Protein Alignment CG1494 and ABCA7

DIOPT Version :10

• Sequence 1: NP_608444.2
• Gene: CG1494 / 33102
• FlyBaseID: FBgn0031169
• Length: 1695
• Species: Drosophila melanogaster
• Sequence 2: NP_061985.2
• Gene: ABCA7 / 10347
• HGNCID: 37
• Length: 2146
• Species: Homo sapiens
• Alignment Length: 1869
• Identity: 405/1869 - (21%)
• Similarity: 691/1869 - (36%)
• Gaps: 506/1869 - (27%)

  Fly   139 ENGLFAGLCFDGSPFVEDQVFEEDTLESYSNIQPMLNYTILLPSELRM---LDGD-------FRM 193
            |:..:||:.|.|         .||:.:...:..|.|.     |..:|:   :|.|       .|.
Human   431 EHRFWAGVVFLG---------PEDSSDPTEHPTPDLG-----PGHVRIKIRMDIDVVTRTNKIRD 481

  Fly   194 ANWMTLYNDDPNTFVLTRLNQPYEGGFVGYVREGFIRLQKSVSESFL-VLTSHKSLPTIQIRRFP 257
            ..|    :..|....||.|.         ||..||:.||..|..:.: ||:.......:.:::.|
Human   482 RFW----DPGPAADPLTDLR---------YVWGGFVYLQDLVERAAVRVLSGANPRAGLYLQQMP 533

  Fly   258 ITGREQDPLMGNLNYGMPFIIIIGFLFPAQLFVWQVVSEKQSQVRQFLINMNIGNLIHFVSWYLK 322
            ......|..:..|:..:|..:.:.:::...|.|..||.||::::|..:..|.:...:.::.|:|.
Human   534 YPCYVDDVFLRVLSRSLPLFLTLAWIYSVTLTVKAVVREKETRLRDTMRAMGLSRAVLWLGWFLS 598

  Fly   323 GLIYEMISSLIIAALLKIRWDQDHGVLTQTPWYILILVLFCYNCAAVAFAIMVAAFFRNALNAVR 387
            .|...::|:.::..:||:     ..:|..:...::.|.|..:..|.|..:.:::|||..|
Human   599 CLGPFLLSAALLVLVLKL-----GDILPYSHPGVVFLFLAAFAVATVTQSFLLSAFFSRA----- 653

  Fly   388 VLTILWIMSYVPTFILSNNLEGNIHALRYVSYALP---------------NVVATLV--IEFLIE 435
                              ||......|.|.|..||               .|.|:|:  :.|...
Human   654 ------------------NLAAACGGLAYFSLYLPYVLCVAWRDRLPAGGRVAASLLSPVAFGFG 700

  Fly   436 RESIVHI-------TWEDSGYRLNYDGGHITVTASSWIFMLNALVYCAIGLYVD----------- 482
            .||:..:       .|.:.|.|...|  ..::...|.:.:|:|.:|.....|::
Human   701 CESLALLEEQGEGAQWHNVGTRPTAD--VFSLAQVSGLLLLDAALYGLATWYLEAVCPGQYGIPE 763

  Fly   483 ---------MWRGGDRSGKKMKKP-------NTNASVQEDPYHERGDSFTHQGQAIGVNSTKIYE 531
                     .|.|    .:..|.|       :....|:|.|          .|.:.||:
Human   764 PWNFPFRRSYWCG----PRPPKSPAPCPTPLDPKVLVEEAP----------PGLSPGVS------ 808

  Fly   532 VEPSHRRFKLKIKKLCKRFATNDRPALNLFSWNVYENEVTVLMGHNGCGKSTLLKILAGLVEPSR 596
                       ::.|.|||..:.:|||...|.:.|:..:|..:||||.||:|.|.||:||..||.
Human   809 -----------VRSLEKRFPGSPQPALRGLSLDFYQGHITAFLGHNGAGKTTTLSILSGLFPPSG 862

  Fly   597 GTVMISSHNIQTERKAASMELGIAFGHDMLLTGFTVIDYLRFICRVKGLHNNIEIDGQSNYFLNV 661
            |:..|..|::::...|....||:...:::|....||.:::.|..|:|||...:....|.    .:
Human   863 GSAFILGHDVRSSMAAIRPHLGVCPQYNVLFDMLTVDEHVWFYGRLKGLSAAVVGPEQD----RL 923

  Fly   662 LQIGGLKTK---RIRTLTDRDLCLVSICCAFVGNSPIILIDDVHSDLDKRTQSLVWNLINEEKSK 723
            ||..||.:|   :.|.|:......:|:..||||.|.::::|:..:.:|..::..:|.|:.:.:..
Human   924 LQDVGLVSKQSVQTRHLSGGMQRKLSVAIAFVGGSQVVILDEPTAGVDPASRRGIWELLLKYREG 988

  Fly   724 RTIILVSNSPALAENIADRMAIMSNGELKCTGTKPFLKNMYGHGYRLTCVKGK-----NYKRD-- 781
            ||:||.::....||.:.||:|:::.|.|.|.|:..||:...|.||.||.||.:     |.|.|
Human   989 RTLILSTHHLDEAELLGDRVAVVAGGRLCCCGSPLFLRRHLGSGYYLTLVKARLPLTTNEKADTD 1053

  Fly   782 -----------------------ELFGMMNSYMPNMSIERDIGYKVTFVL--ENKFEDQFPMLID 821
                                   :|..::..::|...:..::.:::..||  ....:..|..|..
Human  1054 MEGSVDTRQEKKNGSQGSRVGTPQLLALVQHWVPGARLVEELPHELVLVLPYTGAHDGSFATLFR 1118

  Fly   822 DLEENMQQLGVVSFRIRDTSMEEIFLRFGCE---DND---------------------------Q 856
            :|:..:.:|.:..:.|.|||:|||||:...|   |.|                           |
Human  1119 ELDTRLAELRLTGYGISDTSLEEIFLKVVEECAADTDMEDGSCGQHLCTGIAGLDVTLRLKMPPQ 1183

  Fly   857 SGAFQSHENAQVLLEEYYSTLAEANEKGRRTGWKLFFLHGRAVIYKRWIAAHRH------WIVLI 915
            ..|.::.|.|....|....:..:|  .||..||.|.....:|::.||::.|.|.      .|||.
Human  1184 ETALENGEPAGSAPETDQGSGPDA--VGRVQGWALTRQQLQALLLKRFLLARRSRRGLFAQIVLP 1246

  Fly   916 FEVLAMALVAVCTFSSI---FIYGKNYELEPLTFNLSQLHTVDAFVELFSEEEDVKDMHAYYTEL 977
            ...:.:|||    ||.|   |.:.....|.|..:.        |.|..|||:.......|...|.
Human  1247 ALFVGLALV----FSLIVPPFGHYPALRLSPTMYG--------AQVSFFSEDAPGDPGRARLLEA 1299

  Fly   978 L----------YWYDAH------------------------------------------------ 984
            |          ..:.:|
Human  1300 LLQEAGLEEPPVQHSSHRFSAPEVPAEVAKVLASGNWTPESPSPACQCSRPGARRLLPDCPAAAG 1364

  Fly   985 --------------VATLTKNRHNAYALLTQNQFTAH-------VNS-RY--------------- 1012
                          |..||....:.:.:.|..:....       ||. ||
Human  1365 GPPPPQAVTGSGEVVQNLTGRNLSDFLVKTYPRLVRQGLKTKKWVNEVRYGGFSLGGRDPGLPSG 1429

  Fly  1013 ----------------IFGATFDQ--KIVTA-------------WFNNIPLHSAPYALNVVHNAV 1046
                            :.|...|:  |.:||             ||||...||....:|...||:
Human  1430 QELGRSVEELWALLSPLPGGALDRVLKNLTAWAHSLDAQDSLKIWFNNKGWHSMVAFVNRASNAI 1494

  Fly  1047 ARHLFDEEATIDVTLAPLPFRTAINTFPPSSHTF---------GGCLA------FGIC--FVLTF 1094
            .|          ..|.|.|.|.| ::....:|..         |..:|      ..||  |.::|
Human  1495 LR----------AHLPPGPARHA-HSITTLNHPLNLTKEQLSEGALMASSVDVLVSICVVFAMSF 1548

  Fly  1095 IWPAFAIYMITERGSLLKKQQFLAGVRVCSYWTFTVLYDLLFLLIFCACVVVMVAL------YEN 1153
            :..:|.:.:|.||.:..|..|.:.|:....||....|:|:...|: .||:||::.|      |..
Human  1549 VPASFTLVLIEERVTRAKHLQLMGGLSPTLYWLGNFLWDMCNYLV-PACIVVLIFLAFQQRAYVA 1612

  Fly  1154 PNH------DVMLYGYISVTLMLGG---FWVILLAYLMASLCRNPCYGFLWLCGIN----SIGLV 1205
            |.:      .::|||:....||...   |.|...||::.: |.|     |:: |||    :..|.
Human  1613 PANLPALLLLLLLYGWSITPLMYPASFFFSVPSTAYVVLT-CIN-----LFI-GINGSMATFVLE 1670

  Fly  1206 CFSQFYRTHPESMLLEPTFMAMYTVATVICKLFMIYEFKLICM-----DPVVNFTSVEVFKCNSI 1265
            .||.               ..:..|:.::.::|:|  |...|:     |.|.|....:.|:
Human  1671 LFSD---------------QKLQEVSRILKQVFLI--FPHFCLGRGLIDMVRNQAMADAFE---- 1714

  Fly  1266 PNCCIKSNYGTFTAGIYHDLVILTLLDIILLACLFVSEYHSILGFADCRLDTRTNESPDSNQESR 1330
                 :.....|.:.:..::|...||.:::...||:  ..::|      |..|:...|.....|.
Human  1715 -----RLGDRQFQSPLRWEVVGKNLLAMVIQGPLFL--LFTLL------LQHRSQLLPQPRVRSL 1766

  Fly  1331 AFPGILSNDTAALVDKEHTSRLNEEERSKYAA------VGIGIVSKYRRNRV--LRDLDFTLAKS 1387
            ...|....|.|           .|.||....|      |...:...||..|:  :..|...:...
Human  1767 PLLGEEDEDVA-----------RERERVVQGATQGDVLVLRNLTKVYRGQRMPAVDRLCLGIPPG 1820

  Fly  1388 ECLSITGANNSGKTTLLKVVVNETKMNAGQLWIHDYSVNTHRVQCYRMVGYCPQKDSLPSEFTPR 1452
            ||..:.|.|.:|||:..::|..:|..:.|:..:..:||.......:..:|||||.|::....|.|
Human  1821 ECFGLLGVNGAGKTSTFRMVTGDTLASRGEAVLAGHSVAREPSAAHLSMGYCPQSDAIFELLTGR 1885

  Fly  1453 ELLYIHAMLQG-HRHRIGRELSEALLRLVGLTPCWNRSVRMCTTGQIRRLYFAYAVLGSPDLICV 1516
            |.|.:.|.|:| ...::.:.....|.|| ||:...:|.....:.|..|:|..|.|::|.|.::.:
Human  1886 EHLELLARLRGVPEAQVAQTAGSGLARL-GLSWYADRPAGTYSGGNKRKLATALALVGDPAVVFL 1949

  Fly  1517 DGVPAGLDPTGKRIILMMTSTMQAMGSSFLYTMLTGLDAERLSLRTPLLLEGQLWMIRPMDTETE 1581
            |....|:||:.:|.:......:...|.|.:.|..:..:.|.|..|..:::.|:...:........
Human  1950 DEPTTGMDPSARRFLWNSLLAVVREGRSVMLTSHSMEECEALCSRLAIMVNGRFRCLGSPQHLKG 2014

  Fly  1582 NYKSGYQLEVRFKRKVNPNVSMSRATWNLINHFPMSPNKKFSAFMEIKFPDAVLTIERDDSMVFV 1646
            .:.:|:.|.:|                     .|.:.::..:||:..:||.|.|.......:.|.
Human  2015 RFAAGHTLTLR---------------------VPAARSQPAAAFVAAEFPGAELREAHGGRLRFQ 2058

  Fly  1647 LPL-GTTTFSEIFLTLRKDAFEMNIEDYFITRNMLVG-FQIFTYDQHQD 1693
            ||. |....:.:|..|.....|..:||:.:::.||.. |..|:.||.:|
Human  2059 LPPGGRCALARVFGELAVHGAEHGVEDFSVSQTMLEEVFLYFSKDQGKD 2107

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG1494	NP_608444.2	rim_protein	<223..1689	CDD:130324	383/1769 (22%)
		ABC_subfamily_A	541..761	CDD:213230	70/222 (32%)
ABCA7	NP_061985.2	rim_protein	1..2109	CDD:130324	405/1869 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1048..1072		2/23 (9%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1185..1209		5/25 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2104..2146		2/4 (50%)