DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1494 and ABCA9

DIOPT Version :9

Sequence 1:	NP_001259763.1	Gene:	CG1494 / 33102	FlyBaseID:	FBgn0031169	Length:	1695	Species:	Drosophila melanogaster
Sequence 2:	XP_024306297.1	Gene:	ABCA9 / 10350	HGNCID:	39	Length:	1634	Species:	Homo sapiens

Alignment Length:	1858	Identity:	384/1858 - (20%)
Similarity:	707/1858 - (38%)	Gaps:	461/1858 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 KFLLMNWKNHKLQLANPLELLVILLVPPLFTLVAVLMRFFIPVNHRSDT-VYDPIDLDRSWMQMV 72
            |..|..|:..:..|   ||.|.      .|.||..|..||..::...|| ....:||.|
Human    26 KNCLKKWRMKRQTL---LEWLF------SFLLVLFLYLFFSNLHQVHDTPQMSSMDLGR------ 75

  Fly    73 EKLEKARQVADTYNVKGNPFTPHLVIGWAPKRYGIFQAMMRRVQKQ--IEPMTSVGFEDCEEMRE 135
                     .|::|      ..:.||.:||:. ...|.:|.:|...  ::..|.:|:.|.:.|.|
Human    76 ---------VDSFN------DTNYVIAFAPES-KTTQEIMNKVASAPFLKGRTIMGWPDEKSMDE 124

  Fly   136 SVIENGLFAGLCFDGSPFVEDQVFEEDTLESYSNIQPMLNYTILLPSELRMLDGDFRMANWMTLY 200
                  |......|....:....|......|:.:..||                       |..:
Human   125 ------LDLNYSIDAVRVIFTDTFSYHLKFSWGHRIPM-----------------------MKEH 160

  Fly   201 NDDPNTFVLTRLNQPYEGGFVGYVREGFIRLQKSVSESFL-VLTSHKSLPTIQIRRFPITGREQD 264
            .|..............||.  .:..:||:..|.:::.:.: :.|:|    ::..:...:||....
Human   161 RDHSAHCQAVNEKMKCEGS--EFWEKGFVAFQAAINAAIIEIATNH----SVMEQLMSVTGVHMK 219

  Fly   265 --PLMGNLNYGMPFII---IIGFLFPAQLFVWQV---VSEKQSQVRQFLINMNIGNLIHFVSWYL 321
              |.:........|.|   ||.|    ..|::.|   |::::..:...:..|.:.....::||
Human   220 ILPFVAQGGVATDFFIFFCIISF----STFIYYVSVNVTQERQYITSLMTMMGLRESAFWLSW-- 278

  Fly   322 KGLIYE---MISSLIIAALLKIRWDQDHGVLTQTPWYILILVLF-CYNCAAVAFAIMVAAFFRNA 382
             ||:|.   :|.:.::|.::|   .....|||   .::::..|| .|..:.:..|.:::...:..
Human   279 -GLMYAGFILIMATLMALIVK---SAQIVVLT---GFVMVFTLFLLYGLSLITLAFLMSVLIKKP 336

  Fly   383 L---NAVRVLTILW-------IMSYVPTFILSNNLEGNIHALRYVSYALPNVVATLVIEFLIERE 437
            .   ..|.:|.:.|       :.:.:|.|     ||..:..|.             ...|.:...
Human   337 FLTGLVVFLLIVFWGILGFPALYTRLPAF-----LEWTLCLLS-------------PFAFTVGMA 383

  Fly   438 SIVHITWE-DSGYRLNYDGGHITVTASSWIFMLNALVYCAIGLYVD------------------- 482
            .::|:.:: :|...|:.......:.|:.::.:.:.|:|..:.||.|
Human   384 QLIHLDYDVNSNAHLDSSQNPYLIIATLFMLVFDTLLYLVLTLYFDKILPAEYGHRCSPLFFLKS 448

  Fly   483 -MWRGGDRSGKKMKKPNTNASVQEDPYHERGDSFTHQGQAIGVNSTKIYEVEPSHRRF----KLK 542
             .|....|:...:.:..|::    ||  ...|.|                 ||....|    .::
Human   449 CFWFQHGRANHVVLENETDS----DP--TPNDCF-----------------EPVSPEFCGKEAIR 490

  Fly   543 IKKLCKRFATN-DR-PALNLFSWNVYENEVTVLMGHNGCGKSTLLKILAGLVEPSRGTVMISSHN 605
            ||.|.|.:|.. :| .||....:::||.::|.|:||:|.||:|||.||:||..|:.|:|.:.:|.
Human   491 IKNLKKEYAGKCERVEALKGVVFDIYEGQITALLGHSGAGKTTLLNILSGLSVPTSGSVTVYNHT 555

  Fly   606 IQTERKAASMELGIAFGHDMLLTGF-----------TVIDYLRFICRVKGL--HNNIEIDGQSNY 657
            :.   :.|.:|....|      |||           ||.:.||...::||:  |   |::.:...
Human   556 LS---RMADIENISKF------TGFCPQSNVQFGFLTVKENLRLFAKIKGILPH---EVEKEVQR 608

  Fly   658 FLNVLQIGGLKTKRIRTLTDRDLCLVSICCAFVGNSPIILIDDVHSDLDKRTQSLVWNLINEEKS 722
            .:..|::..::....:.|:......::...|.:|:..::|:|:..:.||..::..:|||:.|.||
Human   609 VVQELEMENIQDILAQNLSGGQNRKLTFGIAILGDPQVLLLDEPTAGLDPLSRHRIWNLLKEGKS 673

  Fly   723 KRTIILVSNSPALAENIADRMAIMSNGELKCTGTKPFLKNMYGHGYRLTCVKGKNYKRDELFGMM 787
            .|.|:..:.....|:.:|||...:|||:|||.|:..|||..:|.||.|:....:....:.:..::
Human   674 DRVILFSTQFIDEADILADRKVFISNGKLKCAGSSLFLKKKWGIGYHLSLHLNERCDPESITSLV 738

  Fly   788 NSYMPNMSIERDIGYKVTFVLENKFEDQFPMLIDDLEENMQQLGVVSFRIRDTSMEEIFLRF-GC 851
            ..::.:..:......|:.::|..:..::||.|..||:....| |:..:.:..|::.|:||:. |.
Human   739 KQHISDAKLTAQSEEKLVYILPLERTNKFPELYRDLDRCSNQ-GIEDYGVSITTLNEVFLKLEGK 802

  Fly   852 EDNDQS-----GAFQSHENAQ-----VLLEEYYSTLAEAN------------------------E 882
            ...|:|     |..|: :.|:     |.||:..|:..|..                        :
Human   803 STIDESDIGIWGQLQT-DGAKDIGSLVELEQVLSSFHETRKTISGVALWRQQVCAIAKVRFLKLK 866

  Fly   883 KGRRTGWKLFFLHGRAVIYKRWIAAHRHWIVLIFEVLAMALVAVCTFSSIFIYGKNY--ELEPLT 945
            |.|::.|.:..|.|.:.|.:  :..|     |.:|                .|.|:|  ||.|.|
Human   867 KERKSLWTILLLFGISFIPQ--LLEH-----LFYE----------------SYQKSYPWELSPNT 908

  Fly   946 FNLSQ--------LH---------TVDAFVELFSEEEDVKDMHAYYTELLYWYDAHVATLTKNRH 993
            :.||.        .|         |:|.|:.....:....::.|:.|.
Human   909 YFLSPGQQPQDPLTHLLVINKTGSTIDNFLHSLRRQNIAIEVDAFGTR----------------- 956

  Fly   994 NAYALLTQNQFTAHVNSRYIFGATFDQKIVTAWFNNIPLHSAPYALNVVHNAV------ARHLFD 1052
                  ......::..:..:.|...|.:...| .|...|:..|..|:|:.|.:      :.|:..
Human   957 ------NGTDDPSYNGAIIVSGDEKDHRFSIA-CNTKRLNCFPVLLDVISNGLLGIFNSSEHIQT 1014

  Fly  1053 EEATIDVTLAPLPFRTAINTFPPSSHTFGGCLAFGICFVLTFIWPAFAIYMITERGSLLKKQQFL 1117
            :.:|.........:....|||            |.|....:|. |..|:..|.:.......|..:
Human  1015 DRSTFFEEHMDYEYGYRSNTF------------FWIPMAASFT-PYIAMSSIGDYKKKAHSQLRI 1066

  Fly  1118 AGVRVCSYWTFTVLYDLLFLLIFCACVVVMVALYENPNHDVML-----------YGYISVTLML- 1170
            :|:...:||....|.|:....:....:.:|..:: :|...:.:           .||:|..:.|
Human  1067 SGLYPSAYWFGQALVDVSLYFLILLLMQIMDYIF-SPEEIIFIIQNLLIQILCSIGYVSSLVFLT 1130

  Fly  1171 -------------GGFW----VILLAYLMASLCRNPCYGFLWLCGINSIGLVCFSQFYRTHPESM 1218
                         .|.|    :|::.:.:.:...|. ||||.|             |:.|    |
Human  1131 YVISFIFRNGRKNSGIWSFFFLIVVIFSIVATDLNE-YGFLGL-------------FFGT----M 1177

  Fly  1219 LLEPTFMAMYTVATVICKLFMIYEFKLICMDPVVNFTSVEVFKCNSIPNCCIKSNYGTFTAGIYH 1283
            |:.|        .|:|..||:..|.....||.:....|..|:....||              ..|
Human  1178 LIPP--------FTLIGSLFIFSEISPDSMDYLGASESEIVYLALLIP--------------YLH 1220

  Fly  1284 DLVILTLLDIILLAC---------LFVSEYHSILGFADCRLDTRTN------ESPDSNQESRAFP 1333
            .|:.|.:|..:.:.|         :|             |:..|:|      |.|:..:|.....
Human  1221 FLIFLFILRCLEMNCRKKLMRKDPVF-------------RISPRSNAIFPNPEEPEGEEEDIQME 1272

  Fly  1334 GILSNDTAALVDKEHT-----SRLNEEERSKYAAVGIGIVSKYRRNRVLRDLDFTLAKSECLSIT 1393
            .:.:.:..|:.|.:.|     |.|    |.:||.......||.::....|::.|.:.|.|.:.:.
Human  1273 RMRTVNAMAVRDFDETPVIIASCL----RKEYAGKKKNCFSKRKKKIATRNVSFCVKKGEVIGLL 1333

  Fly  1394 GANNSGKTTLLKVVVNETKMNAGQLWIHDYSVNTHRVQCYRMVGYCPQKDSLPSEFTPRELLYIH 1458
            |.|.:||:|.:|::..:||..|||:.:.    .:...:....:|||||:::|....|.|:.|.::
Human  1334 GHNGAGKSTTIKMITGDTKPTAGQVILK----GSGGGEPLGFLGYCPQENALWPNLTVRQHLEVY 1394

  Fly  1459 AMLQGHRHRIGRELSEALLRLVG---LTPCWNRSVRMCTTGQIRRLYFAYAVLGSPDLICVDGVP 1520
            |.::|.|.   .:...|:.|||.   |.......|:..:.|..|:|.|..::||:|.::.:|...
Human  1395 AAVKGLRK---GDAMIAITRLVDALKLQDQLKAPVKTLSEGIKRKLCFVLSILGNPSVVLLDEPS 1456

  Fly  1521 AGLDPTG-KRIILMMTSTMQAMGSSFLYTMLTGLDAERLSLRTPLLLEGQLWMIRPMDTETENYK 1584
            .|:||.| :::..::.:|.:......|.|.....:||.:..|..:::.|:|..|..:......:.
Human  1457 TGMDPEGQQQMWQVIRATFRNTERGALLTTHYMAEAEAVCDRVAIMVSGRLRCIGSIQHLKSKFG 1521

  Fly  1585 SGYQLEVRFKRKVNPNVSMSRATWNLINHFPM-SPNKKFSAFMEIKFPDAVLTIERDDSMVFVLP 1648
            ..|.||::.|..    ..|......::..||. :..::||:.|..|.|     :|.      |.|
Human  1522 KDYLLEMKLKNL----AQMEPLHAEILRLFPQAAQQERFSSLMVYKLP-----VED------VRP 1571

  Fly  1649 LGTTTFSEIFLTLRKDAFEMNIEDYFITRNMLVGFQIF 1686
            |....|.   |.:.|.:|:  :|:|.::::.|.  |:|
Human  1572 LSQAFFK---LEIVKQSFD--LEEYSLSQSTLE--QVF 1602

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1494	NP_001259763.1	ABC2_membrane_3	<263..480	CDD:289468	40/239 (17%)
		CcmA	541..848	CDD:224054	88/321 (27%)
		ABC_subfamily_A	541..761	CDD:213230	70/234 (30%)
		ABC2_membrane_3	911..>1189	CDD:289468	52/331 (16%)
		ABC2_membrane	<1080..>1188	CDD:304374	21/136 (15%)
		ABC_subfamily_A	1370..1577	CDD:213230	55/210 (26%)
		PRK14255	1371..1586	CDD:172743	54/218 (25%)
ABCA9	XP_024306297.1	ABC2_membrane_3	53..416	CDD:315386	76/450 (17%)
ABCA9	XP_024306297.1	AAA	<245..1609	CDD:333001	329/1569 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148388
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.750