Protein Alignment CG1494 and Abca8a

DIOPT Version :9

• Sequence 1: NP_001259763.1
• Gene: CG1494 / 33102
• FlyBaseID: FBgn0031169
• Length: 1695
• Species: Drosophila melanogaster
• Sequence 2: XP_006533124.3
• Gene: Abca8a / 217258
• MGIID: 2386846
• Length: 1653
• Species: Mus musculus
• Alignment Length: 1704
• Identity: 366/1704 - (21%)
• Similarity: 695/1704 - (40%)
• Gaps: 362/1704 - (21%)

  Fly   164 LESYSNIQPMLNYTILLPSELRMLDGDFRMANWMT--LYNDDPNTFVLTRLNQPYEGGFVGYV-- 224
            ::|:::...|:.||.:.|:..|::| ...:.::||  .....||...:|.|........||.:
Mouse   101 IDSFNDSTFMIVYTPITPTTQRIMD-RVSLVSYMTGRKILASPNEENMTELISMRFSDVVGVIFT 164

  Fly   225 -------------------------------------------REGFIRLQKSVSESFL-VLTSH 245
                                                       |:||:.||.:::.:.: |.|:|
Mouse   165 NAYSYNLKFIKGARIPTIKEHQDHTAHCHSYGEIIYCGLSEFWRDGFVALQAAINAAIIEVTTNH 229

  Fly   246 K------SLPTIQIRRFPITGREQDPLMGNLNYGMPFIIIIGFLFPAQLFVWQVVSEKQSQVRQF 304
            .      ||....|:.....|:|     |.......|..||.| .|...::...|:.::.:::..
Mouse   230 SVMEEMMSLTGKYIKIDSFVGQE-----GTTTDCFLFFCIIRF-SPLTYYISAGVTRERKKMKGL 288

  Fly   305 LINMNIGNLIHFVSWYLKGLIYEMI---SSLIIAALLKIRWDQDHGVLTQ----TPWYILILVLF 362
            :..|.:.:...::||   ||:|.:|   .:|:...::|         |.|    |.:.::..:.|
Mouse   289 MAVMGLRDSAFWLSW---GLLYGVIVFVVTLLSTTIVK---------LVQFVFLTGFMVIFSLFF 341

  Fly   363 CYNCAAVAFAIMVAAFFRNALNAVRVLTILWIMSYVPTFILSNNLEGNIHALRYVSYALPNVVAT 427
            .|..:.::.:.:::...:.:.....|:.:|.:         |....|.....||:..:|..:::.
Mouse   342 FYGLSLISLSFLMSVLLKKSFLTDLVVFLLTV---------SCGSLGFTALYRYLPVSLEWLLSL 397

  Fly   428 L-VIEFLIERESIVHITWEDSGYRLNYD--------GGHITVTASSWIFMLNALVYCAIGLYVD- 482
            | ...|::....::         ||:||        |....|..:.::...:.:.|..:..|.:
Mouse   398 LSPFAFMLGMVQLL---------RLDYDVNSNADPMGNPNEVIGTIFMLFFDGVFYLLLTFYFEK 453

  Fly   483 -------------------MWRGGDRSGKKMKKPNTNASVQEDPYHERGDSFT------HQGQAI 522
                               .|.|       ....|..|...|..|....|||.      |..:||
Mouse   454 VLPSEYGRRHPPLFFLKSSFWSG-------QNPANRTALDNETDYEFSDDSFEPVSMEFHGKEAI 511

  Fly   523 GV-NSTKIYEVEPSHRRFKLKIKKLCKRFATNDRPALNLFSWNVYENEVTVLMGHNGCGKSTLLK 586
            .: |.||.| ::.|.|...||...|                 :||:.::|.::||:|.||||||.
Mouse   512 RIRNLTKDY-IQKSKRTEALKDLTL-----------------DVYKGQITAILGHSGAGKSTLLN 558

  Fly   587 ILAGLVEPSRGTVMISSHNI--QTERKAASMELGIAFGHDMLLTGFTVIDYLRFICRVKGLHNNI 649
            :|:||..|::|.|.|.::.:  .|:.:..|...|:....::.....||.:.||...::||:..:
Mouse   559 VLSGLCVPTKGWVTIHNNKLSEMTDLENISKLTGVCPQCNVQFDFLTVRENLRLFAKIKGIQAH- 622

  Fly   650 EIDGQSNYFLNVLQIGGLKTKRIRTLTDRDLCLVSICCAFVGNSPIILIDDVHSDLDKRTQSLVW 714
            |:|.:....|..|.:...:...::.|:......::...|.:|:..|.|:|:..:.||..::..||
Mouse   623 EVDNEVQRVLLELDMKNTQNILVQNLSGGQKRKLTFGIAILGDPQIFLLDEPTAGLDPFSRHRVW 687

  Fly   715 NLINEEKSKRTIILVSNSPALAENIADRMAIMSNGELKCTGTKPFLKNMYGHGYRLTCVKGKNYK 779
            |.:.|.::.|.::..:.....|:.:|||...:|.|:|||.|:..|||..:|.||.|:....:...
Mouse   688 NFLKERRADRVVLFSTQFMDEADILADRKVFISKGKLKCAGSSLFLKKKWGIGYHLSLQLSETCV 752

  Fly   780 RDELFGMMNSYMPNMSIERDIGYKVTFVLENKFEDQFPMLIDDLEENMQQLGVVSFRIRDTSMEE 844
            .:.:..::..::|:..:..:...|::::|..:..::||.|..|||.: ..||:.::.:..|::.|
Mouse   753 HERITSLVKQHIPDSKLSAESEGKLSYILPLERTNKFPDLYRDLERS-PDLGIENYGVSITTLTE 816

  Fly   845 IFLR-----------FGCEDNDQSGAFQSHEN-AQVLLEEYYSTLAEANEKGR---RTGWKLFFL 894
            :||:           .|..::.|:|..:|.|. |:|  |:..|.|     .||   :.|..|::.
Mouse   817 VFLKLEGKSSIDQSDIGMTEDVQAGGARSPERFAEV--EQLVSLL-----NGRCKMKGGMALWWQ 874

  Fly   895 HGRAVIYKRWIAA--HRHWIVLIFEVLAMALVAVCTFSSIF--IYGKNY--ELEPLTF------- 946
            ...||...|::..  .|..||::..||.:.|:.:.: ::|:  :...:|  ||.|..:
Mouse   875 QLCAVTRLRFLKLKHERKSIVILILVLGIGLLHILS-ANIYRMVRQSDYCWELAPHMYFLTPGQQ 938

  Fly   947 ------NLSQLH----TVDAFVELFSEEEDVKDMHAYYTELLYWYDAHVATLTKNRHNAYALLTQ 1001
                  ||..::    .:|.|:....::....::.|:.|.         .....:::|...:|:.
Mouse   939 PQPPLTNLLIVNKTGAKIDDFIHSLEQQNIALEVDAFGTR---------NGTEDSQYNGAIILSG 994

  Fly  1002 NQFTAHVNSRYIFGATFDQKIVTAWFNNIPLHSAPYALNVVHNAVARHLFDEEATIDVTLAPLPF 1066
            ::      ..|.|         |...|...|:..|..:::|.|.:. .||...|.|
Mouse   995 DE------KNYNF---------TLACNTKRLNCFPVLVDIVSNGLL-GLFAPSAHI--------- 1034

  Fly  1067 RTAINTFP-PSSHTFGGCLAFGICFVLTF--IWPAFAIYMITERGSLLKKQQFLAGVRVCSYWTF 1128
            :|..:||| .:.|.....||:...:||..  :.|..::..|.:..:..:.|.:::|:...:||..
Mouse  1035 QTDRSTFPEENDHRKFDYLAYFFLWVLLMACVPPYISMTSIDDYKNRAQFQLWISGLSPSAYWFG 1099

  Fly  1129 TVLYDLLFLLIFCACVV-VMVALYEN-PNHDVMLYGYISVTLM-LGGF--WVILLAYLMASLCRN 1188
            ..|::   :.::||.:: :.:|.|.: |.......|.:.:.:: :||:  .||.:.|:::.:.|.
Mouse  1100 QALFE---VPVYCALILSIFIAFYASAPPESKFTVGDLFIQILYVGGYAMSVIFMTYVISFIYRK 1161

  Fly  1189 PCYGF-LW-LC-GINSIGLVCFS--QFYRTHPESMLLEPTFMAMYTVATV-ICKL--FMIYEFKL 1245
            ..... || || .|.|...:||.  .::|.....:|:     |:...||: .|.|  |...||..
Mouse  1162 GRKNSGLWSLCFYIVSFFSMCFMLIDYFRDISLFVLI-----ALVPPATLGGCTLLHFENREFSE 1221

  Fly  1246 ICMDPVVNFTSVEVFKCNSIPNCCIKSNYGTFTAGIYHDLVILTLLDIILLACLFVSEYHSILGF 1310
            |..:|...:                  :|..|.|.:.|..:.     :::|.|:     ....|.
Mouse  1222 IIFEPEREY------------------SYLFFLAPLLHFAIF-----VVILRCM-----ERKFGM 1258

  Fly  1311 ADCRLDT------------RTNESPDSNQESRAFPGILSNDTAALVDKEH-----TSRLNEEERS 1358
            ...|.|.            ...|.||...|..:...:.:.:.....|.:.     .|.|.:|.:.
Mouse  1259 KTMRTDPVFRISPRSDRVFNNPEDPDGEDEDVSQERVWTANALTSADFQEKPAIIASCLRKEYKG 1323

  Fly  1359 KYAAVGIGIVSKYRRNRVLRDLDFTLAKSECLSITGANNSGKTTLLKVVVNETKMNAGQLWIHDY 1423
            |...    .|.|.::....|::.|.:.|.|.:.:.|.|.:||:|.:|::..|||.:|||:.:...
Mouse  1324 KKKC----FVLKSKKKIATRNISFCVRKGEVVGLLGHNGAGKSTSIKMITGETKPSAGQVLLKGS 1384

  Fly  1424 SVNTHRVQCYRMVGYCPQKDSLPSEFTPRELLYIHAMLQGHRHRIGRELSEALLRLVGLTPCWNR 1488
            |..    .....:|||||:::|....|.||.|.|.|.::|.|........|.|...:.|......
Mouse  1385 STG----DTPGFLGYCPQENALWLNLTVREHLEIFAAIKGMRKSDANVAIERLADALKLQDQLKS 1445

  Fly  1489 SVRMCTTGQIRRLYFAYAVLGSPDLICVDGVPAGLDPTGKRIILMMTSTMQAMGSSFLYT----M 1549
            .|:..:.|..|:|.|..::||:|.::.:|....|:||.|::      ...||:.::|..|    :
Mouse  1446 PVKTLSEGVKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQ------QMWQAIQATFSNTERGAL 1504

  Fly  1550 LTG---LDAERLSLRTPLLLEGQLWMIRPMDTETENYKSGYQLEVRFK--RKVNP-NVSMSRATW 1608
            ||.   .:||.:..|..:::.|:|..|..:......:...|.||::.|  .:|.| |..:.|.
Mouse  1505 LTTHYMAEAEAVCDRVAIMVSGRLRCIGSIQHLKSKFGKEYLLEMKVKTPSQVEPLNTEIMRL-- 1567

  Fly  1609 NLINHFPMSP-NKKFSAFMEIKFPDAVLTIERDDSMVFVLPLGTTTFSEIFLTLRKDAFEMNIED 1672
                 ||.:. .:::|:.|..|.|       |:|    |.||     |:.|..|.......::|:
Mouse  1568 -----FPQAARQERYSSLMVYKLP-------RED----VQPL-----SQAFFKLETVKQSFDLEE 1611

  Fly  1673 YFITRNMLVGFQIF 1686
            |.::::.|.  |:|
Mouse  1612 YSLSQSTLE--QVF 1623

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG1494	NP_001259763.1	ABC2_membrane_3	<263..480	CDD:289468	37/232 (16%)
		CcmA	541..848	CDD:224054	79/308 (26%)
		ABC_subfamily_A	541..761	CDD:213230	59/221 (27%)
		ABC2_membrane_3	911..>1189	CDD:289468	58/306 (19%)
		ABC2_membrane	<1080..>1188	CDD:304374	22/114 (19%)
		ABC_subfamily_A	1370..1577	CDD:213230	60/213 (28%)
		PRK14255	1371..1586	CDD:172743	59/221 (27%)
Abca8a	XP_006533124.3	rim_protein	<258..1630	CDD:130324	337/1541 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838402
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S12404
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.800