DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1494 and ABCA10

DIOPT Version :9

Sequence 1:	NP_001259763.1	Gene:	CG1494 / 33102	FlyBaseID:	FBgn0031169	Length:	1695	Species:	Drosophila melanogaster
Sequence 2:	NP_001364250.1	Gene:	ABCA10 / 10349	HGNCID:	30	Length:	1543	Species:	Homo sapiens

Alignment Length:	1656	Identity:	347/1656 - (20%)
Similarity:	643/1656 - (38%)	Gaps:	417/1656 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   223 YVREGFIRLQKSVSESFL-VLTSHK------SLPTIQIRRFPITGREQDPLMGNLNYGMPFIIII 280
            |..:||:..|.:::.:.: |.|:|.      |:..|.::..|...:.:  :|....:....:...
Human    83 YWLKGFVAFQAAINAAIIEVTTNHSVMEELTSVIGINMKIPPFISKGE--IMNEWFHFTCLVSFS 145

  Fly   281 GFLFPAQLFVWQVVSEKQSQVRQFLINMNIGNLIHFVSWYLKGLIYEMISSLIIAALLKIRWDQD 345
            .|::.|.|    .|:.::.:.::.:..|.:.....::||.|..:.:..|.|:.:|.
Human   146 SFIYFASL----NVARERGKFKKLMTVMGLRESAFWLSWGLTYICFIFIMSIFMAL--------- 197

  Fly   346 HGVLTQTP-----WYILILVLF-CYNCAAVAFAIMVAAFFRNALNAVRV---------------- 388
              |:|..|     .:::|..|: .|..:.:|.|.:::...|..:.|...
Human   198 --VITSIPIVFHTGFMVIFTLYSLYGLSLIALAFLMSVLIRKPMLAGLAGFLFTVFWGCLGFTVL 260

  Fly   389 -----LTILWIMSYVPTFILSNNLEGNIHALRYVSYALPNVVATLVIEFLIERESIVHITWEDSG 448
                 |::.|::|.:..|..:..:....|...|:|                      .:.:.|.
Human   261 YRQLPLSLGWVLSLLSPFAFTAGMAQITHLDNYLS----------------------GVIFPDP- 302

  Fly   449 YRLNYDGGHITVTASSWIFMLNALVYCAIGLYV-----DMWRGGD------RSGKKMKKPNTNAS 502
                 .|....:.|:.:|...:.|.|....||.     |....||      :|....|..||:..
Human   303 -----SGDSYKMIATFFILAFDTLFYLIFTLYFERVLPDKDGHGDSPLFFLKSSFWSKHQNTHHE 362

  Fly   503 VQE---DPYHERGDSFTHQGQAIGVNSTKIYEVEPS-HRRFKLKIKKLCKRF--ATNDRPALNLF 561
            :.|   :|.|...|||.              .|.|. |.:..::|:.:.|.:  .|....||...
Human   363 IFENEINPEHSSDDSFE--------------PVSPEFHGKEAIRIRNVIKEYNGKTGKVEALQGI 413

  Fly   562 SWNVYENEVTVLMGHNGCGKSTLLKILAGLVEPSRGTVMISSHNIQ----TERKAASMELGIA-- 620
            .:::||.::|.::||||.||||||.||:||...:.|:..|  :|.|    |:.:.....:|..
Human   414 FFDIYEGQITAILGHNGAGKSTLLNILSGLSVSTEGSATI--YNTQLSEITDMEEIRKNIGFCPQ 476

  Fly   621 --FGHDMLLTGFTVIDYLRFICRVKGLHNN----------IEIDGQSNYFLNVLQI-GGLKTKRI 672
              |..|.|    ||.:.||...::||:...          :|:|.||...:...:: ||.|.|
Human   477 FNFQFDFL----TVRENLRVFAKIKGIQPKEVEQEVKRIIMELDMQSIQDIIAKKLSGGQKRK-- 535

  Fly   673 RTLTDRDLCLVSICCAFVGNSPIILIDDVHSDLDKRTQSLVWNLINEEKSKRTIILVSNSPALAE 737
                      :::..|.:|:..::|:|:..:.||..::..||:|:.|.|..|.|:..:.....|:
Human   536 ----------LTLGIAILGDPQVLLLDEPTAGLDPFSRHRVWSLLKEHKVDRLILFSTQFMDEAD 590

  Fly   738 NIADRMAIMSNGELKCTGTKPFLKNMYGHGYRLTCVKGKNYKRDELFGMMNSYMPNMSIERDIGY 802
            .:|||...:|||:|||.|:..|||..:|.||.|:..:.:....:::..::..::|:..:..:...
Human   591 ILADRKVFLSNGKLKCAGSSLFLKRKWGIGYHLSLHRNEMCDTEKITSLIKQHIPDAKLTTESEE 655

  Fly   803 KVTFVLENKFEDQFPMLIDDLEENMQQLGVVSFRIRDTSMEEIFLRFGCEDNDQSGAFQ--SHEN 865
            |:.:.|..:..::||.|..||::...| |:.::.:..||:.|:||....:.......|.  ..|.
Human   656 KLVYSLPLEKTNKFPDLYSDLDKCSDQ-GIRNYAVSVTSLNEVFLNLEGKSAIDEPDFDIGKQEK 719

  Fly   866 AQVL--------LEEYYSTLAEANEKGRRTGWKLFFLHGRAVIYKRWIAA-----------HRHW 911
            ..|.        :|:...:|.|..:           ....|.:::|.|.|           .|..
Human   720 IHVTRNTGDESEMEQVLCSLPETRK-----------AVSSAALWRRQIYAVATLRFLKLRRERRA 773

  Fly   912 IVLIFEVLAMALVAV--------------CTFSSIFIYGKNYELEPLTFNLSQL------HTVDA 956
            ::.:..||.:|.:.:              |...|..:|..:.|..|.|...|.|      ..::.
Human   774 LLCLLLVLGIAFIPIILEKIMYKVTRETHCWEFSPSMYFLSLEQIPKTPLTSLLIVNNTGSNIED 838

  Fly   957 FVELFSEEEDVKDMHAYYTELLYWYDAHVATLTKNR-------HNAYALLTQNQFTAHVNSRYIF 1014
            .|.....::.|.::..:                :||       :|...:::.:|      ..|.|
Human   839 LVHSLKCQDIVLEIDDF----------------RNRNGSDDPSYNGAIIVSGDQ------KDYRF 881

  Fly  1015 GATFDQKIVTAWFNNIPLHSAPYALNVVHNAVA-----RHLFDEEATI----DVTLAPLPFRTAI 1070
            ....:.|         .|:..|..:.:|.||:.     ..|...|:|.    |:.|.
Human   882 SVACNTK---------KLNCFPVLMGIVSNALMGIFNFTELIQMESTSFSRDDIVLD-------- 929

  Fly  1071 NTFPPSSHTFGGCLAF--GICFVLTF---IWPAFAIYMITERGSLLKKQQFLAGVRVCSYWTFTV 1130
                         |.|  |..|:|..   :.|...:..|::....::.|.:::|:...:||....
Human   930 -------------LGFIDGSIFLLLITNCVSPFIGMSSISDYKKNVQSQLWISGLWPSAYWCGQA 981

  Fly  1131 LYD--LLFLLIFCA-CVVVMVALYENPNHDVMLYGYISVTLMLG-GFWVILLAYLMASLCR--NP 1189
            |.|  |.||::|.. .:...:.|....:.::|   ::.|..::| ...:|.|.|:::.:.|  ..
Human   982 LVDIPLYFLILFSIHLIYYFIFLGFQLSWELM---FVLVVCIIGCAVSLIFLTYVLSFIFRKWRK 1043

  Fly  1190 CYGFLWLCGINSIGLVCFSQ-FYRTHPESMLLEPTFMAMYTVATVICKLF------MIYEFKLIC 1247
            ..|| |..|...| |:|.|. ...|..|.:.|            ::|.:|      :.|...||.
Human  1044 NNGF-WSFGFFII-LICVSTIMVSTQYEKLNL------------ILCMIFIPSFTLLGYVMLLIQ 1094

  Fly  1248 MDPVVNFTSVEVFKCNSIPNCCIKSNYGTFTAGIYHDLVILTLLD-------IILLACLFVSEYH 1305
            :|.:.|..|::    |.|..             :...:::.||:.       :.::.||.:...:
Human  1095 LDFMRNLDSLD----NRINE-------------VNKTILLTTLIPYLQSVIFLFVIRCLEMKYGN 1142

  Fly  1306 SILG----FADCRLDTRTNESPDSNQESRAFPGILSNDTAALVDKEHTSRLN-------EEE--- 1356
            .|:.    |   |:..|:.|:..:.:|    |.....|    |..|.....|       |||
Human  1143 EIMNKDPVF---RISPRSRETHPNPEE----PEEEDED----VQAERVQAANALTAPNLEEEPVI 1196

  Fly  1357 -----RSKYAAVGIGIVSKYRRNRVLRDLDFTLAKSECLSITGANNSGKTTLLKVVVNETKMNAG 1416
                 ..:|........|..::...:|::.|.:.|.|.|.:.|.|.:||:|.:|::...||..||
Human  1197 TASCLHKEYYETKKSCFSTRKKKIAIRNVSFCVKKGEVLGLLGHNGAGKSTSIKMITGCTKPTAG 1261

  Fly  1417 QLWI----------HDYSVNTHRVQCYRMVGYCPQKDSLPSEFTPRELLYIHAMLQGHRHRIGRE 1471
            .:.:          ||.|:        :.:|||||::||..:.|.:|.|.::|.::|    :|:|
Human  1262 VVVLQGSRASVRQQHDNSL--------KFLGYCPQENSLWPKLTMKEHLELYAAVKG----LGKE 1314

  Fly  1472 ---LS-EALLRLVGLTPCWNRSVRMCTTGQIRRLYFAYAVLGSPDLICVDGVPAGLDPTGKR--- 1529
               || ..|:..:.|.......|:..:.|..|:|.|..::||:|.::.:|....|:||.|::
Human  1315 DAALSISRLVEALKLQEQLKAPVKTLSEGIKRKLCFVLSILGNPSVVLLDEPFTGMDPEGQQQMW 1379

  Fly  1530 IILMMTSTMQAMGSSFLYTMLTG---LDAERLSLRTPLLLEGQLWMIRPMDTETENYKSGYQLEV 1591
            .||..|...:..|     |:||.   .:||.:..|..:::.|.|..|..:......:...|.||:
Human  1380 QILQATVKNKERG-----TLLTTHYMSEAEAVCDRMAMMVSGTLRCIGSIQHLKNKFGRDYLLEI 1439

  Fly  1592 RFKRKVNPNVSMSRATWNLINHFPMSP-NKKFSAFMEIKFPDAVLTIERDDSMVFVLPLGTTTFS 1655
            :.|..    ..:......::..||.:. .:::|:.|..|.|     :|.      |.||....|.
Human  1440 KMKEP----TQVEALHTEILKLFPQAAWQERYSSLMAYKLP-----VED------VHPLSRAFFK 1489

  Fly  1656 EIFLTLRKDAFEMNIEDYFITRNMLVGFQIF 1686
               |...|..|  |:|:|.:::..|.  |:|
Human  1490 ---LEAMKQTF--NLEEYSLSQATLE--QVF 1513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1494	NP_001259763.1	ABC2_membrane_3	<263..480	CDD:289468	35/243 (14%)
		CcmA	541..848	CDD:224054	90/327 (28%)
		ABC_subfamily_A	541..761	CDD:213230	70/240 (29%)
		ABC2_membrane_3	911..>1189	CDD:289468	55/324 (17%)
		ABC2_membrane	<1080..>1188	CDD:304374	25/118 (21%)
		ABC_subfamily_A	1370..1577	CDD:213230	62/226 (27%)
		PRK14255	1371..1586	CDD:172743	62/234 (26%)
ABCA10	NP_001364250.1	rim_protein	<37..1520	CDD:130324	347/1656 (21%)
ABCA10	NP_001364250.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1153..1177		6/31 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148341
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.750