DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1494 and ABCA2

DIOPT Version :9

Sequence 1:	NP_001259763.1	Gene:	CG1494 / 33102	FlyBaseID:	FBgn0031169	Length:	1695	Species:	Drosophila melanogaster
Sequence 2:	NP_997698.1	Gene:	ABCA2 / 20	HGNCID:	32	Length:	2466	Species:	Homo sapiens

Alignment Length:	1970	Identity:	406/1970 - (20%)
Similarity:	731/1970 - (37%)	Gaps:	575/1970 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   126 GFEDCEEMRESVIENGL----------FAGLCF----DGSPFVEDQVFEEDTLESYSNIQPMLNY 176
            ||.|    .||::...|          ||.:.|    |||                  :.|.::|
Human   612 GFPD----EESIVNYTLNQAYQDNVTVFASVIFQTRKDGS------------------LPPHVHY 654

  Fly   177 TILLPSELRMLDGDFRMANWMTLYNDDPNTFVLTRLNQPYEGGFVGYVREGFIRLQKSVSESFL- 240
            .|...|.......:.|.|.|    ...|||           ||.. |...||:.:|..:..:.:
Human   655 KIRQNSSFTEKTNEIRRAYW----RPGPNT-----------GGRF-YFLYGFVWIQDMMERAIID 703

  Fly   241 VLTSHKSL-PTIQIRRFPITGREQDPLMGNLNYGMPFIIIIGFLFPAQLFVWQVVSEKQSQVRQF 304
            ....|..: |...::.||.....:|..:..:.:.||..::|.:::...:.:..:|:||:.::::.
Human   704 TFVGHDVVEPGSYVQMFPYPCYTRDDFLFVIEHMMPLCMVISWVYSVAMTIQHIVAEKEHRLKEV 768

  Fly   305 LINMNIGNLIHFVSWYLKGLIYEMISSLIIAALLKIRWDQDHG-VLTQTPWYILILVLFCYNCAA 368
            :..|.:.|.:|:|:|::.|.:...||...:.|:||      :| ||..:...|:.|.|..|..|.
Human   769 MKTMGLNNAVHWVAWFITGFVQLSISVTALTAILK------YGQVLMHSHVVIIWLFLAVYAVAT 827

  Fly   369 VAFAIMVAAFFRNALNAVRVLTILWIMSYVPTFILSNNLEGNIHALRYVSY----ALPNVVATLV 429
            :.|..:|:..:..|..|.....|::.:||||...::...|        |::    |....:|:|:
Human   828 IMFCFLVSVLYSKAKLASACGGIIYFLSYVPYMYVAIREE--------VAHDKITAFEKCIASLM 884

  Fly   430 IEFLIERESIVHITWEDSGYRLNY--------DGGHITVTASSWIFMLNALVYCAIGLYVD---- 482
            ........|.....:|.:|..:.:        :|....:..:..:.|::|:||..:..|::
Human   885 STTAFGLGSKYFALYEVAGVGIQWHTFSQSPVEGDDFNLLLAVTMLMVDAVVYGILTWYIEAVHP 949

  Fly   483 ----------------MWRGGDR------SGKKMKKPNTNASVQEDPYHERGDSFTHQGQAIGVN 525
                            .|.|..|      |....:.|..:. ::||             ||..:.
Human   950 GMYGLPRPWYFPLQKSYWLGSGRTEAWEWSWPWARTPRLSV-MEED-------------QACAME 1000

  Fly   526 S-----TKIYEVEPSHRRFKLKIKKLCKRFATNDRPALNLFSWNVYENEVTVLMGHNGCGKSTLL 585
            |     |:..|.||:|....:.:.||.|.:..:.:.|||..|.|:|||:|...:||||.||:|.:
Human  1001 SRRFEETRGMEEEPTHLPLVVCVDKLTKVYKDDKKLALNKLSLNLYENQVVSFLGHNGAGKTTTM 1065

  Fly   586 KILAGLVEPSRGTVMISSHNIQTERKAASMELGIAFGHDMLLTGFTVIDYLRFICRVKGLHNNIE 650
            .||.||..|:.|:..|..|:|:||.......||:...|::|....||.::|.|..|:|.:... |
Human  1066 SILTGLFPPTSGSATIYGHDIRTEMDEIRKNLGMCPQHNVLFDRLTVEEHLWFYSRLKSMAQE-E 1129

  Fly   651 IDGQSNYFLNVLQIGGLKTKRIRTLTDRDLCLVSICCAFVGNSPIILIDDVHSDLDKRTQSLVWN 715
            |..:.:..:..|::...:...::||:......:|:..||||.|..|::|:..:.:|...:..:|:
Human  1130 IRREMDKMIEDLELSNKRHSLVQTLSGGMKRKLSVAIAFVGGSRAIILDEPTAGVDPYARRAIWD 1194

  Fly   716 LINEEKSKRTIILVSNSPALAENIADRMAIMSNGELKCTGTKPFLKNMYGHGYRLTCVK------ 774
            ||.:.|..|||:|.::....|:.:.||:||:|:|:|||.|:..|||..||.|||||.||
Human  1195 LILKYKPGRTILLSTHHMDEADLLGDRIAIISHGKLKCCGSPLFLKGTYGDGYRLTLVKRPAEPG 1259

  Fly   775 ------------GK----NYKRDELFGMMNSYMPNMSIERDIGYKVTFVL--ENKFEDQFPMLID 821
                        |:    :....::...:..::.:..:..|...:::::|  |...:..|..|..
Human  1260 GPQEPGLASSPPGRAPLSSCSELQVSQFIRKHVASCLLVSDTSTELSYILPSEAAKKGAFERLFQ 1324

  Fly   822 DLEENMQQLGVVSFRIRDTSMEEIFLRFGCEDNDQSGAFQSHENAQVLLEE-------------- 872
            .||.::..|.:.||.:.||::||:||:...||       ||.||::..::|
Human  1325 HLERSLDALHLSSFGLMDTTLEEVFLKVSEED-------QSLENSEADVKESRKDVLPGAEGPAS 1382

  Fly   873 ---YYSTLAEANE---------------------------------------------------- 882
               :...||..:|
Human  1383 GEGHAGNLARCSELTQSQASLQSASSVGSARGDEGAGYTDVYGDYRPLFDNPQDPDNVSLQEVEA 1447

  Fly   883 -------KGRRT---GW-KLFFLHGRAVIYKRWIAAHRHWIVLIFEVLAMAL---VAVCTFSSIF 933
                   :|.|.   || |:...||  ::.||:..|.|:...|..::|..|.   ||:....|:.
Human  1448 EALSRVGQGSRKLDGGWLKVRQFHG--LLVKRFHCARRNSKALFSQILLPAFFVCVAMTVALSVP 1510

  Fly   934 IYGKNYELEPLTFNLSQLHT--------------------------------VDAF--------- 957
            ..|   :|.||..:.||.|.                                |..|
Human  1511 EIG---DLPPLVLSPSQYHNYTQPRGNFIPYANEERREYRLRLSPDASPQQLVSTFRLPSGVGAT 1572

  Fly   958 --------------VELFSEEEDV----------------------------------------K 968
                          :.|.|.|..:                                        :
Human  1573 CVLKSPANGSLGPTLNLSSGESRLLAARFFDSMCLESFTQGLPLSNFVPPPPSPAPSDSPASPDE 1637

  Fly   969 DMHAYYTEL------LYWYDA-----------------------------------HVAT----- 987
            |:.|:...|      ..|..|                                   .|.|
Human  1638 DLQAWNVSLPPTAGPEMWTSAPSLPRLVREPVRCTCSAQGTGFSCPSSVGGHPPQMRVVTGDILT 1702

  Fly   988 -LTKNRHNAYALLTQNQFTAHVNSRYIFG-------ATFD------------QKIVTAWFNNIPL 1032
             :|.:..:.|.|.|.::|..|......||       |:|.            ::....::||...
Human  1703 DITGHNVSEYLLFTSDRFRLHRYGAITFGNVLKSIPASFGTRAPPMVRKIAVRRAAQVFYNNKGY 1767

  Fly  1033 HSAPYALNVVHNAVARHLFDEEA------TIDVTLAPLPFRTAINTFPPSSHTFGGCLAFGICFV 1091
            ||.|..||.::||:.|....:..      .|.||..|:...:|..:...........:|..|...
Human  1768 HSMPTYLNSLNNAILRANLPKSKGNPAAYGITVTNHPMNKTSASLSLDYLLQGTDVVIAIFIIVA 1832

  Fly  1092 LTFIWPAFAIYMITERGSLLKKQQFLAGVRVCSYWTFTVLYDLLFLLIFCACVVVMVALYENPNH 1156
            ::|:..:|.::::.|:.:..|..||::|.....||....::|:|..|:...|.|:::.:::.|.:
Human  1833 MSFVPASFVVFLVAEKSTKAKHLQFVSGCNPIIYWLANYVWDMLNYLVPATCCVIILFVFDLPAY 1897

  Fly  1157 D-----------VMLYGYISVTLML--GGFWVILLAYLMASLCRNPCYGFLWLCGIN-SIGLVCF 1207
            .           .:|||: |:|.::  ..||..:           |...:::|..|| .||:..
Human  1898 TSPTNFPAVLSLFLLYGW-SITPIMYPASFWFEV-----------PSSAYVFLIVINLFIGITA- 1949

  Fly  1208 SQFYRTHPESMLLEPTFMAMYTVATVICKLFMIYEFKLICMDPVVNFTSVEVFKCNSIPNCCIKS 1272
                                 ||||.:.:||                   |..|...:.|..:||
Human  1950 ---------------------TVATFLLQLF-------------------EHDKDLKVVNSYLKS 1974

  Fly  1273 NYGTF-TAGIYHDLVILTLLDIILLACLFVSEYHSILGFAD------------------------ 1312
            .:..| ...:.|.|:.:...:       :::||::.:|..|
Human  1975 CFLIFPNYNLGHGLMEMAYNE-------YINEYYAKIGQFDKMKSPFEWDIVTRGLVAMAVEGVV 2032

  Fly  1313 -------C---------RLDTRTNESPD----SNQESRAFPGILSNDTAALVDKEHTSRLNEEER 1357
                   |         |:...|....|    :::..|...|...||   :|..|:.:::
Human  2033 GFLLTIMCQYNFLRRPQRMPVSTKPVEDDVDVASERQRVLRGDADND---MVKIENLTKV----- 2089

  Fly  1358 SKYAAVGIGIVSKYRRNRVLRDLDFTLAKSECLSITGANNSGKTTLLKVVVNETKMNAGQLWIHD 1422
              |.:..||.:....|      |...:...||..:.|.|.:|||:..|::..:.....|:.:::.
Human  2090 --YKSRKIGRILAVDR------LCLGVRPGECFGLLGVNGAGKTSTFKMLTGDESTTGGEAFVNG 2146

  Fly  1423 YSVNTHRVQCYRMVGYCPQKDSLPSEFTPRELLYIHAMLQGHRHRIGRELSEALLRLVGLTPCWN 1487
            :||....:|..:.:|||||.|:|..|.|.||.|.::..|:|...:....:.:..|..:.||...:
Human  2147 HSVLKELLQVQQSLGYCPQCDALFDELTAREHLQLYTRLRGISWKDEARVVKWALEKLELTKYAD 2211

  Fly  1488 RSVRMCTTGQIRRLYFAYAVLGSPDLICVDGVPAGLDPTGKRIILMMTSTMQAMGSSFLYTMLTG 1552
            :.....:.|..|:|..|.|::|.|..|.:|....|:||..:|.:..:...:...|.|.:.|..:.
Human  2212 KPAGTYSGGNKRKLSTAIALIGYPAFIFLDEPTTGMDPKARRFLWNLILDLIKTGRSVVLTSHSM 2276

  Fly  1553 LDAERLSLRTPLLLEGQLWMIRPMDTETENYKSGYQLEVRFKRKVNPNVSMSRATWNLINHFPMS 1617
            .:.|.|..|..:::.|:|..:..:......:..||.:.||.|        .|::..:::..|
Human  2277 EECEALCTRLAIMVNGRLRCLGSIQHLKNRFGDGYMITVRTK--------SSQSVKDVVRFF--- 2330

  Fly  1618 PNKKFSAFMEIKFPDAVLTIERDDSMVFVLPLGTTTFSEIFLTLRKDAFEMNIEDYFITR----N 1678
             |:        .||:|:|.......:.:.|.....:.:::|..:.:.:..:.||||.:::    |
Human  2331 -NR--------NFPEAMLKERHHTKVQYQLKSEHISLAQVFSKMEQVSGVLGIEDYSVSQTTLDN 2386

  Fly  1679 MLVGF---QIFTYDQHQDNP 1695
            :.|.|   |....:|.:..|
Human  2387 VFVNFAKKQSDNLEQQETEP 2406

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1494	NP_001259763.1	ABC2_membrane_3	<263..480	CDD:289468	48/229 (21%)
		CcmA	541..848	CDD:224054	101/330 (31%)
		ABC_subfamily_A	541..761	CDD:213230	74/219 (34%)
		ABC2_membrane_3	911..>1189	CDD:289468	74/460 (16%)
		ABC2_membrane	<1080..>1188	CDD:304374	24/120 (20%)
		ABC_subfamily_A	1370..1577	CDD:213230	52/206 (25%)
		PRK14255	1371..1586	CDD:172743	52/214 (24%)
ABCA2	NP_997698.1	rim_protein	58..2398	CDD:130324	404/1960 (21%)
		ABC_subfamily_A	1021..1240	CDD:213230	74/219 (34%)
		ABC_subfamily_A	2081..2304	CDD:213230	57/235 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148382
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.750