DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG1494 and ABCA5

DIOPT Version :9

Sequence 1:NP_001259763.1 Gene:CG1494 / 33102 FlyBaseID:FBgn0031169 Length:1695 Species:Drosophila melanogaster
Sequence 2:NP_061142.2 Gene:ABCA5 / 23461 HGNCID:35 Length:1642 Species:Homo sapiens


Alignment Length:1817 Identity:376/1817 - (20%)
Similarity:715/1817 - (39%) Gaps:431/1817 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    68 WMQMVEKLEKARQVADTYNVKGNP---FT-PHLVIGWAPKRYGIFQAMMRRVQKQIEP---MTSV 125
            |:.::..:...::..:..|::.||   || .:|::|:.|.. .|..::|::|.....|   :|..
Human    45 WLILISMMHPNKKYEEVPNIELNPMDKFTLSNLILGYTPVT-NITSSIMQKVSTDHLPDVIITEE 108

  Fly   126 GFEDCEEMRESVIENGLFAGLCFDGSPFVEDQVFEEDTLESYSNIQPMLNYTILLPSELRMLDGD 190
            ...:.|.:..|:.:...|.|:.|..|...|.:.|.:                 ::|..       
Human   109 YTNEKEMLTSSLSKPSNFVGVVFKDSMSYELRFFPD-----------------MIPVS------- 149

  Fly   191 FRMANWMTLYNDDPNTFVLTRLNQPYEGGFVGYVREGFIRLQKSVSESFLVLTSHKSL------- 248
                   ::|.|       :|...........|...||..||.|:..:.:.|.::.||       
Human   150 -------SIYMD-------SRAGCSKSCEAAQYWSSGFTVLQASIDAAIIQLKTNVSLWKELEST 200

  Fly   249 --------PTIQIRRFPITGREQDPLMGNLNYGMPFIIIIGFLFPAQLFV-WQVVSEKQSQVRQF 304
                    ..::|..||              .|:..|.::....|...|: ..:|:||:.::::|
Human   201 KAVIMGETAVVEIDTFP--------------RGVILIYLVIAFSPFGYFLAIHIVAEKEKKIKEF 251

  Fly   305 LINMNIGNLIHFVSWYL--KGLIYEMISSLIIAALLKIRWDQDHGVLTQTPWYILILVLFCYNCA 367
            |..|.:.:...::||.|  ..||:.|...:.:.|...:.:.|...:       ::.|:.|.|..:
Human   252 LKIMGLHDTAFWLSWVLLYTSLIFLMSLLMAVIATASLLFPQSSSI-------VIFLLFFLYGLS 309

  Fly   368 AVAFAIMVAAFFRNALNAVRVLTILWIMSYVPTFILSNNLEGNIHALRYVSYALPNVVATLV--- 429
            :|.||:|:...|:.:.:       :.|:.:..|...     |.|..:..:..:.|..:..|.   
Human   310 SVFFALMLTPLFKKSKH-------VGIVEFFVTVAF-----GFIGLMIILIESFPKSLVWLFSPF 362

  Fly   430 --IEFLIERESIVHITWEDSGYRL-NYDGGHITVTASSWIFMLNALVYCAIGLYVDM-------- 483
              ..|:|....::|:...:.|... |...|...:..:..:..||::.|..:.:|:|.        
Human   363 CHCTFVIGIAQVMHLEDFNEGASFSNLTAGPYPLIITIIMLTLNSIFYVLLAVYLDQVIPGEFGL 427

  Fly   484 ------------WRGGDRSGKKMKKPNTNASVQEDPYHERGDSFTH-----QGQAIGVNSTKIYE 531
                        |....|:.:::.:.|.|.::          ||:.     ..:.:|..:.:|..
Human   428 RRSSLYFLKPSYWSKSKRNYEELSEGNVNGNI----------SFSEIIEPVSSEFVGKEAIRISG 482

  Fly   532 VEPSHRRFKLKIKKLCKRFATNDRPALNLFSWNVYENEVTVLMGHNGCGKSTLLKILAGLVEPSR 596
            ::.::|:....::            ||...|:::||.::|.|:||:|.|||||:.||.||..||.
Human   483 IQKTYRKKGENVE------------ALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSD 535

  Fly   597 GTVMISSHNIQ--TERKAASMELGIAFGHDMLLTGFTVIDYLRFICRVKGLHNNIEIDGQSNYFL 659
            |...|..|.:.  .|...|...:||....|:.....||.:.|..:..:||:..|..|.......|
Human   536 GFASIYGHRVSEIDEMFEARKMIGICPQLDIHFDVLTVEENLSILASIKGIPANNIIQEVQKVLL 600

  Fly   660 NVLQIGGLKTKRIRTLTDRDLCLVSICCAFVGNSPIILIDDVHSDLDKRTQSLVWNLINEEKSKR 724
            : |.:..:|..:.:.|:......:|:..|.:||..|:|:|:..:.:|..::.:||||:...|:.|
Human   601 D-LDMQTIKDNQAKKLSGGQKRKLSLGIAVLGNPKILLLDEPTAGMDPCSRHIVWNLLKYRKANR 664

  Fly   725 TIILVSNSPALAENIADRMAIMSNGELKCTGTKPFLKNMYGHGYRLTCVKGKNYKRDELFGMMNS 789
            ..:..::....|:.:|||.|::|.|.|||.|:..|||:.:|.||||:....|....:.|..::..
Human   665 VTVFSTHFMDEADILADRKAVISQGMLKCVGSSMFLKSKWGIGYRLSMYIDKYCATESLSSLVKQ 729

  Fly   790 YMPNMSIERDIGYKVTFVLENKFEDQFPMLIDDLEENMQQLGVVSFRIRDTSMEEIFLRFGCE-D 853
            ::|..::.:....::.:.|..|..|:|..|...|:.: ..|||:|:.:..|::|::||:...| :
Human   730 HIPGATLLQQNDQQLVYSLPFKDMDKFSGLFSALDSH-SNLGVISYGVSMTTLEDVFLKLEVEAE 793

  Fly   854 NDQ----------------SGAFQSHENAQVLLEEYYSTLAEANEKGRRTGWKLFFLHGRAVIYK 902
            .||                |.:|...|.:.::|.|..:.|...     .:.||          .:
Human   794 IDQADYSVFTQQPLEEEMDSKSFDEMEQSLLILSETKAALVST-----MSLWK----------QQ 843

  Fly   903 RWIAAHRHWIVLIFE---VLAMALVAVCTFS-SIFIY-----GKN-----------YELEP---- 943
            .:..|..|:..|..|   |.::.|:.:..|: .||::     .||           |.|:|    
Human   844 MYTIAKFHFFTLKRESKSVRSVLLLLLIFFTVQIFMFLVHHSFKNAVVPIKLVPDLYFLKPGDKP 908

  Fly   944 ---LTFNLSQLHTVDAFVELFSEEEDVKDMHAYYTELLYWYDAHVATLTKNRHNAYALLTQNQFT 1005
               .|..|.|          .|.:.|:.|:.:::|.    .:..|..:..:.:.:.|..:.....
Human   909 HKYKTSLLLQ----------NSADSDISDLISFFTS----QNIMVTMINDSDYVSVAPHSAALNV 959

  Fly  1006 AHVNSRYIFGATFDQKIVTAWFNNIPLHSAPYALNVVHNAVARHL------------FDEEATID 1058
            .|....|:|.|.         ||:..::|.|..:|::.|....||            |.:|.|..
Human   960 MHSEKDYVFAAV---------FNSTMVYSLPILVNIISNYYLYHLNVTETIQIWSTPFFQEITDI 1015

  Fly  1059 VTLAPLPFRTAINTFPPSSHTFGGCLAFGICFVLTFIWPAFAIYMITERGSLLKKQQFLAGVRVC 1123
            |....|.|:.|:               .||  ::|.:.|.||:............|..|:|:...
Human  1016 VFKIELYFQAAL---------------LGI--IVTAMPPYFAMENAENHKIKAYTQLKLSGLLPS 1063

  Fly  1124 SYWTFTVLYDL-LFLLIFCACVVVMVALYENPNHDVMLYG-------YISVTLMLGGF--WVILL 1178
            :||....:.|: ||.:|....:..::|.:         ||       :::|...|.|:  .|||.
Human  1064 AYWIGQAVVDIPLFFIILILMLGSLLAFH---------YGLYFYTVKFLAVVFCLIGYVPSVILF 1119

  Fly  1179 AYLMA-----SLCRNPCYGFLWLCGINSIGLVCFSQFYRTHPESMLLEPTFMAMYTVATVI---- 1234
            .|:.:     .|.....:.|::    :...|.|.:          :.|.||...||:||::    
Human  1120 TYIASFTFKKILNTKEFWSFIY----SVAALACIA----------ITEITFFMGYTIATILHYAF 1170

  Fly  1235 CKLFMIYEFKLICMDPVVNFTSVEVFKCNSIPNCCIKSNYGTFTAGIYHDLVILTLLDIILLACL 1299
            |.:..||.. |.|:   ::|..:      |..|  ::.|..|:..   .|.:.:.::...|...|
Human  1171 CIIIPIYPL-LGCL---ISFIKI------SWKN--VRKNVDTYNP---WDRLSVAVISPYLQCVL 1220

  Fly  1300 FV---SEYHSILGFADCR-------LDTRTN-----ESPDSNQESRAF----------------- 1332
            ::   ..|....|....|       |.|::.     |.||:..|....                 
Human  1221 WIFLLQYYEKKYGGRSIRKDPFFRNLSTKSKNRKLPEPPDNEDEDEDVKAERLKVKELMGCQCCE 1285

  Fly  1333 --PGILSNDTAALVDKEHTSRLNEEERSKYAAVGIGIVSKYRRNRVLRDLDFTLAKSECLSITGA 1395
              |.|:.::.....|.:....|:.:.:.        :.:||        :.|.:.|.|.|.:.|.
Human  1286 EKPSIMVSNLHKEYDDKKDFLLSRKVKK--------VATKY--------ISFCVKKGEILGLLGP 1334

  Fly  1396 NNSGKTTLLKVVVNETKMNAGQLWIHDYSVNTHR----VQCYRMVGYCPQKDSLPSEFTPRELLY 1456
            |.:||:|::.::|.:.:..:||:::.|||..|..    ::|   :|||||.:.|..:.|.:|...
Human  1335 NGAGKSTIINILVGDIEPTSGQVFLGDYSSETSEDDDSLKC---MGYCPQINPLWPDTTLQEHFE 1396

  Fly  1457 IHAMLQGHRHRIGRELSEALLRLVGLTPCWNRSVRMCTTGQIRRLYFAYAVLGSPDLICVDGVPA 1521
            |:..::|......:|:...:...:.|.....::|:....|..|:|.||.::||:|.:..:|....
Human  1397 IYGAVKGMSASDMKEVISRITHALDLKEHLQKTVKKLPAGIKRKLCFALSMLGNPQITLLDEPST 1461

  Fly  1522 GLDPTG---------------KRIILMMTSTMQAMGSSFLYTMLTGLDAERLSLRTPLLLEGQLW 1571
            |:||..               ||..::.|..|:              :||.:..|..:::.|||.
Human  1462 GMDPKAKQHMWRAIRTAFKNRKRAAILTTHYME--------------EAEAVCDRVAIMVSGQLR 1512

  Fly  1572 MIRPMDTETENYKSGYQLEVRFKRKVNPNVSMSRATWNLINHFP-MSPNKKFSAFMEIKFPDAVL 1635
            .|..:......:..||.||::.|..:. |:.:.|....:...|| .|..:.||:.:..|.|    
Human  1513 CIGTVQHLKSKFGKGYFLEIKLKDWIE-NLEVDRLQREIQYIFPNASRQESFSSILAYKIP---- 1572

  Fly  1636 TIERDDSMVFVLPLGTTTFSEIFLTLRKDAFEMNIEDYFITRNMLVGFQIF---TYDQHQDN 1694
               ::|         ..:.|:.|..|.:......||:|..::..|.  |:|   |.:|.:::
Human  1573 ---KED---------VQSLSQSFFKLEEAKHAFAIEEYSFSQATLE--QVFVELTKEQEEED 1620

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG1494NP_001259763.1 ABC2_membrane_3 <263..480 CDD:289468 41/225 (18%)
CcmA 541..848 CDD:224054 89/308 (29%)
ABC_subfamily_A 541..761 CDD:213230 66/221 (30%)
ABC2_membrane_3 911..>1189 CDD:289468 66/331 (20%)
ABC2_membrane <1080..>1188 CDD:304374 26/122 (21%)
ABC_subfamily_A 1370..1577 CDD:213230 55/225 (24%)
PRK14255 1371..1586 CDD:172743 54/233 (23%)
ABCA5NP_061142.2 ABC2_membrane_4 202..403 CDD:289500 41/233 (18%)
ABC2_membrane_3 <214..416 CDD:289468 43/234 (18%)
CcmA 476..788 CDD:224054 92/325 (28%)
ABC_subfamily_A 478..701 CDD:213230 68/235 (29%)
ABC2_membrane_3 <943..1224 CDD:289468 69/344 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1249..1268 4/18 (22%)
CcmA 1290..1615 CDD:224054 83/376 (22%)
ABC_subfamily_A 1290..1521 CDD:213230 58/263 (22%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0059
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D131191at2759
OrthoFinder 1 1.000 - - FOG0000051
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.820

Return to query results.
Submit another query.