DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1494 and AgaP_AGAP006379

DIOPT Version :9

Sequence 1:	NP_001259763.1	Gene:	CG1494 / 33102	FlyBaseID:	FBgn0031169	Length:	1695	Species:	Drosophila melanogaster
Sequence 2:	XP_557048.3	Gene:	AgaP_AGAP006379 / 1276992	VectorBaseID:	AGAP006379	Length:	1643	Species:	Anopheles gambiae

Alignment Length:	1780	Identity:	446/1780 - (25%)
Similarity:	787/1780 - (44%)	Gaps:	238/1780 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTVRSYIRKFLLMNWKNHKLQLANPLELLVILLVPPLFTLVAVLMRFFI-PVNHRSDTVYD--PI 62
            |...|...||:|:.|||..:|..:.::.|..:|:|.....:.:::|..: |....:.|:::  ||
Mosquito     1 MASTSRWNKFVLLLWKNWIIQKRHYIQTLFEILIPVFCCAMLIVVRGLVDPEQVLTPTIFERLPI 65

  Fly    63 ----DLDRSWMQMVEKLEKARQVADTYNVKGNPFTPHLVIGWAPKRYGIFQAMMRRVQKQ----I 119
                |||.::                     .|.|  |.:.::|:. .|.|.::....|:    .
Mosquito    66 GSLRDLDTAF---------------------PPVT--LSLAYSPQN-AILQKLLDDALKEEITNT 106

  Fly   120 EPMTSVGFEDCEEMRESVIENGLFAGLCFDGSPFVEDQVFEEDTLESYSNIQPM---LNYTILLP 181
            ..::.|...:..|:...:::.....|:.|.               :||:||..:   |.|.|.||
Mosquito   107 RAVSLVPLPNARELESLLMQRNYIGGIEFP---------------DSYTNITDLPQKLRYAIRLP 156

  Fly   182 SELRMLDGDFRMANWMTLYNDDPNTFVLTRLNQPYEGGFVGYVREGFIRLQKSVSESFL-VLTSH 245
            .|||.....|  .||.|.:...|....|...||. :||...|.||||:.||.::|.:|: ...:.
Mosquito   157 GELRFTGWTF--GNWRTNFMVVPFVQGLRNANQS-DGGSPNYWREGFLTLQAAISRTFIRRQRAD 218

  Fly   246 KSLPTIQIRRFPITGREQDPLMGNLNYGMPFIIIIGFLFPAQLFVWQVVSEKQSQVRQFLINMNI 310
            ..||.:.:||||.....:|.::..:...:|.||:|.|.:.....|..:..||:.|:::.:..|.:
Mosquito   219 YDLPDVSLRRFPYPPYYEDLVLVAMERLLPMIILISFFYTCINTVKFITIEKEKQLKEAMKIMGL 283

  Fly   311 GNLIHFVSWYLKGLIYEM--ISSLIIAALLKIRWDQDHGVLTQTPWYILILVLFCYNCAAVAFAI 373
            .|.:|:.:|:::.|:..:  ||.||......:..:.|..|:....|.:|......|....:.|..
Mosquito   284 PNWLHWTAWFVRCLVLLLITISLLIFLISANLTPNTDLSVIEYADWSVLWFFFLSYILVTICFCF 348

  Fly   374 MVAAFFRNALNAVRVLTILWIMSYVPTFILSNNLEGNIHALRYVSYALPNVVATLVIEFLIERES 438
            |::.||..|..|..:..::|.:..:|..|...|.:......:..|..|.|...:..|..:|..|:
Mosquito   349 MMSVFFNKANTAAGIAGLMWFLFAIPFNIAVQNYDEMAMGSKVASSLLSNTAMSFGIMNIIRLEA 413

  Fly   439 -IVHITWEDSGYRLNYDGGHITVTASSWIFMLNALVYCAIGLYV--------------------D 482
             .|.:.|.:. :.....|...:|.....:|:::||:|.||.||.                    |
Mosquito   414 DQVGLQWHNL-FSAPSMGDEFSVGLVMVMFVVDALLYLAIALYFEQVMPGEFGVAKPWNFLFTRD 477

  Fly   483 MWRGG---DRSGKKMKKPNTNASVQEDPYHERGDSFTHQGQAIGVNSTKIYEVEPSHRRFKLKIK 544
            .|:..   |.||..       |..:..||.|:..:....|..| ||..|:|.
Mosquito   478 FWKRNRIEDGSGDW-------AKAESSPYFEQEPNIDRAGVRI-VNLRKVYG------------- 521

  Fly   545 KLCKRFATNDRPALNLFSWNVYENEVTVLMGHNGCGKSTLLKILAGLVEPSRGTVMISSHNIQTE 609
               |:.|..   .|||   |:::.::|||:||||.||:|.:.:|.|:..|:.||.:::.::|:.:
Mosquito   522 ---KKVAVE---GLNL---NMFDGQITVLLGHNGAGKTTTMSMLTGMFSPTSGTALVNGYDIRKD 577

  Fly   610 RKAASMELGIAFGHDMLLTGFTVIDYLRFICRVKGLHNNIEIDGQSNYFLNVLQIGGLKTKRIRT 674
            .:.....||:...|::|....||.::|:|..::||:..: :...:...::|:|::...:..:..|
Mosquito   578 IEGVRFSLGLCPQHNVLFNELTVAEHLKFFSQLKGVPGD-KTAAEIEKYVNLLELTDKRNAQSHT 641

  Fly   675 LTDRDLCLVSICCAFVGNSPIILIDDVHSDLDKRTQSLVWNLINEEKSKRTIILVSNSPALAENI 739
            |:......:.:..|..|.|.::|:|:..|.:|...:..:|:||.:||..||:||.::....|:.:
Mosquito   642 LSGGMKRKLGVGIALCGGSRVVLLDEPTSGMDPSARRALWDLIQKEKVGRTVILSTHFMDEADVL 706

  Fly   740 ADRMAIMSNGELKCTGTKPFLKNMYGHGYRLTCVKGKNYKRDELFGMMNSYMPNMSIERDIGYKV 804
            .||:|||:.|:|:..|:..|||...|.||||.|||.....:..:..::..|:|.:.|:.|||.::
Mosquito   707 GDRIAIMAEGKLRAIGSPFFLKKSLGAGYRLICVKEPTCDKKRVLEILKKYIPEVRIDTDIGTEL 771

  Fly   805 TFVLENKFEDQFPMLIDDLEENMQQLGVVSFRIRDTSMEEIFLR-----FGCEDNDQ---SGAFQ 861
            :|||...:...|..::::||:.|:..|:.|:.|..|:|||:|||     |..||:..   ||...
Mosquito   772 SFVLREDYLKVFQPMLEELEDKMRSCGISSYGISLTTMEEVFLRAGSDSFQAEDSTNHTASGYID 836

  Fly   862 SHENAQVLLEEYYSTLAEANEKGRRTGWKLFFLHGRAVIYKRWIAAHRHWIVLIFEVLAMALVAV 926
            .:||:.:...|..:.|         .|.|..|....|..||:::...|.||.|..::|...|..:
Mosquito   837 MNENSDIYSLEGLTLL---------DGSKRLFQQINAQFYKKFLTTIRSWITLSMQMLIPILFVL 892

  Fly   927 CTFSSIFIYGKNYELEPLTFNLSQ-------LHTVD-------AFVELFSEEEDVKDMHAYYTEL 977
            .::..........:|..|..||.:       |.|.|       ||.:.|..|.:|..
Mosquito   893 LSYLIFLNSSTGRDLPELKINLDRYSGSLTVLQTTDGFESVTAAFRDRFRTEPNVHQ-------- 949

  Fly   978 LYWYDAHVATLTKNRHNAYALLTQNQFTAHVNSRYIFGATFDQKIVTAWFNNIPLHSAPYALNVV 1042
            |...|..:.|...|:        .:|..|..|:||..||:.|:.:.||||||...||||.|:|::
Mosquito   950 LIVIDEDMTTFILNK--------SSQDIATFNTRYWAGASLDRSVCTAWFNNKAYHSAPLAVNMI 1006

  Fly  1043 HNAVARHLFDEEATIDVTLAPLPFR--TAINTFPPSSHTFGGCLAFGICFVLTFIWPAFAIYMIT 1105
            :||:.:.:. ....:.|:..|||:|  |.:......::. |..|||...|.:.|:...|.::.|.
Mosquito  1007 YNALLQSIC-PNCELQVSNKPLPYRLDTQLQRLETGANA-GFQLAFNTGFAMAFVSALFILFYIK 1069

  Fly  1106 ERGSLLKKQQFLAGVRVCSYWTFTVLYDLLFLLIFCACVVVMVALYENPNHDVM-LYGYISVTLM 1169
            ||.:..|..||::||.|..:||.:.|:|.:..::...|.:..:|:.:....... ..|.:.:.|:
Mosquito  1070 ERTTRAKLLQFVSGVNVTLFWTISYLWDYMIFVLSALCYLATLAIIQQDGWSTFDQLGRVLLVLL 1134

  Fly  1170 LGGFWVILLAYLMASLCRNPCYGFLWLCGINSI-GLVCFSQFYRTHPESMLLEPT---------F 1224
            |..|..:.:.||.|.|...|..||:.:..:|.: |.:.|:.......|.:.|:..         |
Mosquito  1135 LYAFSSLPVTYLFAYLFHVPATGFVKMMLLNVLSGTIFFTAVSLLRFEGIDLDDVADVLEWIFLF 1199

  Fly  1225 MAMYTVATVICKLFMIYEFKLICMDPVVNFT-SVEVFKCNSIPNCCIKSNYGTF--TAGIYHDLV 1286
            ...:::...:..|.|:...:.:|.......| ..|..||..:|.||..|.: ||  ..||..:|:
Mosquito  1200 FPSFSLTQSMNALNMVGGREALCQRACEQITFCTEALKCALVPQCCGTSAF-TFDQQTGINRNLL 1263

  Fly  1287 ILTLLDIILLACLFVSEYHSILGFADCRLDTRTNESPDSNQESRAFPGILSNDTAALVDKEHTSR 1351
            ....:.::..|.:.:.:|.     ...:|.:|:                 :|......|:|.|..
Mosquito  1264 FFAGIGVVSFAIILLVDYR-----VAKKLFSRS-----------------ANGVTMSSDQEETDS 1306

  Fly  1352 LNEEERSKYAAVGIGIVSKYRRNRVLRDLDFTLAK-------------SECLSITGANNSGKTTL 1403
            ...||:.:.||...|.::.|  |.||::|.....|             |||..:.|.|.:|||:.
Mosquito  1307 DVLEEKRRIAACSSGELASY--NLVLKELSKNYGKFVAVNKLSVGVRHSECFGLLGINGAGKTST 1369

  Fly  1404 LKVVVNETKMNAGQLWIHDYSVNTHRVQCYRMVGYCPQKDSLPSEFTPRELLYIHAMLQGHRHRI 1468
            .|::..:..:..|..|::..::.|...:.::.:|||||.|:|..:.|.||.|:|.|:::|.|.|.
Mosquito  1370 FKMMTGDENITGGDAWVNGINLRTDMNRVHKHIGYCPQFDALLEDLTGRETLHIFALMRGVRRRE 1434

  Fly  1469 GRELSEALLRLVGLTPCWNRSVRMCTTGQIRRLYFAYAVLGSPDLICVDGVPAGLDPTGKRIILM 1533
            ...:|..|...:..|...::..:..:.|..|:|..|.|:||:|.::.:|....|:||..||....
Mosquito  1435 INGVSLTLAEELNFTKHLDKRTKAYSGGNKRKLSTALALLGNPSVVYLDEPTTGMDPGAKRQFWN 1499

  Fly  1534 MTSTMQAMGSSFLYTMLTGLDAERLSLRTPLLLEGQLWMIRPMDTETENYKSGYQLEVRFKRKVN 1598
            :...::..|.|.:.|..:..:.|.|..|..:::.|:...:.........:..|:.|.|:.|| ..
Mosquito  1500 VICKIRNSGKSIVLTSHSMEECEALCTRLAIMVNGEFKCLGSTQHLKNKFSEGFLLTVKTKR-TE 1563

  Fly  1599 PNVSMSRATWNLINHFPMSPNKKFSAFMEIKFPDAVLTIERDDSMVFVLPLGTTTFSEIFLTLRK 1663
            |:.:                 ::..:|:..||..|||..|..||:.|.:......:|.:|..:..
Mosquito  1564 PDAA-----------------ERVKSFVTSKFVGAVLKEEYQDSLTFHIARTNQRWSAMFGLMES 1611

  Fly  1664 DAFEMNIEDYFITRNMLVGFQIFTY 1688
            ....:.||||.:.:..|.  |:|.:
Mosquito  1612 SKHRLGIEDYALGQTTLE--QVFLF 1634

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1494	NP_001259763.1	ABC2_membrane_3	<263..480	CDD:289468	50/219 (23%)
		CcmA	541..848	CDD:224054	93/306 (30%)
		ABC_subfamily_A	541..761	CDD:213230	62/219 (28%)
		ABC2_membrane_3	911..>1189	CDD:289468	79/294 (27%)
		ABC2_membrane	<1080..>1188	CDD:304374	30/108 (28%)
		ABC_subfamily_A	1370..1577	CDD:213230	58/219 (26%)
		PRK14255	1371..1586	CDD:172743	58/227 (26%)
AgaP_AGAP006379	XP_557048.3	ABC2_membrane_3	<246..455	CDD:289468	49/209 (23%)
		CcmA	511..789	CDD:224054	87/301 (29%)
		ABC_subfamily_A	511..728	CDD:213230	67/240 (28%)
		ABC2_membrane_3	877..1214	CDD:289468	89/354 (25%)
		ABC_subfamily_A	1328..1546	CDD:213230	56/217 (26%)
		drrA	1335..1636	CDD:130256	78/320 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19229
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X215
TreeFam	0	0.000	Not matched by this tool.
	6	5.920