DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG1494 and Abca4

DIOPT Version :9

Sequence 1:NP_001259763.1 Gene:CG1494 / 33102 FlyBaseID:FBgn0031169 Length:1695 Species:Drosophila melanogaster
Sequence 2:NP_031404.1 Gene:Abca4 / 11304 MGIID:109424 Length:2310 Species:Mus musculus


Alignment Length:2042 Identity:438/2042 - (21%)
Similarity:786/2042 - (38%) Gaps:539/2042 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    23 ANPLELLVILLVPPLFTLVAVLMRFFIP-------VNHRSDTVYDPID----LDRSWMQMVEKL- 75
            :|||..:......||  |:..::  |.|       :...:::.::.:|    |.::|.::..:: 
Mouse   379 SNPLTKIAWRAAKPL--LMGKIL--FTPDSPAARRIMKNANSTFEELDRVRKLVKAWEEVGPQIW 439

  Fly    76 ---EKARQVADTYNVKGNP--------------FTPHLVIGW---APKRYGIFQAMMRRVQKQIE 120
               ||:.|:....:...:|              .|...|:.:   .|:            :||.:
Mouse   440 YFFEKSTQMTVIRDTLQHPTVKDFINRQLGEEGITTEAVLNFFSNGPQ------------EKQAD 492

  Fly   121 PMTSVGFEDCEEMRESVI---------------------------------ENGLFAGLCFDGS- 151
            .|||..:.|...:.:..:                                 ||..:||:.|.|. 
Mouse   493 DMTSFDWRDIFNITDRFLRLANQYLECLVLDKFESYDDEVQLTQRALSLLEENRFWAGVVFPGMY 557

  Fly   152 PFVEDQVFEEDTLESYSNIQPMLNYTILLPSELRMLDGDFRMANWMTLYNDDPNTFVLTRLNQPY 216
            |:.             |::.|.:.|.|.:..::.......:...|    :..|..       .|.
Mouse   558 PWA-------------SSLPPHVKYKIRMDIDVVEKTNKIKDRYW----DSGPRA-------DPV 598

  Fly   217 EGGFVGYVREGFIRLQKSVSESFLVLTSHKSLPTI--QIRRFPITGREQDPLMGNLNYGMPFIII 279
            |.  ..|:..||..||..| |..:|.:..::.|.|  .:::.|......|..|..||...|..::
Mouse   599 ED--FRYIWGGFAYLQDMV-EQGIVKSQMQAEPPIGVYLQQMPYPCFVDDSFMIILNRCFPIFMV 660

  Fly   280 IGFLFPAQLFVWQVVSEKQSQVRQFLINMNIGNLIHFVSWYLKGLIYEMISSLIIAALLKIRWDQ 344
            :.:::...:.|..:|.||:.::::.|.|..:.|.:.:.:|:|.......:|..::...:.     
Mouse   661 LAWIYSVSMTVKGIVLEKELRLKETLKNQGVSNAVIWCTWFLDSFSIMALSIFLLTLFIM----- 720

  Fly   345 DHG-VLTQTPWYILILVLFCYNCAAVAFAIMVAAFFRNALNAVRVLTILWIMSYVPTFI------ 402
             || :|..:..:||.|.|..:..|.:..:.:::..|..|..|.....:::...|:|..:      
Mouse   721 -HGRILHYSDPFILFLFLLAFATATIMQSFLLSTLFSKASLAAACSGVIYFTLYLPHVLCFAWQD 784

  Fly   403 -LSNNLEGNIHALRYVSYALPNVVATLVIEFLIE-RESIVHITWEDSGYRLNYDGGHITVTASSW 465
             ::.:|:..:..|..|::....       |:|:. .|..:.:.|.:.| :...:|...:...|..
Mouse   785 RMTADLKTTVSLLSSVAFGFGT-------EYLVRFEEQGLGLQWSNIG-KSPLEGDEFSFLLSMK 841

  Fly   466 IFMLNALVYCAIGLYVDM--------------------WRGGD----RSGKKMKKPNTNASVQED 506
            :.:|:|.:|..:..|:|.                    |.||:    |..:.::|........||
Mouse   842 MMLLDAALYGLLAWYLDQVFPGDYGTPLPWYFLLQESYWLGGEGCSTREERALEKTEPLTEEMED 906

  Fly   507 PYHERG--DSFTHQ---GQAIGVNSTKIYEVEPSHRRFKLKIKKLCKRFATNDRPALNLFSWNVY 566
            |.|..|  |||..:   |...||                 .:|.|.|.|..:.|||::..:...|
Mouse   907 PEHPEGMNDSFFERELPGLVPGV-----------------CVKNLVKVFEPSGRPAVDRLNITFY 954

  Fly   567 ENEVTVLMGHNGCGKSTLLKILAGLVEPSRGTVMISSHNIQTERKAASMELGIAFGHDMLLTGFT 631
            ||::|..:||||.||:|.|.||.||:.|:.|||:|...:|:|........||:...|::|....|
Mouse   955 ENQITAFLGHNGAGKTTTLSILTGLLPPTSGTVLIGGKDIETNLDVVRQSLGMCPQHNILFHHLT 1019

  Fly   632 VIDYLRFICRVKGL---HNNIEIDGQSNYFLNVLQIGGLKTKRIRTLTD------RDLCLVSICC 687
            |.:::.|..::||.   ...:|::.       :|:..||..||.....|      |.|   |:..
Mouse  1020 VAEHILFYAQLKGRSWEEAQLEMEA-------MLEDTGLHHKRNEEAQDLSGGMQRKL---SVAI 1074

  Fly   688 AFVGNSPIILIDDVHSDLDKRTQSLVWNLINEEKSKRTIILVSNSPALAENIADRMAIMSNGELK 752
            ||||:|.::::|:..|.:|..::..:|:|:.:.:|.||||:.::....|:.:.||:||:|.|.|.
Mouse  1075 AFVGDSKVVVLDEPTSGVDPYSRRSIWDLLLKYRSGRTIIMSTHHMDEADLLGDRIAIISQGRLY 1139

  Fly   753 CTGTKPFLKNMYGHGYRLTCV-KGKNYKR------------------------------------ 780
            |:||..||||.:|.|:.||.| |.||.:.                                    
Mouse  1140 CSGTPLFLKNCFGTGFYLTLVRKMKNIQSQRGGCEGVCSCTSKGFSTRCPTRVDEITEEQVLDGD 1204

  Fly   781 -DELFGMMNSYMPNMSIERDIGYKVTFVLENK-FEDQ-FPMLIDDLEENMQQLGVVSFRIRDTSM 842
             .||..::..::|...:...||.::.|:|.|| |:.: :..|..:|||.:..||:.||.|.||.:
Mouse  1205 VQELMDLVYHHVPEAKLVECIGQELIFLLPNKNFKQRAYASLFRELEETLADLGLSSFGISDTPL 1269

  Fly   843 EEIFLRF----GCEDNDQSGAFQSHENAQV---------LLEEYYSTLAEANE----------KG 884
            |||||:.    |.......||.|..|.|.:         .|.:|    |:|..          ||
Mouse  1270 EEIFLKVTEDAGAGSMFVGGAQQKREQAGLRHPCSAPTEKLRQY----AQAPHTCSPGQVDPPKG 1330

  Fly   885 R------------RTGWKLFFLHGRAVIYKRW---IAAHRHWIVLI-----FEVLAMAL-VAVCT 928
            :            .||.:|...|.:|::.||:   |.:.:.::..|     |..||:.| :.|..
Mouse  1331 QPSPEPEDPGVPFNTGARLILQHVQALLVKRFHHTIRSRKDFVAQIVLPATFVFLALMLSIIVPP 1395

  Fly   929 FSSI-------FIYGKNYEL----EPLTFNLSQLHTV----DAFVELFSEEEDVKD--------- 969
            |...       ::||..|..    ||...:|..|..|    ..|.....:||.:.:         
Mouse  1396 FGEFPALTLHPWMYGHQYTFFSMDEPNNEHLEVLADVLLNRPGFGNRCLKEEWLPEYPCINATSW 1460

  Fly   970 ---------MHAYYTELLYWYDAHVATLTK----------------------------------- 990
                     .|.:..:  .|..||.:...|                                   
Mouse  1461 KTPSVSPNITHLFQKQ--KWTAAHPSPSCKCSTREKLTMLPECPEGAGGLPPPQRTQRSTEVLQD 1523

  Fly   991 --NRH------NAYALLTQNQFTAH--VNSRYIFGATFDQKI----------------------- 1022
              ||:      ..|..|.::...:.  ||.:...|.:...|:                       
Mouse  1524 LTNRNISDYLVKTYPALIRSSLKSKFWVNEQRYGGISIGGKLPAIPISGEALVGFLSGLGQMMNV 1588

  Fly  1023 -------------------------VTAWFNNIPLHSAPYALNVVHNAVARHLF-----DEEATI 1057
                                     :..||||...|:....|||.|||:.|...     .||..|
Mouse  1589 SGGPVTREASKEMLDFLKHLETTDNIKVWFNNKGWHALVSFLNVAHNAILRASLPRDRDPEEYGI 1653

  Fly  1058 DVTLAPLPF-RTAINTFPPSSHTFGGCLAFGICFVLTFIWPAFAIYMITERGSLLKKQQFLAGVR 1121
            .|...||.. :..::.....:.:....:|..:.|.::|:..:|.:|:|.||.:..|..||::||.
Mouse  1654 TVISQPLNLTKEQLSDITVLTTSVDAVVAICVIFAMSFVPASFVLYLIQERVTKAKHLQFISGVS 1718

  Fly  1122 VCSYWTFTVLYDLLFLLIFCACVV-VMVAL----YENPNH------DVMLYGYISVTLMLGG--- 1172
            ..:||....|:|::...:....|| :.:..    |.:|::      .:||||:..:.:|...   
Mouse  1719 PTTYWLTNFLWDIMNYAVSAGLVVGIFIGFQKKAYTSPDNLPALVSLLMLYGWAVIPMMYPASFL 1783

  Fly  1173 FWVILLAYLMASLCRNPCYGFLWLCGINSIGLVCFSQFYRTHPESMLLEPTFMAMYTVATVICKL 1237
            |.|...||:..| |.|     |:: ||||..:....:.:..: .::|   .|.||      :.||
Mouse  1784 FEVPSTAYVALS-CAN-----LFI-GINSSAITFVLELFENN-RTLL---RFNAM------LRKL 1831

  Fly  1238 FMIYEFKLICM-----DPVVNFTSVEVFKCNSIPNCCIKSNYG-TFTAG------IYHDLVILTL 1290
            .::  |...|:     |..::....:|:           :.:| .::|.      |..:||.:.:
Mouse  1832 LIV--FPHFCLGRGLIDLALSQAVTDVY-----------AQFGEEYSANPFQWDLIGKNLVAMAI 1883

  Fly  1291 LDIILLACLFVSEYHSIL--GFADCRLDTRTNESPD-SNQESRAFPGILSNDTAALVDKEHTSRL 1352
            ..::......:.::|..|  ..|:...:...:|..| :.:..|...|  .|.|..|       :|
Mouse  1884 EGVVYFLLTLLIQHHFFLTRWIAEPAREPVFDEDDDVAEERQRVMSG--GNKTDIL-------KL 1939

  Fly  1353 NEEERSKYAAVGIGIVSKYRRNRVLRDLDFTLAKSECLSITGANNSGKTTLLKVVVNETKMNAGQ 1417
            ||..: .|:......|.:         |...:...||..:.|.|.:||||..|::..:|.:.:|.
Mouse  1940 NELTK-VYSGSSSPAVDR---------LCVGVRPGECFGLLGVNGAGKTTTFKMLTGDTTVTSGD 1994

  Fly  1418 LWIHDYSVNTHRVQCYRMVGYCPQKDSLPSEFTPRELLYIHAMLQGHRHRIGRELSEALLRLVGL 1482
            ..:...|:.|.....::.:|||||.|::....|.||.||::|.|:|...:...:::...::.:||
Mouse  1995 ATVAGKSILTSISDVHQNMGYCPQFDAIDDLLTGREHLYLYARLRGVPSKEIEKVANWGIQSLGL 2059

  Fly  1483 TPCWNRSVRMCTTGQIRRLYFAYAVLGSPDLICVDGVPAGLDPTGKRIILMMTSTMQAMGSSFLY 1547
            :...:|.....:.|..|:|..|.|:.|.|.|:.:|....|:||..:|::.....::...|.:.:.
Mouse  2060 SLYADRLAGTYSGGNKRKLSTAIALTGCPPLLLLDEPTTGMDPQARRMLWNTIVSIIREGRAVVL 2124

  Fly  1548 TMLTGLDAERLSLRTPLLLEGQLWMIRPMDTETENYKSGYQLEVRFKR-------KVNPNVSMSR 1605
            |..:..:.|.|..|..::::|....:..:......:..||.:.::.|.       .:||      
Mouse  2125 TSHSMEECEALCTRLAIMVKGTFQCLGTIQHLKYKFGDGYIVTMKIKSPKDDLLPDLNP------ 2183

  Fly  1606 ATWNLINHFPMSPNKKFSAFMEIKFPDAVLTIERDDSMV-FVLPLGTTTFSEIFLTLRKDAFEMN 1669
                            ...|.:..||.:|.. ||..||: |.:|  :::.:.||..|......:.
Mouse  2184 ----------------VEQFFQGNFPGSVQR-ERHHSMLQFQVP--SSSLARIFQLLISHKDSLL 2229

  Fly  1670 IEDYFITRNML----VGF---QIFTYD 1689
            ||:|.:|:..|    |.|   |..|||
Mouse  2230 IEEYSVTQTTLDQVFVNFAKQQTETYD 2256

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG1494NP_001259763.1 ABC2_membrane_3 <263..480 CDD:289468 41/225 (18%)
CcmA 541..848 CDD:224054 112/355 (32%)
ABC_subfamily_A 541..761 CDD:213230 76/228 (33%)
ABC2_membrane_3 911..>1189 CDD:289468 81/429 (19%)
ABC2_membrane <1080..>1188 CDD:304374 32/121 (26%)
ABC_subfamily_A 1370..1577 CDD:213230 50/206 (24%)
PRK14255 1371..1586 CDD:172743 50/214 (23%)
Abca4NP_031404.1 rim_protein 1..2271 CDD:130324 438/2042 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 891..910 4/18 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1311..1344 5/36 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2266..2310
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167838486
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0059
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D131191at2759
OrthoFinder 1 1.000 - - FOG0000051
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
65.750

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