DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1494 and Abca5

DIOPT Version :9

Sequence 1:	NP_001259763.1	Gene:	CG1494 / 33102	FlyBaseID:	FBgn0031169	Length:	1695	Species:	Drosophila melanogaster
Sequence 2:	NP_671752.2	Gene:	Abca5 / 217265	MGIID:	2386607	Length:	1642	Species:	Mus musculus

Alignment Length:	1827	Identity:	377/1827 - (20%)
Similarity:	709/1827 - (38%)	Gaps:	451/1827 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 WMQMVEKLEKARQVADTYNVKGNPF----TPHLVIGWAPKRYGIFQAMMRRVQKQIEPMTSVGFE 128
            |:.:|..:...::..:..:::.:|.    ..::::|:.|.. .|..::|:||.....|...|..|
Mouse    45 WLILVSMMHPNKKYEEVSDIELSPMDKFSLSNVILGYTPVT-NITSSIMQRVSTDHLPKVIVTEE 108

  Fly   129 DCEE---MRESVIENGLFAGLCFDGSPFVEDQVFEEDTLESYSNIQPMLNYTILLPSELRMLDGD 190
            ...|   :..|:.::..|.|:.|            :||: ||               |||...
Mouse   109 YANEKELVAASLSKSSNFVGVVF------------KDTM-SY---------------ELRFFP-- 143

  Fly   191 FRMANWMTLYNDDPNTFVLTRLNQPYEG-----GFVGYVREGFIRLQKSVSESFLVLTSHKSL-- 248
             .|....::|.:.            .||     ....|...||..||.|:..:.:.|.::.|:
Mouse   144 -EMIPVSSIYMNS------------REGCSKTCDAAQYWSLGFTVLQASIDAAIIQLKTNVSVWS 195

  Fly   249 -------------PTIQIRRFPITGREQDPLMGNLNYGMPFIIIIGFLFPAQLFV-WQVVSEKQS 299
                         ..::|..||              .|:..|.::....|...|: ..:|:||:.
Mouse   196 ELESTKAVIMGEAAVVEIDTFP--------------RGVILIYLVIAFSPFGYFLAIHIVAEKEK 246

  Fly   300 QVRQFLINMNIGNLIHFVSWYL--KGLIYEMISSLIIAALLKIRWDQDHGVLTQTPWYILILVLF 362
            ::::||..|.:.:...::||.|  ..||:.|  ||::|.:...     ..:..|:...::.|:.|
Mouse   247 KLKEFLKIMGLHDTAFWLSWVLLYASLIFLM--SLLMAVIATA-----SSLFPQSSSIVIFLLFF 304

  Fly   363 CYNCAAVAFAIMVAAFFRNALNAVRVLTILWIMSYVPTFILSNNLEGNIHALRYVSYALPNVVAT 427
            .|..::|.||:|:...|:.:.:       :.::.:..|.:.     |.:..|..:..:.|..:..
Mouse   305 LYGLSSVFFALMLTPLFKKSKH-------VGVVEFFVTVVF-----GFVGLLIVLIESFPRSLVW 357

  Fly   428 LV-----IEFLIERESIVHI-TWEDSGYRLNYDGGHITVTASSWIFMLNALVYCAIGLYVDM--- 483
            |.     ..|||....::|: .:.:.....|...|...:..:..:..|:::.|..:.:|:|.
Mouse   358 LFSPLCQCAFLIGIAQVMHLEDFNEGALFSNLTEGPYPLIITIIMLALDSVFYVLLAVYLDQVIP 422

  Fly   484 -----------------WRGGDRSGKKMKKPNTNASVQEDPYHERGDSFTHQGQAIGVNSTKIYE 531
                             |....|:.|::.:.|.|.::..:...|...|     :.||..:.:|..
Mouse   423 GEFGLRRSSLYFLKPSYWSKNKRNYKELSEGNINGNISLNEIVEPVSS-----EFIGKEAIRISG 482

  Fly   532 VEPSHRRFKLKIKKLCKRFATNDRPALNLFSWNVYENEVTVLMGHNGCGKSTLLKILAGLVEPSR 596
            ::.|:|:            .|.:..||...|:::||.::|.|:||:|.|||||:.||.||..||.
Mouse   483 IQKSYRK------------KTENVEALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSD 535

  Fly   597 GTVMISSHNIQ--TERKAASMELGIAFGHDMLLTGFTVIDYLRFICRVKGLHNNIEIDGQSNYFL 659
            |...|..|.:.  .|...|...:||....|:.....||.:.|..:..:||:..|..|.......|
Mouse   536 GFASIYGHRVSEIDEMFEARKMIGICPQSDINFDVLTVEENLSILASIKGIPANNIIQEVQKVLL 600

  Fly   660 NVLQIGGLKTKRIRTLTDRDLCLVSICCAFVGNSPIILIDDVHSDLDKRTQSLVWNLINEEKSKR 724
            : |.:..:|..:.:.|:......:|:..|.:||..|:|:|:..:.:|..::.:||||:...|:.|
Mouse   601 D-LDMQAIKDNQAKKLSGGQKRKLSVGIAVLGNPKILLLDEPTAGMDPCSRHIVWNLLKYRKANR 664

  Fly   725 TIILVSNSPALAENIADRMAIMSNGELKCTGTKPFLKNMYGHGYRLTCVKGKNYKRDELFGMMNS 789
            ..:..::....|:.:|||.|::|.|.|||.|:..|||:.:|.||||:....:....:.|..::..
Mouse   665 VTVFSTHFMDEADILADRKAVISQGMLKCVGSSIFLKSKWGIGYRLSMYIDRYCATESLSSLVRQ 729

  Fly   790 YMPNMSI----ERDIGYKVTFVLENKFEDQFPMLIDDLEENMQQLGVVSFRIRDTSMEEIFLRFG 850
            ::|..::    ::.:.|.:.|...:||...|..|  |:..|   |||:|:.:..|::|::||:..
Mouse   730 HIPAAALLQQNDQQLVYSLPFKDMDKFSGLFSAL--DIHSN---LGVISYGVSMTTLEDVFLKLE 789

  Fly   851 C-----------------EDNDQSGAFQSHENAQVLLEEYYSTLAEANEKGRRTGWKLFFLHGRA 898
            .                 |:...|.:|...|.:.::|.|     .:|:.....:.||
Mouse   790 VEAEIDQADYSVFTQQPREEETDSKSFDEMEQSLLILSE-----TKASSVSTMSLWK-------- 841

  Fly   899 VIYKRWIAAHRHWIVLIFE---VLAMALVAVCTFS-SIFIYGKNYELEPLTFNLSQLHTVDAFVE 959
              .:....|..|::.|..|   |.|:.|:.:..|: .||::..::..:      :.:..:....:
Mouse   842 --QQVSTIAKFHFLSLKRESKSVRAVLLLLLIFFAVQIFMFFLHHSFK------NAVVPIKLVPD 898

  Fly   960 LFSEEEDVKDMHAYYTELLYWYDAHVATLTKNRHNAYALLTQNQFTAHVN--------SRYIFGA 1016
            |:..:...|. |.|.|.||      :...|.:..|...     :|.||.|        |.|:..|
Mouse   899 LYFLKPGDKP-HKYKTSLL------LQNSTDSDINGLI-----EFFAHQNIMVAMFNDSDYVSAA 951

  Fly  1017 TFD----------QKIVTAWFNNIPLHSAPYALNVVHNAVARHL------------FDEEATIDV 1059
            ...          ..:.:|.||:..::..|..:|::.|....||            |.:|.|..|
Mouse   952 PHSAALNVVRSEKDYVFSAVFNSTMVYCLPVMMNIISNYYLYHLNVTEAIQTWSTPFIQEITDIV 1016

  Fly  1060 TLAPLPFRTAINTFPPSSHTFGGCLAFGICFVLTFIWPAFAIYMITERGSLLKKQQFLAGVRVCS 1124
            ....|.|:.|:               .||  ::|.:.|.||:............|..|:|:...:
Mouse  1017 FKIELYFQAAL---------------LGI--IVTAMPPYFAMENAENHKIKAYTQLKLSGLLPSA 1064

  Fly  1125 YWTFTVLYDLLFLLIFCACVVVMVALYENPNHDVMLY--GYISVTLMLGGF--WVILLAYLMA-- 1183
            ||....:.|:  .|.|...::::.:|:.. :|.:..|  .:::|...|..:  .|||..|:.:
Mouse  1065 YWVGQAVVDI--PLFFVVLILMLGSLFAF-HHGLYFYPAKFLAVVFCLIAYVPSVILFTYIASFT 1126

  Fly  1184 ---SLCRNPCYGFLWLCGINSIGLVCFSQFYRTHPESMLLEPTFMAMYTVATVICKLFMIYEFKL 1245
               .|.....:.|::    :...|.|.:          :.|.||...|.|..|....|
Mouse  1127 FKKILNTKEFWSFIY----SVTALACVA----------ITETTFFLQYAVTAVFHYTF------- 1170

  Fly  1246 ICMDPVVNFTSVEVFKCNSIP-----NCCIKSNYGTFTAGIYHDL----------------VILT 1289
                            |.:||     .|.|     :|..|.:.::                ||:.
Mouse  1171 ----------------CIAIPIYPLLGCLI-----SFIKGSWKNMPKNENTYNPWDRLLVAVIMP 1214

  Fly  1290 LLDIILLACLFVSEYHSILGFADCRLD-----------------TRTNESPDSNQESRAF----- 1332
            .|..||...| :..|..|.|....|.|                 ...||..|.:.::...
Mouse  1215 YLQCILWIFL-LQHYEKIHGGRSIRKDPFFRALSQKAKNKKFPEPPINEDEDEDVKAERLKVKEL 1278

  Fly  1333 ---------PGILSNDTAALVDKEHTSR---LNEEERSKYAAVGIGIVSKYRRNRVLRDLDFTLA 1385
                     |.|:    ...:.||:..:   |:..:.:|       :.:||        :.|.:.
Mouse  1279 MGCQCCEEKPAIM----VCNLHKEYDDKKDFLHSRKTTK-------VATKY--------ISFCVK 1324

  Fly  1386 KSECLSITGANNSGKTTLLKVVVNETKMNAGQLWIHDY----SVNTHRVQCYRMVGYCPQKDSLP 1446
            |.|.|.:.|.|.:||:|::..:|.:.:..:|::::.||    |.:...::|   :|||||.:.|.
Mouse  1325 KGEILGLLGPNGAGKSTVINTLVGDVEPTSGKIFLGDYGSHSSEDDESIKC---MGYCPQTNPLW 1386

  Fly  1447 SEFTPRELLYIHAMLQGHRHRIGRELSEALLRLVGLTPCWNRSVRMCTTGQIRRLYFAYAVLGSP 1511
            .:.|.:|...|:..::|......:|:...:.:.:.|.....::|:....|..|:|.||.::||:|
Mouse  1387 PDLTLQEHFEIYGAVKGMSPGDMKEVISRITKALDLKEHLQKTVKKLPAGIKRKLCFALSMLGNP 1451

  Fly  1512 DLICVDGVPAGLDPTG---------------KRIILMMTSTMQAMGSSFLYTMLTGLDAERLSLR 1561
            .:..:|....|:||..               ||..|:.|..|:              :||.:..|
Mouse  1452 QVTLLDEPSTGMDPRAKQHMWRAIRTAFKNKKRAALLTTHYME--------------EAEAVCDR 1502

  Fly  1562 TPLLLEGQLWMIRPMDTETENYKSGYQLEVRFKRKVNPNVSMSRATWNLINHFP-MSPNKKFSAF 1625
            ..:::.|||..|..:......:..||.||::.|..:. |:.:.|....:...|| .|..:.||:.
Mouse  1503 VAIMVSGQLRCIGTVQHLKSKFGKGYFLEIKLKDWIE-NLEIDRLQREIQYIFPNASRQESFSSI 1566

  Fly  1626 MEIKFPDAVLTIERDDSMVFVLPLGTTTFSEIFLTLRKDAFEMNIEDYFITRNMLVGFQIF---T 1687
            :..|.|       ::|         ..:.|:.|..|.:......||:|..::..|.  |:|   |
Mouse  1567 LAFKIP-------KED---------VQSLSQSFAKLEEAKRTFAIEEYSFSQATLE--QVFVELT 1613

  Fly  1688 YDQHQDN 1694
            .:|.:::
Mouse  1614 KEQEEED 1620

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1494	NP_001259763.1	ABC2_membrane_3	<263..480	CDD:289468	41/225 (18%)
		CcmA	541..848	CDD:224054	91/312 (29%)
		ABC_subfamily_A	541..761	CDD:213230	67/221 (30%)
		ABC2_membrane_3	911..>1189	CDD:289468	63/320 (20%)
		ABC2_membrane	<1080..>1188	CDD:304374	24/116 (21%)
		ABC_subfamily_A	1370..1577	CDD:213230	54/225 (24%)
		PRK14255	1371..1586	CDD:172743	53/233 (23%)
Abca5	NP_671752.2	rim_protein	<84..1618	CDD:130324	372/1784 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820