DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1494 and ABCA1

DIOPT Version :9

Sequence 1:	NP_001259763.1	Gene:	CG1494 / 33102	FlyBaseID:	FBgn0031169	Length:	1695	Species:	Drosophila melanogaster
Sequence 2:	NP_005493.2	Gene:	ABCA1 / 19	HGNCID:	29	Length:	2261	Species:	Homo sapiens

Alignment Length:	1995	Identity:	413/1995 - (20%)
Similarity:	777/1995 - (38%)	Gaps:	490/1995 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 KLQLANPLELLVILLVPPLFTLVAVLMRFFIPVNHRSDTV---YDPIDLDRSWMQMVEKLE---- 76
            :|.:.:.||.:...|.|.::|        |:..:...|.|   .|..|.|..|.|.::.|:
Human   405 ELAVFHDLEGMWEELSPKIWT--------FMENSQEMDLVRMLLDSRDNDHFWEQQLDGLDWTAQ 461

  Fly    77 -----KARQVADTYNVKGNPFTPHLVIGWAPKRYGIFQAMMRRVQK--------QIEPM-TSVGF 127
                 .|:...|..:..|:.:|      |. :.:......:|.:.:        ::||: |.|..
Human   462 DIVAFLAKHPEDVQSSNGSVYT------WR-EAFNETNQAIRTISRFMECVNLNKLEPIATEVWL 519

  Fly   128 EDCEEMRESVIENGLFAGLCFDGSPFVEDQVFEEDTLESYSNIQPMLNYTILLPS----ELRMLD 188
              ..:..|.:.|...:||:.|.|                   |.|   .:|.||.    ::||..
Human   520 --INKSMELLDERKFWAGIVFTG-------------------ITP---GSIELPHHVKYKIRMDI 560

  Fly   189 GDFRMAN------WMTLYNDDPNTFVLTRLNQPYEGGFVGYVREGFIRLQKSVSESFL-VLTSHK 246
            .:....|      |      ||....     .|:|.  :.||..||..||..|.::.: |||..:
Human   561 DNVERTNKIKDGYW------DPGPRA-----DPFED--MRYVWGGFAYLQDVVEQAIIRVLTGTE 612

  Fly   247 SLPTIQIRRFPITGREQDPLMGNLNYGMPFIIIIGFLFPAQLFVWQVVSEKQSQVRQFLINMNIG 311
            ....:.:::.|......|..:..::..||..:.:.:::...:.:..:|.||::::::.:..|.:.
Human   613 KKTGVYMQQMPYPCYVDDIFLRVMSRSMPLFMTLAWIYSVAVIIKGIVYEKEARLKETMRIMGLD 677

  Fly   312 NLIHFVSWYLKGLIYEMISSLIIAALLKIRWDQDHGVLTQTPWYILILVLFCYNCAAVAFAIMVA 376
            |.|.:.||::..||..::|:.::..:||:     ..:|..:...::.:.|..:....:....:::
Human   678 NSILWFSWFISSLIPLLVSAGLLVVILKL-----GNLLPYSDPSVVFVFLSVFAVVTILQCFLIS 737

  Fly   377 AFFRNALNAVRVLTILWIMSYVPTFILSNNLEGNIHALRYVSYALPNVVATLVIE---------F 432
            ..|..|..|.....|::...|:| ::|.      :....||.:.| .:.|:|:..         |
Human   738 TLFSRANLAAACGGIIYFTLYLP-YVLC------VAWQDYVGFTL-KIFASLLSPVAFGFGCEYF 794

  Fly   433 LIERESIVHITWEDSGYR--LNYDGGHITVTASSWIFMLNALVYCAIGLYVDMWRGGDRSGKKMK 495
            .:..|..:.:.| |:.:.  :..||.::|.:.|..:|  :..:|..:..|::....|...   :.
Human   795 ALFEEQGIGVQW-DNLFESPVEEDGFNLTTSVSMMLF--DTFLYGVMTWYIEAVFPGQYG---IP 853

  Fly   496 KPNTNASVQEDPYHERGDSFTHQGQAIGVNSTKIYEV----EPSHRRFKLKIKKLCKRFATNDRP 556
            :|......:...:.|..|..:|.|.    |..:|.|:    ||:|.:..:.|:.|.|.:....:.
Human   854 RPWYFPCTKSYWFGEESDEKSHPGS----NQKRISEICMEEEPTHLKLGVSIQNLVKVYRDGMKV 914

  Fly   557 ALNLFSWNVYENEVTVLMGHNGCGKSTLLKILAGLVEPSRGTVMISSHNIQTERKAASMELGIAF 621
            |::..:.|.||.::|..:||||.||:|.:.||.||..|:.||..|...:|::|.......||:..
Human   915 AVDGLALNFYEGQITSFLGHNGAGKTTTMSILTGLFPPTSGTAYILGKDIRSEMSTIRQNLGVCP 979

  Fly   622 GHDMLLTGFTVIDYLRFICRVKGL---HNNIEIDGQSNYFLNVLQIGGLKTKRIRTLT------- 676
            .|::|....||.:::.|..|:|||   |...|::..:   |:|    ||.:.::::.|
Human   980 QHNVLFDMLTVEEHIWFYARLKGLSEKHVKAEMEQMA---LDV----GLPSSKLKSKTSQLSGGM 1037

  Fly   677 DRDLCLVSICCAFVGNSPIILIDDVHSDLDKRTQSLVWNLINEEKSKRTIILVSNSPALAENIAD 741
            .|.|   |:..||||.|.::::|:..:.:|..::..:|.|:.:.:..|||||.::....|:.:.|
Human  1038 QRKL---SVALAFVGGSKVVILDEPTAGVDPYSRRGIWELLLKYRQGRTIILSTHHMDEADVLGD 1099

  Fly   742 RMAIMSNGELKCTGTKPFLKNMYGHGYRLTCVK-------------------------------- 774
            |:||:|:|:|.|.|:..||||..|.||.||.||
Human  1100 RIAIISHGKLCCVGSSLFLKNQLGTGYYLTLVKKDVESSLSSCRNSSSTVSYLKKEDSVSQSSSD 1164

  Fly   775 ---GKNYKRDEL-------FGMMNSYMPNMSIERDIGYKVTFVL--ENKFEDQFPMLIDDLEENM 827
               |.:::.|.|       ..::..::....:..|||:::|:||  |...|..|..|..::::.:
Human  1165 AGLGSDHESDTLTIDVSAISNLIRKHVSEARLVEDIGHELTYVLPYEAAKEGAFVELFHEIDDRL 1229

  Fly   828 QQLGVVSFRIRDTSMEEIFLRF----GCEDNDQSGAFQSHENAQVLLEEYYSTL--------AEA 880
            ..||:.|:.|.:|::|||||:.    |.:.....|...:..|.:...:: .|.|        |:.
Human  1230 SDLGISSYGISETTLEEIFLKVAEESGVDAETSDGTLPARRNRRAFGDK-QSCLRPFTEDDAADP 1293

  Fly   881 NE-----KGRRT---------------GWKLFFLHGRAVIYKRWIAAHRH------WIVLIFEVL 919
            |:     :.|.|               ||||......|:::||.:.|.|.      .|||....:
Human  1294 NDSDIDPESRETDLLSGMDGKGSYQVKGWKLTQQQFVALLWKRLLIARRSRKGFFAQIVLPAVFV 1358

  Fly   920 AMALVAVCTFSSIF-IYGK--NYELEPLTFN----------------LSQLHTV----------- 954
            .:|||    ||.|. .:||  :.||:|..:|                |..|:.:
Human  1359 CIALV----FSLIVPPFGKYPSLELQPWMYNEQYTFVSNDAPEDTGTLELLNALTKDPGFGTRCM 1419

  Fly   955 -----------------------DAFVELFS---------------EEEDVKDM----------- 970
                                   ...::||.               ..:.:|.|
Human  1420 EGNPIPDTPCQAGEEEWTTAPVPQTIMDLFQNGNWTMQNPSPACQCSSDKIKKMLPVCPPGAGGL 1484

  Fly   971 -----HAYYTELL----------YWYDAHVATLTKN----------RHNAYALLTQN-------- 1002
                 .....::|          |....:|..:.|:          |:..::|...|
Human  1485 PPPQRKQNTADILQDLTGRNISDYLVKTYVQIIAKSLKNKIWVNEFRYGGFSLGVSNTQALPPSQ 1549

  Fly  1003 -------QFTAH------------VNSRYIFGATFDQK-IVTAWFNNIPLHSAPYALNVVHNAVA 1047
                   |...|            :||...|....|.| .|..||||...|:....|||::||:.
Human  1550 EVNDAIKQMKKHLKLAKDSSADRFLNSLGRFMTGLDTKNNVKVWFNNKGWHAISSFLNVINNAIL 1614

  Fly  1048 RHLFDEEATIDVTLAPLPFRTAINTFPPSSH---------------TFGGCLAFGIC--FVLTFI 1095
            |        .::.....|....|..|   :|               |....:...||  |.::|:
Human  1615 R--------ANLQKGENPSHYGITAF---NHPLNLTKQQLSEVALMTTSVDVLVSICVIFAMSFV 1668

  Fly  1096 WPAFAIYMITERGSLLKKQQFLAGVRVCSYWTFTVLYDLLFLLIFCACVVVMVALYENPNHDVML 1160
            ..:|.:::|.||.|..|..||::||:...||....::|:...::....|:::...::..:
Human  1669 PASFVVFLIQERVSKAKHLQFISGVKPVIYWLSNFVWDMCNYVVPATLVIIIFICFQQKS----- 1728

  Fly  1161 YGYISVT--------LMLGGFWVILLAYLMASLCRNPCYGFLWLCGIN-------SIGLVCFSQF 1210
              |:|.|        |:|.|:.:..|.|..:.:.:.|...::.|..:|       |:.......|
Human  1729 --YVSSTNLPVLALLLLLYGWSITPLMYPASFVFKIPSTAYVVLTSVNLFIGINGSVATFVLELF 1791

  Fly  1211 YRTHPESMLLEPTFMAMYTVATVICKLFMIYEFKLICMDPVVNFTSVEVFKCNSIPNCCIKSNYG 1275
                        |...:..:..::..:|:|  |...|:...:    :::.|..::.:...:....
Human  1792 ------------TDNKLNNINDILKSVFLI--FPHFCLGRGL----IDMVKNQAMADALERFGEN 1838

  Fly  1276 TFTAGIYHDL------------VILTLLDIILLACLFVSEYHSILGFADCRLDTRTNESPDSNQE 1328
            .|.:.:..||            |:..|:.:::....|:....     .:.:|....:|..|..:|
Human  1839 RFVSPLSWDLVGRNLFAMAVEGVVFFLITVLIQYRFFIRPRP-----VNAKLSPLNDEDEDVRRE 1898

  Fly  1329 -SRAFPGILSNDTAALVDKEHTSRLNEEERSKYAAVGIGIVSKYRRNRVLRDLDFTLAKSECLSI 1392
             .|...|...||...:  ||.|.....:.:.....:.:||                 ...||..:
Human  1899 RQRILDGGGQNDILEI--KELTKIYRRKRKPAVDRICVGI-----------------PPGECFGL 1944

  Fly  1393 TGANNSGKTTLLKVVVNETKMNAGQLWIHDYSV--NTHRVQCYRMVGYCPQKDSLPSEFTPRELL 1455
            .|.|.:||::..|::..:|.:..|..:::..|:  |.|.|  ::.:|||||.|::....|.||.:
Human  1945 LGVNGAGKSSTFKMLTGDTTVTRGDAFLNKNSILSNIHEV--HQNMGYCPQFDAITELLTGREHV 2007

  Fly  1456 YIHAMLQGHRHRIGRELSEALLRLVGLTPCWNRSVRMCTTGQIRRLYFAYAVLGSPDLICVDGVP 1520
            ...|:|:|...:...::.|..:|.:||.....:.....:.|..|:|..|.|::|.|.::.:|...
Human  2008 EFFALLRGVPEKEVGKVGEWAIRKLGLVKYGEKYAGNYSGGNKRKLSTAMALIGGPPVVFLDEPT 2072

  Fly  1521 AGLDPTGKRIILMMTSTMQAMGSSFLYTMLTGLDAERLSLRTPLLLEGQLWMIRPMDTETENYKS 1585
            .|:||..:|.:.....::...|.|.:.|..:..:.|.|..|..:::.|:...:..:......:..
Human  2073 TGMDPKARRFLWNCALSVVKEGRSVVLTSHSMEECEALCTRMAIMVNGRFRCLGSVQHLKNRFGD 2137

  Fly  1586 GYQLEVRFKRKVNPNVSMSRATWNLINHFPMSPNKKFSAFMEIKFPDAVLTIERDDSMVFVLPLG 1650
            ||.:.||.... ||::                  |....|..:.||.:||..:..:.:.:.||..
Human  2138 GYTIVVRIAGS-NPDL------------------KPVQDFFGLAFPGSVLKEKHRNMLQYQLPSS 2183

  Fly  1651 TTTFSEIFLTLRKDAFEMNIEDYFITRNML-VGFQIFTYDQHQDN 1694
            .::.:.||..|.:....::||||.:::..| ..|..|..||..|:
Human  2184 LSSLARIFSILSQSKKRLHIEDYSVSQTTLDQVFVNFAKDQSDDD 2228

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1494	NP_001259763.1	ABC2_membrane_3	<263..480	CDD:289468	40/227 (18%)
		CcmA	541..848	CDD:224054	103/360 (29%)
		ABC_subfamily_A	541..761	CDD:213230	71/229 (31%)
		ABC2_membrane_3	911..>1189	CDD:289468	78/434 (18%)
		ABC2_membrane	<1080..>1188	CDD:304374	26/117 (22%)
		ABC_subfamily_A	1370..1577	CDD:213230	48/208 (23%)
		PRK14255	1371..1586	CDD:172743	48/216 (22%)
ABCA1	NP_005493.2	rim_protein	6..2236	CDD:130324	413/1995 (21%)
ABCA1	NP_005493.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1283..1312		4/28 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820