DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG1494 and ABCA3

DIOPT Version :10

Sequence 1:NP_608444.2 Gene:CG1494 / 33102 FlyBaseID:FBgn0031169 Length:1695 Species:Drosophila melanogaster
Sequence 2:NP_001080.2 Gene:ABCA3 / 21 HGNCID:33 Length:1704 Species:Homo sapiens


Alignment Length:1864 Identity:449/1864 - (24%)
Similarity:794/1864 - (42%) Gaps:344/1864 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 IRKFLLMNWKNHKLQLANPLELLVILLVPPLFTLVAVLMRFFI-PVNHRSDTVYDPIDLDRSWMQ 70
            :|:..|:.|||:.||....|..::.|.:|.||:.:.:.:|..| ..|..:.|:|..        |
Human     4 LRQLALLLWKNYTLQKRKVLVTVLELFLPLLFSGILIWLRLKIQSENVPNATIYPG--------Q 60

  Fly    71 MVEKLEKARQVADTYNVKGNPFTPHLVIGWAPKRYGIFQAMMRRVQKQ-IEPMTSVGF---EDCE 131
            .:::|    .:..|:...|:.:.    :.:.|......:.:...|::. :..|...||   :|.|
Human    61 SIQEL----PLFFTFPPPGDTWE----LAYIPSHSDAAKTVTETVRRALVINMRVRGFPSEKDFE 117

  Fly   132 E-MRESVIENGLFAGLCFDGSPFVEDQVFEEDTLESYSNIQPM-------LNYTILLPSELRMLD 188
            : :|.....:.:.|.:.|: .||...:             :|:       |.::....:.:....
Human   118 DYIRYDNCSSSVLAAVVFE-HPFNHSK-------------EPLPLAVKYHLRFSYTRRNYMWTQT 168

  Fly   189 GDF---RMANWMT--LYNDDPNTFVLTRLNQPYE-----GGFVGYVREGFIRLQKSVSESFLVLT 243
            |.|   ....|.|  |:...||.       .|.|     ||..||:||||:.:|.:|..:  ::.
Human   169 GSFFLKETEGWHTTSLFPLFPNP-------GPREPTSPDGGEPGYIREGFLAVQHAVDRA--IME 224

  Fly   244 SHKSLP--------TIQIRRFPITGREQDPLMGNLNYGMPFIIIIGFLFPAQLFVWQVVSEKQSQ 300
            .|....        |:.|:|||......||.:..:.|.:|.::::.|.:.|......||.||:.:
Human   225 YHADAATRQLFQRLTVTIKRFPYPPFIADPFLVAIQYQLPLLLLLSFTYTALTIARAVVQEKERR 289

  Fly   301 VRQFLINMNIGNLIHFVSWYLKGLIYEMISSLIIAALLKIRWDQDHGVLTQTPWYILILVLFCYN 365
            :::::..|.:.:.:|:.:|:|...::.:|::..:..|..::...:..||:::...:::..|.|:.
Human   290 LKEYMRMMGLSSWLHWSAWFLLFFLFLLIAASFMTLLFCVKVKPNVAVLSRSDPSLVLAFLLCFA 354

  Fly   366 CAAVAFAIMVAAFFRNALNAVRVLTILWIMSYVPTFILSNNLEGNIHALRYVSYALPNVVATLVI 430
            .:.::|:.||:.||..|..|......|:..:|:|.|.::........:.:..|..|.||...:..
Human   355 ISTISFSFMVSTFFSKANMAAAFGGFLYFFTYIPYFFVAPRYNWMTLSQKLCSCLLSNVAMAMGA 419

  Fly   431 EFLIERESI-VHITWEDSGYRLNYDG----GHITVTASSWIFMLNALVYCAIGLYVD-------- 482
            :.:.:.|:. :.|.|.|....:|.|.    |.:.     .:.:|::::|..:..|::        
Human   420 QLIGKFEAKGMGIQWRDLLSPVNVDDDFCFGQVL-----GMLLLDSVLYGLVTWYMEAVFPGQFG 479

  Fly   483 ------------MWRGGDRSGKKMKKPNTNASVQEDPYHERGDSFTHQGQAIGVNSTKIYEVEPS 535
                        .|.|         ||...|..:|:      ||...:..     ..:.:|.||.
Human   480 VPQPWYFFIMPSYWCG---------KPRAVAGKEEE------DSDPEKAL-----RNEYFEAEPE 524

  Fly   536 HRRFKLKIKKLCK--RFATNDRPALNLFSWNVYENEVTVLMGHNGCGKSTLLKILAGLVEPSRGT 598
            .....:|||.|.|  |....||.|:...:.|:||.::|||:||||.||:|.|.:|.||..|:.|.
Human   525 DLVAGIKIKHLSKVFRVGNKDRAAVRDLNLNLYEGQITVLLGHNGAGKTTTLSMLTGLFPPTSGR 589

  Fly   599 VMISSHNIQTERKAASMELGIAFGHDMLLTGFTVIDYLRFICRVKGLHNN---IEIDGQSNYFLN 660
            ..||.:.|..:.......||:...||:|....||.::|.|..::|||...   .|:.       .
Human   590 AYISGYEISQDMVQIRKSLGLCPQHDILFDNLTVAEHLYFYAQLKGLSRQKCPEEVK-------Q 647

  Fly   661 VLQIGGLKTK---RIRTLTDRDLCLVSICCAFVGNSPIILIDDVHSDLDKRTQSLVWNLINEEKS 722
            :|.|.||:.|   |.|.|:......:||..|.:..|.::::|:..|.:|..::..:|:|:..:||
Human   648 MLHIIGLEDKWNSRSRFLSGGMRRKLSIGIALIAGSKVLILDEPTSGMDAISRRAIWDLLQRQKS 712

  Fly   723 KRTIILVSNSPALAENIADRMAIMSNGELKCTGTKPFLKNMYGHGYRLTCVKGKNYKRDELFGMM 787
            .|||:|.::....|:.:.||:|||:.|||:|.|:..|||..||.||.:|.||..:...:::..::
Human   713 DRTIVLTTHFMDEADLLGDRIAIMAKGELQCCGSSLFLKQKYGAGYHMTLVKEPHCNPEDISQLV 777

  Fly   788 NSYMPNMSIERDIGYKVTFVLENKFEDQFPMLIDDLEENMQQLGVVSFRIRDTSMEEIFLRFG-- 850
            :.::||.::|...|.:::|:|..:...:|..|...||:..::||:.||....|:|||:|||.|  
Human   778 HHHVPNATLESSAGAELSFILPRESTHRFEGLFAKLEKKQKELGIASFGASITTMEEVFLRVGKL 842

  Fly   851 --------------------------CEDNDQSGAFQSHENAQVLLEEYYSTLAEANEKGRRTGW 889
                                      ..|::..||....:....|:||            .||..
Human   843 VDSSMDIQAIQLPALQYQHERRASDWAVDSNLCGAMDPSDGIGALIEE------------ERTAV 895

  Fly   890 KL---FFLHGR---AVIYKRWIAAHRHWIVLIFEVL------AMALVAVCTFSSIF--------- 933
            ||   ..||.:   |:..|:...:.|.|.::..:||      .:||:|:...|.:|         
Human   896 KLNTGLALHCQQFWAMFLKKAAYSWREWKMVAAQVLVPLTCVTLALLAINYSSELFDDPMLRLTL 960

  Fly   934 -IYGKN---YELEPLTFNLSQL---HTVDAFVELFSEEEDVKDMHAYYTELLYWYDAHVATLTKN 991
             .||:.   :.: |.|..|.|.   |..||   |.:|.::.:::.....|.|.            
Human   961 GEYGRTVVPFSV-PGTSQLGQQLSEHLKDA---LQAEGQEPREVLGDLEEFLI------------ 1009

  Fly   992 RHNAYALLTQNQFTAHV-----NSRYIFGATF----DQKIVTAWFNNIPLHSAPYALNVVHNAVA 1047
                        |.|.|     |.|.:..|:|    ::.:|.|.|||...||...||.||.|.:.
Human  1010 ------------FRASVEGGGFNERCLVAASFRDVGERTVVNALFNNQAYHSPATALAVVDNLLF 1062

  Fly  1048 RHLFDEEATIDVTLAPLP---FRTAINTFPPSSHTFGGCLAFGICFVLTFIWPAFAIYMITERGS 1109
            :.|....|:|.|:..|.|   .:.|.:.|......|.  :|..:.|.:.|:...|:|..::||..
Human  1063 KLLCGPHASIVVSNFPQPRSALQAAKDQFNEGRKGFD--IALNLLFAMAFLASTFSILAVSERAV 1125

  Fly  1110 LLKKQQFLAGVRVCSYWTFTVLYDLLFLLIFCACVVVMVALYENPNHDVMLY---GYISVT---L 1168
            ..|..||::||.|.|:|...:|:||:..||....::|:...:     ||..:   |:::.|   |
Human  1126 QAKHVQFVSGVHVASFWLSALLWDLISFLIPSLLLLVVFKAF-----DVRAFTRDGHMADTLLLL 1185

  Fly  1169 MLGGFWVILLAYLM------ASLCRNPCYGFLWLCGINSIGLVCFSQFYRTHPE--SMLLEPTFM 1225
            :|.|:.:|.|.|||      |:........|..|.||.:..:|...:......|  |..|:..|:
Human  1186 LLYGWAIIPLMYLMNFFFLGAATAYTRLTIFNILSGIATFLMVTIMRIPAVKLEELSKTLDHVFL 1250

  Fly  1226 AM--YTVATVICKLFMIYEFKLICMDPVV--------NFTSVEVFKCNSIPNCCIKSNYGTFTAG 1280
            .:  :.:...:...:..||.:..|....|        |....|.|...|.|      ..|.|.|.
Human  1251 VLPNHCLGMAVSSFYENYETRRYCTSSEVAAHYCKKYNIQYQENFYAWSAP------GVGRFVAS 1309

  Fly  1281 IYHD----LVILTLLDIILLACLFVSEYHSILGFADC---------RLDTRTNESPDSNQESRAF 1332
            :...    |::|.|::..||..|     ..||    |         .|.||....|:....:...
Human  1310 MAASGCAYLILLFLIETNLLQRL-----RGIL----CALRRRRTLTELYTRMPVLPEDQDVADER 1365

  Fly  1333 PGILSNDTAALVDKEHTSRLNEEERSKYAAVGIGIVSKYRRNRV----LRDLDFTLAKSECLSIT 1393
            ..||:....:|:   ||..:.:|            :||....||    :..|...:.|.||..:.
Human  1366 TRILAPSPDSLL---HTPLIIKE------------LSKVYEQRVPLLAVDRLSLAVQKGECFGLL 1415

  Fly  1394 GANNSGKTTLLKVVVNETKMNAGQLWIHDYSVNTHRVQCYRMVGYCPQKDSLPSEFTPRELLYIH 1458
            |.|.:||||..|::..|..:.:|..::..:.:::...:..:.:|||||.|:|....|.||:|.::
Human  1416 GFNGAGKTTTFKMLTGEESLTSGDAFVGGHRISSDVGKVRQRIGYCPQFDALLDHMTGREMLVMY 1480

  Fly  1459 AMLQG--HRHRIGRELSEALLRLVGLTPCWNRSVRMCTTGQIRRLYFAYAVLGSPDLICVDGVPA 1521
            |.|:|  .|| ||..:...|..|: |.|..|:.||..:.|..|:|....|::|.|.:|.:|....
Human  1481 ARLRGIPERH-IGACVENTLRGLL-LEPHANKLVRTYSGGNKRKLSTGIALIGEPAVIFLDEPST 1543

  Fly  1522 GLDPTGKRIILMMTSTMQAMGSSFLYTMLTGLDAERLSLRTPLLLEGQLWMIRPMDTETENYKSG 1586
            |:||..:|::....:..:..|.:.:.|..:..:.|.|..|..::::||...:.........:.||
Human  1544 GMDPVARRLLWDTVARARESGKAIIITSHSMEECEALCTRLAIMVQGQFKCLGSPQHLKSKFGSG 1608

  Fly  1587 YQLEVRFKRKVNPNVSMSRATWNLINHFPMSPNKKFSAFMEIKFPDAVLTIERDDSMVFVLPLGT 1651
            |.|..:.:.:......                 ::|.||:::.||.:||..|....:.:.||...
Human  1609 YSLRAKVQSEGQQEAL-----------------EEFKAFVDLTFPGSVLEDEHQGMVHYHLPGRD 1656

  Fly  1652 TTFSEIFLTLRKDAFEMNIEDYFITRNMLVGFQIFTYDQHQDNP 1695
            .:::::|..|.|...:..::||.:::..|.  |:|....|...|
Human  1657 LSWAKVFGILEKAKEKYGVDDYSVSQISLE--QVFLSFAHLQPP 1698

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG1494NP_608444.2 rim_protein <223..1689 CDD:130324 400/1617 (25%)
ABC_subfamily_A 541..761 CDD:213230 79/227 (35%)
ABCA3NP_001080.2 rim_protein 1..>43 CDD:130324 12/38 (32%)
rim_protein <131..1699 CDD:130324 420/1721 (24%)

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