DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1494 and Abca13

DIOPT Version :9

Sequence 1:	NP_001259763.1	Gene:	CG1494 / 33102	FlyBaseID:	FBgn0031169	Length:	1695	Species:	Drosophila melanogaster
Sequence 2:	NP_839990.2	Gene:	Abca13 / 268379	MGIID:	2388707	Length:	5034	Species:	Mus musculus

Alignment Length:	1763	Identity:	387/1763 - (21%)
Similarity:	688/1763 - (39%)	Gaps:	388/1763 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   135 ESVIENGLFAGLCFDGSPFVEDQVFEEDTLESYSNIQPMLNYTILLPSELRMLDGDFRMANWMTL 199
            |.:.:|...|.:.|:.|      :.......:...:.|.:.|||.......|.....:..:|
Mouse  3419 ELMQQNSFLASIIFNSS------LRHRHIRSAPHKLPPHVTYTIRTNVLYSMRTDMIKNPSW--- 3474

  Fly   200 YNDDPNTFVLTRLNQPYEGGF-VGYVREGFIRLQKSVSESFLVL-TSHKSL-PTIQIRRFPITGR 261
             ...|.       |.| .||| ..|:   |:.||..:..:.:|: |..:|| ||.|.:..|....
Mouse  3475 -KFHPQ-------NLP-AGGFKYNYI---FVPLQDMIERAIIVVQTGQESLEPTTQAQAAPYPCH 3527

  Fly   262 EQDPLMGNLNYGMPFIIIIGFLFPAQLFVWQVVSEKQSQVRQFLINMNIGNLIHFVSWYLKGLIY 326
            ..|..:.|:.:..|.|:::.::......|.::|.|::.|:.:::..|.:...|||:||:|:.:..
Mouse  3528 TSDLFLNNVGFFFPLIMMLTWMVAVASMVRKLVYEREIQIEEYMRMMGLHPTIHFLSWFLENMAT 3592

  Fly   327 EMISSLIIAALLKIRWDQDHGVLTQTPWYILILVLFCYNCAAVAFAIMVAAFFRNALNAVRVLTI 391
            ..:||..:|.:||:     .|:...:..:|:.|.|..:..:||..:..::.||..|..|....::
Mouse  3593 LALSSAALAVILKM-----SGIFMHSDAFIIFLYLLDFGVSAVMMSYFLSVFFNQANTAALCTSL 3652

  Fly   392 LWIMSYVP---TFILSNNLEGNIHALRYVSYALPNVVATL----------VIEFLIERESIVHIT 443
            .:::|::|   ..:|.|.|          |:|:..::..|          .|.||..:|.  .|.
Mouse  3653 GYMISFLPYVVLLVLHNQL----------SFAIQTLLCLLSTTAFGQGVFFITFLEGQEE--GIQ 3705

  Fly   444 WEDSGYRLNYDGGHITVTASSWIFMLNALVYCAIGLYV-DMWRGGDRSGKKMKKP---------- 497
            |.:. ||....|| :|.....|:.:.:|::|...|.|. ::..|....||....|
Mouse  3706 WGNM-YRAPEPGG-MTFGWVCWMILFDAILYFLGGWYFSNLVPGTFGLGKPWYFPFTASYWKSIC 3768

  Fly   498 ----------------------NTNASVQEDPYHERGDSFTHQGQAIGVNSTKIYEVEPSHRRFK 540
                                  |...|.|..|....|.   :.|.|: ::.||.||   .|   |
Mouse  3769 GLMERRRCSLSSGLFFFNEDFGNKGLSQQNGPGEMEGG---NPGVAL-ISVTKEYE---DH---K 3823

  Fly   541 LKIKKLCKRFATNDRPALNLFSWNVYENEVTVLMGHNGCGKSTLLKILAGLVEPSRGTVMISSHN 605
            :.:::|...|               :.:::|.|:|.||.||:|::.:|.||..|:.||:.|:..|
Mouse  3824 VAVQELTLTF---------------HRDQITALLGTNGAGKTTIISMLMGLFPPTSGTITINGKN 3873

  Fly   606 IQTERKAASMELGIAFGHDMLLTGFTVIDYLRFICRVKG-LHNNIEIDGQSNYFLNVLQI----- 664
            :||:......|||:....|:||...||.::|.....:|. .....|:..|.|..|:.:::
Mouse  3874 LQTDLSKVREELGVCPQQDVLLDNLTVREHLMLFASIKAPWWTTKELQQQVNKTLDEVELTQHQH 3938

  Fly   665 -------GGLKTKRIRTLTDRDLCLVSICCAFVGNSPIILIDDVHSDLDKRTQSLVWNLINEEKS 722
                   ||:|.|            :||..||:|.|..:::|:..|.:|..::..:|:::.:.:.
Mouse  3939 KPAGVLSGGMKRK------------LSIGIAFMGMSKTVVLDEPSSGVDPCSRRSLWDILLKYRE 3991

  Fly   723 KRTIILVSNSPALAENIADRMAIMSNGELKCTGTKPFLKNMYGHGYRLTCVKGKNYKRDE----- 782
            .||||..::....||.::|.:|::..|.|:|......||..||.|..||..|..:....:
Mouse  3992 GRTIIFTTHHLDEAEMLSDHVAVLQQGRLRCYAPPADLKETYGQGLTLTLSKQPSILETQEPKDV 4056

  Fly   783 --LFGMMNSYMPNMSIERDIGYKVTFVLENKFEDQ--FPMLIDDLEENMQQLGVVSFRIRDTSME 843
              :..::..|:|...::...|.::|:.:. |..|:  |..|...|::|:|.|.:..:.|.||::|
Mouse  4057 ARVTSLIQIYIPQAFLKDSCGGELTYTIP-KDADRTCFKGLCQALDQNLQHLHLTGYGISDTTLE 4120

  Fly   844 EIFLRFGCEDNDQSGAFQSHENAQVLLEEYYSTLAEANEKGRRT-----------GWKLFFLHGR 897
            |:||.. .:|.::..........:...|.....|:..|.....|           |.:|......
Mouse  4121 EVFLML-LQDTNKKSYITPDNKVEPQNERPVGPLSPHNVSPLSTPPEGALPEPIGGCQLLLGQAV 4184

  Fly   898 AVIYKRWIAAHRHW--------IVLIFEVLAMALVAV----CTFSSIFIYGKNYELEPLTFNLSQ 950
            |::.||.:...|.|        :.::|..|||.|..|    .|:..:.:...:||.....|..|.
Mouse  4185 ALLRKRLLHTLRAWKSTTSDLLLPVLFVALAMGLFMVQPLAITYPPLKLTPGHYETAETYFFSSG 4249

  Fly   951 LHTVD---AFVELFSEEEDVKDMHAYYTELLYWY---------------------DAHVATLTKN 991
            .|..|   ..:..|.:::.| ...|:......|:                     .|...:||..
Mouse  4250 NHGPDLTHVLLRKFRDQDPV-CADAFRMNSSSWHRDPYSGPESQDSCGCLKCPNKSAGAPSLTNC 4313

  Fly   992 RHNAYALLTQNQFTAHVNSRYI-------------FGATF-----DQKIVTA--------WFNNI 1030
            .  .:.||..:.:..   ..|:             ||...     |.|..|:        |:|..
Mouse  4314 L--GHTLLNLSGYDV---EEYLLVPSAKPRLGGWSFGGQIPNDAEDVKTNTSKPRTLAKVWYNQK 4373

  Fly  1031 PLHSAPYALNVVHNAVARHLFDEEATID-----VTLAPLPFRTAINTFPPSSHTFGGCL------ 1084
            ..||.|..||.::|.:..|.....| :|     :||              .||.:||.|
Mouse  4374 GFHSLPSYLNHLNNLILWHHLPANA-VDWRQYGITL--------------YSHPYGGALLNEDRI 4423

  Fly  1085 -------AFGICFVLTF--IWPAFAIYMITERGSLLKKQQFLAGVRVCSYWTFTVLYDLLFLLI- 1139
                   ...:|.||.|  :..:....::.:|.:..|:.|.::|:...:||....|||:||.|:
Mouse  4424 LESIRQCGVALCIVLGFSILSASIGSSVVRDRVTGAKRLQHISGLGHRTYWLINFLYDMLFYLVS 4488

  Fly  1140 FCACVVVMVALY-------ENPNHDVMLYGYISVTLMLGGFWVILLAYLMASLCRNPCYGFLWLC 1197
            .|.||.|:.|..       ||.....:|       |.|.|:.:|...|||:.:..:....|:...
Mouse  4489 VCLCVAVIGAFQLTAFTFRENLAATALL-------LALFGYAMIPWMYLMSRIFSSSDVAFISYI 4546

  Fly  1198 GINSIGLVCFSQFYRTHPESMLLE--PTFMAMYTVATVICKLFMIYE-----FKLICM------- 1248
            .:|.|..:|          :||:.  |..:|:.:.|..:.|::.:.:     |...|:
Mouse  4547 SLNFIFGLC----------TMLMTTMPRLLAIISKAQNLQKIYNVLKWAFTIFPQFCLGQGLIEL 4601

  Fly  1249 -------DPVVNF---TSVEVFKCNSIPNCCIKSNYGTFTAGIYHDLVI----LTLLDIILLACL 1299
                   |...||   :.|..|:.|             |...|:.:|.:    |.||.::|...|
Mouse  4602 CYNQIKYDLTHNFGIDSYVSPFEMN-------------FLGWIFVELTLQGTFLLLLRLMLHGDL 4653

  Fly  1300 F-VSEYHSIL-----GFADCRLDTRTNESPDSNQESRAFPGILSNDTAALVDKEHTSRLNEEERS 1358
            . ....||:|     ...|..::|         ::.|...|....|...|.:      |::..||
Mouse  4654 LRWPRDHSVLQDIVKPAKDIDVET---------EQMRVLEGRTGGDMMVLCN------LSKSYRS 4703

  Fly  1359 KYAAVGIGIVSKYRRNRVLRDLDFTLAKSECLSITGANNSGKTTLLKVVVNETKMNAGQLWIH-- 1421
            .:..          :...:..:...:.:.||..:.|.|.:||:|..|::..||..::|...|.
Mouse  4704 VFGG----------KTTAVHGISLGIPRGECFGLLGVNGAGKSTTFKILNGETPPSSGYTVIRTP 4758

  Fly  1422 --DYSVNTHRVQCYRMVGYCPQKDSLPSEFTPRELLYIHAMLQGHRHRIGRELSEALLRLVGLTP 1484
              |........:...::|||||:|:|....|..|.|..:..|:|...:...|::..|:|.:.|..
Mouse  4759 QGDMVDLASAGKAGILIGYCPQQDALDELLTGWEHLQYYCRLRGIPKQYIPEVAADLVRRLHLES 4823

  Fly  1485 CWNRSVRMCTTGQIRRLYFAYAVLGSPDLICVDGVPAGLDPTGKRIILMMTSTMQAM-GSSFLYT 1548
            ..::.|...:.|..|:|..|.|::|.||::.:|...:|:||..|| .|..|.|.:.. |.:.:.|
Mouse  4824 HVDKPVATYSGGTRRKLSTALALVGKPDILLLDEPSSGMDPCSKR-YLWQTITQEVRDGCAAVLT 4887

  Fly  1549 MLTGLDAERLSLRTPLLLEGQLWMIRPMDTETENYKSGYQLEVRFKRKVNPNVSMSRATWNLINH 1613
            ..:..:.|.|..|..::::|....:.|.......:..||.::|                |   .|
Mouse  4888 SHSMEECEALCTRLAIMVDGSFRCLGPPQHIKNRFGDGYTVKV----------------W---LH 4933

  Fly  1614 FPMSPNKKFSAFMEIKFPDAVLTIERDDSMVFVLPLGTTTFSEIFLTLRKDAFEMNIEDYFITRN 1678
            ...|.....|..:::.||......:|.:.:.:.:.......:::|..|..:...:|||.|.|::.
Mouse  4934 KEGSQPSAVSDCLKLHFPGIQFKGQRLNLLEYHVQKSWECLADLFKVLENNKSLLNIEHYSISQT 4998

  Fly  1679 MLVGFQIF 1686
            .|.  |:|
Mouse  4999 TLE--QVF 5004

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1494	NP_001259763.1	ABC2_membrane_3	<263..480	CDD:289468	53/229 (23%)
		CcmA	541..848	CDD:224054	85/328 (26%)
		ABC_subfamily_A	541..761	CDD:213230	59/232 (25%)
		ABC2_membrane_3	911..>1189	CDD:289468	78/367 (21%)
		ABC2_membrane	<1080..>1188	CDD:304374	34/130 (26%)
		ABC_subfamily_A	1370..1577	CDD:213230	54/211 (26%)
		PRK14255	1371..1586	CDD:172743	54/219 (25%)
Abca13	NP_839990.2	rim_protein	3036..5019	CDD:130324	387/1763 (22%)
		ABC_subfamily_A	3815..4030	CDD:213230	65/247 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	4135..4165		4/29 (14%)
		ABC_subfamily_A	4692..4919	CDD:213230	58/243 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838502
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19229
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.850