DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1494 and AgaP_AGAP003680

DIOPT Version :9

Sequence 1:	NP_001259763.1	Gene:	CG1494 / 33102	FlyBaseID:	FBgn0031169	Length:	1695	Species:	Drosophila melanogaster
Sequence 2:	XP_313462.4	Gene:	AgaP_AGAP003680 / 1274354	VectorBaseID:	AGAP003680	Length:	777	Species:	Anopheles gambiae

Alignment Length:	818	Identity:	167/818 - (20%)
Similarity:	330/818 - (40%)	Gaps:	148/818 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   514 SFTHQGQAIGVNSTKIYEVEP-----SHRRFKLKIKKLCKRFATNDRP--ALNLFSWNVYENEVT 571
            :||....|:..:.|.:..::.     |.::..:.::...|.:.|..:|  .|:..:..|.:..:.
Mosquito    12 TFTSNNIAVPGSETSVATIDDGGTMWSRQQNAVSVRHAFKSYGTKKKPNQVLSNLNMTVAKGTIY 76

  Fly   572 VLMGHNGCGKSTLLKILAGLVEPSRGTVMISSHNIQTERKAASMELGIAFGH---DMLLTG-FTV 632
            .|:|.:||||:|||..:.|....:.|.:.:......|:.....   |...|:   ::.|.| |::
Mosquito    77 GLLGASGCGKTTLLSCIVGRKRLNSGEIWVLGGKPGTKGSGVP---GARVGYMPQEIALYGEFSI 138

  Fly   633 IDYLRFICRVKGLHNNIEIDGQSNYFLNVLQIGGLKTKRIRTLTDRDLCLVSICCAFVGNSPIIL 697
            .:.:.:...:.|:|.: ||..:..:.||.|.:.. :::.::.|:......||...|.:.:..:::
Mosquito   139 RETMMYFGWIFGMHTS-EIVERLQFLLNFLDLPS-ESRLVKNLSGGQQRRVSFAVALMHDPELLI 201

  Fly   698 IDDVHSDLDKRTQSLVWN-LINEEKS-KRTIILVSNSPALAENIADRMAIMSNGELKCTGTKPFL 760
            :|:....:|...:..:|| |::..|: ::|:|:.::....|.. |..:.:|.:|.|....:...|
Mosquito   202 LDEPTVGVDPLLRQSIWNHLVHITKAGQKTVIITTHYIEEARQ-AHTIGLMRSGRLLAEESPSCL 265

  Fly   761 KNMYGHGYRLTCVKGKNYKRDELFGMMNSYMPNMSIERDIGYKVTFVLENKFEDQFPMLIDDLEE 825
            .:|    ||.:.::....|.....|..|.....::|..:|... .....||.::  |:.:.
Mosquito   266 LSM----YRCSSLEDVFLKLSRKQGQANVAPAELNISNNISLS-ALAFGNKKDN--PVYVS---- 319

  Fly   826 NMQQLGVVSFRIRDTSMEEIFLRFGCEDNDQSGAFQSHENAQVLLEEYYSTLAEANEKGRRTGWK 890
              |:.|||......:  :|:.:      :|.:|:..:............|...|.:.....:|..
Mosquito   320 --QESGVVGLNFHQS--KEVLI------SDSNGSTIAINGLNGSAPGAISQAVECDNCTECSGCS 374

  Fly   891 LFFLHG--RAVIYKRWIAAHRHWIVLIFEVLAMALVAVCTFSSIFIYGKN-YELEPLTFNLSQLH 952
            .|...|  ||::.|.::...|:..|::| :.|:.::.|..|  ....|:: ..|:....|.....
Mosquito   375 NFTSKGKIRALLVKNFLRMWRNVGVMLF-IFALPVMQVILF--CLAIGRDPTNLKMAIVNGEMNS 436

  Fly   953 TVDAFVELFSEEEDVKDMHAYYTELLYWYDAHV-ATLTKNRH-------------NAY-ALLTQN 1002
            |:.|        :...|....:|.|...|.:|: .|:.|..:             ||: ||...:
Mosquito   437 TIGA--------DCAFDPGCSFTNLSCRYLSHLNTTIVKEYYSDLDSALGAVRDGNAWGALYFTD 493

  Fly  1003 QFTAHVNSRYIFG-----ATFDQKIVTAWFN------NIPLHSAPYALNVVHNAVARHLF---DE 1053
            .||..:.:|...|     .|.||..:..|.:      .|.|:.   .|.|.:...|:.|.   |.
Mosquito   494 NFTDALVARIALGRDADDETLDQSEIRVWLDMSNQQIGIMLNR---DLQVAYREFAQQLLRVCDN 555

  Fly  1054 EATI-DVTLAPLPFRTAI-NTFPPSSHTFGGCLAFGICFVLTFIWPAFAI---YMITERGSLLKK 1113
            ...: ||   |:.|:..| .|..||   |...:|.|:...:.| :.|.|:   .:|.||...|..
Mosquito   556 NPKLGDV---PIQFKAPIYGTNDPS---FTDFVAPGVILTIVF-FLAVALTSSALIIERTEGLLD 613

  Fly  1114 QQFLAGVRVCSYWTFTVLYDLLF------LLIFCA----CVVVMVALYENPNHDVMLYGYISVTL 1168
            :.::|||...         ::||      .::.|.    .::.|:.::...|:     |.|.
Mosquito   614 RSWVAGVTPS---------EILFSHVITQFVVMCGQTALVLIFMIVVFGVTNN-----GEIG--- 661

  Fly  1169 MLGGFWVILLAYLMASLCRNPCYGFL--WLCGI--NSIGLVCFSQFYRT-------HP-ESMLLE 1221
                 |:::|. ::..|| ..|:||:  .:|.:  |:|.| ....||.|       .| |.|.|.
Mosquito   662 -----WIVVLT-ILQGLC-GMCFGFVISAICELERNAIQL-ALGSFYPTLLLSGVIWPIEGMPLV 718

  Fly  1222 PTFMAM---YTVATVICKLFMIYEFKLICMDPVVNFTS 1256
            ..::::   .|:||...:..:...:.::..|..:.|.|
Mosquito   719 LRYVSLCLPLTLATTSLRSILARGWSIMEPDVYMGFVS 756

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1494	NP_001259763.1	ABC2_membrane_3	<263..480	CDD:289468
		CcmA	541..848	CDD:224054	63/314 (20%)
		ABC_subfamily_A	541..761	CDD:213230	46/227 (20%)
		ABC2_membrane_3	911..>1189	CDD:289468	68/322 (21%)
		ABC2_membrane	<1080..>1188	CDD:304374	24/120 (20%)
		ABC_subfamily_A	1370..1577	CDD:213230
		PRK14255	1371..1586	CDD:172743
AgaP_AGAP003680	XP_313462.4	CcmA	42..310	CDD:224054	55/278 (20%)
		ABC_DR_subfamily_A	44..256	CDD:213197	45/217 (21%)
		ABC2_membrane_3	398..766	CDD:289468	88/405 (22%)
		ABC2_membrane	570..738	CDD:279410	45/196 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810