Protein Alignment CG1494 and AgaP_AGAP012156

DIOPT Version :9

• Sequence 1: NP_001259763.1
• Gene: CG1494 / 33102
• FlyBaseID: FBgn0031169
• Length: 1695
• Species: Drosophila melanogaster
• Sequence 2: XP_552044.3
• Gene: AgaP_AGAP012156 / 1280527
• VectorBaseID: AGAP012156
• Length: 1663
• Species: Anopheles gambiae
• Alignment Length: 1800
• Identity: 432/1800 - (24%)
• Similarity: 799/1800 - (44%)
• Gaps: 273/1800 - (15%)

  Fly     9 KFLLMNWKNHKLQLANPLELLVILLVPPLFTLVAVLMRFFIPVNH-RSDTVYDPIDLDRSWMQMV 72
            ||:|:.|||..:...:.|:....:.:|.|..::.:::|..:.... ...|:::|::|:     .:
Mosquito     8 KFVLLLWKNWIITKRHYLQTFFEIAIPVLACILLIVIRGLVDAEEFEQPTIFNPLELN-----TI 67

  Fly    73 EKLEKARQVAD--TYNVKGNPFTPHLVIGWAPKRYGIFQAMMRRVQKQI-EPMTSVGFEDCEEMR 134
            ..|.|..|:..  .|::..:|.:|            :.|:::.|....: |.:..:.|...:.::
Mosquito    68 SHLRKNSQIDPPIIYSIAYSPQSP------------LLQSIVERSTAYLDEELAVIAFNSSQTLQ 120

  Fly   135 ESVIENGLFAGLCFDGSPFVEDQVFEEDTLESYSNIQPMLNYTIL---LPSELRMLDGDFRMA-- 194
            ..:..|.:..|:.|.               :.|:|:..:...|:|   .|||:|    .||..
Mosquito   121 AHLQVNNILVGIEFP---------------DIYANLTQLPEQTVLSLRYPSEMR----TFRETGT 166

  Fly   195 ----NWMTLYNDDPNTFVLTRLNQPY-----------EGGF-VGYVREGFIRLQKSVSESFLVLT 243
                ||.|           .||..|:           :||: ..|..|.|:::|.::|.|.|...
Mosquito   167 EFWNNWQT-----------ERLFPPFQVPGARQFERDDGGYPANYYNETFLQIQSAISRSILQQR 220

  Fly   244 S-HKSLPTIQIRRFPITGREQDPLMGNLNYGMPFIIIIGFLFPAQLFVWQVVSEKQSQVRQFLIN 307
            . :...|.:.:.|:|......|.|:..|...:|.||:|.|.:.....|..:..||:.|:::.:..
Mosquito   221 DPNYQFPDVYLSRYPYPPFYSDNLLVGLENLLPLIIVIAFFYTCINTVKYITVEKERQLKEAMKI 285

  Fly   308 MNIGNLIHFVSWYLKGLIYEMISSLIIAALL--KIRWDQDHGVLTQTPWYILILVLFCYNCAAVA 370
            |.:.:.:|:.:|::|.:...:||..||..||  .|..:.:..:.|...|:.:...||.|:.|.:.
Mosquito   286 MGLSSWLHWSAWFVKCISLLLISISIITVLLCVSITTNTELAIFTFANWFAIWFYLFIYSLATIT 350

  Fly   371 FAIMVAAFFRNALNAVRVLTILWIMSYVPTFILSNNLEGNIHALRYVSYALPNVVATLVIEFLIE 435
            |..|::.||..|..|..:..::|.:..:|..|..:|.:....:.:.......|...:.....::.
Mosquito   351 FCFMMSTFFSKANTASGIAGLMWFVFVMPYNIAFSNYDTMSLSAKLALCLFHNSGMSFGFMLIMR 415

  Fly   436 RESIVH-ITWEDSGYRLNYDGGHITVTASSWIFMLNALVYCAIGLYVD----------------- 482
            .|...: :.|.:....:..| ..::|.|:..:.:.:|::|..|.|||:
Mosquito   416 HEGTTNGLQWSNMFDPVTVD-DDLSVGATMMMLLADAVIYLVIALYVEKVFPGEYGVAEPWYFPV 479

  Fly   483 ---MW------RGGDRSGKKMKKPNTNASVQEDPYHERGDSFTHQGQAIGVNSTKIYEVEPSHRR 538
               .|      .||:..|::.              |:.|.|.|             .|.||..:.
Mosquito   480 TKKFWTSQVTPEGGEDGGEQQ--------------HDTGGSTT-------------VEAEPVGKY 517

  Fly   539 FKLKIKKLCKRFATNDRPALNLFSWNVYENEVTVLMGHNGCGKSTLLKILAGLVEPSRGTVMISS 603
            ..::||.|.|.| ...:.|:.....:::|:::|||:||||.||:|.:.:|.|:..|:.||.:|:.
Mosquito   518 AGIRIKGLRKVF-NKTKVAVKGLHLSMFEDQITVLLGHNGAGKTTTMSMLTGVFSPTSGTALIND 581

  Fly   604 HNIQTERKAASMELGIAFGHDMLLTGFTVIDYLRFICRVKGLHNNIEIDGQSNYFLNVLQI---- 664
            .:|:|..:.|...||:...|::|....||.::::|..|:||:.:. .|..:.:::::|||:
Mosquito   582 CDIRTNIEGARKSLGLCPQHNVLFNEMTVSEHIKFFARLKGVESK-GIPQEIDHYVSVLQLEDKR 645

  Fly   665 --------GGLKTKRIRTLTDRDLCLVSICCAFVGNSPIILIDDVHSDLDKRTQSLVWNLINEEK 721
                    ||:|.|            :::..|..|.|.::..|:..|.:|...:..:|:|:.:||
Mosquito   646 HAQSHTLSGGMKRK------------LAVGVALCGGSKVVFCDEPTSGMDPTARRALWDLLIQEK 698

  Fly   722 SKRTIILVSNSPALAENIADRMAIMSNGELKCTGTKPFLKNMYGHGYRLTCVKGKNYKRDELFGM 786
            ..|||:|.::....|:.:.||:|||::||||..|:..|||..:|.||||.|||........:..:
Mosquito   699 KGRTILLSTHFMDEADILGDRIAIMADGELKAAGSSFFLKKRFGVGYRLICVKEDGCDSTRVTDL 763

  Fly   787 MNSYMPNMSIERDIGYKVTFVLENKFEDQFPMLIDDLEENMQQLGVVSFRIRDTSMEEIFLRFGC 851
            |..::||:.::.|||.::::||::::...|..|:.|||.:...||:.|:.|..|::||:|||.|.
Mosquito   764 MRKHIPNLDVDTDIGTELSYVLDDEYTALFQPLLQDLETHSTSLGISSYGISLTTLEEVFLRVGS 828

  Fly   852 E----DNDQSGAFQ---------SHENAQVLLEEYYSTLAEANEKGRRTGWKLFFLHGRAVIYKR 903
            :    |...:|..|         :...:.|.|     ||.:.:.| ..||:.|.....:|::.|:
Mosquito   829 DSHALDKKPNGTDQPAQPYALTETSNGSTVTL-----TLDDQDHK-LLTGFPLLSNQLQAMLLKK 887

  Fly   904 WIAAHRHWIVLIFEV------LAMALVAVCTFSSIFIYGKNYELEPLTFNLSQLHTVDAFVELFS 962
            .||..|.||.|:.::      :.|.:|.|.:|....    :....|:.|: |...||..   |..
Mosquito   888 AIATKRSWIALLVQIFIPIFFVIMTVVIVRSFPDAL----SLPALPIAFD-SYSSTVTV---LEG 944

  Fly   963 EEEDVKDMHAYYTELLY---WYDAHVATLTKNRHNAYALLTQNQFTAHVNSRYIFGATFDQKIVT 1024
            ...|...:.||  :.|:   .....:.|:|:...: |.|....|....||:.::.||:......|
Mosquito   945 TSADTSVIQAY--QQLFEGAGSSRSLVTVTEPMVD-YILKRYEQNLPQVNNEFMVGASITPTNHT 1006

  Fly  1025 AWFNNIPLHSAPYALNVVHNAVARHLFDEEATIDVTLAPLPFRTAIN-TFPPSSHTFGGCLAFGI 1088
            .|||....|:||.|::..:||:.|.:. .:.:|.:|..|||||.... |...:.:..|..|||..
Mosquito  1007 VWFNAQGFHTAPLAVSTFYNAMLRTVC-AQCSILITNDPLPFRPETRFTQLQAGNNMGFQLAFNT 1070

  Fly  1089 CFVLTFIWPAFAIYMITERGSLLKKQQFLAGVRVCSYWTFTVLYDLL-FLLIFCACVVVMVALYE 1152
            .|.:.|:...:.::.|.||.:..|..||::|..|..:|..:.|:|.: |.:.....|.|:.|..|
Mosquito  1071 GFAMAFVAALYIMFYIKERVTRSKLLQFVSGANVLGFWLISFLWDFMTFFVTIMFYVAVLAAFQE 1135

  Fly  1153 NPNHDVMLYGYISVTLMLGGFWVILLAYLMASLCRNPCYGFLWLCGIN---------SIGLVCFS 1208
            :........|.:::.:::.||..:.|.||::.....|..||:.:..:|         ::.|:.|.
Mosquito  1136 DGWSTGDEIGRVTLVMVVFGFAFLPLTYLLSFAFDIPASGFVKVMILNIFTGTIFFMTVFLLLFD 1200

  Fly  1209 QFYRTH-PESM----LLEPTFMAMYTVATVICKLFMIYEFKLICMDPVVNFTSVEVFKCNSIPNC 1268
            .|...| .|.|    |:.|.|...::::.               |:..|....|...:|..||||
Mosquito  1201 GFDLRHVAEGMEWAFLIFPLFALSHSLSN---------------MNIAVATQQVCDSQCALIPNC 1250

  Fly  1269 -----------CIKSNYGTF-TAGIYHDLV---ILTLLDIILLACLFVSEYHSILGFADCRLDTR 1318
                       |..:...|| ..||..:|:   ::.|:..:||.|:   ||..|     .|:..|
Mosquito  1251 TPELLCRVFPQCCNTEIFTFERTGISRNLMYMFVVGLISFLLLMCI---EYRVI-----DRVFKR 1307

  Fly  1319 TNESPDSNQESRAFPGILSNDTAALVDKEHTSRLNEEERSKYAAVGIGIVSKYRRNRVLRDLDFT 1383
            .::......||...      |:...::|.....|.|.|.:....|...:...|::...:..|...
Mosquito  1308 KSKQAAPPSESDEI------DSDVRMEKLRVRGLTEGEIAANNLVLRDVTKYYKKFLAVNQLSLA 1366

  Fly  1384 LAKSECLSITGANNSGKTTLLKVVVNETKMNAGQLWIHDYSVNTHRVQCYRMVGYCPQKDSLPSE 1448
            :..|:|..:.|.|.:||||..|::..:..::.|:.|::..|:|::..:.:|.:|||||.|:|..:
Mosquito  1367 VEHSQCFGLLGVNGAGKTTTFKMMTGDENISYGEAWVNGVSLNSNMNEVHRRIGYCPQFDALIDD 1431

  Fly  1449 FTPRELLYIHAMLQGHRHRIGRELSEALLRLVGLTPCWNRSVRMCTTGQIRRLYFAYAVLGSPDL 1513
            .|.||.|.|.|:|:|........||..|...:......::..:..:.|..|:|..|.|::|:|.:
Mosquito  1432 LTGRETLRIFALLRGIPKSEIAALSSRLAEELNFAKHIDKQTKAYSGGNKRKLSTALALMGNPAV 1496

  Fly  1514 ICVDGVPAGLDPTGKRIILMMTSTMQAMGSSFLYTMLTGLDAERLSLRTPLLLEGQLWMIRPMDT 1578
            :.:|....|:||..:|.:..:....:|.|.:.:.|..:..:.|.|..|..:::.|:...:.....
Mosquito  1497 VYLDEPTTGMDPGARRQLWDVVCKERAAGKAIVLTSHSMEECEALCTRLAIMVNGEFKCLGSTQH 1561

  Fly  1579 ETENYKSGYQLEVRFKRKVNPNVSMSRATWNLINHFPMSPNKKFSAFMEIKFPDAVLTIERDDSM 1643
            ....:.:||.|.::.||.            .::|...:...|::  .:| :||:|.|..|..:|:
Mosquito  1562 LKNKFSNGYFLTIKLKRT------------EVLNTGRIDEVKQY--IVE-RFPEAELKEEYLESV 1611

  Fly  1644 VFVLPLGTTTFSEIFLTLRKDAFEMNIEDYFITRNMLVGFQIFTY 1688
            .:.:|...|.:|.:|..:......::||||.:.:..|.  |:|.|
Mosquito  1612 TYQIPSANTRWSTMFGIMEDAKKVLDIEDYALGQTSLE--QVFLY 1654

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG1494	NP_001259763.1	ABC2_membrane_3	<263..480	CDD:289468	48/219 (22%)
		CcmA	541..848	CDD:224054	101/318 (32%)
		ABC_subfamily_A	541..761	CDD:213230	70/231 (30%)
		ABC2_membrane_3	911..>1189	CDD:289468	73/288 (25%)
		ABC2_membrane	<1080..>1188	CDD:304374	28/108 (26%)
		ABC_subfamily_A	1370..1577	CDD:213230	53/206 (26%)
		PRK14255	1371..1586	CDD:172743	53/214 (25%)
AgaP_AGAP012156	XP_552044.3	ABC2_membrane_3	<200..460	CDD:289468	58/260 (22%)
		CcmA	520..826	CDD:224054	102/319 (32%)
		ABC_subfamily_A	520..738	CDD:213230	70/231 (30%)
		ABC2_membrane_3	895..1239	CDD:289468	88/370 (24%)
		DUF2298	<1069..>1228	CDD:295230	37/158 (23%)
		CcmA	1343..1657	CDD:224054	79/328 (24%)
		ABC_subfamily_A	1345..1563	CDD:213230	54/217 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19229
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X215
TreeFam	0	0.000	Not matched by this tool.
	6	5.920