DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG1494 and Abca2

DIOPT Version :10

Sequence 1:NP_608444.2 Gene:CG1494 / 33102 FlyBaseID:FBgn0031169 Length:1695 Species:Drosophila melanogaster
Sequence 2:XP_006497672.1 Gene:Abca2 / 11305 MGIID:99606 Length:2464 Species:Mus musculus


Alignment Length:2092 Identity:425/2092 - (20%)
Similarity:753/2092 - (35%) Gaps:606/2092 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MTVRSYIRKFL-------LMNWKNH---KLQLANPLELLVILLVPPLFTLVAVLMRFFIPVNHRS 55
            :.:.:.||.||       .:.|...   .|||......|.:..:||     |:...|.:|.....
Mouse   524 LNISTEIRSFLEQGRLQQHLQWLQQYVADLQLHPEAMNLSLEELPP-----ALRQDFSLPNGTAL 583

  Fly    56 DTVYDPID-LDRSWMQMVEKLEKARQVADTYNVKGNPFTPHLVIGWAPKRYGIFQAMMRRVQKQI 119
            ....|.|| ....|:|.:.|:.     .|.:  ||.|....:|      .|.:.||....|.   
Mouse   584 LQQLDTIDNAACGWIQFMSKVS-----VDIF--KGFPDEESIV------NYTLNQAYQDNVT--- 632

  Fly   120 EPMTSVGFEDCEEMRESVIENGLFAGLCF----DGSPFVEDQVFEEDTLESYSNIQPMLNYTILL 180
                                  :||.:.|    |||                  :.|.::|.|..
Mouse   633 ----------------------VFASVIFQTRKDGS------------------LPPHVHYKIRQ 657

  Fly   181 PSELRMLDGDFRMANWMTLYNDDPNTFVLTRLNQPYEGGFVGYVREGFIRLQKSVSESFL-VLTS 244
            .|.......:.|.|.|    ...|||           ||.. |...||:.:|..:..:.: ....
Mouse   658 NSSFTEKTNEIRRAYW----RPGPNT-----------GGRF-YFLYGFVWIQDMMERAIINTFVG 706

  Fly   245 HKSL-PTIQIRRFPITGREQDPLMGNLNYGMPFIIIIGFLFPAQLFVWQVVSEKQSQVRQFLINM 308
            |..: |...::.||.....:|..:..:.:.||..::|.:::...:.:..:|:||:.::::.:..|
Mouse   707 HDVVEPGNYVQMFPYPCYTRDDFLFVIEHMMPLCMVISWVYSVAMTIQHIVAEKEHRLKEVMKTM 771

  Fly   309 NIGNLIHFVSWYLKGLIYEMISSLIIAALLKIRWDQDHG-VLTQTPWYILILVLFCYNCAAVAFA 372
            .:.|.:|:|:|::.|.:...||...:.|:||      :| ||..:...|:.|.|..|..|.:.|.
Mouse   772 GLNNAVHWVAWFITGFVQLSISVTALTAILK------YGQVLMHSHVLIIWLFLAVYAVATIMFC 830

  Fly   373 IMVAAFFRNALNAVRVLTILWIMSYVPTFILSNNLEGNIHALRYVSY----ALPNVVATLVIEFL 433
            .:|:..:..|..|.....|::.:||||...::...|        |::    |....:|:|:....
Mouse   831 FLVSVLYSKAKLASACGGIIYFLSYVPYMYVAIREE--------VAHDKITAFEKCIASLMSTTA 887

  Fly   434 IERESIVHITWEDSGYRLNY--------DGGHITVTASSWIFMLNALVYCAIGLYVD-------- 482
            ....|.....:|.:|..:.:        :|....:..:..:.|::.:||..:..|::        
Mouse   888 FGLGSKYFALYEVAGVGIQWHTFSQSPVEGDDFNLLLAVTMLMVDTVVYGVLTWYIEAVHPGMYG 952

  Fly   483 ------------MWRGGDRSGKKMKKPNTNASVQEDPY-HERGDSFTHQGQAIGVNS-----TKI 529
                        .|.|..|         |.|.....|: |....|...:.||..:.|     |:.
Mouse   953 LPRPWYFPLQKSYWLGSGR---------TEAWEWSWPWAHTPRLSVMEEDQACAMESRHFEETRG 1008

  Fly   530 YEVEPSHRRFKLKIKKLCKRFATNDRPALNLFSWNVYENEVTVLMGHNGCGKSTLLKILAGLVEP 594
            .|.||:|....:.:.||.|.:..:.:.|||..|.|:|||:|...:||||.||:|.:.||.||..|
Mouse  1009 MEEEPTHLPLVVCVDKLTKVYKNDKKMALNKLSLNLYENQVVSFLGHNGAGKTTTMSILTGLFPP 1073

  Fly   595 SRGTVMISSHNIQTERKAASMELGIAFGHDMLLTGFTVIDYLRFICRVKGLHNNIEIDGQSNYFL 659
            :.|:..|..|:|:||.......||:...|::|....||.::|.|..|:|.:... ||..:::..:
Mouse  1074 TSGSATIYGHDIRTEMDEIRKNLGMCPQHNVLFDRLTVEEHLWFYSRLKSMAQE-EIRKETDKMI 1137

  Fly   660 NVLQIGGLKTKRIRTLTDRDLCLVSICCAFVGNSPIILIDDVHSDLDKRTQSLVWNLINEEKSKR 724
            ..|::...:...::||:......:|:..||||.|..|::|:..:.:|...:..:|:||.:.|..|
Mouse  1138 EDLELSNKRHSLVQTLSGGMKRKLSVAIAFVGGSRAIILDEPTAGVDPYARRAIWDLILKYKPGR 1202

  Fly   725 TIILVSNSPALAENIADRMAIMSNGELKCTGTKPFLKNMYGHGYRLTCVKG-------------- 775
            ||:|.::....|:.:.||:||:|:|:|||.|:..|||..||.|||||.||.              
Mouse  1203 TILLSTHHMDEADLLGDRIAIISHGKLKCCGSPLFLKGAYGDGYRLTLVKQPAEPGTSQEPGLAS 1267

  Fly   776 --------KNYKRDELFGMMNSYMPNMSIERDIGYKVTFVLENKF--EDQFPMLIDDLEENMQQL 830
                    .:....::...:..::.:..:..|...:::::|.::.  :..|..|...||.::..|
Mouse  1268 SPSGCPRLSSCSEPQVSQFIRKHVASSLLVSDTSTELSYILPSEAVKKGAFERLFQQLEHSLDAL 1332

  Fly   831 GVVSFRIRDTSMEEIFLRFGCEDNDQSGAFQSHENAQV--------------------------- 868
            .:.||.:.||::||:||:...||       ||.||::.                           
Mouse  1333 HLSSFGLMDTTLEEVFLKVSEED-------QSLENSEADVKESRKDVLPGAEGLTAVGGQAGNLA 1390

  Fly   869 --------------------------------------------------LLEEYYSTLAEANEK 883
                                                              |.|.....||:..:.
Mouse  1391 RCSELAQSQASLQSASSVGSARGEEGTGYSDGYGDYRPLFDNLQDPDNVSLQEAEMEALAQVGQG 1455

  Fly   884 GRR-TGW--KLFFLHGRAVIYKRWIAAHRHWIVLIFEVLAMAL---VAVCTFSSIFIYGKNYELE 942
            .|: .||  |:...||  ::.||:..|.|:...|..::|..|.   ||:....|:...|   :|.
Mouse  1456 SRKLEGWWLKMRQFHG--LLVKRFHCARRNSKALCSQILLPAFFVCVAMTVALSVPEIG---DLP 1515

  Fly   943 PLTFNLSQLHTVDA----FVELFSEEE-------------------------------------- 965
            ||..:.||.|....    |:...:||.                                      
Mouse  1516 PLVLSPSQYHNYTQPRGNFIPYANEERQEYRLRLSPDASPQQLVSTFRLPSGVGATCVLKSPANG 1580

  Fly   966 ------------------------------------------------------DVKDMHAYYTE 976
                                                                  |...:.|:...
Mouse  1581 SLGPMLNLSSGESRLLAARFFDSMCLESFTQGLPLSNFVPPPPSPAPSDSPVSPDEDSLQAWNMS 1645

  Fly   977 L------LYWYDA-----------------------------------HVAT------LTKNRHN 994
            |      ..|..|                                   .|.|      :|.:..:
Mouse  1646 LPPTAGPETWTSAPSLPRLVHEPVRCTCSAQGTGFSCPSSVGGHPPQMRVVTGDILTDITGHNVS 1710

  Fly   995 AYALLTQNQFTAHVNSRYIFG-------ATFD------------QKIVTAWFNNIPLHSAPYALN 1040
            .|.|.|.::|..|......||       |:|.            :::....:||...||.|..||
Mouse  1711 EYLLFTSDRFRLHRYGAITFGNVQKSIPASFGARVPPMVRKIAVRRVAQVLYNNKGYHSMPTYLN 1775

  Fly  1041 VVHNAVARHLFDEEA------TIDVTLAPLPFRTAINTFPPSSHTFGGCLAFGICFVLTFIWPAF 1099
            .::||:.|....:..      .|.||..|:...:|..:...........:|..|...::|:..:|
Mouse  1776 SLNNAILRANLPKSKGNPAAYGITVTNHPMNKTSASLSLDYLLQGTDVVIAIFIIVAMSFVPASF 1840

  Fly  1100 AIYMITERGSLLKKQQFLAGVRVCSYWTFTVLYDLLFLLIFCACVVVMVALYENPNHD------- 1157
            .::::.|:.:..|..||::|.....||....::|:|..|:...|.|:::.:::.|.:.       
Mouse  1841 VVFLVAEKSTKAKHLQFVSGCNPVIYWLANYVWDMLNYLVPATCCVIILFVFDLPAYTSPTNFPA 1905

  Fly  1158 ----VMLYGYISVTLML--GGFWVILLAYLMASLCRNPCYGFLWLCGIN-SIGLVCFSQFYRTHP 1215
                .:|||: |:|.::  ..||..:           |...:::|..|| .||:..         
Mouse  1906 VLSLFLLYGW-SITPIMYPASFWFEV-----------PSSAYVFLIVINLFIGITA--------- 1949

  Fly  1216 ESMLLEPTFMAMYTVATVICKLFMIYEFKLICMDPVVNFTSVEVFKCNSIPNCCIKSNYGTF-TA 1279
                         ||||.:.:||                   |..|...:.|..:||.:..| ..
Mouse  1950 -------------TVATFLLQLF-------------------EHDKDLKVVNSYLKSCFLIFPNY 1982

  Fly  1280 GIYHDLVILTLLDIILLACLFVSEYHSILGFAD-------------------------------C 1313
            .:.|.|:.:...:       :::||::.:|..|                               |
Mouse  1983 NLGHGLMEMAYNE-------YINEYYAKIGQFDKMKSPFEWDIVTRGLVAMTVEGFVGFFLTIMC 2040

  Fly  1314 ---------RLDTRTNESPD----SNQESRAFPGILSNDTAALVDKEHTSRLNEEERSKYAAVGI 1365
                     ||...|....|    :::..|...|...||   :|..|:.:::       |.:..|
Mouse  2041 QYNFLRQPQRLPVSTKPVEDDVDVASERQRVLRGDADND---MVKIENLTKV-------YKSRKI 2095

  Fly  1366 GIVSKYRRNRVLRDLDFTLAKSECLSITGANNSGKTTLLKVVVNETKMNAGQLWIHDYSVNTHRV 1430
            |.:....|      |...:...||..:.|.|.:|||:..|::..:.....|:.:::.:||....:
Mouse  2096 GRILAVDR------LCLGVRPGECFGLLGVNGAGKTSTFKMLTGDESTTGGEAFVNGHSVLKDLL 2154

  Fly  1431 QCYRMVGYCPQKDSLPSEFTPRELLYIHAMLQGHRHRIGRELSEALLRLVGLTPCWNRSVRMCTT 1495
            |..:.:|||||.|:|..|.|.||.|.::..|:|...:...::.:..|..:.||...::.....:.
Mouse  2155 QVQQSLGYCPQFDALFDELTAREHLQLYTRLRGIPWKDEAQVVKWALEKLELTKYADKPAGTYSG 2219

  Fly  1496 GQIRRLYFAYAVLGSPDLICVDGVPAGLDPTGKRIILMMTSTMQAMGSSFLYTMLTGLDAERLSL 1560
            |..|:|..|.|::|.|..|.:|....|:||..:|.:..:...:...|.|.:.|..:..:.|.|..
Mouse  2220 GNKRKLSTAIALIGYPAFIFLDEPTTGMDPKARRFLWNLILDLIKTGRSVVLTSHSMEECEALCT 2284

  Fly  1561 RTPLLLEGQLWMIRPMDTETENYKSGYQLEVRFKRKVNPNVSMSRATWNLINHFPMSPNKKFSAF 1625
            |..:::.|:|..:..:......:..||.:.||.|...|.                    |....|
Mouse  2285 RLAIMVNGRLRCLGSIQHLKNRFGDGYMITVRTKSSQNV--------------------KDVVRF 2329

  Fly  1626 MEIKFPDAVLTIERDDSMVFVLPLGTTTFSEIFLTLRKDAFEMNIEDYFITR----NMLVGF--- 1683
            ....||:|:|.......:.:.|.....:.:::|..:.:....:.||||.:::    |:.|.|   
Mouse  2330 FNRNFPEAMLKERHHTKVQYQLKSEHISLAQVFSKMEQVVGVLGIEDYSVSQTTLDNVFVNFAKK 2394

  Fly  1684 QIFTYDQHQDNP 1695
            |....:|.:..|
Mouse  2395 QSDNVEQQEAEP 2406

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG1494NP_608444.2 rim_protein <223..1689 CDD:130324 376/1847 (20%)
ABC_subfamily_A 541..761 CDD:213230 74/219 (34%)
Abca2XP_006497672.1 rim_protein 58..2398 CDD:130324 423/2082 (20%)

Return to query results.
Submit another query.