Protein Alignment CG1494 and Abca5

DIOPT Version :9

• Sequence 1: NP_001259763.1
• Gene: CG1494 / 33102
• FlyBaseID: FBgn0031169
• Length: 1695
• Species: Drosophila melanogaster
• Sequence 2: NP_775429.1
• Gene: Abca5 / 286970
• RGDID: 628661
• Length: 1642
• Species: Rattus norvegicus
• Alignment Length: 1825
• Identity: 378/1825 - (20%)
• Similarity: 710/1825 - (38%)
• Gaps: 447/1825 - (24%)

  Fly    68 WMQMVEKLEKARQVADTYNVKGNP----FTPHLVIGWAPKRYGIFQAMMRRVQKQIEPMTSVGFE 128
            |:.::..:...::..:..:::.:|    ...:|::|:.|.. ....::|:||.....|...|..|
  Rat    45 WLILISMMHPNKKYEEVSDIELSPMDKSILSNLILGYTPVT-NTTSSVMQRVSTDHLPDVLVTEE 108

  Fly   129 DCEE---MRESVIENGLFAGLCFDGSPFVEDQVFEEDTLESYSNIQPMLNYTILLPSELRMLDGD 190
            ...|   :..|:.:...|.|:.|                      :.:::|      |||....
  Rat   109 YASEKELLASSLSKPSNFVGVVF----------------------KDVMSY------ELRFFPD- 144

  Fly   191 FRMANWMTLYNDDPNTFVLTRLNQPYEGGFVGYVREGFIRLQKSVSESFLVLTSHKSL------- 248
              |....::|.|       :|...........|...||..||.|:..:.:.|.::.||
  Rat   145 --MVPVSSVYMD-------SRAGCSKSCDAAQYWSSGFTALQASIDAAIIQLKTNVSLWRELEST 200

  Fly   249 --------PTIQIRRFPITGREQDPLMGNLNYGMPFIIIIGFLFPAQLFV-WQVVSEKQSQVRQF 304
                    ..::|..||              .|:..|.::....|...|: ..:|:||:.::::|
  Rat   201 KAVIMGEAAVVEIDTFP--------------RGVILIYLVIAFSPFGYFLAIHIVAEKEKRLKEF 251

  Fly   305 LINMNIGNLIHFVSWYL--KGLIYEMISSLIIAALLKIRWDQDHGVLTQTPWYILILVLFCYNCA 367
            |..|.:.:...::||.|  ..||:.|  ||::|.:...     ..:..|:...::.|:.|.|..:
  Rat   252 LKIMGLHDTAFWLSWVLLYTSLIFLM--SLLMAVIATA-----SSLFPQSSSIVIFLLFFLYGLS 309

  Fly   368 AVAFAIMVAAFFRNALNAVRVLTILWIMSYVPTFILSNNLEGNIHALRYVSYALPNVVATLV--- 429
            :|.||:|:...|:.:.:       :.::.:..|.:.     |.:..|..:..:.|..:..|.
  Rat   310 SVFFALMLTPLFKKSKH-------VGVVEFFVTVVF-----GFVGLLIVLVESFPRSLVWLFSPL 362

  Fly   430 --IEFLIERESIVHITWEDSG--YRLNYDGGH---ITVTASSWIFMLNALVYCAIGLYVDM---- 483
              ..|||....::|:...:.|  :....:|.:   ||:|    :..|:::.|..:.:|:|.
  Rat   363 CQCAFLIGIAQVMHLEDFNEGALFSSLTEGPYPLIITLT----MLALDSVFYALLAVYLDQVIPG 423

  Fly   484 ----------------WRGGDRSGKKMKKPNTNASVQEDPYHERGDSFTHQGQAIGVNSTKIYEV 532
                            |....|:.|::.:.|.|.::..:...|...|     :.||..:.:|..:
  Rat   424 EFGLRRSSLYFLKPSYWSKNKRNYKELSEGNINGNISLNEIVEPVSS-----EFIGKEAIRISGI 483

  Fly   533 EPSHRRFKLKIKKLCKRFATNDRPALNLFSWNVYENEVTVLMGHNGCGKSTLLKILAGLVEPSRG 597
            :.::|:....::            ||...|:::||.::|.|:||:|.|||||:.||.||..||.|
  Rat   484 QKAYRKKNETVE------------ALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSDG 536

  Fly   598 TVMISSHNIQ--TERKAASMELGIAFGHDMLLTGFTVIDYLRFICRVKGLHNNIEIDGQSNYFLN 660
            ...|..|.:.  .|...|...:||....||.....||.:.|..:..|||:..|..|.......|:
  Rat   537 FASIYGHRVSEIDEMFEARKMIGICPQSDMNFDVLTVEENLSILASVKGIPANNIIQEVQKVLLD 601

  Fly   661 VLQIGGLKTKRIRTLTDRDLCLVSICCAFVGNSPIILIDDVHSDLDKRTQSLVWNLINEEKSKRT 725
             |.:..:|..:.:.|:......:|:..|.:||..|:|:|:..:.:|..::.:||||:...|:.|.
  Rat   602 -LDMQAIKDNQAKKLSGGQKRKLSLGIAVLGNPKILLLDEPTAGMDPCSRHIVWNLLKYRKANRV 665

  Fly   726 IILVSNSPALAENIADRMAIMSNGELKCTGTKPFLKNMYGHGYRLTCVKGKNYKRDELFGMMNSY 790
            .:..::....|:.:|||.|::|.|.|||.|:..|||:.:|.||||:....:....:.|..::..:
  Rat   666 TVFSTHFMDEADILADRKAVISQGMLKCVGSSIFLKSKWGIGYRLSMYIDRYCATESLSSLVRQH 730

  Fly   791 MPNMSI----ERDIGYKVTFVLENKFEDQFPMLIDDLEENMQQLGVVSFRIRDTSMEEIFLRFGC 851
            :|..::    ::.|.|.:.|...:||...|..|  |:..|   |||:|:.:..|::|::||:...
  Rat   731 IPAAALLQQNDQQIVYSLPFKDMDKFSGLFSAL--DIHSN---LGVISYGVSMTTLEDVFLKLEV 790

  Fly   852 -----------------EDNDQSGAFQSHENAQVLLEEYYSTLAEANEKGRR---TGWKLFFLHG 896
                             |:...|.:|...|.:.::|.|..::|.......::   |..|..||.
  Rat   791 EAEIDQADYSVFTQQPREEETDSKSFDEMEQSLLILSETKASLVSTMSLWKQQVSTIAKFHFLS- 854

  Fly   897 RAVIYKRWIAAHRHWIVLIFEVLAMALVAVCTFSSIFIYGKN-----------YELEP------- 943
                .||...:.|..::|:....|:.:.......|.    ||           |.|:|
  Rat   855 ----LKRESKSVRSVLLLLLIFFAVQIFMFLVHHSF----KNAVVPIKLVPDLYFLKPGDKPHKY 911

  Fly   944 LTFNLSQLHTVDAFVELFSEEEDVKDMHAYYTE----LLYWYDAHVATLTKNRHNAYALLTQNQF 1004
            .|..|.|..|          :.|:.|:..::|:    :..:.|:...:...  |:|...:.|::
  Rat   912 KTSLLLQNST----------DSDINDLIDFFTQQNIIVAMFNDSDYVSAAP--HSAALNVVQSE- 963

  Fly  1005 TAHVNSRYIFGATFDQKIVTAWFNNIPLHSAPYALNVVHNAVARHL------------FDEEATI 1057
                 ..|:|         ||.||:..::|.|..:|::.|....||            |.:|.|.
  Rat   964 -----KDYVF---------TAVFNSTMVYSLPVMMNIISNYYLYHLNVTDTIQIWSTPFIQEITD 1014

  Fly  1058 DVTLAPLPFRTAINTFPPSSHTFGGCLAFGICFVLTFIWPAFAIYMITERGSLLKKQQFLAGVRV 1122
            .|....|.|:.|:               .||  ::|.:.|.||:............|..|:|:..
  Rat  1015 IVFKVELYFQAAL---------------LGI--IVTAMPPYFAMENAENHKIKAYTQLKLSGLLP 1062

  Fly  1123 CSYWTFTVLYDL-LFLLIFCACVVVMVALYENPNHDVMLY--GYISVTLMLGGF--WVILLAYLM 1182
            .:||....:.|: ||.::....:..:.|.:    |.:..|  .:::|...|..:  .|||..|:.
  Rat  1063 SAYWIGQAVVDIPLFFVVLTLMLGSLFAFH----HGLYFYPVKFLAVVFCLIAYVPSVILFTYIA 1123

  Fly  1183 A-----SLCRNPCYGFLWLCGINSIGLVCFSQFYRTHPESMLLEPTFMAMYTVATVICKLFMIYE 1242
            :     .|.....:.|::    :...|.|.:          :.|.||...|.|..|....|
  Rat  1124 SFTFKKILNTKEFWSFIY----SVTALACVA----------VTEITFFLGYGVTAVFHYTF---- 1170

  Fly  1243 FKLICMDPVVNFTSVEVFKCNSIP-----NCCIKSNYGTF-----TAGIYHD------LVILTLL 1291
                               |.:||     .|.|....|::     |...|:.      .||:..|
  Rat  1171 -------------------CIAIPIYPLLGCLISFIKGSWKNIPKTENAYNPWDRLLVAVIMPYL 1216

  Fly  1292 DIILLACLFVSEYHSILGFADCRLD-----------------TRTNESPDSNQESRAF------- 1332
            ..:|...| :..|....|....|.|                 ...||..|.:.::...
  Rat  1217 QCVLWIFL-LQHYEKKHGGRSIRKDPLFRALSQKAKHKKFPEPPINEDEDEDVKAERLKVKELMG 1280

  Fly  1333 -------PGILSNDTAALVDKEHTSR---LNEEERSKYAAVGIGIVSKYRRNRVLRDLDFTLAKS 1387
                   |.|:..:    :.||:..:   |:..:.:|       :.:||        :.|.:.|.
  Rat  1281 CQCCEEKPAIMVYN----LHKEYDDKKDFLHSRKTTK-------VATKY--------VSFCVKKG 1326

  Fly  1388 ECLSITGANNSGKTTLLKVVVNETKMNAGQLWIHDYSVNTHR----VQCYRMVGYCPQKDSLPSE 1448
            |.|.:.|.|.:||:|::.::|.:.:..:|::::.||..:::.    .:|   :|||||.:.|..:
  Rat  1327 EILGLLGPNGAGKSTIINILVGDVEPTSGKIFLGDYGSHSNEDDESTKC---MGYCPQTNPLWPD 1388

  Fly  1449 FTPRELLYIHAMLQGHRHRIGRELSEALLRLVGLTPCWNRSVRMCTTGQIRRLYFAYAVLGSPDL 1513
            .|.:|...|:..::|......:|:...:.:.:.|.....::|:....|..|:|.||.::||:|.:
  Rat  1389 ITLQEHFEIYGAVKGMSSGDMKEVISRITKALDLKEHLQKTVKKLPAGIKRKLCFALSMLGNPQV 1453

  Fly  1514 ICVDGVPAGLDPTG---------------KRIILMMTSTMQAMGSSFLYTMLTGLDAERLSLRTP 1563
            ..:|....|:||..               ||..|:.|..|:              :||.:..|..
  Rat  1454 TLLDEPSTGMDPRAKQHMWRAIRTAFKNKKRAALLTTHYME--------------EAEAVCDRVA 1504

  Fly  1564 LLLEGQLWMIRPMDTETENYKSGYQLEVRFKRKVNPNVSMSRATWNLINHFP-MSPNKKFSAFME 1627
            :::.|||..|..:......:..||.||::.|..:. |:.:.|....:...|| .|..:.||:.:.
  Rat  1505 IMVSGQLRCIGTVQHLKSKFGKGYFLEIKLKDWIE-NLEIDRLQREIQYIFPNASRQESFSSILA 1568

  Fly  1628 IKFPDAVLTIERDDSMVFVLPLGTTTFSEIFLTLRKDAFEMNIEDYFITRNMLVGFQIF---TYD 1689
            .|.|       ::|         ..:.|:.|..|.:......||:|..::..|.  |:|   |.:
  Rat  1569 YKIP-------KED---------VQSLSQSFAKLEEAKHTFAIEEYSFSQATLE--QVFVELTKE 1615

  Fly  1690 QHQDN 1694
            |.:::
  Rat  1616 QEEED 1620

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG1494	NP_001259763.1	ABC2_membrane_3	<263..480	CDD:289468	44/229 (19%)
		CcmA	541..848	CDD:224054	93/312 (30%)
		ABC_subfamily_A	541..761	CDD:213230	68/221 (31%)
		ABC2_membrane_3	911..>1189	CDD:289468	62/321 (19%)
		ABC2_membrane	<1080..>1188	CDD:304374	24/117 (21%)
		ABC_subfamily_A	1370..1577	CDD:213230	53/225 (24%)
		PRK14255	1371..1586	CDD:172743	52/233 (22%)
Abca5	NP_775429.1	ABC2_membrane_3	<214..416	CDD:289468	46/238 (19%)
		CcmA	476..788	CDD:224054	96/329 (29%)
		ABC_subfamily_A	478..701	CDD:213230	70/235 (30%)
		ABC2_membrane_3	<957..1224	CDD:289468	66/339 (19%)
		CcmA	1288..1615	CDD:224054	84/381 (22%)
		ABC_subfamily_A	1290..1521	CDD:213230	58/266 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820