Protein Alignment CG1494 and ABCA3

DIOPT Version :9

• Sequence 1: NP_001259763.1
• Gene: CG1494 / 33102
• FlyBaseID: FBgn0031169
• Length: 1695
• Species: Drosophila melanogaster
• Sequence 2: NP_001080.2
• Gene: ABCA3 / 21
• HGNCID: 33
• Length: 1704
• Species: Homo sapiens
• Alignment Length: 1864
• Identity: 449/1864 - (24%)
• Similarity: 794/1864 - (42%)
• Gaps: 344/1864 - (18%)

  Fly     7 IRKFLLMNWKNHKLQLANPLELLVILLVPPLFTLVAVLMRFFI-PVNHRSDTVYDPIDLDRSWMQ 70
            :|:..|:.|||:.||....|..::.|.:|.||:.:.:.:|..| ..|..:.|:|..        |
Human     4 LRQLALLLWKNYTLQKRKVLVTVLELFLPLLFSGILIWLRLKIQSENVPNATIYPG--------Q 60

  Fly    71 MVEKLEKARQVADTYNVKGNPFTPHLVIGWAPKRYGIFQAMMRRVQKQ-IEPMTSVGF---EDCE 131
            .:::|    .:..|:...|:.:.    :.:.|......:.:...|::. :..|...||   :|.|
Human    61 SIQEL----PLFFTFPPPGDTWE----LAYIPSHSDAAKTVTETVRRALVINMRVRGFPSEKDFE 117

  Fly   132 E-MRESVIENGLFAGLCFDGSPFVEDQVFEEDTLESYSNIQPM-------LNYTILLPSELRMLD 188
            : :|.....:.:.|.:.|: .||...:             :|:       |.::....:.:....
Human   118 DYIRYDNCSSSVLAAVVFE-HPFNHSK-------------EPLPLAVKYHLRFSYTRRNYMWTQT 168

  Fly   189 GDF---RMANWMT--LYNDDPNTFVLTRLNQPYE-----GGFVGYVREGFIRLQKSVSESFLVLT 243
            |.|   ....|.|  |:...||.       .|.|     ||..||:||||:.:|.:|..:  ::.
Human   169 GSFFLKETEGWHTTSLFPLFPNP-------GPREPTSPDGGEPGYIREGFLAVQHAVDRA--IME 224

  Fly   244 SHKSLP--------TIQIRRFPITGREQDPLMGNLNYGMPFIIIIGFLFPAQLFVWQVVSEKQSQ 300
            .|....        |:.|:|||......||.:..:.|.:|.::::.|.:.|......||.||:.:
Human   225 YHADAATRQLFQRLTVTIKRFPYPPFIADPFLVAIQYQLPLLLLLSFTYTALTIARAVVQEKERR 289

  Fly   301 VRQFLINMNIGNLIHFVSWYLKGLIYEMISSLIIAALLKIRWDQDHGVLTQTPWYILILVLFCYN 365
            :::::..|.:.:.:|:.:|:|...::.:|::..:..|..::...:..||:::...:::..|.|:.
Human   290 LKEYMRMMGLSSWLHWSAWFLLFFLFLLIAASFMTLLFCVKVKPNVAVLSRSDPSLVLAFLLCFA 354

  Fly   366 CAAVAFAIMVAAFFRNALNAVRVLTILWIMSYVPTFILSNNLEGNIHALRYVSYALPNVVATLVI 430
            .:.::|:.||:.||..|..|......|:..:|:|.|.::........:.:..|..|.||...:..
Human   355 ISTISFSFMVSTFFSKANMAAAFGGFLYFFTYIPYFFVAPRYNWMTLSQKLCSCLLSNVAMAMGA 419

  Fly   431 EFLIERESI-VHITWEDSGYRLNYDG----GHITVTASSWIFMLNALVYCAIGLYVD-------- 482
            :.:.:.|:. :.|.|.|....:|.|.    |.:.     .:.:|::::|..:..|::
Human   420 QLIGKFEAKGMGIQWRDLLSPVNVDDDFCFGQVL-----GMLLLDSVLYGLVTWYMEAVFPGQFG 479

  Fly   483 ------------MWRGGDRSGKKMKKPNTNASVQEDPYHERGDSFTHQGQAIGVNSTKIYEVEPS 535
                        .|.|         ||...|..:|:      ||...:..     ..:.:|.||.
Human   480 VPQPWYFFIMPSYWCG---------KPRAVAGKEEE------DSDPEKAL-----RNEYFEAEPE 524

  Fly   536 HRRFKLKIKKLCK--RFATNDRPALNLFSWNVYENEVTVLMGHNGCGKSTLLKILAGLVEPSRGT 598
            .....:|||.|.|  |....||.|:...:.|:||.::|||:||||.||:|.|.:|.||..|:.|.
Human   525 DLVAGIKIKHLSKVFRVGNKDRAAVRDLNLNLYEGQITVLLGHNGAGKTTTLSMLTGLFPPTSGR 589

  Fly   599 VMISSHNIQTERKAASMELGIAFGHDMLLTGFTVIDYLRFICRVKGLHNN---IEIDGQSNYFLN 660
            ..||.:.|..:.......||:...||:|....||.::|.|..::|||...   .|:.       .
Human   590 AYISGYEISQDMVQIRKSLGLCPQHDILFDNLTVAEHLYFYAQLKGLSRQKCPEEVK-------Q 647

  Fly   661 VLQIGGLKTK---RIRTLTDRDLCLVSICCAFVGNSPIILIDDVHSDLDKRTQSLVWNLINEEKS 722
            :|.|.||:.|   |.|.|:......:||..|.:..|.::::|:..|.:|..::..:|:|:..:||
Human   648 MLHIIGLEDKWNSRSRFLSGGMRRKLSIGIALIAGSKVLILDEPTSGMDAISRRAIWDLLQRQKS 712

  Fly   723 KRTIILVSNSPALAENIADRMAIMSNGELKCTGTKPFLKNMYGHGYRLTCVKGKNYKRDELFGMM 787
            .|||:|.::....|:.:.||:|||:.|||:|.|:..|||..||.||.:|.||..:...:::..::
Human   713 DRTIVLTTHFMDEADLLGDRIAIMAKGELQCCGSSLFLKQKYGAGYHMTLVKEPHCNPEDISQLV 777

  Fly   788 NSYMPNMSIERDIGYKVTFVLENKFEDQFPMLIDDLEENMQQLGVVSFRIRDTSMEEIFLRFG-- 850
            :.::||.::|...|.:::|:|..:...:|..|...||:..::||:.||....|:|||:|||.|
Human   778 HHHVPNATLESSAGAELSFILPRESTHRFEGLFAKLEKKQKELGIASFGASITTMEEVFLRVGKL 842

  Fly   851 --------------------------CEDNDQSGAFQSHENAQVLLEEYYSTLAEANEKGRRTGW 889
                                      ..|::..||....:....|:||            .||..
Human   843 VDSSMDIQAIQLPALQYQHERRASDWAVDSNLCGAMDPSDGIGALIEE------------ERTAV 895

  Fly   890 KL---FFLHGR---AVIYKRWIAAHRHWIVLIFEVL------AMALVAVCTFSSIF--------- 933
            ||   ..||.:   |:..|:...:.|.|.::..:||      .:||:|:...|.:|
Human   896 KLNTGLALHCQQFWAMFLKKAAYSWREWKMVAAQVLVPLTCVTLALLAINYSSELFDDPMLRLTL 960

  Fly   934 -IYGKN---YELEPLTFNLSQL---HTVDAFVELFSEEEDVKDMHAYYTELLYWYDAHVATLTKN 991
             .||:.   :.: |.|..|.|.   |..||   |.:|.::.:::.....|.|.
Human   961 GEYGRTVVPFSV-PGTSQLGQQLSEHLKDA---LQAEGQEPREVLGDLEEFLI------------ 1009

  Fly   992 RHNAYALLTQNQFTAHV-----NSRYIFGATF----DQKIVTAWFNNIPLHSAPYALNVVHNAVA 1047
                        |.|.|     |.|.:..|:|    ::.:|.|.|||...||...||.||.|.:.
Human  1010 ------------FRASVEGGGFNERCLVAASFRDVGERTVVNALFNNQAYHSPATALAVVDNLLF 1062

  Fly  1048 RHLFDEEATIDVTLAPLP---FRTAINTFPPSSHTFGGCLAFGICFVLTFIWPAFAIYMITERGS 1109
            :.|....|:|.|:..|.|   .:.|.:.|......|.  :|..:.|.:.|:...|:|..::||..
Human  1063 KLLCGPHASIVVSNFPQPRSALQAAKDQFNEGRKGFD--IALNLLFAMAFLASTFSILAVSERAV 1125

  Fly  1110 LLKKQQFLAGVRVCSYWTFTVLYDLLFLLIFCACVVVMVALYENPNHDVMLY---GYISVT---L 1168
            ..|..||::||.|.|:|...:|:||:..||....::|:...:     ||..:   |:::.|   |
Human  1126 QAKHVQFVSGVHVASFWLSALLWDLISFLIPSLLLLVVFKAF-----DVRAFTRDGHMADTLLLL 1185

  Fly  1169 MLGGFWVILLAYLM------ASLCRNPCYGFLWLCGINSIGLVCFSQFYRTHPE--SMLLEPTFM 1225
            :|.|:.:|.|.|||      |:........|..|.||.:..:|...:......|  |..|:..|:
Human  1186 LLYGWAIIPLMYLMNFFFLGAATAYTRLTIFNILSGIATFLMVTIMRIPAVKLEELSKTLDHVFL 1250

  Fly  1226 AM--YTVATVICKLFMIYEFKLICMDPVV--------NFTSVEVFKCNSIPNCCIKSNYGTFTAG 1280
            .:  :.:...:...:..||.:..|....|        |....|.|...|.|      ..|.|.|.
Human  1251 VLPNHCLGMAVSSFYENYETRRYCTSSEVAAHYCKKYNIQYQENFYAWSAP------GVGRFVAS 1309

  Fly  1281 IYHD----LVILTLLDIILLACLFVSEYHSILGFADC---------RLDTRTNESPDSNQESRAF 1332
            :...    |::|.|::..||..|     ..||    |         .|.||....|:....:...
Human  1310 MAASGCAYLILLFLIETNLLQRL-----RGIL----CALRRRRTLTELYTRMPVLPEDQDVADER 1365

  Fly  1333 PGILSNDTAALVDKEHTSRLNEEERSKYAAVGIGIVSKYRRNRV----LRDLDFTLAKSECLSIT 1393
            ..||:....:|:   ||..:.:|            :||....||    :..|...:.|.||..:.
Human  1366 TRILAPSPDSLL---HTPLIIKE------------LSKVYEQRVPLLAVDRLSLAVQKGECFGLL 1415

  Fly  1394 GANNSGKTTLLKVVVNETKMNAGQLWIHDYSVNTHRVQCYRMVGYCPQKDSLPSEFTPRELLYIH 1458
            |.|.:||||..|::..|..:.:|..::..:.:::...:..:.:|||||.|:|....|.||:|.::
Human  1416 GFNGAGKTTTFKMLTGEESLTSGDAFVGGHRISSDVGKVRQRIGYCPQFDALLDHMTGREMLVMY 1480

  Fly  1459 AMLQG--HRHRIGRELSEALLRLVGLTPCWNRSVRMCTTGQIRRLYFAYAVLGSPDLICVDGVPA 1521
            |.|:|  .|| ||..:...|..|: |.|..|:.||..:.|..|:|....|::|.|.:|.:|....
Human  1481 ARLRGIPERH-IGACVENTLRGLL-LEPHANKLVRTYSGGNKRKLSTGIALIGEPAVIFLDEPST 1543

  Fly  1522 GLDPTGKRIILMMTSTMQAMGSSFLYTMLTGLDAERLSLRTPLLLEGQLWMIRPMDTETENYKSG 1586
            |:||..:|::....:..:..|.:.:.|..:..:.|.|..|..::::||...:.........:.||
Human  1544 GMDPVARRLLWDTVARARESGKAIIITSHSMEECEALCTRLAIMVQGQFKCLGSPQHLKSKFGSG 1608

  Fly  1587 YQLEVRFKRKVNPNVSMSRATWNLINHFPMSPNKKFSAFMEIKFPDAVLTIERDDSMVFVLPLGT 1651
            |.|..:.:.:......                 ::|.||:::.||.:||..|....:.:.||...
Human  1609 YSLRAKVQSEGQQEAL-----------------EEFKAFVDLTFPGSVLEDEHQGMVHYHLPGRD 1656

  Fly  1652 TTFSEIFLTLRKDAFEMNIEDYFITRNMLVGFQIFTYDQHQDNP 1695
            .:::::|..|.|...:..::||.:::..|.  |:|....|...|
Human  1657 LSWAKVFGILEKAKEKYGVDDYSVSQISLE--QVFLSFAHLQPP 1698

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG1494	NP_001259763.1	ABC2_membrane_3	<263..480	CDD:289468	44/221 (20%)
		CcmA	541..848	CDD:224054	107/314 (34%)
		ABC_subfamily_A	541..761	CDD:213230	79/227 (35%)
		ABC2_membrane_3	911..>1189	CDD:289468	83/323 (26%)
		ABC2_membrane	<1080..>1188	CDD:304374	35/119 (29%)
		ABC_subfamily_A	1370..1577	CDD:213230	60/212 (28%)
		PRK14255	1371..1586	CDD:172743	59/220 (27%)
ABCA3	NP_001080.2	ABC2_membrane_3	<271..469	CDD:289468	40/202 (20%)
		CcmA	530..839	CDD:224054	108/315 (34%)
		ABC_subfamily_A	530..751	CDD:213230	79/227 (35%)
		ABC2_membrane_3	923..1261	CDD:289468	92/372 (25%)
		ABC_subfamily_A	1381..1602	CDD:213230	62/234 (26%)
		drrA	1397..1692	CDD:130256	79/315 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148317
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19229
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X215
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.850