)
		ABC_subfamily_A	541..761	CDD:213230	72/222 (32%)
Abca7	NP_997481.2	rim_protein	1..2127	CDD:130324	406/2021 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1044..1086		2/41 (5%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2129..2170		1/4 (25%)