DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1494 and abca12

DIOPT Version :9

Sequence 1:	NP_001259763.1	Gene:	CG1494 / 33102	FlyBaseID:	FBgn0031169	Length:	1695	Species:	Drosophila melanogaster
Sequence 2:	XP_031748843.1	Gene:	abca12 / 101731410	XenbaseID:	XB-GENE-6041943	Length:	7516	Species:	Xenopus tropicalis

Alignment Length:	1899	Identity:	408/1899 - (21%)
Similarity:	762/1899 - (40%)	Gaps:	389/1899 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LLMNWKNHKLQLANPL-----ELLVILLVPPLFTLVAVLMRFFIPVN--HRSDTVYDPIDLDRSW 68
            ||..|  .|||.|..|     |||...::..:.|       .|:..|  |.::|:...:::....
Frog  5769 LLNQW--DKLQQAGTLIGRLQELLNNSVIDNILT-------NFLNTNASHINNTINSALNIINLL 5824

  Fly    69 MQMVEKLEKARQVADTYNVKGNPFTPHLVIGWAPKRYGIFQAMMRRVQKQIEPMTSVGFEDCEEM 133
            ...:..:::.:.:|...|                   .:...|   ...:|:||.||     |||
Frog  5825 NTNINNIQQFQPIATVIN-------------------NLLSCM---TYNRIQPMNSV-----EEM 5862

  Fly   134 RESVIE----NGLFAGLCFDGSPFVEDQVFEEDTLESYS--NIQPMLNYTILLPSELRMLDGDFR 192
            :...:|    |.|||.:.||        :..|.|.:|.:  |:...:.|||.:...|.......|
Frog  5863 QAKAVELQNNNKLFAAVAFD--------LPSETTGQSKASFNLPKQIKYTISMEPVLSEDTNIIR 5919

  Fly   193 MANWMTLYNDDPNTFVLTRLNQPYEGGFVGYVREGFIRLQKSVSESFLVLTSHKSLPTI--QIRR 255
            .:.|                 .|.....:.....||:.||:::..:.:.:.::||:..:  |.:.
Frog  5920 KSYW-----------------TPVPASSLNKYSRGFVYLQENIDRAIIEMQTNKSVANVGLQYQS 5967

  Fly   256 FPITGREQDPLMGNLNYGMPFIIIIGFLFPAQLFVWQVVSEKQSQVRQFLINMNIGNLIHFVSWY 320
            .|....::|..:.::.|.:|..::|.::.....||.::|.||:.::.:::..|.:.:..||.:|:
Frog  5968 VPFPCYKRDRFLASMGYTLPIALMITWVLFISAFVKKIVHEKEMRLHEYMRMMGVNSSSHFCAWF 6032

  Fly   321 LKGLIYEMISSLIIAALLKIRWDQDHGVLTQTPWYILILVLFCYNCAAVAFAIMVAAFFRNALNA 385
            ::...:.:|:..|:..|||.     ..:|..:..:||.|:...|:...:|.:.:::.||.|...|
Frog  6033 IESASFLLITVSILVLLLKF-----GQILPSSNGFILFLLFLDYSLTIIAMSYLISVFFHNTNVA 6092

  Fly   386 VRVLTILWIMSYVPTFILSNNLEGNIHALRYVSYAL-----PNVVATLVIEFLIERESIVHITWE 445
            ....::::|:::.|..:::....    .|.:.:..|     |..::..:...:...|..|.|.|.
Frog  6093 GLSGSLIYIITFFPFIVIATKSS----VLSFSAKTLLCIFSPTALSNAIQYVVYYEEQSVGIQWS 6153

  Fly   446 DSGYRLNYDGGHITVTASSWIFMLNALVYCAIGLYVDMWRGGDRS------------------GK 492
            :. |.....|..:|.....|:..::|::|..:|.|:.|...|...                  |.
Frog  6154 NM-YISPLLGDSMTFGWLCWLLFIDAMIYFLVGFYIRMVFPGKYGIPAPWYFPFQMSFWLKCCGL 6217

  Fly   493 KMKKPNTNAS------VQEDPYHERGDSFTHQGQAIGVNSTKIYEVEPSHRRFKLKIKKLCKRFA 551
            :..:|..::.      :.::.||::|    .:.....:|     |.||:.....:.:..|.|.|
Frog  6218 ESLRPTKSSGLTFTNIMADNIYHKKG----AENDLCSLN-----EQEPNDLTVGVSLHGLTKVF- 6272

  Fly   552 TNDRPALNLFSWNVYENEVTVLMGHNGCGKSTLLKILAGLVEPSRGTVMISSHNIQTERKAASME 616
             ..:.|:|..:.|.||..:|.|:||||.||:|.|.:|.||...|.||:.:...:|:|....|...
Frog  6273 -QSKTAVNNLNLNFYEGHITALLGHNGAGKTTTLSMLTGLFGASSGTIYVYGDDIRTNLDRARSN 6336

  Fly   617 LGIAFGHDMLLTGFTVIDYLRFICRVKGLH-----------NNIEIDGQSNYFLNVLQI--GGLK 668
            :|:...:|:.....|..::|.....:|..|           .|::..|..|:....::.  ||:|
Frog  6337 MGVCMQYDVHFDHLTTKEHLLLYGSIKAPHWTRAHLHIEVKRNLKDTGLYNHRHKPVKALSGGMK 6401

  Fly   669 TKRIRTLTDRDLCLVSICCAFVGNSPIILIDDVHSDLDKRTQSLVWNLINEEKSKRTIILVSNSP 733
            .|            :|||.|.:|.|.::::|:..:.:|..::..:|.:|:::|..:||||.::..
Frog  6402 RK------------LSICIALIGGSKVVILDEPTTGVDPCSRRSIWEVISKQKKDKTIILSTHHL 6454

  Fly   734 ALAENIADRMAIMSNGELKCTGTKPFLKNMYGHGYRLTCVKG-KNYKRDE------LFGMMNSYM 791
            ..||.::||:|.:..|.|||.||..:||..:|.||.||..|. .|.:..|      :..::.|::
Frog  6455 DEAEVLSDRIAFLEQGGLKCCGTPLYLKQKFGSGYHLTLTKKFPNRENQEECDVELVTDLIKSHI 6519

  Fly   792 PNMSIERDIGYKVTFVLEN---KFEDQFPMLIDDLEENMQQLGVVSFRIRDTSMEEIFLRFG--- 850
            |...::.|:|.::.::|.:   :....:..|:..|:..|..|.:..:.|.||::||:||:..
Frog  6520 PEACLKEDVGGELVYLLPSFNAEISGAYLSLLQALDSRMNDLHIGCYGISDTTIEEVFLKLTDNL 6584

  Fly   851 CEDNDQSGAFQS-------------HENAQVLLEEYYSTLAE----ANEKGRRTGWKLFFLHGRA 898
            .||...:.|:.|             |...::.|..|..|..:    .||: :.||..|......|
Frog  6585 DEDEQDAMAWSSTKTVVPIPNEENLHVQDELSLTNYRFTDRDDQPLTNEE-KLTGVSLLLKKIMA 6648

  Fly   899 VIYKRWIAAHRHW--------IVLIFEVLAMALVAVCTFSSIF--------IYGKNYELEPL-TF 946
            :..||:..:.|:|        :.::|.|:||.|.::.:.:..|        :||.:.:.... .:
Frog  6649 IFIKRFHNSRRNWKGLISQVLLPVLFVVIAMGLGSLSSSAVSFPELLLTPDLYGTSSQSVAFGLY 6713

  Fly   947 NLSQLHTVDAF----------------------VELFSEEED--------------VKD------ 969
            |.|..:.|.|.                      :.|::.:..              |.|
Frog  6714 NESSSNLVSAMNSFPGIDNSCLNQNSNCLSQNGLGLWTSDNQSLSYGSCNCSTGAPVCDASSAAP 6778

  Fly   970 --MHAYYTELLYWYDAHVATLTKNRHNAYALLTQNQFTAHVNSRY---IFGATF----------- 1018
              ...:..::||       .::.....:|.|.|..||   :..||   .||..:
Frog  6779 PHRRTFSEQMLY-------NVSGYNMESYLLTTNLQF---IQKRYGGWSFGIPWVSSKLETLVPQ 6833

  Fly  1019 --DQKIVTAWFNNIPLHSAPYALNVVHNAVAR-HLFDEEA---TIDVTLAPLPFR--------TA 1069
              :..|...||||...||.|..:|...|.:.| :|...|:   :|.|...||...        |.
Frog  6834 NPNMTISKVWFNNDGPHSLPAFINSFSNFLLRTNLPSNESDQYSISVASKPLSGTVIQTSTTVTL 6898

  Fly  1070 INTFPPSSHTFGGCLAFGICFVLTFIWPAFAIYMITERGSLLKKQQFLAGVRVCSYWTFTVLYDL 1134
            :||.      ...|:..|......    :||.|::.|..|..|:.|.:|||....||....:||.
Frog  6899 VNTL------IALCVLAGYSITTA----SFATYVVKEHHSGAKRLQHIAGVGETCYWVTNFIYDS 6953

  Fly  1135 LFLLIFCACVVVMVALYENPN-HDVMLYGYISVTLMLGGFWVILLAYLMASLCRNPCYGFLWLCG 1198
            :..||..:..:..:|:::.|. :|....|.:|:..:|.||......||:|...::|...|:....
Frog  6954 IIYLIPVSLSLATIAIFKLPAFYDYPNLGAMSLLFILFGFATFSWMYLLAGTFKSPGNAFITYVS 7018

  Fly  1199 IN---------SIGLVCFSQFYRTHPES--MLLEPTFMAMYTVATVICKLF----------MIYE 1242
            ||         |..:|.|....|:..:|  ..|..|    |||.|.:.|:|          |:.:
Frog  7019 INLFIGINTIISTSVVYFLYVQRSPSDSDYQSLNQT----YTVLTDVFKIFPQFCFGYGMIMLSQ 7079

  Fly  1243 FKLICMDPVV-------NFTSVEVFKCNSIPNCCIKSNYGTFTAGIYHDLVILTLLDIILLACLF 1300
            .:.:.|...:       |..|:::... .:....|:..:......:.:|.:|.:....:...|:
Frog  7080 QQALQMQSAIYGGTSTTNIFSMDILGW-MLSAMAIQGAFCFLLRLLINDGIIFSFKSFVKRNCM- 7142

  Fly  1301 VSEYHSILGFADCRLDTRT-NESPDSNQESRAFPGILSNDTAALVDKEHTSRLNEEERSKYAAVG 1364
             ..|..:....:...|.|. .|..||.|   |.|.:|.......|               |..||
Frog  7143 -KSYLVVTKNPEEDEDVRAERERVDSGQ---ADPDLLQLQGLTKV---------------YHHVG 7188

  Fly  1365 IGIVSKYRRNRVLRDLDFTLAKSECLSITGANNSGKTTLLKVVVNETKMNAGQLWIHDYSVNTHR 1429
            ..:|:       :.::..::...||..:.|.|.:||||..|::..:...:.|.:.:.:.:.|...
Frog  7189 KNMVA-------VNNMTLSIPAGECFGLLGVNGAGKTTTFKMLTGDVAPSKGNIQVRNNAGNLEN 7246

  Fly  1430 VQCYR----MVGYCPQKDSLPSEFTPRELLYIHAMLQGHRHRIGRELSEALLRLVGLTPCWNRSV 1490
            |..:.    ..|||||:|:|....|..|.||.:|.|.|...:..:.:|.:||:.:.|....:|:.
Frog  7247 VLGFNTDWSAFGYCPQEDALDELLTGEEHLYFYARLHGIPEKKIKAVSFSLLQKLQLVQYKDRTT 7311

  Fly  1491 RMCTTGQIRRLYFAYAVLGSPDLICVDGVPAGLDPTGKRIILMMTSTMQAMGSSFLYTMLTGLDA 1555
            ...:.|..|:|..|.|::|.|.::.:|...:|:||..||.:..:.|.......:.:.|..:..:.
Frog  7312 AAYSCGTRRKLSTALALIGRPSILLLDEPSSGMDPKTKRHLWKIISEEVKEKCAVVLTSHSMEEC 7376

  Fly  1556 ERLSLRTPLLLEGQLWMIRPMDTETENYKSGYQLEVRFKRKVNPNVSMSRATWNLINHFPMSPNK 1620
            |.|..|..::::|:...|..:......:.||:.:::..|   :.:|::...|..:..|||.:..|
Frog  7377 EALCTRLAIMVKGKFQCIGSLQHIKSRFGSGFTVKMHLK---DSSVNVEALTSFMCRHFPNTYLK 7438

  Fly  1621 -KFSAFMEIKFPDA---------VLTIERDDSMVFVLPLGTTTFSEIFLT--------------- 1660
             :....:|...|..         :|...:.|..:....:..||..|:|:.
Frog  7439 DQHFTMVEYHVPVTAGGVAGIFDLLEANKSDLDIIHFSVSQTTLDEVFINFAQSQVSPDNSSVNS 7503

  Fly  1661 --LRKDAFEMNIED 1672
              |:::||.  |||
Frog  7504 QELQQNAFV--IED 7515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1494	NP_001259763.1	ABC2_membrane_3	<263..480	CDD:289468	44/221 (20%)
		CcmA	541..848	CDD:224054	91/329 (28%)
		ABC_subfamily_A	541..761	CDD:213230	66/232 (28%)
		ABC2_membrane_3	911..>1189	CDD:289468	76/367 (21%)
		ABC2_membrane	<1080..>1188	CDD:304374	29/108 (27%)
		ABC_subfamily_A	1370..1577	CDD:213230	51/210 (24%)
		PRK14255	1371..1586	CDD:172743	51/218 (23%)
abca12	XP_031748843.1	rim_protein	4..>82	CDD:130324
abca12	XP_031748843.1	rim_protein	5675..7493	CDD:130324	402/1873 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010