DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1494 and LOC101883122

DIOPT Version :9

Sequence 1:	NP_001259763.1	Gene:	CG1494 / 33102	FlyBaseID:	FBgn0031169	Length:	1695	Species:	Drosophila melanogaster
Sequence 2:	XP_021333309.1	Gene:	LOC101883122 / 101883122	-ID:	-	Length:	2391	Species:	Danio rerio

Alignment Length:	1752	Identity:	350/1752 - (19%)
Similarity:	628/1752 - (35%)	Gaps:	528/1752 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 IFQAMMRRVQK--------QIEPMTSVGFEDCEEMRESVIENGLFAGLCFDGSPFVEDQVFEEDT 163
            :|.|..:..|:        .::..:||.       .|:::.|...|.|..|  .|....||.:
Zfish   414 VFNATSQSAQQLTQILKCFDLDKFSSVS-------TEALLVNQALALLDLD--RFWAGLVFTD-- 467

  Fly   164 LESYSNIQP--MLNYTILLPSELRMLDGDFRMANWMTLYNDDPNTFVLTRLNQPYEGGFVGYVRE 226
            |...|:.||  .:.|.|.:..:........:..:|.....|:|       ||.      :.|||.
Zfish   468 LGDPSDPQPPTHIRYKIRMDVQDTERTDKLKERSWSPTARDNP-------LND------LRYVRG 519

  Fly   227 GFIRLQKSVSESFLVL-TSHKSLPTIQIRRFPITGREQDPLMGNLNYGMPFIIIIGFLFPAQLFV 290
            ||:.||..|..:.:.| |..:....:..::.|......|..:..:...:|..:::.|.:.....:
Zfish   520 GFVYLQDMVDRAIIKLQTGVQQTLGVYAQQMPYPCYMDDAFVSAIGTMLPMFLVLAFNYSVSEII 584

  Fly   291 WQVVSEKQSQVRQFLINMNIGNLIHFVSWYLKGLIYEMISSLIIAALLK----IRWDQDHGVLTQ 351
            ..:|.||:.::::.|....:.|....:.|:.:.:|..|:...:|:.::|    :|: .|..|:
Zfish   585 KGLVLEKERRLKEVLRVSGVSNSTIRLCWFAENMILLMVPCALISVMVKYGKVLRY-SDPSVI-- 646

  Fly   352 TPWYILILVLFCYNCAAVAFAIMVAAFFRNALNAVRVLTILWIMSYVPTFILSNNLEGNIHALRY 416
                .:.|::||  .|.|.....::.||..|..|.....:|:.:.|:|            |.|.|
Zfish   647 ----FVFLLVFC--LATVMQCFFISVFFSRANLAAACGGLLYFLLYLP------------HVLCY 693

  Fly   417 V--------SYALPNVVATLVIEFLIERESIVHITWEDSGYRLNY--------DGGHITVTASSW 465
            .        :....::::.:...:..|..|    |:|..|..:.:        |....:...|.:
Zfish   694 AWRDVLGFGAKIATSLLSCVAFGYGCENFS----TYEAQGVGIQWSNIRSSPQDNDRYSFIVSIF 754

  Fly   466 IFMLNALVYCAIGLYVDMWRGGDRSGKKMKKPNTNASVQEDPYHERGDSFTHQGQAIG------- 523
            :.:.:||:|..:..|::....|.....|             |::....|....|..:|
Zfish   755 MMLFDALIYWTLTWYIENVYPGQYGIAK-------------PWYFPFTSSYWCGSRVGSDGHPDL 806

  Fly   524 ----VNSTKIYEVEPSHRRFKLKIKKLCKRFATNDRPALNLFSWNVYENEVTVLMGHNGCGKSTL 584
                .|.:...|..||..:..:.|:.|.|.:.|.::.|::..|.:.|::.:|..:||||.||:|.
Zfish   807 LQDLENQSGFLEKPPSGLKPGVCIRNLVKVYKTGNKLAVDGLSLDFYQDHITSFLGHNGAGKTTT 871

  Fly   585 LKILAGLVEPSRGTVMISSHNIQTERKAASMELGIAFGHDMLLTGFTVIDYLRFICRVKGLHN-- 647
            :.||.||..|:.||..|:.::|:|:......:||:...|::|....||.:::.|..|:||..:
Zfish   872 MSILTGLFAPTSGTAYINGYDIRTDMDCIRKQLGMCPQHNVLFDDLTVEEHIYFYARLKGRSSKE 936

  Fly   648 -NIEIDGQSNYFLNVLQIGGLKTKRIRTLTDRDLC---------LVSICCAFVGNSPIILIDDVH 702
             ..|||       .:::..||..||      :||.         .:|:..||||.|.::::|:..
Zfish   937 VKKEID-------QMIKDVGLPHKR------KDLAKNLSGGMQRKLSVAIAFVGGSNVVILDEPT 988

  Fly   703 SDLDKRTQSLVWNLINEEKSKRTIILVSNSPALAENIADRMAIMSNGELKCTGTKPFLKNMYGHG 767
            :.:|...:..:|.|:.:.|..|||||.::....|:.:.||:||:|:|.::|.|:..|||..||.|
Zfish   989 AGVDPYARRGIWELLLKYKQGRTIILSTHHMDEADILGDRVAIISHGRVQCCGSSLFLKKTYGRG 1053

  Fly   768 YRLTCVKGKNYKR----------------------------------DELFGMMNSYMPNMSIER 798
            |.||..:. |.:|                                  .::..::..::|......
Zfish  1054 YYLTIARA-NQERAPAQCVPSPEEFDQSSLDEGICSDSISSLDPPDVSDVSRLVRRHVPEAEFLE 1117

  Fly   799 DIGYKVTFVL------ENKFEDQFPMLIDDLEENMQQLGVVSFRIRDTSMEEIFLRFGCEDNDQS 857
            .:|.::.:||      ...|...|..|  |||:|  .|||.|:.|.|||:|||||:..   .|..
Zfish  1118 AVGQELVYVLPYSGATNGSFATLFKEL--DLEKN--TLGVTSYGISDTSLEEIFLKVA---EDTG 1175

  Fly   858 GAFQSHE--------NAQVLLEEYYSTLAE---------------------------ANEKGRR- 886
            ...:||:        ::::..::..|:..|                           ||.||..
Zfish  1176 VDVESHDKPKQKPRSSSRISGKQSISSALECRDAKTVKNEAKVRFASRVEDTHRPMCANGKGSDV 1240

  Fly   887 -TGWKLFFLHGRAVIYKRWIAAHRHWIVLIFEVLAMALVAVC---TFSSI---FIYGKNYELEPL 944
             .||.|......|:..||:..|.|....:|.:|: |....||   .||.|   |....:.||:|.
Zfish  1241 INGWSLIRQQFLALFIKRFHHARRSRKGIIAQVV-MPAFFVCLALIFSLIVPPFNEYPSLELQPW 1304

  Fly   945 TFNLSQLHTVDAF-------VELFS--------------EEEDVKDMHAYYTELLYWY----DAH 984
            .:...| :|..:|       ||..:              ....:..:....|....|:    |..
Zfish  1305 MYGAPQ-NTFYSFDGPGVVQVEKVTNALLNSPGFGTRCMSTNPIPRLPCVSTGSTNWFTPAVDPS 1368

  Fly   985 VATL-----------------------------------------TKN----------------- 991
            ::.:                                         |:|
Zfish  1369 ISDIFDKGNWTMQNPSPACQCSTAERSFMLPDCPPGAGGLPPPQRTQNTTDTLQNVTGRNMTDFL 1433

  Fly   992 ----------RHNAYAL--------LTQNQFTAHVNS-RYIFGAT-FDQK--------------- 1021
                      |:..:::        |.::..|..|:. |.:|..: |.|.
Zfish  1434 LKTYQKSGKIRYGGFSVGGVNSQVRLNESDITTLVSDLRSVFNVSQFKQSEDIFQAIRLFLLELG 1498

  Fly  1022 ---IVTAWFNNIPLHSAPYALNVVHNAVARHLF-----DEEATIDVTLAPLPF-RTAINTFPPSS 1077
               .:..||.|...||....|||..|...|...     .|:..|.....||.. |..::|...:|
Zfish  1499 TRDNMKVWFYNPGWHSLVSFLNVASNGALRGNLPAGRRPEDYGITTFNHPLNLTREQLSTAALAS 1563

  Fly  1078 HTFGGCLAFGICFVLTFIWPAFAIYMITERGSLLKKQQFLAGVRVCSYWTFTVLYDLLFLLIFCA 1142
            .:....:|..:.|.::||..:|.:::|.||.:..|..||::||....||.....:|:...::.|.
Zfish  1564 SSTDVVVAICVIFAMSFIPASFVLFLIQERVTKAKHLQFVSGVNPTIYWLANFAWDMCNYIVPCV 1628

  Fly  1143 CVVVMVALYEN------PNHDVM-----LYGYISVTLMLGGFWVILLAYLMASLCRNPCYGFLWL 1196
            .|:::...::.      ||...:     |||: |:|.|:                    |.|.::
Zfish  1629 IVIIIFLCFQQKSYVSPPNLPALILLLALYGW-SITPMM--------------------YPFSFV 1672

  Fly  1197 CGINS---IGLVCFSQFYRTHPESMLLEPTFMAMYTVATVICKLFMIYEFKLICMDPVVNFTSVE 1258
            ..:.|   :.|.|.:.|...:.             :|||.:.:||         .||  |.|.:.
Zfish  1673 FSVPSTAYVVLTCINLFIGING-------------SVATFVMELF---------DDP--NITRIN 1713

  Fly  1259 --------VFKCNSIPNCCI-------KSNYGTFTAGIYH------------------DLVILTL 1290
                    ||     |:.|:       ..|....|  :|.                  :|..:::
Zfish  1714 DIVKQALLVF-----PHFCLGRGLMDMAKNQAVAT--LYQNLGEDRFVNPLTWNMVGKNLFAMSI 1771

  Fly  1291 LDIILLACLFVSEYHSILGFADCRLDTRTNESPDSNQESRAFPGILSNDTAALVDKEHTSRLNEE 1355
            ...::.|...:.:|...     |:  .|:.:||               .|::..:.|..:|  |.
Zfish  1772 QGAVMFAVTLLIQYKFF-----CK--PRSVKSP---------------FTSSAEEDEDVAR--ER 1812

  Fly  1356 ERSKYAAVGIGIVSKYRRNRVLRDLDFTLAKSECLSITGANNSGKTTLLKVVVNETKMNAG--QL 1418
            ||         :.:...:..:|...|.|....            |..:|.||:::|..|.|  ..
Zfish  1813 ER---------VYNGGAQKDLLHICDLTKVLL------------KNPVLAVVLDQTLENTGFSSA 1856

  Fly  1419 WIHDYSVNTHRVQCYRMVGYCPQKD---SLPSEFTPRELLYIHAMLQGHRHRIGRELSEALLRLV 1480
            .|.::..|.            |:.:   .:|| |..|.:  .:|..|. ..::.:.|...|..|.
Zfish  1857 VISNFLFNG------------PESERPAGMPS-FDWRNV--FNATSQS-AQQLTQILKVCLHLLK 1905

  Fly  1481 GLTPCWNRSVRMCTTGQIRRLYFAYAVLGSPDLICVDGVPAGLDPTGKRIILMMTSTMQAMG 1542
            |:|..|:.:.|......:|.:...:..|              .|...:.||.:.|...|.:|
Zfish  1906 GVTKSWSPTARDNPLNDLRYVRGGFVYL--------------QDMVDRAIIKLQTGVQQTLG 1953

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1494	NP_001259763.1	ABC2_membrane_3	<263..480	CDD:289468	41/236 (17%)
		CcmA	541..848	CDD:224054	103/358 (29%)
		ABC_subfamily_A	541..761	CDD:213230	70/231 (30%)
		ABC2_membrane_3	911..>1189	CDD:289468	73/421 (17%)
		ABC2_membrane	<1080..>1188	CDD:304374	26/118 (22%)
		ABC_subfamily_A	1370..1577	CDD:213230	34/178 (19%)
		PRK14255	1371..1586	CDD:172743	34/177 (19%)
LOC101883122	XP_021333309.1	AAA	1..1833	CDD:333001	319/1588 (20%)
LOC101883122	XP_021333309.1	AAA	1835..>2372	CDD:333001	31/161 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010