Protein Alignment CG1494 and ABCA4

DIOPT Version :10

• Sequence 1: NP_608444.2
• Gene: CG1494 / 33102
• FlyBaseID: FBgn0031169
• Length: 1695
• Species: Drosophila melanogaster
• Sequence 2: NP_000341.2
• Gene: ABCA4 / 24
• HGNCID: 34
• Length: 2273
• Species: Homo sapiens
• Alignment Length: 1911
• Identity: 406/1911 - (21%)
• Similarity: 736/1911 - (38%)
• Gaps: 497/1911 - (26%)

  Fly   105 YGIFQAMMRRVQKQIEPMTSVGFEDCEEMRE------SVIENGLF-AGLCF-DGSPFVEDQVFEE 161
            :.|....:|.|.:.:|.:....||...:..:      |::|..:| ||:.| |..|:.
Human   503 FNITDRTLRLVNQYLECLVLDKFESYNDETQLTQRALSLLEENMFWAGVVFPDMYPWT------- 560

  Fly   162 DTLESYSNIQPMLNYTILLPSELRMLDGDFRMANWMTLYNDDPNTFVLTRLNQPYEGGFVGYVRE 226
                  |::.|.:.|.|.:..::.......:...|    :..|..       .|.|.  ..|:..
Human   561 ------SSLPPHVKYKIRMDIDVVEKTNKIKDRYW----DSGPRA-------DPVED--FRYIWG 606

  Fly   227 GFIRLQKSVSESFLVLTSHKSLPT-IQIRRFPITGREQDPLMGNLNYGMPFIIIIGFLFPAQLFV 290
            ||..||..|.:...........|. |.:::.|......|..|..||...|..:::.:::...:.|
Human   607 GFAYLQDMVEQGITRSQVQAEAPVGIYLQQMPYPCFVDDSFMIILNRCFPIFMVLAWIYSVSMTV 671

  Fly   291 WQVVSEKQSQVRQFLINMNIGNLIHFVSWYLKGLIYEMISSLIIAALLKIRWDQDHG-VLTQTPW 354
            ..:|.||:.::::.|.|..:.|.:.:.:|:|.......:|..::...:.      || :|..:..
Human   672 KSIVLEKELRLKETLKNQGVSNAVIWCTWFLDSFSIMSMSIFLLTIFIM------HGRILHYSDP 730

  Fly   355 YILILVLFCYNCAAVAFAIMVAAFFRNALNAVRVLTILWIMSYVPTFI-------LSNNLEGNIH 412
            :||.|.|..::.|.:....:::.||..|..|.....:::...|:|..:       ::..|:..:.
Human   731 FILFLFLLAFSTATIMLCFLLSTFFSKASLAAACSGVIYFTLYLPHILCFAWQDRMTAELKKAVS 795

  Fly   413 ALRYVSYALPNVVATLVIEFLIE-RESIVHITWEDSGYRLNYDGGHITVTASSWIFMLNALVYCA 476
            .|..|::....       |:|:. .|..:.:.|.:.| ....:|...:...|..:.:|:|.||..
Human   796 LLSPVAFGFGT-------EYLVRFEEQGLGLQWSNIG-NSPTEGDEFSFLLSMQMMLLDAAVYGL 852

  Fly   477 IGLYVDM--------------------WRGGD----RSGKKMKKPNTNASVQEDPYHERG--DSF 515
            :..|:|.                    |.||:    |..:.::|........|||.|..|  |||
Human   853 LAWYLDQVFPGDYGTPLPWYFLLQESYWLGGEGCSTREERALEKTEPLTEETEDPEHPEGIHDSF 917

  Fly   516 ---THQGQAIGVNSTKIYEVEPSHRRFKLKIKKLCKRFATNDRPALNLFSWNVYENEVTVLMGHN 577
               .|.|...||                 .:|.|.|.|....|||::..:...|||::|..:|||
Human   918 FEREHPGWVPGV-----------------CVKNLVKIFEPCGRPAVDRLNITFYENQITAFLGHN 965

  Fly   578 GCGKSTLLKILAGLVEPSRGTVMISSHNIQTERKAASMELGIAFGHDMLLTGFTVIDYLRFICRV 642
            |.||:|.|.||.||:.|:.|||::...:|:|...|....||:...|::|....||.:::.|..::
Human   966 GAGKTTTLSILTGLLPPTSGTVLVGGRDIETSLDAVRQSLGMCPQHNILFHHLTVAEHMLFYAQL 1030

  Fly   643 KGLHN---NIEIDGQSNYFLNVLQIGGLKTKRIRTLTD------RDLCLVSICCAFVGNSPIILI 698
            ||...   .:|::.       :|:..||..||.....|      |.|   |:..||||::.::::
Human  1031 KGKSQEEAQLEMEA-------MLEDTGLHHKRNEEAQDLSGGMQRKL---SVAIAFVGDAKVVIL 1085

  Fly   699 DDVHSDLDKRTQSLVWNLINEEKSKRTIILVSNSPALAENIADRMAIMSNGELKCTGTKPFLKNM 763
            |:..|.:|..::..:|:|:.:.:|.||||:.::....|:.:.||:||::.|.|.|:||..||||.
Human  1086 DEPTSGVDPYSRRSIWDLLLKYRSGRTIIMSTHHMDEADLLGDRIAIIAQGRLYCSGTPLFLKNC 1150

  Fly   764 YGHGYRLTCV-KGKNYKR-------------------------------------DELFGMMNSY 790
            :|.|..||.| |.||.:.                                     :||..::..:
Human  1151 FGTGLYLTLVRKMKNIQSQRKGSEGTCSCSSKGFSTTCPAHVDDLTPEQVLDGDVNELMDVVLHH 1215

  Fly   791 MPNMSIERDIGYKVTFVLENK-FEDQ-FPMLIDDLEENMQQLGVVSFRIRDTSMEEIFLRFGCED 853
            :|...:...||.::.|:|.|| |:.: :..|..:|||.:..||:.||.|.||.:|||||:. .||
Human  1216 VPEAKLVECIGQELIFLLPNKNFKHRAYASLFRELEETLADLGLSSFGISDTPLEEIFLKV-TED 1279

  Fly   854 NDQ-----SGAFQSHENAQVLLEEYYSTLAEANEKGR---------------------------- 885
            :|.     .||.|..||    :...:..|....:.|:
Human  1280 SDSGPLFAGGAQQKREN----VNPRHPCLGPREKAGQTPQDSNVCSPGAPAAHPEGQPPPEPECP 1340

  Fly   886 ----RTGWKLFFLHGRAVIYKRW---IAAHRHWIVLI-----FEVLAMAL-VAVCTFSSI----- 932
                .||.:|...|.:|::.||:   |.:|:.::..|     |..||:.| :.:..|...
Human  1341 GPQLNTGTQLVLQHVQALLVKRFQHTIRSHKDFLAQIVLPATFVFLALMLSIVIPPFGEYPALTL 1405

  Fly   933 --FIYGKNYELEPLTFNLSQLHTVDAFV------------------------------------- 958
              :|||:.|....:....|:..||.|.|
Human  1406 HPWIYGQQYTFFSMDEPGSEQFTVLADVLLNKPGFGNRCLKEGWLPEYPCGNSTPWKTPSVSPNI 1470

  Fly   959 -ELFSEE---------------------------------------------EDVKDMH------ 971
             :||.::                                             :|:.|.:
Human  1471 TQLFQKQKWTQVNPSPSCRCSTREKLTMLPECPEGAGGLPPPQRTQRSTEILQDLTDRNISDFLV 1535

  Fly   972 AYYTELL-------YWYDAHVATLTKNRHNAYAL------------------------------- 998
            ..|..|:       :|       :.:.|:...::
Human  1536 KTYPALIRSSLKSKFW-------VNEQRYGGISIGGKLPVVPITGEALVGFLSDLGRIMNVSGGP 1593

  Fly   999 LTQN------QFTAHVNSRYIFGATFDQKIVTAWFNNIPLHSAPYALNVVHNAVARHLF-----D 1052
            :|:.      .|..|:.:         :..:..||||...|:....|||.|||:.|...     .
Human  1594 ITREASKEIPDFLKHLET---------EDNIKVWFNNKGWHALVSFLNVAHNAILRASLPKDRSP 1649

  Fly  1053 EEATIDVTLAPLPF-RTAINTFPPSSHTFGGCLAFGICFVLTFIWPAFAIYMITERGSLLKKQQF 1116
            ||..|.|...||.. :..::.....:.:....:|..:.|.::|:..:|.:|:|.||.:..|..||
Human  1650 EEYGITVISQPLNLTKEQLSEITVLTTSVDAVVAICVIFSMSFVPASFVLYLIQERVNKSKHLQF 1714

  Fly  1117 LAGVRVCSYWTFTVLYDLLFLLIFCACVV-VMVAL----YENPNH------DVMLYGYISVTLML 1170
            ::||...:||....|:|::...:....|| :.:..    |.:|.:      .::|||:..:.:|.
Human  1715 ISGVSPTTYWVTNFLWDIMNYSVSAGLVVGIFIGFQKKAYTSPENLPALVALLLLYGWAVIPMMY 1779

  Fly  1171 GG---FWVILLAYLMASLCRNPCYGFLWLCGINSIGLVCFSQFYRTHPESMLLEPTFMAMYTVAT 1232
            ..   |.|...||:..| |.|     |:: ||||..:....:.:..:          ..:.....
Human  1780 PASFLFDVPSTAYVALS-CAN-----LFI-GINSSAITFILELFENN----------RTLLRFNA 1827

  Fly  1233 VICKLFMIYEFKLICM-----DPVVNFTSVEVFKCNSIPNCCIKSNYG-TFTAGIYH-DL----- 1285
            |:.||.::  |...|:     |..::....:|:           :.:| ..:|..:| ||
Human  1828 VLRKLLIV--FPHFCLGRGLIDLALSQAVTDVY-----------ARFGEEHSANPFHWDLIGKNL 1879

  Fly  1286 -------VILTLLDIILLACLFVSEYHSILGFADCRLDTRTNESPD-SNQESRAFPGILSNDTAA 1342
                   |:..||.:::....|:|::     .|:...:...:|..| :.:..|...|  .|.|..
Human  1880 FAMVVEGVVYFLLTLLVQRHFFLSQW-----IAEPTKEPIVDEDDDVAEERQRIITG--GNKTDI 1937

  Fly  1343 LVDKEHTSRLNEEERSKYAAVGIGIVSKYRRNRVLRDLDFTLAKSECLSITGANNSGKTTLLKVV 1407
            |       ||:|..:. |.......|.:         |...:...||..:.|.|.:||||..|::
Human  1938 L-------RLHELTKI-YPGTSSPAVDR---------LCVGVRPGECFGLLGVNGAGKTTTFKML 1985

  Fly  1408 VNETKMNAGQLWIHDYSVNTHRVQCYRMVGYCPQKDSLPSEFTPRELLYIHAMLQGHRHRIGREL 1472
            ..:|.:.:|...:...|:.|:..:.::.:|||||.|::....|.||.||::|.|:|.......::
Human  1986 TGDTTVTSGDATVAGKSILTNISEVHQNMGYCPQFDAIDELLTGREHLYLYARLRGVPAEEIEKV 2050

  Fly  1473 SEALLRLVGLTPCWNRSVRMCTTGQIRRLYFAYAVLGSPDLICVDGVPAGLDPTGKRIILMMTST 1537
            :...::.:|||...:......:.|..|:|..|.|::|.|.|:.:|....|:||..:|::..:..:
Human  2051 ANWSIKSLGLTVYADCLAGTYSGGNKRKLSTAIALIGCPPLVLLDEPTTGMDPQARRMLWNVIVS 2115

  Fly  1538 MQAMGSSFLYTMLTGLDAERLSLRTPLLLEGQLWMIRPMDTETENYKSGYQLEVRFKR------- 1595
            :...|.:.:.|..:..:.|.|..|..::::|....:..:......:..||.:.::.|.
Human  2116 IIREGRAVVLTSHSMEECEALCTRLAIMVKGAFRCMGTIQHLKSKFGDGYIVTMKIKSPKDDLLP 2180

  Fly  1596 KVNPNVSMSRATWNLINHFPMSPNKKFSAFMEIKFPDAVLTIERDDSMVFVLPLGTTTFSEIFLT 1660
            .:||                      ...|.:..||.:|.. ||..:|: ...:.:::.:.||..
Human  2181 DLNP----------------------VEQFFQGNFPGSVQR-ERHYNML-QFQVSSSSLARIFQL 2221

  Fly  1661 LRKDAFEMNIEDYFITRNMLVGFQIF 1686
            |......:.||:|.:|:..|  .|:|
Human  2222 LLSHKDSLLIEEYSVTQTTL--DQVF 2245

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG1494	NP_608444.2	rim_protein	<223..1689	CDD:130324	384/1785 (22%)
		ABC_subfamily_A	541..761	CDD:213230	74/228 (32%)
ABCA4	NP_000341.2	rim_protein	1..2272	CDD:130324	406/1911 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	891..911		5/19 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1284..1345		7/64 (11%)
		Essential for ATP binding and ATPase activity. /evidence=ECO:0000269|PubMed:31481235	2244..2249		1/2 (50%)